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B4HCY7

- B4HCY7_DROPE

UniProt

B4HCY7 - B4HCY7_DROPE

Protein

Histone deacetylase

Gene

Rpd3

Organism
Drosophila persimilis (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

    GO - Molecular functioni

    1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
    Gene namesi
    Name:Rpd3Imported
    Synonyms:Dper\GL22935Imported
    ORF Names:Dper_GL22935Imported, GL22935Imported
    OrganismiDrosophila persimilis (Fruit fly)Imported
    Taxonomic identifieri7234 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000008744: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0160525. Dper\Rpd3.

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliB4HCY7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    KOiK06067.
    OrthoDBiEOG7DNNTW.
    PhylomeDBiB4HCY7.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSiPR01270. HDASUPER.
    PR01271. HISDACETLASE.

    Sequencei

    Sequence statusi: Complete.

    B4HCY7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQSHSKKRVC YYYDSDIGNY YYGQGHPMKP HRIRMTHNLL LNYGLYRKME    50
    IYRPHKATDD EMTKFHSDEY VRFLRSIRPE NMTEYKKQMQ RFNVGEDCPV 100
    FDGLYEFCQL SAGGSVAAAV KLNKQASEIC INWGGGLHHA KKSEASGFCY 150
    VNDIVLGILE LLKYHQRVLY IDIDVHHGDG VEEAFYTADR VMTVSFHKYG 200
    EYFPGTGDLR DIGAGKGKYY AVNIPLRDGM DDDAYESIFV PIISKVMETF 250
    QPAAVVLQCG ADSLTGDRLG CFNLTVKGHG KCVDFVKKYN LPFLMVGGGG 300
    YTIRNVSRCW TYETSVALAV DIANELPYNY YFEYFGPDFK LHISPSNMTN 350
    QNTSEYLEKI KNRLFENLRM LPHAPGVQIQ AIPEDAINDE SDDEDKVDKD 400
    DRLPQSDKDK RIVPENEYSD SEDEGEGGRR DNRAYKGQRQ RPRLDKDNNS 450
    NKASSEASSE IKDEKEKVDG ADGEESTASN ANSNSNNNSS SNNKSDNDSS 500
    APASRATTGG GSGSGSGSGS GAKTAKENNI 530
    Length:530
    Mass (Da):59,309
    Last modified:September 23, 2008 - v1
    Checksum:i82E7E0CE5F01317B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH479537 Genomic DNA. Translation: EDW33672.1.
    RefSeqiXP_002028716.1. XM_002028680.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0188550; FBpp0187042; FBgn0160525.
    GeneIDi6603751.
    KEGGidpe:Dper_GL22935.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH479537 Genomic DNA. Translation: EDW33672.1 .
    RefSeqi XP_002028716.1. XM_002028680.1.

    3D structure databases

    ProteinModelPortali B4HCY7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0188550 ; FBpp0187042 ; FBgn0160525 .
    GeneIDi 6603751.
    KEGGi dpe:Dper_GL22935.

    Organism-specific databases

    FlyBasei FBgn0160525. Dper\Rpd3.

    Phylogenomic databases

    KOi K06067.
    OrthoDBi EOG7DNNTW.
    PhylomeDBi B4HCY7.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSi PR01270. HDASUPER.
    PR01271. HISDACETLASE.
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MSH-3 / Tucson 14011-0111.49Imported.

    Entry informationi

    Entry nameiB4HCY7_DROPE
    AccessioniPrimary (citable) accession number: B4HCY7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 23, 2008
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3