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Protein

Histone deacetylase

Gene

Dper\GL22163

Organism
Drosophila persimilis (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei98SubstrateUniRule annotation1
Active sitei140Proton acceptorUniRule annotation1
Binding sitei148Substrate; via carbonyl oxygenUniRule annotation1
Metal bindingi175Divalent metal cationUniRule annotation1
Metal bindingi177Divalent metal cationUniRule annotation1
Metal bindingi264Divalent metal cationUniRule annotation1
Binding sitei303SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
Name:Dper\GL22163Imported
ORF Names:Dper_GL22163Imported, GL22163Imported
OrganismiDrosophila persimilis (Fruit fly)Imported
Taxonomic identifieri7234 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000008744 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0159755. Dper\GL22163.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliB4GF88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 318Hist_deacetylInterPro annotationAdd BLAST296

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

KOiK11404.
OMAiPRAWTHL.
OrthoDBiEOG091G067J.
PhylomeDBiB4GF88.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

B4GF88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDRRVSYFY NADVGNFHYG AGHPMKPQRL AVTHSLVMNY GLDKKMKIYR
60 70 80 90 100
PYKASAQDML RFHSDEYIAY LQQVTPQNIQ CNSVAYTKYL AHFSVGEDCP
110 120 130 140 150
VFDGLFDFCA MYTGASLEGA QKLNHNHSDI CINWSGGLHH AKKFEASGFC
160 170 180 190 200
YVNDIVIGIL ELLKYHPRVL YIDIDVHHGD GVQEAFYLTD RVMTASFHKY
210 220 230 240 250
GNYFFPGTGD MYELGAESGR YYSVNVPLKE GIDDQSYFQV FKPIISAIMD
260 270 280 290 300
FYRPTAIVLQ CGADSLAGDR LGCFSLSTRG HGECVKFVKE LNVPTLVVGG
310 320 330 340 350
GGYTLRNVAR CWTHETSLLV DQDIDNDLPI TEYYEFFGPD FTLHPEINSR
360 370 380 390 400
QDNANSKQYL EMIVKHVYEN LKMCQHSPSV QMVQTPPDMD IEELRNKEET
410 420 430
DPDVRISQTD DDKSVEAKNE FYDGDQDQDK PDSAES
Length:436
Mass (Da):49,588
Last modified:September 23, 2008 - v1
Checksum:i417FE70CAF8CC48C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH479182 Genomic DNA. Translation: EDW34273.1.
RefSeqiXP_002017173.1. XM_002017137.1.

Genome annotation databases

EnsemblMetazoaiFBtr0187778; FBpp0186270; FBgn0159755.
GeneIDi6591398.
KEGGidpe:Dper_GL22163.

Similar proteinsi

Entry informationi

Entry nameiB4GF88_DROPE
AccessioniPrimary (citable) accession number: B4GF88
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: September 27, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported