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Protein

Neuropathy target esterase sws

Gene

sws

Organism
Drosophila persimilis (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei977NucleophilePROSITE-ProRule annotation1
Active sitei1097Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi176 – 303cNMP 1Sequence analysisAdd BLAST128
Nucleotide bindingi474 – 601cNMP 2Sequence analysisAdd BLAST128
Nucleotide bindingi590 – 717cNMP 3Sequence analysisAdd BLAST128

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropathy target esterase swsBy similarity
Alternative name(s):
Swiss cheeseBy similarity (EC:3.1.1.5)
Gene namesi
Name:swsBy similarity
ORF Names:GL15243
OrganismiDrosophila persimilis (Fruit fly)
Taxonomic identifieri7234 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000008744 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0152847. Dper\GL15243.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity

  • Note: Sws tethers Pka-C3 to the membrane.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35LumenalSequence analysisAdd BLAST35
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Topological domaini57 – 1435CytoplasmicSequence analysisAdd BLAST1379

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003892241 – 1435Neuropathy target esterase swsAdd BLAST1435

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei443PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiB4H3U8.

Interactioni

Subunit structurei

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini944 – 1110PNPLAPROSITE-ProRule annotationAdd BLAST167

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi948 – 953GXGXXGPROSITE-ProRule annotation6
Motifi975 – 979GXSXGPROSITE-ProRule annotation5
Motifi1097 – 1099DGA/GPROSITE-ProRule annotation3

Sequence similaritiesi

Belongs to the NTE family.Sequence analysis
Contains 3 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 PNPLA (patatin-like phospholipase) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK14676.
OMAiCAQVGIL.
OrthoDBiEOG091G00XM.
PhylomeDBiB4H3U8.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
PS51635. PNPLA. 1 hit.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4H3U8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVLELLRVS GSNMYYSTFL ADAWCYYISN QITMTMYLYC ALGVLSMLFI
60 70 80 90 100
GWFVYFKRLA RLRLRHEIAR SLSAVTMASG GDLRGPRFRK RDKMLFYGRR
110 120 130 140 150
MLRKMKNVSG QMYSSGKGYK RRAVIRFARR ILQLRRENMP LEVRTVEPPA
160 170 180 190 200
EYLEETMEGS DRVPPDALYM LQSIRIFGHF EKPIFLRLCK HTQLLELMGG
210 220 230 240 250
DYLFKITDPD DSVYIVQSGM INVYISNADG STLSLKTVRK GESVTSLLSF
260 270 280 290 300
IDVLSGNPSY YKTVTAKAIE KSVVIRLPMA AFQEVFKDSP DVMIRVIQVI
310 320 330 340 350
MIRLQRVLFT ALRNYLGLNA ELVQNHMRFK GSSQGAGPSV YCSQTTRQAT
360 370 380 390 400
GSASATATAA AASGTAGSTH TAVPRPASSL SRYSQDEQHT LSDPNPGIPN
410 420 430 440 450
LELSGDSVNT LFGEVNGGAR LNSYPPLYHQ RESDGNLSTR RGSITQQEQP
460 470 480 490 500
EVGPVPSIDM RLVKSSAVDS LRKELGLPEQ DAHIIDPFVE VREMEPNVTL
510 520 530 540 550
ITEGNADDVC VWFVMTGTLA VYQGNADATR IKQDKTDLLI HYVHPGEIVG
560 570 580 590 600
GLAMLTGEAS AYTIRSRNHS RVAFIRRAAI YQIMRQRPRI VLDLGNGVVR
610 620 630 640 650
RLSPLVRQCD YALDWIFLES GRALYRQDES SDSTYIVLSG RMRSVITHPG
660 670 680 690 700
GKKEIVGEYG KGDLVGIVEM ITETSRTTTV MAVRDSELAK LPEGLFNAIK
710 720 730 740 750
LRYPIVVTKL ISFLSHRFLG SMQTRTTTGA PGAPVEANPV THKYSTVALV
760 770 780 790 800
PITDDVPLTP FTYELYHSLC AIGPVLRLTS DLARKQLGMN IFDASNEYRL
810 820 830 840 850
TSWLAQQEDR NIITLYQCDN ALSPWTQRCM RQADVVLIVG LGDHSHLVGK
860 870 880 890 900
FEREIDRLAL RTQKELVLLY PETASSKPAN TLSWLNARPW VTKHHHVLCV
910 920 930 940 950
KRIFTRKSQY RINDLYSRVL LSEPNMHSDF SRLARWLTGN SIGLVLGGGG
960 970 980 990 1000
ARGAAHIGML KAIQEAGIPI DMVGGVSIGA LMGALWCSER NITTVTQKAR
1010 1020 1030 1040 1050
EWSKKMTKWF LQLLDLTYPI TSMFSGREFN KTIHETFGDV NIEDLWIPYF
1060 1070 1080 1090 1100
TLTTDITASC HRIHTNGSLW RYVRSSMSLS GYMPPLCDPK DGHLLLDGGY
1110 1120 1130 1140 1150
VNNLPGHLWR YCRASMSIAG VFPPFCDYRD GHLLLDGCYT NNVPADVMHN
1160 1170 1180 1190 1200
LGAAHIIAID VGSQDDTDLT NYGDDLSGWW LLYKKWNPFT APVKVPDLPD
1210 1220 1230 1240 1250
IQSRLAYVSC VRQLEEVKNS DYCEYIRPLI NKYQTLSCAG CPETYGLNPS
1260 1270 1280 1290 1300
DLFSEDEDCD GYISEPTTLN TDVRRYQVPR GGNSLSLSET EMDMDSDVEM
1310 1320 1330 1340 1350
DLKMERKMDK ATQSTPPLQS KAQILRRKHS KEEARHEWEI KREQKQELAR
1360 1370 1380 1390 1400
EQELEREREL SQKGTTAGAT GYTPNAVIAT QTSLIFMDEE DEMDKKKTKD
1410 1420 1430
NDRDEVRGSA EDTGKEKEED KENRSNTNNE TKNYL
Length:1,435
Mass (Da):161,521
Last modified:September 23, 2008 - v1
Checksum:iEB711ED07D5D9BB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH479207 Genomic DNA. Translation: EDW31049.1.
RefSeqiXP_002025527.1. XM_002025491.1.

Genome annotation databases

EnsemblMetazoaiFBtr0180858; FBpp0179350; FBgn0152847.
GeneIDi6600422.
KEGGidpe:Dper_GL15243.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH479207 Genomic DNA. Translation: EDW31049.1.
RefSeqiXP_002025527.1. XM_002025491.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiB4H3U8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0180858; FBpp0179350; FBgn0152847.
GeneIDi6600422.
KEGGidpe:Dper_GL15243.

Organism-specific databases

FlyBaseiFBgn0152847. Dper\GL15243.

Phylogenomic databases

KOiK14676.
OMAiCAQVGIL.
OrthoDBiEOG091G00XM.
PhylomeDBiB4H3U8.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
PS51635. PNPLA. 1 hit.
PS01237. UPF0028. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSWS_DROPE
AccessioniPrimary (citable) accession number: B4H3U8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: September 23, 2008
Last modified: November 30, 2016
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.