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UniProtKB - B4GRT8 (B4GRT8_DROPE)

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Protein

Malate dehydrogenase

Gene

Dper\GL24873

Organism
Drosophila persimilis (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processTricarboxylic acid cycleUniRule annotation
LigandNADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:Dper\GL24873Imported
ORF Names:Dper_GL24873Imported, GL24873Imported
OrganismiDrosophila persimilis (Fruit fly)Imported
Taxonomic identifieri7234 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
Proteomesi
  • UP000008744 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0162461. Dper\GL24873.

Structurei

3D structure databases

ProteinModelPortaliB4GRT8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 149Ldh_1_NInterPro annotationAdd BLAST143
Domaini151 – 250Ldh_1_CInterPro annotationAdd BLAST100

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

KOiK00026.
OrthoDBiEOG091G0AVO.
PhylomeDBiB4GRT8.

Family and domain databases

InterProiView protein in InterPro
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiView protein in PROSITE
PS00068. MDH. 1 hit.

Sequencei

Sequence statusi: Complete.

B4GRT8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARTAFKVAV VGAGGGIGQP LSLLLRQIEG IDELALHDLR GTKGVAADTG 
        60         70         80         90        100
HISEQGTVSG YVGNEQLVPA LQGANLVVVT AGMPRVPGMT RDSLMQANGG 
       110        120        130        140        150
IAITVTRAMA CACPEALIAI TTNPINIIVP TAAEVLKEAG VFNPRRLFGV 
       160        170        180        190        200
TTLDVVRSRK FIGDHMNIDP EKVNIPVIGG HTGPTILPLF SQCQPEFRGD 
       210        220        230        240        250
TEDIERLTHR IKEAGTEVVM AKGGAGSATL SMAYATSSFV KSLIRAHNGQ 
       260        270        280        290        300
EGIWNALLWH HVWKMSPSSQ GPLELGKEGI KRXXXXXXXX XXXXXXXXXX 
       310        320        330        340 
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXF SLIL
Length:344
Mass (Da):36,759
Last modified:September 23, 2008 - v1
Checksum:i5CFBF66F33981F94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH479188 Genomic DNA. Translation: EDW40473.1.
RefSeqiXP_002021317.1. XM_002021281.1.

Genome annotation databases

EnsemblMetazoaiFBtr0190488; FBpp0188980; FBgn0162461.
GeneIDi6595805.
KEGGidpe:Dper_GL24873.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH479188 Genomic DNA. Translation: EDW40473.1.
RefSeqiXP_002021317.1. XM_002021281.1.

3D structure databases

ProteinModelPortaliB4GRT8.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0190488; FBpp0188980; FBgn0162461.
GeneIDi6595805.
KEGGidpe:Dper_GL24873.

Organism-specific databases

FlyBaseiFBgn0162461. Dper\GL24873.

Phylogenomic databases

KOiK00026.
OrthoDBiEOG091G0AVO.
PhylomeDBiB4GRT8.

Family and domain databases

InterProiView protein in InterPro
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiView protein in PROSITE
PS00068. MDH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB4GRT8_DROPE
AccessioniPrimary (citable) accession number: B4GRT8
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: June 7, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.