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B4GES0

- B4GES0_DROPE

UniProt

B4GES0 - B4GES0_DROPE

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Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene
Dper\GL21749, Dper_GL21749, GL21749
Organism
Drosophila persimilis (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferase
Gene namesi
Name:Dper\GL21749Imported
ORF Names:Dper_GL21749Imported, GL21749Imported
OrganismiDrosophila persimilis (Fruit fly)
Taxonomic identifieri7234 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000008744: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0159342. Dper\GL21749.

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Sequence similaritiesi

Contains 1 DOT1 domain.UniRule annotation

Phylogenomic databases

KOiK11427.
OrthoDBiEOG7W6WJV.
PhylomeDBiB4GES0.

Family and domain databases

InterProiIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021169. Histone_H3-K79_MeTrfase_met.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFiPIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4GES0-1 [UniParc]FASTAAdd to Basket

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MATPQVKDLV LRSPSGSPET IAYAWPLQIG HGQDKHDNGI DIIDTIKFVC     50
DDLPSIQSAF EEINLNQIDT ACYKTMTNLV DRFNKAVDSI VALEKGTSLP 100
AERLNKFAHP SLLRHILQLV YNAAVLDPDK LNQYEPFSPE VYGETSYELV 150
PADAQACHRT VRTTRDRAKR EANVGQQHNN HHHHHNNNHN NNHSSNNNNN 200
NNHLQREREQ SNGPTGGSTI NQRHQSQSPA NVSGGGLGGA AGGGATAAAS 250
KTRQQLQQQQ QQQQQRSLDM ESSTESDGEA TNGNGGNTTT TTTTTSASNG 300
GGGGGSSGPM TRRLWYDFSS SKGKSSQSDD EENNNSNSNG GNTSVTGVRQ 350
ARAATQKKRK KLTRKAAIAS KSAAAAQREA EAAAAVALAS KDSSSKEDAP 400
RAASAGPGRK GRMKKGAGGR GRKSLKIVGL DALHKQTVLS TTQDSAAKKL 450
PAAPGTVDQQ LTSLLTETMS HRELDIPAAP QDTPYGLQIL LECLRSQYMS 500
FMDVMKSNAY LPQIQKNIAQ EQERMSRLKN RASQLDKQIK VLIDDSVALL 550
KVRMNELGIN VNSPNDLIAQ AKEIVGRHKD LQHTVSKMRN EVTFYEGEQK 600
MLLSKQLKNL PEYQKLCGNG PINGKVKLEL PSELSETTAH ELVLKEIANT 650
LSQRKKLYAQ VSTIEQETTV LQKTAEDRST AASLLAQGTN ITLASSSSTS 700
SSSSAGSSGS ASAPNPALNP APPKASGVKG SRRSREHRVR SQEWPEVPEV 750
GKIQEENPEV LALKIVETCR QIEAGTFQAK TSAAPYQLNG KNKEPQMPTG 800
AAASVSIKSS PGAAGGHHYK DSTLMPAPKQ QQQQMQVQQL QVAPSLLPKC 850
ELPGMGMGLS LGLSLAGLSA RKQESPKVAN FEDRLKSIIT TALNEDQEQR 900
SKAIPPEIPS QPSPSPLQSP VSKRSKQQQQ QLPPSSLHNI ITVSTQGLMH 950
LNANTTISPI TPPLPGPGAG ATASTAPPPP ANLPYGAYGG KSTPTGKYQA 1000
AKEQHSKYSP ARQQQHTPSS GAASVPPPPP PQVPVSSHMA ALYAAGQPTA 1050
PTPADLGYQR RRASVSASSY EHFLVQQQQQ QQQHALMMAA AAHVAQRQRA 1100
EEHHQQQQQQ QQQQQQQHRL QQQHLHHHHH HHPLSHSHPQ EFKAPPADNL 1150
LQRSSSRDQL VEPPPQQQPH NMELLPRASS ANSDYGAYRV RPPSRPSSNS 1200
SQPDYTQVSP AKMALRRHLS QEKLNQHVTP QPTPPPQGLP PPPTGKTIGD 1250
LVNGEIERTL EISHQTIINA AVNMSTSGTQ FMERAFNERA SSNERLLINL 1300
NAQRPERVHV RPLSDESQEA HPTNYVSSGG AAAAQAAAAG QGSNNSNLAT 1350
LAHVAYVQKS APQSGGRTAA PATPTPARSV RDSYQTVALP RAEMKGCIEA 1400
YFHDEQKTKN VGSAGAGAAG GGAAALRGPR LNGANPPLEG LAASLQDHVR 1450
ARKYKEETEE RQRRAAAAAS SSASAPSAGA ADLQQHYGQA PPAHSYLHHP 1500
IHHGAANLNG SGSSSSSGST PHKVELGVKR TSPLAPHHQP SRPSKIPHYE 1550
QPHVHAHAHA HLYANGGQVL QPPPAHDATT PSPTPSSSSS SCGRRSNTNN 1600
GKMLVEPPLL MSPEINSLMG DERPLQLSTN THHVMQQQQH HHQQQHHHHN 1650
HQQQQHLRVA AHLGHSHGHS HSHNNSSSHS SHGHSHSHGH SHSHSTTPTL 1700
GVMQRNANAN ANNAADDGKL YVGQSQEIGT KAHQYPLQPP PAQVFNNKEQ 1750
KQKSHNRLYH QHKYSTRLSS HAQWVAEDLT IKKVEPEKES VSDEGSSTSD 1800
SKSDST 1806
Length:1,806
Mass (Da):194,712
Last modified:September 23, 2008 - v1
Checksum:iEED38F4916C44DE9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH479182 Genomic DNA. Translation: EDW34105.1.
RefSeqiXP_002017005.1. XM_002016969.1.

Genome annotation databases

EnsemblMetazoaiFBtr0187364; FBpp0185856; FBgn0159342.
GeneIDi6592037.
KEGGidpe:Dper_GL21749.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH479182 Genomic DNA. Translation: EDW34105.1 .
RefSeqi XP_002017005.1. XM_002016969.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0187364 ; FBpp0185856 ; FBgn0159342 .
GeneIDi 6592037.
KEGGi dpe:Dper_GL21749.

Organism-specific databases

FlyBasei FBgn0159342. Dper\GL21749.

Phylogenomic databases

KOi K11427.
OrthoDBi EOG7W6WJV.
PhylomeDBi B4GES0.

Family and domain databases

InterProi IPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021169. Histone_H3-K79_MeTrfase_met.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF08123. DOT1. 1 hit.
[Graphical view ]
PIRSFi PIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51569. DOT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MSH-3 / Tucson 14011-0111.49.

Entry informationi

Entry nameiB4GES0_DROPE
AccessioniPrimary (citable) accession number: B4GES0
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: June 11, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3