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B4GES0 (B4GES0_DROPE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specific RuleBase RU271113

EC=2.1.1.43 RuleBase RU271113
Alternative name(s):
Histone H3-K79 methyltransferase RuleBase RU271113
Gene names
Name:Dper\GL21749 EMBL EDW34105.1
ORF Names:Dper_GL21749 EMBL EDW34105.1, GL21749 FlyBase FBgn0159342
OrganismDrosophila persimilis (Fruit fly) [Complete proteome]
Taxonomic identifier7234 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length1806 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. RuleBase RU271113

Subcellular location

Nucleus By similarity RuleBase RU271113.

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones By similarity. RuleBase RU271113

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family. RuleBase RU271113

Contains 1 DOT1 domain. RuleBase RU271113

Ontologies

Keywords
   Cellular componentNucleus RuleBase RU271113
   LigandS-adenosyl-L-methionine RuleBase RU271113
   Molecular functionChromatin regulator RuleBase RU271113
Methyltransferase RuleBase RU271113
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhistone-lysine N-methyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
B4GES0 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: EED38F4916C44DE9

FASTA1,806194,712
        10         20         30         40         50         60 
MATPQVKDLV LRSPSGSPET IAYAWPLQIG HGQDKHDNGI DIIDTIKFVC DDLPSIQSAF 

        70         80         90        100        110        120 
EEINLNQIDT ACYKTMTNLV DRFNKAVDSI VALEKGTSLP AERLNKFAHP SLLRHILQLV 

       130        140        150        160        170        180 
YNAAVLDPDK LNQYEPFSPE VYGETSYELV PADAQACHRT VRTTRDRAKR EANVGQQHNN 

       190        200        210        220        230        240 
HHHHHNNNHN NNHSSNNNNN NNHLQREREQ SNGPTGGSTI NQRHQSQSPA NVSGGGLGGA 

       250        260        270        280        290        300 
AGGGATAAAS KTRQQLQQQQ QQQQQRSLDM ESSTESDGEA TNGNGGNTTT TTTTTSASNG 

       310        320        330        340        350        360 
GGGGGSSGPM TRRLWYDFSS SKGKSSQSDD EENNNSNSNG GNTSVTGVRQ ARAATQKKRK 

       370        380        390        400        410        420 
KLTRKAAIAS KSAAAAQREA EAAAAVALAS KDSSSKEDAP RAASAGPGRK GRMKKGAGGR 

       430        440        450        460        470        480 
GRKSLKIVGL DALHKQTVLS TTQDSAAKKL PAAPGTVDQQ LTSLLTETMS HRELDIPAAP 

       490        500        510        520        530        540 
QDTPYGLQIL LECLRSQYMS FMDVMKSNAY LPQIQKNIAQ EQERMSRLKN RASQLDKQIK 

       550        560        570        580        590        600 
VLIDDSVALL KVRMNELGIN VNSPNDLIAQ AKEIVGRHKD LQHTVSKMRN EVTFYEGEQK 

       610        620        630        640        650        660 
MLLSKQLKNL PEYQKLCGNG PINGKVKLEL PSELSETTAH ELVLKEIANT LSQRKKLYAQ 

       670        680        690        700        710        720 
VSTIEQETTV LQKTAEDRST AASLLAQGTN ITLASSSSTS SSSSAGSSGS ASAPNPALNP 

       730        740        750        760        770        780 
APPKASGVKG SRRSREHRVR SQEWPEVPEV GKIQEENPEV LALKIVETCR QIEAGTFQAK 

       790        800        810        820        830        840 
TSAAPYQLNG KNKEPQMPTG AAASVSIKSS PGAAGGHHYK DSTLMPAPKQ QQQQMQVQQL 

       850        860        870        880        890        900 
QVAPSLLPKC ELPGMGMGLS LGLSLAGLSA RKQESPKVAN FEDRLKSIIT TALNEDQEQR 

       910        920        930        940        950        960 
SKAIPPEIPS QPSPSPLQSP VSKRSKQQQQ QLPPSSLHNI ITVSTQGLMH LNANTTISPI 

       970        980        990       1000       1010       1020 
TPPLPGPGAG ATASTAPPPP ANLPYGAYGG KSTPTGKYQA AKEQHSKYSP ARQQQHTPSS 

      1030       1040       1050       1060       1070       1080 
GAASVPPPPP PQVPVSSHMA ALYAAGQPTA PTPADLGYQR RRASVSASSY EHFLVQQQQQ 

      1090       1100       1110       1120       1130       1140 
QQQHALMMAA AAHVAQRQRA EEHHQQQQQQ QQQQQQQHRL QQQHLHHHHH HHPLSHSHPQ 

      1150       1160       1170       1180       1190       1200 
EFKAPPADNL LQRSSSRDQL VEPPPQQQPH NMELLPRASS ANSDYGAYRV RPPSRPSSNS 

      1210       1220       1230       1240       1250       1260 
SQPDYTQVSP AKMALRRHLS QEKLNQHVTP QPTPPPQGLP PPPTGKTIGD LVNGEIERTL 

      1270       1280       1290       1300       1310       1320 
EISHQTIINA AVNMSTSGTQ FMERAFNERA SSNERLLINL NAQRPERVHV RPLSDESQEA 

      1330       1340       1350       1360       1370       1380 
HPTNYVSSGG AAAAQAAAAG QGSNNSNLAT LAHVAYVQKS APQSGGRTAA PATPTPARSV 

      1390       1400       1410       1420       1430       1440 
RDSYQTVALP RAEMKGCIEA YFHDEQKTKN VGSAGAGAAG GGAAALRGPR LNGANPPLEG 

      1450       1460       1470       1480       1490       1500 
LAASLQDHVR ARKYKEETEE RQRRAAAAAS SSASAPSAGA ADLQQHYGQA PPAHSYLHHP 

      1510       1520       1530       1540       1550       1560 
IHHGAANLNG SGSSSSSGST PHKVELGVKR TSPLAPHHQP SRPSKIPHYE QPHVHAHAHA 

      1570       1580       1590       1600       1610       1620 
HLYANGGQVL QPPPAHDATT PSPTPSSSSS SCGRRSNTNN GKMLVEPPLL MSPEINSLMG 

      1630       1640       1650       1660       1670       1680 
DERPLQLSTN THHVMQQQQH HHQQQHHHHN HQQQQHLRVA AHLGHSHGHS HSHNNSSSHS 

      1690       1700       1710       1720       1730       1740 
SHGHSHSHGH SHSHSTTPTL GVMQRNANAN ANNAADDGKL YVGQSQEIGT KAHQYPLQPP 

      1750       1760       1770       1780       1790       1800 
PAQVFNNKEQ KQKSHNRLYH QHKYSTRLSS HAQWVAEDLT IKKVEPEKES VSDEGSSTSD 


SKSDST 

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References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MSH-3 / Tucson 14011-0111.49.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH479182 Genomic DNA. Translation: EDW34105.1.
RefSeqXP_002017005.1. XM_002016969.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0187364; FBpp0185856; FBgn0159342.
GeneID6592037.
KEGGdpe:Dper_GL21749.

Organism-specific databases

FlyBaseFBgn0159342. Dper\GL21749.

Phylogenomic databases

KOK11427.
OrthoDBEOG7W6WJV.

Family and domain databases

InterProIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021169. Histone_H3-K79_MeTrfase_met.
[Graphical view]
PfamPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFPIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
PROSITEPS51569. DOT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB4GES0_DROPE
AccessionPrimary (citable) accession number: B4GES0
Entry history
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: April 16, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)