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Protein

Serine/threonine-protein phosphatase Pgam5, mitochondrial

Gene

Pgam5

Organism
Drosophila persimilis (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. phosphoprotein phosphatase activity Source: UniProtKB

GO - Biological processi

  1. protein dephosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase Pgam5, mitochondrialBy similarity (EC:3.1.3.16)
Alternative name(s):
Phosphoglycerate mutase family member 5 homologBy similarity
Gene namesi
Name:Pgam5By similarity
ORF Names:GL20215
OrganismiDrosophila persimilis (Fruit fly)
Taxonomic identifieri7234 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000008744 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0157810. Dper\GL20215.

Subcellular locationi

  1. Mitochondrion outer membrane Sequence AnalysisBy similarity; Single-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2317HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Serine/threonine-protein phosphatase Pgam5, mitochondrialPRO_0000390707Add
BLAST

Interactioni

Subunit structurei

Interacts with Pk92B/ASK1.By similarity

Structurei

3D structure databases

ProteinModelPortaliB4GXS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK15637.
OrthoDBiEOG7966H1.
PhylomeDBiB4GXS1.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.

Sequencei

Sequence statusi: Complete.

B4GXS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKFTAFACG TGAGLLTFYL TKLNEPKAAV HNSWTRSEKP VDPCALWDHN
60 70 80 90 100
WDLRDPKSLV KPVKNDLSQE QNRYNTELEK VVPKHARHII LIRHGEYLDV
110 120 130 140 150
GDTDETHHLT ERGREQAKYT GKRLCELGIK WDKVIASTMV RAQETADIIL
160 170 180 190 200
NEIDYEKTKV KNCAFLREGA PIPPQPPVGH WKPEASQFFR DGARIEAAFR
210 220 230 240 250
RYFYRAYPDQ TKDSYTLLVG HGNVIRYFVC RALQFPPEAW LRISINHASI
260 270 280
TWLTISPSGN VSIKYLGDTG FMPVNHLTNR IPRAAKNVV
Length:289
Mass (Da):33,113
Last modified:September 23, 2008 - v1
Checksum:i4D179957B2D1BA3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH479196 Genomic DNA. Translation: EDW27548.1.
RefSeqiXP_002023400.1. XM_002023364.1.

Genome annotation databases

EnsemblMetazoaiFBtr0185830; FBpp0184322; FBgn0157810.
GeneIDi6598375.
KEGGidpe:Dper_GL20215.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH479196 Genomic DNA. Translation: EDW27548.1.
RefSeqiXP_002023400.1. XM_002023364.1.

3D structure databases

ProteinModelPortaliB4GXS1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0185830; FBpp0184322; FBgn0157810.
GeneIDi6598375.
KEGGidpe:Dper_GL20215.

Organism-specific databases

FlyBaseiFBgn0157810. Dper\GL20215.

Phylogenomic databases

KOiK15637.
OrthoDBiEOG7966H1.
PhylomeDBiB4GXS1.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MSH-3 / Tucson 14011-0111.49.

Entry informationi

Entry nameiPGAM5_DROPE
AccessioniPrimary (citable) accession number: B4GXS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: September 23, 2008
Last modified: January 7, 2015
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.