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B4GAM2 (CALYP_DROPE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 28. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase calypso

EC=3.4.19.12
Alternative name(s):
BAP1 homolog
Gene names
Name:calypso
ORF Names:GL10684
OrganismDrosophila persimilis (Fruit fly) [Complete proteome]
Taxonomic identifier7234 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length475 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Polycomb group (PcG) protein. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1). Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Component of the PR-DUB complex, at least composed of calypso and Asx By similarity.

Subcellular location

Nucleus By similarity. Note: Localizes to PcG response elements (PREs) By similarity.

Sequence similarities

Belongs to the peptidase C12 family. BAP1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 475475Ubiquitin carboxyl-terminal hydrolase calypso
PRO_0000395830

Sites

Active site1301Nucleophile By similarity
Active site2121Proton donor By similarity
Site2271Important for enzyme activity By similarity

Sequences

Sequence LengthMass (Da)Tools
B4GAM2 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 02746ECD4125FDD8

FASTA47552,100
        10         20         30         40         50         60 
MNVAAGGPGT ASASTTAANS IFNNSLLASA TGATTMPMAQ LADGWLELES DPGLFTLLLE 

        70         80         90        100        110        120 
DFGCHDVQVE EVYDLQKPIE SPYGFIFLFR WIEERRARRK IVETTAEIFV KDEEAISSIF 

       130        140        150        160        170        180 
FAQQVVPNSC ATHALLSVLL NCNENNLQLG DTLSRLKVHT KGMSPENKGL AIGNTPELAC 

       190        200        210        220        230        240 
AHNSHAIPQA RRRLERTGAG VASCRFTGEA FHFVSFVPIS GQLFELDGLK PYPMNHGGWE 

       250        260        270        280        290        300 
DHEDWTDKFR RVMAERLGIA TGEQDIRFNL MAVVPDRRIA ITHKLKMLRT NQAIVSGTLQ 

       310        320        330        340        350        360 
KLLKADEQGE SGNGDQQRPD TPTTLLEPSA FTAKDLQLLL KNLDTEIAIN EQNLADENDR 

       370        380        390        400        410        420 
RHMFKVDASR RTHNYDKFIC TFLSMLAHQG VLGELVSQHL LPSKKVSGQS AANRISKQNS 

       430        440        450        460        470 
AASSAGANAG AAAGVTPKSQ QQQQQPQTAA SKNGKSPGKT PGRRRKGRNK CRKRK 

« Hide

References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MSH-3 / Tucson 14011-0111.49.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH479181 Genomic DNA. Translation: EDW31974.1.
RefSeqXP_002016084.1. XM_002016048.1.

3D structure databases

ProteinModelPortalB4GAM2.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSC12.A09.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0176299; FBpp0174791; FBgn0148294.
GeneID6590516.
KEGGdpe:Dper_GL10684.

Organism-specific databases

FlyBaseFBgn0148294. Dper\GL10684.

Phylogenomic databases

KOK08588.
OrthoDBEOG7GN2M2.
PhylomeDBB4GAM2.

Family and domain databases

Gene3D3.40.532.10. 1 hit.
InterProIPR001578. Peptidase_C12_UCH.
[Graphical view]
PANTHERPTHR10589. PTHR10589. 1 hit.
PfamPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSPR00707. UBCTHYDRLASE.
ProtoNetSearch...

Entry information

Entry nameCALYP_DROPE
AccessionPrimary (citable) accession number: B4GAM2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase