B4GRT8 (B4GRT8_DROPE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Malate dehydrogenase RuleBase RU003405
EC=1.1.1.37 RuleBase RU003405

Gene names

Name:	Dper\GL24873 EMBL EDW40473.1
ORF Names:	Dper_GL24873 EMBL EDW40473.1, GL24873 FlyBase FBgn0162461

Organism

Drosophila persimilis (Fruit fly) [Complete proteome]

Taxonomic identifier

7234 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › obscura group › pseudoobscura subgroup

Protein attributes

Sequence length	344 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-malate + NAD+ = oxaloacetate + NADH.
Sequence similarities	Belongs to the LDH/MDH superfamily. MDH type 1 family. RuleBase RU004065

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle RuleBase RU003405
Ligand	NAD RuleBase RU003405
Molecular function	Oxidoreductase RuleBase RU003405
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro malate metabolic process Inferred from electronic annotation. Source: InterPro tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	L-malate dehydrogenase activity Inferred from electronic annotation. Source: UniProtKB-EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B4GRT8 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 5CFBF66F33981F94	FASTA	344	36,759
	10 20 30 40 50 60 MARTAFKVAV VGAGGGIGQP LSLLLRQIEG IDELALHDLR GTKGVAADTG HISEQGTVSG 70 80 90 100 110 120 YVGNEQLVPA LQGANLVVVT AGMPRVPGMT RDSLMQANGG IAITVTRAMA CACPEALIAI 130 140 150 160 170 180 TTNPINIIVP TAAEVLKEAG VFNPRRLFGV TTLDVVRSRK FIGDHMNIDP EKVNIPVIGG 190 200 210 220 230 240 HTGPTILPLF SQCQPEFRGD TEDIERLTHR IKEAGTEVVM AKGGAGSATL SMAYATSSFV 250 260 270 280 290 300 KSLIRAHNGQ EGIWNALLWH HVWKMSPSSQ GPLELGKEGI KRXXXXXXXX XXXXXXXXXX 310 320 330 340 XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXF SLIL

References

[1]	"Evolution of genes and genomes on the Drosophila phylogeny." Drosophila 12 genomes consortium Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MSH-3 / Tucson 14011-0111.49.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH479188 Genomic DNA. Translation: EDW40473.1.
RefSeq	XP_002021317.1. XM_002021281.1.
3D structure databases
ProteinModelPortal	B4GRT8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6595805.
KEGG	dpe:Dper_GL24873.
Organism-specific databases
FlyBase	FBgn0162461. Dper\GL24873.
Phylogenomic databases
KO	K00026.
OrthoDB	EOG74R1R7.
Family and domain databases
Gene3D	3.40.50.720. 1 hit. 3.90.110.10. 1 hit.
InterPro	IPR001557. L-lactate/malate_DH. IPR022383. Lactate/malate_DH_C. IPR001236. Lactate/malate_DH_N. IPR015955. Lactate_DH/Glyco_Ohase_4_C. IPR001252. Malate_DH_AS. IPR010097. Malate_DH_type1. IPR016040. NAD(P)-bd_dom. [Graphical view]
PANTHER	PTHR11540. PTHR11540. 1 hit. PTHR11540:SF1. PTHR11540:SF1. 1 hit.
Pfam	PF02866. Ldh_1_C. 1 hit. PF00056. Ldh_1_N. 1 hit. [Graphical view]
PIRSF	PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAM	SSF56327. SSF56327. 1 hit.
TIGRFAMs	TIGR01772. MDH_euk_gproteo. 1 hit.
PROSITE	PS00068. MDH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B4GRT8_DROPE

Accession

Primary (citable) accession number: B4GRT8

Entry history

Integrated into UniProtKB/TrEMBL:	September 23, 2008
Last sequence update:	September 23, 2008
Last modified:	December 11, 2013
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)