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Protein

Histone deacetylase

Gene

Rpd3

Organism
Drosophila persimilis (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei97SubstrateUniRule annotation1
Active sitei139Proton acceptorUniRule annotation1
Binding sitei147Substrate; via carbonyl oxygenUniRule annotation1
Metal bindingi174Divalent metal cationUniRule annotation1
Metal bindingi176Divalent metal cationUniRule annotation1
Metal bindingi262Divalent metal cationUniRule annotation1
Binding sitei301SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
Name:Rpd3Imported
Synonyms:Dper\GL22935Imported
ORF Names:Dper_GL22935Imported, GL22935Imported
OrganismiDrosophila persimilis (Fruit fly)Imported
Taxonomic identifieri7234 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000008744 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0160525. Dper\Rpd3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliB4HCY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 316Hist_deacetylInterPro annotationAdd BLAST291

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

KOiK06067.
OMAiKRVCYFF.
OrthoDBiEOG091G067J.
PhylomeDBiB4HCY7.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
IPR037138. His_deacetylse_dom_sf.
IPR023696. Ureohydrolase_dom_sf.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.
SUPFAMiSSF52768. SSF52768. 1 hit.

Sequencei

Sequence statusi: Complete.

B4HCY7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSHSKKRVC YYYDSDIGNY YYGQGHPMKP HRIRMTHNLL LNYGLYRKME
60 70 80 90 100
IYRPHKATDD EMTKFHSDEY VRFLRSIRPE NMTEYKKQMQ RFNVGEDCPV
110 120 130 140 150
FDGLYEFCQL SAGGSVAAAV KLNKQASEIC INWGGGLHHA KKSEASGFCY
160 170 180 190 200
VNDIVLGILE LLKYHQRVLY IDIDVHHGDG VEEAFYTADR VMTVSFHKYG
210 220 230 240 250
EYFPGTGDLR DIGAGKGKYY AVNIPLRDGM DDDAYESIFV PIISKVMETF
260 270 280 290 300
QPAAVVLQCG ADSLTGDRLG CFNLTVKGHG KCVDFVKKYN LPFLMVGGGG
310 320 330 340 350
YTIRNVSRCW TYETSVALAV DIANELPYNY YFEYFGPDFK LHISPSNMTN
360 370 380 390 400
QNTSEYLEKI KNRLFENLRM LPHAPGVQIQ AIPEDAINDE SDDEDKVDKD
410 420 430 440 450
DRLPQSDKDK RIVPENEYSD SEDEGEGGRR DNRAYKGQRQ RPRLDKDNNS
460 470 480 490 500
NKASSEASSE IKDEKEKVDG ADGEESTASN ANSNSNNNSS SNNKSDNDSS
510 520 530
APASRATTGG GSGSGSGSGS GAKTAKENNI
Length:530
Mass (Da):59,309
Last modified:September 23, 2008 - v1
Checksum:i82E7E0CE5F01317B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH479537 Genomic DNA. Translation: EDW33672.1.
RefSeqiXP_002028716.1. XM_002028680.1.

Genome annotation databases

EnsemblMetazoaiFBtr0188550; FBpp0187042; FBgn0160525.
GeneIDi6603751.
KEGGidpe:Dper_GL22935.

Similar proteinsi

Entry informationi

Entry nameiB4HCY7_DROPE
AccessioniPrimary (citable) accession number: B4HCY7
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: November 22, 2017
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported