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Protein

Histone deacetylase

Gene

Dper\GL13309

Organism
Drosophila persimilis (Fruit fly)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi884ZincUniRule annotation1
Metal bindingi886ZincUniRule annotation1
Metal bindingi892ZincUniRule annotation1
Metal bindingi965ZincUniRule annotation1
Active sitei1017UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorSAAS annotation, HydrolaseSAAS annotation
Biological processTranscription, Transcription regulationSAAS annotation
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseSAAS annotation (EC:3.5.1.98SAAS annotation)
Gene namesi
Name:Dper\GL13309Imported
ORF Names:Dper_GL13309Imported, GL13309Imported
OrganismiDrosophila persimilis (Fruit fly)Imported
Taxonomic identifieri7234 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000008744 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0150915 Dper\GL13309

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliB4H3A6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini892 – 1198Hist_deacetylInterPro annotationAdd BLAST307

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili617 – 637Sequence analysisAdd BLAST21
Coiled coili830 – 858Sequence analysisAdd BLAST29

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

KOiK11406
OMAiKCECIRG
OrthoDBiEOG091G0EQO
PhylomeDBiB4H3A6

Family and domain databases

Gene3Di3.40.800.201 hit
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR017320 Histone_deAcase_II_euk
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 2 hits
PfamiView protein in Pfam
PF00850 Hist_deacetyl, 1 hit
PIRSFiPIRSF037911 HDAC_II_euk, 4 hits
PRINTSiPR01270 HDASUPER
SUPFAMiSSF52768 SSF52768, 1 hit

Sequencei

Sequence statusi: Complete.

B4H3A6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSPDDRIPI HDLPPEAGSD ERLLHIGPVP LTLDFKPHPA VDIDQQIMEL
60 70 80 90 100
KKSQELQKQR LIHSFQEKSK QMELEHKLQL EHKYQFAVHS HGAFQELREQ
110 120 130 140 150
TMVTAAAAAA AAVVEEHHRQ QQQQQQHHHH HHHQQQQQQQ QQQQQQQQQQ
160 170 180 190 200
HHHQQQREQQ QQRERREREV MKRKENCSAN ASPEVKQILN CFIMSRKSQA
210 220 230 240 250
AASNGTTTTS PYRNRGVVKS SSGESLPAGT VTSAHPYKIP QPPSSLLKYE
260 270 280 290 300
SDFPLRKTAS EPNLLKIRLK QSVIERKARN GGPAGARRHE RLLQAAQRRQ
310 320 330 340 350
QKNSVLTNSN STPDSGPNSP PSSTGLSVGV VGSRGSPTSA PIQEENEEGS
360 370 380 390 400
QYQPGQRSSI NDLPLFSSPS LPNISLGRPH LPNSAQVQAQ AQAQAQAQAQ
410 420 430 440 450
ASAQAQAQAQ ARATAMFAAL HQHVAAAGGQ PTYYNQLGMS FVGRQPTGPL
460 470 480 490 500
AMMPATGIAP QQPSPVVRSA SATSTSSSQA SLVGDVAPPQ AHAASTILPS
510 520 530 540 550
SSSYMQQLGG VTAGSAVNLH AAAVAAAAAA AAAAAGSLPP TNSHGHGHGY
560 570 580 590 600
GHGHGHGHGH GHGHGHALYG GHPHNTPITD AQVAQVHLHK QGHRPLGRTQ
610 620 630 640 650
SAPLPLGHPM LTGAGQLNVA QTHYENSEAE RQAYQHQVLT QKLRQTVLTR
660 670 680 690 700
SGAATAAGVR ESQLKEEEDD SAAEVMDLTD KKKPPKTVLT STIATSTSQS
710 720 730 740 750
LPEALAAAAA VYRTSPSAAT TPSAAVAGGS GTKVNSLQRD QEYLQQQREL
760 770 780 790 800
LLLQNNEELA KRLMRPLSRT LSSPLVPLGP HGLSQLADTG QWLGQQLPPI
810 820 830 840 850
ATSSSADHIP PVNLTLPHRQ HRQFMNHFYT ANLQHQRQQQ QQQQQQQQQQ
860 870 880 890 900
EQQHLQQTPP SASLPPHKIT TGLAYDPLML KHSCICGDNA QHPEHSGRLQ
910 920 930 940 950
SVWARLNETD LVKRCDRLRA RKATQEELQT VHTEAHAMLF GSNQCQLTRP
960 970 980 990 1000
KLETTLAASF VRLSCGGLGV DLDTTWNEHH TATAARMAAG CVIDLAFKTA
1010 1020 1030 1040 1050
KGDLRNGFAV VRPPGHHAEA NLAMGFCFFN SIAIAAKRLR QQMPEMRRIL
1060 1070 1080 1090 1100
IVDWDVHHGN GTQQAFYQSP DILYLSIHRH DDGNFFPGTG GPTECGSGAG
1110 1120 1130 1140 1150
LGFNVNISWS GALNPPLGDA EYIAAFRTVV MPIAKGFNPD IVLVSSGFDA
1160 1170 1180 1190 1200
ATGHPAPLGG YHVSPACFGF MTRELLQLAN GKVVLALEGG YDLAAICDSA
1210 1220 1230 1240 1250
QDPELERPPC QNAINTLQKT IAIQQTHWPC VRMLEHTVGL SALETLKVEH
1260 1270 1280
EESETINAMA GLSMQSMHRT LSRDDSEEPM DQDETK
Length:1,286
Mass (Da):139,549
Last modified:September 23, 2008 - v1
Checksum:i665A3F5CD8C5B73E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH479205 Genomic DNA Translation: EDW30799.1
RefSeqiXP_002025300.1, XM_002025264.1

Genome annotation databases

EnsemblMetazoaiFBtr0178924; FBpp0177416; FBgn0150915
GeneIDi6600200
KEGGidpe:Dper_GL13309

Similar proteinsi

Entry informationi

Entry nameiB4H3A6_DROPE
AccessioniPrimary (citable) accession number: B4H3A6
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: March 28, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported