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B4GES0

- B4GES0_DROPE

UniProt

B4GES0 - B4GES0_DROPE

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Protein
Histone-lysine N-methyltransferase, H3 lysine-79 specific
Gene
Dper\GL21749, Dper_GL21749, GL21749
Organism
Drosophila persimilis (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionineUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
    Alternative name(s):
    Histone H3-K79 methyltransferase
    Gene namesi
    Name:Dper\GL21749Imported
    ORF Names:Dper_GL21749Imported, GL21749Imported
    OrganismiDrosophila persimilis (Fruit fly)
    Taxonomic identifieri7234 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000008744: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0159342. Dper\GL21749.

    Subcellular locationi

    Nucleus By similarity UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 DOT1 domain.UniRule annotation

    Phylogenomic databases

    KOiK11427.
    OrthoDBiEOG7W6WJV.
    PhylomeDBiB4GES0.

    Family and domain databases

    InterProiIPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR021169. Histone_H3-K79_MeTrfase_met.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF08123. DOT1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51569. DOT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4GES0-1 [UniParc]FASTAAdd to Basket

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    MATPQVKDLV LRSPSGSPET IAYAWPLQIG HGQDKHDNGI DIIDTIKFVC     50
    DDLPSIQSAF EEINLNQIDT ACYKTMTNLV DRFNKAVDSI VALEKGTSLP 100
    AERLNKFAHP SLLRHILQLV YNAAVLDPDK LNQYEPFSPE VYGETSYELV 150
    PADAQACHRT VRTTRDRAKR EANVGQQHNN HHHHHNNNHN NNHSSNNNNN 200
    NNHLQREREQ SNGPTGGSTI NQRHQSQSPA NVSGGGLGGA AGGGATAAAS 250
    KTRQQLQQQQ QQQQQRSLDM ESSTESDGEA TNGNGGNTTT TTTTTSASNG 300
    GGGGGSSGPM TRRLWYDFSS SKGKSSQSDD EENNNSNSNG GNTSVTGVRQ 350
    ARAATQKKRK KLTRKAAIAS KSAAAAQREA EAAAAVALAS KDSSSKEDAP 400
    RAASAGPGRK GRMKKGAGGR GRKSLKIVGL DALHKQTVLS TTQDSAAKKL 450
    PAAPGTVDQQ LTSLLTETMS HRELDIPAAP QDTPYGLQIL LECLRSQYMS 500
    FMDVMKSNAY LPQIQKNIAQ EQERMSRLKN RASQLDKQIK VLIDDSVALL 550
    KVRMNELGIN VNSPNDLIAQ AKEIVGRHKD LQHTVSKMRN EVTFYEGEQK 600
    MLLSKQLKNL PEYQKLCGNG PINGKVKLEL PSELSETTAH ELVLKEIANT 650
    LSQRKKLYAQ VSTIEQETTV LQKTAEDRST AASLLAQGTN ITLASSSSTS 700
    SSSSAGSSGS ASAPNPALNP APPKASGVKG SRRSREHRVR SQEWPEVPEV 750
    GKIQEENPEV LALKIVETCR QIEAGTFQAK TSAAPYQLNG KNKEPQMPTG 800
    AAASVSIKSS PGAAGGHHYK DSTLMPAPKQ QQQQMQVQQL QVAPSLLPKC 850
    ELPGMGMGLS LGLSLAGLSA RKQESPKVAN FEDRLKSIIT TALNEDQEQR 900
    SKAIPPEIPS QPSPSPLQSP VSKRSKQQQQ QLPPSSLHNI ITVSTQGLMH 950
    LNANTTISPI TPPLPGPGAG ATASTAPPPP ANLPYGAYGG KSTPTGKYQA 1000
    AKEQHSKYSP ARQQQHTPSS GAASVPPPPP PQVPVSSHMA ALYAAGQPTA 1050
    PTPADLGYQR RRASVSASSY EHFLVQQQQQ QQQHALMMAA AAHVAQRQRA 1100
    EEHHQQQQQQ QQQQQQQHRL QQQHLHHHHH HHPLSHSHPQ EFKAPPADNL 1150
    LQRSSSRDQL VEPPPQQQPH NMELLPRASS ANSDYGAYRV RPPSRPSSNS 1200
    SQPDYTQVSP AKMALRRHLS QEKLNQHVTP QPTPPPQGLP PPPTGKTIGD 1250
    LVNGEIERTL EISHQTIINA AVNMSTSGTQ FMERAFNERA SSNERLLINL 1300
    NAQRPERVHV RPLSDESQEA HPTNYVSSGG AAAAQAAAAG QGSNNSNLAT 1350
    LAHVAYVQKS APQSGGRTAA PATPTPARSV RDSYQTVALP RAEMKGCIEA 1400
    YFHDEQKTKN VGSAGAGAAG GGAAALRGPR LNGANPPLEG LAASLQDHVR 1450
    ARKYKEETEE RQRRAAAAAS SSASAPSAGA ADLQQHYGQA PPAHSYLHHP 1500
    IHHGAANLNG SGSSSSSGST PHKVELGVKR TSPLAPHHQP SRPSKIPHYE 1550
    QPHVHAHAHA HLYANGGQVL QPPPAHDATT PSPTPSSSSS SCGRRSNTNN 1600
    GKMLVEPPLL MSPEINSLMG DERPLQLSTN THHVMQQQQH HHQQQHHHHN 1650
    HQQQQHLRVA AHLGHSHGHS HSHNNSSSHS SHGHSHSHGH SHSHSTTPTL 1700
    GVMQRNANAN ANNAADDGKL YVGQSQEIGT KAHQYPLQPP PAQVFNNKEQ 1750
    KQKSHNRLYH QHKYSTRLSS HAQWVAEDLT IKKVEPEKES VSDEGSSTSD 1800
    SKSDST 1806
    Length:1,806
    Mass (Da):194,712
    Last modified:September 23, 2008 - v1
    Checksum:iEED38F4916C44DE9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH479182 Genomic DNA. Translation: EDW34105.1.
    RefSeqiXP_002017005.1. XM_002016969.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0187364; FBpp0185856; FBgn0159342.
    GeneIDi6592037.
    KEGGidpe:Dper_GL21749.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH479182 Genomic DNA. Translation: EDW34105.1 .
    RefSeqi XP_002017005.1. XM_002016969.1.

    3D structure databases

    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0187364 ; FBpp0185856 ; FBgn0159342 .
    GeneIDi 6592037.
    KEGGi dpe:Dper_GL21749.

    Organism-specific databases

    FlyBasei FBgn0159342. Dper\GL21749.

    Phylogenomic databases

    KOi K11427.
    OrthoDBi EOG7W6WJV.
    PhylomeDBi B4GES0.

    Family and domain databases

    InterProi IPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR021169. Histone_H3-K79_MeTrfase_met.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF08123. DOT1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51569. DOT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MSH-3 / Tucson 14011-0111.49.

    Entry informationi

    Entry nameiB4GES0_DROPE
    AccessioniPrimary (citable) accession number: B4GES0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 23, 2008
    Last sequence update: September 23, 2008
    Last modified: June 11, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Miscellaneous

    In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones By similarity.UniRule annotation

    Keywords - Technical termi

    Complete proteome

    External Data

    Dasty 3

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