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B4GES0

- B4GES0_DROPE

UniProt

B4GES0 - B4GES0_DROPE

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Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

Dper\GL21749

Organism
Drosophila persimilis (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferaseUniRule annotation
Gene namesi
Name:Dper\GL21749Imported
ORF Names:Dper_GL21749Imported, GL21749Imported
OrganismiDrosophila persimilis (Fruit fly)Imported
Taxonomic identifieri7234 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000008744: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0159342. Dper\GL21749.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation
Contains 1 DOT1 domain.UniRule annotation

Phylogenomic databases

KOiK11427.
OrthoDBiEOG7W6WJV.
PhylomeDBiB4GES0.

Family and domain databases

InterProiIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021169. Histone_H3-K79_MeTrfase_met.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFiPIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4GES0-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MATPQVKDLV LRSPSGSPET IAYAWPLQIG HGQDKHDNGI DIIDTIKFVC
60 70 80 90 100
DDLPSIQSAF EEINLNQIDT ACYKTMTNLV DRFNKAVDSI VALEKGTSLP
110 120 130 140 150
AERLNKFAHP SLLRHILQLV YNAAVLDPDK LNQYEPFSPE VYGETSYELV
160 170 180 190 200
PADAQACHRT VRTTRDRAKR EANVGQQHNN HHHHHNNNHN NNHSSNNNNN
210 220 230 240 250
NNHLQREREQ SNGPTGGSTI NQRHQSQSPA NVSGGGLGGA AGGGATAAAS
260 270 280 290 300
KTRQQLQQQQ QQQQQRSLDM ESSTESDGEA TNGNGGNTTT TTTTTSASNG
310 320 330 340 350
GGGGGSSGPM TRRLWYDFSS SKGKSSQSDD EENNNSNSNG GNTSVTGVRQ
360 370 380 390 400
ARAATQKKRK KLTRKAAIAS KSAAAAQREA EAAAAVALAS KDSSSKEDAP
410 420 430 440 450
RAASAGPGRK GRMKKGAGGR GRKSLKIVGL DALHKQTVLS TTQDSAAKKL
460 470 480 490 500
PAAPGTVDQQ LTSLLTETMS HRELDIPAAP QDTPYGLQIL LECLRSQYMS
510 520 530 540 550
FMDVMKSNAY LPQIQKNIAQ EQERMSRLKN RASQLDKQIK VLIDDSVALL
560 570 580 590 600
KVRMNELGIN VNSPNDLIAQ AKEIVGRHKD LQHTVSKMRN EVTFYEGEQK
610 620 630 640 650
MLLSKQLKNL PEYQKLCGNG PINGKVKLEL PSELSETTAH ELVLKEIANT
660 670 680 690 700
LSQRKKLYAQ VSTIEQETTV LQKTAEDRST AASLLAQGTN ITLASSSSTS
710 720 730 740 750
SSSSAGSSGS ASAPNPALNP APPKASGVKG SRRSREHRVR SQEWPEVPEV
760 770 780 790 800
GKIQEENPEV LALKIVETCR QIEAGTFQAK TSAAPYQLNG KNKEPQMPTG
810 820 830 840 850
AAASVSIKSS PGAAGGHHYK DSTLMPAPKQ QQQQMQVQQL QVAPSLLPKC
860 870 880 890 900
ELPGMGMGLS LGLSLAGLSA RKQESPKVAN FEDRLKSIIT TALNEDQEQR
910 920 930 940 950
SKAIPPEIPS QPSPSPLQSP VSKRSKQQQQ QLPPSSLHNI ITVSTQGLMH
960 970 980 990 1000
LNANTTISPI TPPLPGPGAG ATASTAPPPP ANLPYGAYGG KSTPTGKYQA
1010 1020 1030 1040 1050
AKEQHSKYSP ARQQQHTPSS GAASVPPPPP PQVPVSSHMA ALYAAGQPTA
1060 1070 1080 1090 1100
PTPADLGYQR RRASVSASSY EHFLVQQQQQ QQQHALMMAA AAHVAQRQRA
1110 1120 1130 1140 1150
EEHHQQQQQQ QQQQQQQHRL QQQHLHHHHH HHPLSHSHPQ EFKAPPADNL
1160 1170 1180 1190 1200
LQRSSSRDQL VEPPPQQQPH NMELLPRASS ANSDYGAYRV RPPSRPSSNS
1210 1220 1230 1240 1250
SQPDYTQVSP AKMALRRHLS QEKLNQHVTP QPTPPPQGLP PPPTGKTIGD
1260 1270 1280 1290 1300
LVNGEIERTL EISHQTIINA AVNMSTSGTQ FMERAFNERA SSNERLLINL
1310 1320 1330 1340 1350
NAQRPERVHV RPLSDESQEA HPTNYVSSGG AAAAQAAAAG QGSNNSNLAT
1360 1370 1380 1390 1400
LAHVAYVQKS APQSGGRTAA PATPTPARSV RDSYQTVALP RAEMKGCIEA
1410 1420 1430 1440 1450
YFHDEQKTKN VGSAGAGAAG GGAAALRGPR LNGANPPLEG LAASLQDHVR
1460 1470 1480 1490 1500
ARKYKEETEE RQRRAAAAAS SSASAPSAGA ADLQQHYGQA PPAHSYLHHP
1510 1520 1530 1540 1550
IHHGAANLNG SGSSSSSGST PHKVELGVKR TSPLAPHHQP SRPSKIPHYE
1560 1570 1580 1590 1600
QPHVHAHAHA HLYANGGQVL QPPPAHDATT PSPTPSSSSS SCGRRSNTNN
1610 1620 1630 1640 1650
GKMLVEPPLL MSPEINSLMG DERPLQLSTN THHVMQQQQH HHQQQHHHHN
1660 1670 1680 1690 1700
HQQQQHLRVA AHLGHSHGHS HSHNNSSSHS SHGHSHSHGH SHSHSTTPTL
1710 1720 1730 1740 1750
GVMQRNANAN ANNAADDGKL YVGQSQEIGT KAHQYPLQPP PAQVFNNKEQ
1760 1770 1780 1790 1800
KQKSHNRLYH QHKYSTRLSS HAQWVAEDLT IKKVEPEKES VSDEGSSTSD

SKSDST
Length:1,806
Mass (Da):194,712
Last modified:September 23, 2008 - v1
Checksum:iEED38F4916C44DE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH479182 Genomic DNA. Translation: EDW34105.1.
RefSeqiXP_002017005.1. XM_002016969.1.

Genome annotation databases

EnsemblMetazoaiFBtr0187364; FBpp0185856; FBgn0159342.
GeneIDi6592037.
KEGGidpe:Dper_GL21749.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH479182 Genomic DNA. Translation: EDW34105.1 .
RefSeqi XP_002017005.1. XM_002016969.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0187364 ; FBpp0185856 ; FBgn0159342 .
GeneIDi 6592037.
KEGGi dpe:Dper_GL21749.

Organism-specific databases

FlyBasei FBgn0159342. Dper\GL21749.

Phylogenomic databases

KOi K11427.
OrthoDBi EOG7W6WJV.
PhylomeDBi B4GES0.

Family and domain databases

InterProi IPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021169. Histone_H3-K79_MeTrfase_met.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF08123. DOT1. 1 hit.
[Graphical view ]
PIRSFi PIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51569. DOT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MSH-3 / Tucson 14011-0111.49Imported.

Entry informationi

Entry nameiB4GES0_DROPE
AccessioniPrimary (citable) accession number: B4GES0
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: October 1, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3