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B4H4I3

- TRMB_DROPE

UniProt

B4H4I3 - TRMB_DROPE

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

GL18335

Organism
Drosophila persimilis (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei70 – 701S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Binding sitei148 – 1481S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Active sitei151 – 1511UniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
  2. tRNA binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine, tRNA-binding

Enzyme and pathway databases

UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
ORF Names:GL18335
OrganismiDrosophila persimilis (Fruit fly)
Taxonomic identifieri7234 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000008744: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0155936. Dper\GL18335.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 247247tRNA (guanine-N(7)-)-methyltransferasePRO_0000370572Add
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni93 – 942S-adenosyl-L-methionine bindingUniRule annotation
Regioni128 – 1292S-adenosyl-L-methionine bindingUniRule annotation
Regioni226 – 2283S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

KOiK03439.
OrthoDBiEOG7PS1GC.
PhylomeDBiB4H4I3.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_03055. tRNA_methyltr_TrmB_euk.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4H4I3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVTTTPENEV LTSTSAVTGL PQKRYYRQRA HSNPIADHCF DYPARPEDVD
60 70 80 90 100
WRSLYPSIRA DQEVSFADIG CGYGGFLVTL GELFPEKISI GMEIRVKVSD
110 120 130 140 150
YVLDRITALR QKSSGTGAYQ NIACLRTNAM KYLPNYFRKG QLEKMFFLYP
160 170 180 190 200
DPHFKRAKHK WRIINQALLS EYAYVLRKGG LVYTMTDVED LHNWIVTHMD
210 220 230 240
EHPLYERLDE EEANTDPITP KLYQSSEEGA KVVRNKGDHF LAIFRRL
Length:247
Mass (Da):28,564
Last modified:September 23, 2008 - v1
Checksum:i57A11AE87FB0F0FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH479209 Genomic DNA. Translation: EDW32734.1.
RefSeqiXP_002025838.1. XM_002025802.1.

Genome annotation databases

EnsemblMetazoaiFBtr0183950; FBpp0182442; FBgn0155936.
GeneIDi6600770.
KEGGidpe:Dper_GL18335.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH479209 Genomic DNA. Translation: EDW32734.1 .
RefSeqi XP_002025838.1. XM_002025802.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0183950 ; FBpp0182442 ; FBgn0155936 .
GeneIDi 6600770.
KEGGi dpe:Dper_GL18335.

Organism-specific databases

FlyBasei FBgn0155936. Dper\GL18335.

Phylogenomic databases

KOi K03439.
OrthoDBi EOG7PS1GC.
PhylomeDBi B4H4I3.

Enzyme and pathway databases

UniPathwayi UPA00989 .

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_03055. tRNA_methyltr_TrmB_euk.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MSH-3 / Tucson 14011-0111.49.

Entry informationi

Entry nameiTRMB_DROPE
AccessioniPrimary (citable) accession number: B4H4I3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3