Dper\GL24873

Functionⁱ

Catalytic activityⁱ

(S)-malate + NAD⁺ = oxaloacetate + NADH.UniRule annotation

GO - Molecular functionⁱ

L-malate dehydrogenase activity Source: UniProtKB-EC

Complete GO annotation...

GO - Biological processⁱ

carbohydrate metabolic process Source: InterPro
malate metabolic process Source: InterPro
tricarboxylic acid cycle Source: UniProtKB-KW

Complete GO annotation...

Keywordsⁱ

Molecular function	OxidoreductaseUniRule annotation
Biological process	Tricarboxylic acid cycleUniRule annotation
Ligand	NADUniRule annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesⁱ	Name:Dper\GL24873Imported ORF Names:Dper_GL24873Imported, GL24873Imported
Organismⁱ	Drosophila persimilis (Fruit fly)Imported
Taxonomic identifierⁱ	7234 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophila › Sophophora › obscura group › pseudoobscura subgroup
Proteomesⁱ	UP000008744 Componentⁱ: Unassembled WGS sequence

Organism-specific databases

Drosophila genome database More...FlyBaseⁱ	FBgn0162461. Dper\GL24873.

FlyBaseⁱ

FBgn0162461. Dper\GL24873.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B4GRT8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	7 – 149	Ldh_1_NInterPro annotationAdd BLAST		143
Domainⁱ	151 – 250	Ldh_1_CInterPro annotationAdd BLAST		100

Sequence similaritiesⁱ

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

KEGG Orthology (KO) More...KOⁱ	K00026.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AVO.
PhylomeDBⁱ	B4GRT8.

Family and domain databases

InterProⁱ	View protein in InterPro IPR022383. Lactate/malate_DH_C. IPR001236. Lactate/malate_DH_N. IPR015955. Lactate_DH/Glyco_Ohase_4_C. IPR001252. Malate_DH_AS. IPR010097. Malate_DH_type1. IPR016040. NAD(P)-bd_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02866. Ldh_1_C. 1 hit. PF00056. Ldh_1_N. 1 hit.
SUPFAMⁱ	SSF51735. SSF51735. 1 hit. SSF56327. SSF56327. 1 hit.
TIGRFAMsⁱ	TIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00068. MDH. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

B4GRT8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MARTAFKVAV VGAGGGIGQP LSLLLRQIEG IDELALHDLR GTKGVAADTG 
        60         70         80         90        100
HISEQGTVSG YVGNEQLVPA LQGANLVVVT AGMPRVPGMT RDSLMQANGG 
       110        120        130        140        150
IAITVTRAMA CACPEALIAI TTNPINIIVP TAAEVLKEAG VFNPRRLFGV 
       160        170        180        190        200
TTLDVVRSRK FIGDHMNIDP EKVNIPVIGG HTGPTILPLF SQCQPEFRGD 
       210        220        230        240        250
TEDIERLTHR IKEAGTEVVM AKGGAGSATL SMAYATSSFV KSLIRAHNGQ 
       260        270        280        290        300
EGIWNALLWH HVWKMSPSSQ GPLELGKEGI KRXXXXXXXX XXXXXXXXXX 
       310        320        330        340 
XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXF SLIL

Length:344

Mass (Da):36,759

Last modified:September 23, 2008 - v1

Checksum:ⁱ5CFBF66F33981F94

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH479188 Genomic DNA. Translation: EDW40473.1.
NCBI Reference Sequences More...RefSeqⁱ	XP_002021317.1. XM_002021281.1.

Genome annotation databases

EnsemblMetazoaⁱ	FBtr0190488; FBpp0188980; FBgn0162461.
GeneIDⁱ	6595805.
KEGGⁱ	dpe:Dper_GL24873.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CH479188 Genomic DNA. Translation: EDW40473.1.
NCBI Reference Sequences More...RefSeqⁱ	XP_002021317.1. XM_002021281.1.

3D structure databases

ProteinModelPortalⁱ	B4GRT8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblMetazoaⁱ	FBtr0190488; FBpp0188980; FBgn0162461.
GeneIDⁱ	6595805.
KEGGⁱ	dpe:Dper_GL24873.

Organism-specific databases

Drosophila genome database More...FlyBaseⁱ	FBgn0162461. Dper\GL24873.

FlyBaseⁱ

FBgn0162461. Dper\GL24873.

Phylogenomic databases

KEGG Orthology (KO) More...KOⁱ	K00026.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0AVO.
PhylomeDBⁱ	B4GRT8.

Family and domain databases

InterProⁱ	View protein in InterPro IPR022383. Lactate/malate_DH_C. IPR001236. Lactate/malate_DH_N. IPR015955. Lactate_DH/Glyco_Ohase_4_C. IPR001252. Malate_DH_AS. IPR010097. Malate_DH_type1. IPR016040. NAD(P)-bd_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02866. Ldh_1_C. 1 hit. PF00056. Ldh_1_N. 1 hit.
SUPFAMⁱ	SSF51735. SSF51735. 1 hit. SSF56327. SSF56327. 1 hit.
TIGRFAMsⁱ	TIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00068. MDH. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B4GRT8_DROPE
Accessionⁱ	B4GRT8Primary (citable) accession number: B4GRT8
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	September 23, 2008
	Last sequence update:	September 23, 2008
	Last modified:	July 5, 2017
	This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB - B4GRT8 (B4GRT8_DROPE)

Your basket is currently empty.

Malate dehydrogenase

Select a section on the left to see content.

Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Organism-specific databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B4GRT8 (B4GRT8_DROPE)

Your basket is currently empty.

Malate dehydrogenase

Dper\GL24873

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ