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B4GC97

- B4GC97_DROPE

UniProt

B4GC97 - B4GC97_DROPE

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Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Gene

Dper\GL11120

Organism
Drosophila persimilis (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Note: Binds 1 2Fe-2S cluster.UniRule annotation
  • Note: Binds 1 3Fe-4S cluster.UniRule annotation
  • Note: Binds 1 4Fe-4S cluster.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: InterPro
  2. electron carrier activity Source: InterPro
  3. oxidoreductase activity Source: InterPro

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Ligandi

2Fe-2SUniRule annotation, 3Fe-4SUniRule annotation, 4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
Name:Dper\GL11120Imported
ORF Names:Dper_GL11120Imported, GL11120Imported
OrganismiDrosophila persimilis (Fruit fly)Imported
Taxonomic identifieri7234 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000008744: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0148730. Dper\GL11120.

Subcellular locationi

Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB4GC97.
SMRiB4GC97. Positions 44-282.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.UniRule annotation
Contains 1 2Fe-2S ferredoxin-type domain.UniRule annotation
Contains 1 4Fe-4S ferredoxin-type domain.UniRule annotation

Phylogenomic databases

KOiK00235.
OrthoDBiEOG7H4DTN.
PhylomeDBiB4GC97.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4GC97-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLVNEARQVL SRASSLAARH QLRAISNGTA QLDQQAQPKE AKEPQIKKFE
60 70 80 90 100
IYRWSPDNAG EKPHMQTYEV NLRDCGPMVL DALIKIKNEM DPTLTFRRSC
110 120 130 140 150
REGICGSCAM NIGGINTLAC ISKIDTNTSK SLKVYPLPHM YVVRDLVPDM
160 170 180 190 200
NNFYEQYKNI QPWLQRKNEA GEKKGRAQYL QSVEDRSKLD GLYECILCAC
210 220 230 240 250
CSTSCPSYWW NAEKYLGPAV LMQAYRWIID SRDENSAERL SKLKDPFSVY
260 270 280 290
RCHTIMNCTR TCPKGLNPGR AIAEIKKLLA GFASKPAPKL ETAALHK
Length:297
Mass (Da):33,656
Last modified:September 23, 2008 - v1
Checksum:iE842C1A32CE707AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH479181 Genomic DNA. Translation: EDW31415.1.
RefSeqiXP_002015525.1. XM_002015489.1.

Genome annotation databases

EnsemblMetazoaiFBtr0176735; FBpp0175227; FBgn0148730.
GeneIDi6590052.
KEGGidpe:Dper_GL11120.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH479181 Genomic DNA. Translation: EDW31415.1 .
RefSeqi XP_002015525.1. XM_002015489.1.

3D structure databases

ProteinModelPortali B4GC97.
SMRi B4GC97. Positions 44-282.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0176735 ; FBpp0175227 ; FBgn0148730 .
GeneIDi 6590052.
KEGGi dpe:Dper_GL11120.

Organism-specific databases

FlyBasei FBgn0148730. Dper\GL11120.

Phylogenomic databases

KOi K00235.
OrthoDBi EOG7H4DTN.
PhylomeDBi B4GC97.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01006 .

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view ]
Pfami PF13085. Fer2_3. 1 hit.
[Graphical view ]
SUPFAMi SSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsi TIGR00384. dhsB. 1 hit.
PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MSH-3 / Tucson 14011-0111.49Imported.

Entry informationi

Entry nameiB4GC97_DROPE
AccessioniPrimary (citable) accession number: B4GC97
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: November 26, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3