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B4HEM4

- PDE6_DROSE

UniProt

B4HEM4 - PDE6_DROSE

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Protein

cGMP-specific 3',5'-cyclic phosphodiesterase

Gene
Pde6, GM25848
Organism
Drosophila sechellia (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Has a role regulating cGMP transport in Malpighian tubule principal cells By similarity.By similarity

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

Cofactori

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei730 – 7301Proton donor By similarity
Metal bindingi734 – 7341Divalent metal cation 1 By similarity
Metal bindingi770 – 7701Divalent metal cation 1 By similarity
Metal bindingi771 – 7711Divalent metal cation 1 By similarity
Metal bindingi771 – 7711Divalent metal cation 2 By similarity
Metal bindingi956 – 9561Divalent metal cation 1 By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cGMP metabolic process Source: UniProtKB
  2. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cGMP-specific 3',5'-cyclic phosphodiesterase (EC:3.1.4.35)
Gene namesi
Name:Pde6
ORF Names:GM25848
OrganismiDrosophila sechellia (Fruit fly)
Taxonomic identifieri7238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000001292: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0180704. Dsec\GM25848.

Subcellular locationi

Cell membrane; Lipid-anchor; Cytoplasmic side By similarity By similarity

GO - Cellular componenti

  1. membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12021202cGMP-specific 3',5'-cyclic phosphodiesteraseBy similarityPRO_0000363696Add
BLAST
Propeptidei1203 – 12053Removed in mature form By similarityBy similarityPRO_0000363697

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1202 – 12021Cysteine methyl ester By similarityBy similarity
Lipidationi1202 – 12021S-farnesyl cysteine By similarityBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Interactioni

Subunit structurei

Interacts with PrBP By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliB4HEM4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini259 – 411153GAF 1Add
BLAST
Domaini443 – 624182GAF 2Add
BLAST

Sequence similaritiesi

Contains 2 GAF domains.

Keywords - Domaini

Repeat

Phylogenomic databases

KOiK13763.
OrthoDBiEOG7RRF69.
PhylomeDBiB4HEM4.

Family and domain databases

Gene3Di1.10.1300.10. 2 hits.
3.30.450.40. 3 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 2 hits.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 3 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B4HEM4-1 [UniParc]FASTAAdd to Basket

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MTDVSSPAGG AASPVEMTTS SSPAATTSAS SSKPLTNGAN KTTISTTAGG     50
VAPGDVPGTG SGAIPASSSS GNQVKLEHHH RQSNNNRPAA TNRSSETKLR 100
SPAGESDGAS RLMTPAGSSS SPSQSPSQTQ ASIQTQTSQQ DRLTKASTTA 150
SQQDVDEVAR LFEEKPEAFE KWLTERAPPE ALSRLQEFIE NRKPHKRPSV 200
TSDLFQQWMA ASPTVQQKSP RSLSNSSASS LPECRRHLMD LDEGELFMEL 250
IRDVANELDI DVLCHKILVN VGLLTHADRG SLFLAKGTPT NKYLVAKLFD 300
VTQKTALKDA VARASAEEII IPFGIGIAGM VAQTKQMINI KEAYKDARFN 350
CEIDLKTGYK TNAILCMPIC NYEGDIIGVA QIINKTNGCM EFDEHDVEIF 400
RRYLTFCGIG IQNAQLFEMS VQEYRRNQIL LNLARSIFEE QNNLECLVTK 450
IMTEARELLK CERCSVFLVD LDCCEASHLE KIIEKPNQPA TRAIKSADSF 500
EEKKMRNRFT VLFELGGEYQ AANVSRPSVS ELSSSTLAQI AQFVATTGQT 550
VNICDVIEWV RDHNQIRAED EIDSTQAILC MPIMNAQKKV IGVAQLINKA 600
NGVPFTDSDA SIFEAFAIFC GLGIHNTQMY ENACKLMAKQ KVALECLSYH 650
ATASQDQTEK LTQDVIAEAE SYNLYSFTFT DFELVDDDTC RAVLRMFMQC 700
NLVSQFQIPY DVLCRWVLSV RKNYRPVKYH NWRHALNVAQ TMFAMLKTGK 750
MERFMTDLEI LGLLVACLCH DLDHRGTNNA FQTKTESPLA ILYTTSTMEH 800
HHFDQCVMIL NSEGNNIFQT GFAGLGAGTF GSGRGTGGGS NSNFPGDRVL 850
QIARRTIFFF VPELDAEDDV VDSVVDSVVE LSVVVLVLDS VLVAALSPED 900
YRSVMKTVES AILSTDLAMY FKKRNAFLEL VENGEFDWQG EEKKDLLCGM 950
MMTACDVSAI AKPWEVQHKV AKLVADEFFD QGDLEKLQLN TQPVAMMDRE 1000
RKDELPKMQV GFIDVICLPL YRVLCDTFPW ITPLYEGTLE NRRNWQDLAE 1050
KVEMGLTWID HDTIDKPVEE FAACADEEIK DIEFTVTTLN CNQQSQHGSE 1100
DSHTPEHQRS GSRLSMKKTG ALGKAVRSKL SKTLYNSMDG SKPKTSLKLL 1150
ESHVSEDMDD KSPTSPSQPQ ASGSMGRMSA SSSTSSAGGQ MVDKSKKRSK 1200
LCALL 1205
Length:1,205
Mass (Da):133,207
Last modified:September 23, 2008 - v1
Checksum:iA2D9562B2022719C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH480815 Genomic DNA. Translation: EDW42181.1.
RefSeqiXP_002031195.1. XM_002031159.1.

Genome annotation databases

EnsemblMetazoaiFBtr0208833; FBpp0207325; FBgn0180704.
GeneIDi6606390.
KEGGidse:Dsec_GM25848.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH480815 Genomic DNA. Translation: EDW42181.1 .
RefSeqi XP_002031195.1. XM_002031159.1.

3D structure databases

ProteinModelPortali B4HEM4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0208833 ; FBpp0207325 ; FBgn0180704 .
GeneIDi 6606390.
KEGGi dse:Dsec_GM25848.

Organism-specific databases

FlyBasei FBgn0180704. Dsec\GM25848.

Phylogenomic databases

KOi K13763.
OrthoDBi EOG7RRF69.
PhylomeDBi B4HEM4.

Family and domain databases

Gene3Di 1.10.1300.10. 2 hits.
3.30.450.40. 3 hits.
InterProi IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF01590. GAF. 2 hits.
PF00233. PDEase_I. 2 hits.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view ]
SUPFAMi SSF55781. SSF55781. 3 hits.
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rob3c / Tucson 14021-0248.25.

Entry informationi

Entry nameiPDE6_DROSE
AccessioniPrimary (citable) accession number: B4HEM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi