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B4H4I3

- TRMB_DROPE

UniProt

B4H4I3 - TRMB_DROPE

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
GL18335
Organism
Drosophila persimilis (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei70 – 701S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding sitei148 – 1481S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Active sitei151 – 1511 By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
  2. tRNA binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    RNA-binding, S-adenosyl-L-methionine, tRNA-binding

    Enzyme and pathway databases

    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferase
    tRNA(m7G46)-methyltransferase
    Gene namesi
    ORF Names:GL18335
    OrganismiDrosophila persimilis (Fruit fly)
    Taxonomic identifieri7234 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000008744: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0155936. Dper\GL18335.

    Subcellular locationi

    Nucleus By similarity UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 247247tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
    PRO_0000370572Add
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni93 – 942S-adenosyl-L-methionine binding By similarity
    Regioni128 – 1292S-adenosyl-L-methionine binding By similarity
    Regioni226 – 2283S-adenosyl-L-methionine binding By similarity

    Sequence similaritiesi

    Phylogenomic databases

    KOiK03439.
    OrthoDBiEOG7PS1GC.
    PhylomeDBiB4H4I3.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_03055. tRNA_methyltr_TrmB_euk.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR025763. Trm8_euk.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4H4I3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVTTTPENEV LTSTSAVTGL PQKRYYRQRA HSNPIADHCF DYPARPEDVD    50
    WRSLYPSIRA DQEVSFADIG CGYGGFLVTL GELFPEKISI GMEIRVKVSD 100
    YVLDRITALR QKSSGTGAYQ NIACLRTNAM KYLPNYFRKG QLEKMFFLYP 150
    DPHFKRAKHK WRIINQALLS EYAYVLRKGG LVYTMTDVED LHNWIVTHMD 200
    EHPLYERLDE EEANTDPITP KLYQSSEEGA KVVRNKGDHF LAIFRRL 247
    Length:247
    Mass (Da):28,564
    Last modified:September 23, 2008 - v1
    Checksum:i57A11AE87FB0F0FE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH479209 Genomic DNA. Translation: EDW32734.1.
    RefSeqiXP_002025838.1. XM_002025802.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0183950; FBpp0182442; FBgn0155936.
    GeneIDi6600770.
    KEGGidpe:Dper_GL18335.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH479209 Genomic DNA. Translation: EDW32734.1 .
    RefSeqi XP_002025838.1. XM_002025802.1.

    3D structure databases

    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0183950 ; FBpp0182442 ; FBgn0155936 .
    GeneIDi 6600770.
    KEGGi dpe:Dper_GL18335.

    Organism-specific databases

    FlyBasei FBgn0155936. Dper\GL18335.

    Phylogenomic databases

    KOi K03439.
    OrthoDBi EOG7PS1GC.
    PhylomeDBi B4H4I3.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_03055. tRNA_methyltr_TrmB_euk.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR025763. Trm8_euk.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MSH-3 / Tucson 14011-0111.49.

    Entry informationi

    Entry nameiTRMB_DROPE
    AccessioniPrimary (citable) accession number: B4H4I3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: September 23, 2008
    Last modified: July 9, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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