Dper\GL24873

Functionⁱ

Catalytic activityⁱ

(S)-malate + NAD⁺ = oxaloacetate + NADH.UniRule annotation

GO - Molecular functionⁱ

L-malate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processⁱ

cellular carbohydrate metabolic process Source: InterPro
malate metabolic process Source: InterPro
tricarboxylic acid cycle Source: UniProtKB-KW

Complete GO annotation...

Keywords - Molecular functionⁱ

OxidoreductaseUniRule annotation

Keywords - Biological processⁱ

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandⁱ

NADUniRule annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Malate dehydrogenaseUniRule annotation Automatic assertion according to rulesⁱ RuleBase:RU003405 (EC:1.1.1.37UniRule annotation Automatic assertion according to rulesⁱ RuleBase:RU003405 )
Gene namesⁱ	Name:Dper\GL24873Imported Automatic assertion inferred from database entriesⁱ EMBL:EDW40473.1 ORF Names:Dper_GL24873Imported Automatic assertion inferred from database entriesⁱ EMBL:EDW40473.1 , GL24873Imported Automatic assertion inferred from database entriesⁱ FlyBase:FBgn0162461
Organismⁱ	Drosophila persimilis (Fruit fly)Imported Automatic assertion inferred from database entriesⁱ Proteomes:UP000008744
Taxonomic identifierⁱ	7234 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › obscura group › pseudoobscura subgroup
Proteomesⁱ	UP000008744: Unassembled WGS sequence

Organism-specific databases

FlyBaseⁱ	FBgn0162461. Dper\GL24873.

FlyBaseⁱ

FBgn0162461. Dper\GL24873.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B4GRT8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the LDH/MDH superfamily. MDH type 1 family.UniRule annotation

Phylogenomic databases

KOⁱ	K00026.
OrthoDBⁱ	EOG74R1R7.
PhylomeDBⁱ	B4GRT8.

Family and domain databases

Gene3Dⁱ	3.40.50.720. 1 hit. 3.90.110.10. 1 hit.
InterProⁱ	IPR001557. L-lactate/malate_DH. IPR022383. Lactate/malate_DH_C. IPR001236. Lactate/malate_DH_N. IPR015955. Lactate_DH/Glyco_Ohase_4_C. IPR001252. Malate_DH_AS. IPR010097. Malate_DH_type1. IPR016040. NAD(P)-bd_dom. [Graphical view]
PANTHERⁱ	PTHR11540. PTHR11540. 1 hit.
Pfamⁱ	PF02866. Ldh_1_C. 1 hit. PF00056. Ldh_1_N. 1 hit. [Graphical view]
PIRSFⁱ	PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMⁱ	SSF56327. SSF56327. 1 hit.
TIGRFAMsⁱ	TIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEⁱ	PS00068. MDH. 1 hit. [Graphical view]

Sequenceⁱ

Sequence statusⁱ: Complete.

B4GRT8-1 [UniParc]FASTA Add to Basket

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        10         20         30         40         50
MARTAFKVAV VGAGGGIGQP LSLLLRQIEG IDELALHDLR GTKGVAADTG 
        60         70         80         90        100
HISEQGTVSG YVGNEQLVPA LQGANLVVVT AGMPRVPGMT RDSLMQANGG 
       110        120        130        140        150
IAITVTRAMA CACPEALIAI TTNPINIIVP TAAEVLKEAG VFNPRRLFGV 
       160        170        180        190        200
TTLDVVRSRK FIGDHMNIDP EKVNIPVIGG HTGPTILPLF SQCQPEFRGD 
       210        220        230        240        250
TEDIERLTHR IKEAGTEVVM AKGGAGSATL SMAYATSSFV KSLIRAHNGQ 
       260        270        280        290        300
EGIWNALLWH HVWKMSPSSQ GPLELGKEGI KRXXXXXXXX XXXXXXXXXX 
       310        320        330        340 
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXF SLIL

Length:344

Mass (Da):36,759

Last modified:September 23, 2008 - v1

Checksum:ⁱ5CFBF66F33981F94

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH479188 Genomic DNA. Translation: EDW40473.1.
RefSeqⁱ	XP_002021317.1. XM_002021281.1.

Genome annotation databases

GeneIDⁱ	6595805.
KEGGⁱ	dpe:Dper_GL24873.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH479188 Genomic DNA. Translation: EDW40473.1.
RefSeqⁱ	XP_002021317.1. XM_002021281.1.

3D structure databases

ProteinModelPortalⁱ	B4GRT8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	6595805.
KEGGⁱ	dpe:Dper_GL24873.

Organism-specific databases

FlyBaseⁱ	FBgn0162461. Dper\GL24873.

FlyBaseⁱ

FBgn0162461. Dper\GL24873.

Phylogenomic databases

KOⁱ	K00026.
OrthoDBⁱ	EOG74R1R7.
PhylomeDBⁱ	B4GRT8.

Family and domain databases

Gene3Dⁱ	3.40.50.720. 1 hit. 3.90.110.10. 1 hit.
InterProⁱ	IPR001557. L-lactate/malate_DH. IPR022383. Lactate/malate_DH_C. IPR001236. Lactate/malate_DH_N. IPR015955. Lactate_DH/Glyco_Ohase_4_C. IPR001252. Malate_DH_AS. IPR010097. Malate_DH_type1. IPR016040. NAD(P)-bd_dom. [Graphical view]
PANTHERⁱ	PTHR11540. PTHR11540. 1 hit.
Pfamⁱ	PF02866. Ldh_1_C. 1 hit. PF00056. Ldh_1_N. 1 hit. [Graphical view]
PIRSFⁱ	PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMⁱ	SSF56327. SSF56327. 1 hit.
TIGRFAMsⁱ	TIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEⁱ	PS00068. MDH. 1 hit. [Graphical view]
ProtoNetⁱ	Search...

Publicationsⁱ

"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain:
MSH-3 / Tucson 14011-0111.49
Imported
Automatic assertion inferred from database entriesⁱ
- Proteomes:UP000008744
.

Entry informationⁱ

Entry nameⁱ

B4GRT8_DROPE

Accessionⁱ

Primary (citable) accession number: B4GRT8

Entry historyⁱ

Integrated into UniProtKB/TrEMBL:	September 23, 2008
Last sequence update:	September 23, 2008
Last modified:	January 7, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry statusⁱ

Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

B4GRT8 - B4GRT8_DROPE

UniProt

B4GRT8 - B4GRT8_DROPE

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Malate dehydrogenase

Select a section on the left to see content.

Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywords - Molecular functionⁱ

Keywords - Biological processⁱ

Keywords - Ligandⁱ

Names & Taxonomyⁱ

Organism-specific databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Publicationsⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

External Data

Similar proteinsⁱ

UniProtKB

Proteomes

UniRef

Supporting data

UniParc

Help

B4GRT8 - B4GRT8_DROPE

UniProt

B4GRT8 - B4GRT8_DROPE

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Malate dehydrogenase

Dper\GL24873

Select a section on the left to see content.

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>Provides information on the tertiary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>Contains the literature citations that are the sources of data used to annotate the entry. Each reference is numbered and contains several subsections allowing a precise description of a given citation.</p><p><a href='../manual/publications_section' target='_top'>More...</a></p>Publicationsi

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

External Data

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Publicationsⁱ

Entry informationⁱ

Miscellaneousⁱ