SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B4H3U8

- SWS_DROPE

UniProt

B4H3U8 - SWS_DROPE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Neuropathy target esterase sws

Gene
sws, GL15243
Organism
Drosophila persimilis (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain By similarity.By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei977 – 9771 By similarityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi176 – 303128cNMP 1Add
BLAST
Nucleotide bindingi474 – 601128cNMP 2Add
BLAST
Nucleotide bindingi590 – 717128cNMP 3Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB

GO - Biological processi

  1. glial cell apoptotic process Source: UniProtKB
  2. membrane lipid metabolic process Source: UniProtKB
  3. membrane organization Source: UniProtKB
  4. nervous system development Source: UniProtKB-KW
  5. neuron apoptotic process Source: UniProtKB
  6. phosphatidylcholine metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase

Keywords - Biological processi

Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropathy target esterase sws
Alternative name(s):
Swiss cheese (EC:3.1.1.5)
Gene namesi
Name:sws
ORF Names:GL15243
OrganismiDrosophila persimilis (Fruit fly)
Taxonomic identifieri7234 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000008744: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0152847. Dper\GL15243.

Subcellular locationi

Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity
Note: Sws tethers Pka-C3 to the membrane By similarity.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535Lumenal Reviewed predictionAdd
BLAST
Transmembranei36 – 5621Helical; Reviewed predictionAdd
BLAST
Topological domaini57 – 14351379Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14351435Neuropathy target esterase swsPRO_0000389224Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei443 – 4431Phosphoserine By similarityBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiB4H3U8.

Interactioni

Subunit structurei

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws By similarity.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini944 – 1110167PatatinAdd
BLAST

Sequence similaritiesi

Belongs to the NTE family.
Contains 1 patatin domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK14676.
OrthoDBiEOG7QRQT1.
PhylomeDBiB4H3U8.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4H3U8-1 [UniParc]FASTAAdd to Basket

« Hide

MDVLELLRVS GSNMYYSTFL ADAWCYYISN QITMTMYLYC ALGVLSMLFI     50
GWFVYFKRLA RLRLRHEIAR SLSAVTMASG GDLRGPRFRK RDKMLFYGRR 100
MLRKMKNVSG QMYSSGKGYK RRAVIRFARR ILQLRRENMP LEVRTVEPPA 150
EYLEETMEGS DRVPPDALYM LQSIRIFGHF EKPIFLRLCK HTQLLELMGG 200
DYLFKITDPD DSVYIVQSGM INVYISNADG STLSLKTVRK GESVTSLLSF 250
IDVLSGNPSY YKTVTAKAIE KSVVIRLPMA AFQEVFKDSP DVMIRVIQVI 300
MIRLQRVLFT ALRNYLGLNA ELVQNHMRFK GSSQGAGPSV YCSQTTRQAT 350
GSASATATAA AASGTAGSTH TAVPRPASSL SRYSQDEQHT LSDPNPGIPN 400
LELSGDSVNT LFGEVNGGAR LNSYPPLYHQ RESDGNLSTR RGSITQQEQP 450
EVGPVPSIDM RLVKSSAVDS LRKELGLPEQ DAHIIDPFVE VREMEPNVTL 500
ITEGNADDVC VWFVMTGTLA VYQGNADATR IKQDKTDLLI HYVHPGEIVG 550
GLAMLTGEAS AYTIRSRNHS RVAFIRRAAI YQIMRQRPRI VLDLGNGVVR 600
RLSPLVRQCD YALDWIFLES GRALYRQDES SDSTYIVLSG RMRSVITHPG 650
GKKEIVGEYG KGDLVGIVEM ITETSRTTTV MAVRDSELAK LPEGLFNAIK 700
LRYPIVVTKL ISFLSHRFLG SMQTRTTTGA PGAPVEANPV THKYSTVALV 750
PITDDVPLTP FTYELYHSLC AIGPVLRLTS DLARKQLGMN IFDASNEYRL 800
TSWLAQQEDR NIITLYQCDN ALSPWTQRCM RQADVVLIVG LGDHSHLVGK 850
FEREIDRLAL RTQKELVLLY PETASSKPAN TLSWLNARPW VTKHHHVLCV 900
KRIFTRKSQY RINDLYSRVL LSEPNMHSDF SRLARWLTGN SIGLVLGGGG 950
ARGAAHIGML KAIQEAGIPI DMVGGVSIGA LMGALWCSER NITTVTQKAR 1000
EWSKKMTKWF LQLLDLTYPI TSMFSGREFN KTIHETFGDV NIEDLWIPYF 1050
TLTTDITASC HRIHTNGSLW RYVRSSMSLS GYMPPLCDPK DGHLLLDGGY 1100
VNNLPGHLWR YCRASMSIAG VFPPFCDYRD GHLLLDGCYT NNVPADVMHN 1150
LGAAHIIAID VGSQDDTDLT NYGDDLSGWW LLYKKWNPFT APVKVPDLPD 1200
IQSRLAYVSC VRQLEEVKNS DYCEYIRPLI NKYQTLSCAG CPETYGLNPS 1250
DLFSEDEDCD GYISEPTTLN TDVRRYQVPR GGNSLSLSET EMDMDSDVEM 1300
DLKMERKMDK ATQSTPPLQS KAQILRRKHS KEEARHEWEI KREQKQELAR 1350
EQELEREREL SQKGTTAGAT GYTPNAVIAT QTSLIFMDEE DEMDKKKTKD 1400
NDRDEVRGSA EDTGKEKEED KENRSNTNNE TKNYL 1435
Length:1,435
Mass (Da):161,521
Last modified:September 23, 2008 - v1
Checksum:iEB711ED07D5D9BB0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH479207 Genomic DNA. Translation: EDW31049.1.
RefSeqiXP_002025527.1. XM_002025491.1.

Genome annotation databases

EnsemblMetazoaiFBtr0180858; FBpp0179350; FBgn0152847.
GeneIDi6600422.
KEGGidpe:Dper_GL15243.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH479207 Genomic DNA. Translation: EDW31049.1 .
RefSeqi XP_002025527.1. XM_002025491.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi B4H3U8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0180858 ; FBpp0179350 ; FBgn0152847 .
GeneIDi 6600422.
KEGGi dpe:Dper_GL15243.

Organism-specific databases

FlyBasei FBgn0152847. Dper\GL15243.

Phylogenomic databases

KOi K14676.
OrthoDBi EOG7QRQT1.
PhylomeDBi B4H3U8.

Family and domain databases

Gene3Di 2.60.120.10. 3 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 3 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEi PS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MSH-3 / Tucson 14011-0111.49.

Entry informationi

Entry nameiSWS_DROPE
AccessioniPrimary (citable) accession number: B4H3U8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi