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B4GAM2

- CALYP_DROPE

UniProt

B4GAM2 - CALYP_DROPE

Protein

Ubiquitin carboxyl-terminal hydrolase calypso

Gene

calypso

Organism
Drosophila persimilis (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Polycomb group (PcG) protein. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1). Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei130 – 1301NucleophileBy similarity
    Active sitei212 – 2121Proton donorBy similarity
    Sitei227 – 2271Important for enzyme activityBy similarity

    GO - Molecular functioni

    1. chromatin binding Source: UniProtKB
    2. ubiquitin-specific protease activity Source: UniProtKB
    3. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. chromatin silencing Source: UniProtKB
    2. monoubiquitinated histone H2A deubiquitination Source: UniProtKB
    3. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Chromatin regulator, Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC12.A09.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase calypso (EC:3.4.19.12)
    Alternative name(s):
    BAP1 homolog
    Gene namesi
    Name:calypso
    ORF Names:GL10684
    OrganismiDrosophila persimilis (Fruit fly)
    Taxonomic identifieri7234 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000008744: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0148294. Dper\GL10684.

    Subcellular locationi

    Nucleus By similarity
    Note: Localizes to PcG response elements (PREs).By similarity

    GO - Cellular componenti

    1. nuclear chromatin Source: UniProtKB
    2. PR-DUB complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 475475Ubiquitin carboxyl-terminal hydrolase calypsoPRO_0000395830Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the PR-DUB complex, at least composed of calypso and Asx.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliB4GAM2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C12 family. BAP1 subfamily.Curated

    Phylogenomic databases

    KOiK08588.
    OrthoDBiEOG7GN2M2.
    PhylomeDBiB4GAM2.

    Family and domain databases

    Gene3Di3.40.532.10. 1 hit.
    InterProiIPR001578. Peptidase_C12_UCH.
    [Graphical view]
    PANTHERiPTHR10589. PTHR10589. 1 hit.
    PfamiPF01088. Peptidase_C12. 1 hit.
    [Graphical view]
    PRINTSiPR00707. UBCTHYDRLASE.

    Sequencei

    Sequence statusi: Complete.

    B4GAM2-1 [UniParc]FASTAAdd to Basket

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    MNVAAGGPGT ASASTTAANS IFNNSLLASA TGATTMPMAQ LADGWLELES    50
    DPGLFTLLLE DFGCHDVQVE EVYDLQKPIE SPYGFIFLFR WIEERRARRK 100
    IVETTAEIFV KDEEAISSIF FAQQVVPNSC ATHALLSVLL NCNENNLQLG 150
    DTLSRLKVHT KGMSPENKGL AIGNTPELAC AHNSHAIPQA RRRLERTGAG 200
    VASCRFTGEA FHFVSFVPIS GQLFELDGLK PYPMNHGGWE DHEDWTDKFR 250
    RVMAERLGIA TGEQDIRFNL MAVVPDRRIA ITHKLKMLRT NQAIVSGTLQ 300
    KLLKADEQGE SGNGDQQRPD TPTTLLEPSA FTAKDLQLLL KNLDTEIAIN 350
    EQNLADENDR RHMFKVDASR RTHNYDKFIC TFLSMLAHQG VLGELVSQHL 400
    LPSKKVSGQS AANRISKQNS AASSAGANAG AAAGVTPKSQ QQQQQPQTAA 450
    SKNGKSPGKT PGRRRKGRNK CRKRK 475
    Length:475
    Mass (Da):52,100
    Last modified:September 23, 2008 - v1
    Checksum:i02746ECD4125FDD8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH479181 Genomic DNA. Translation: EDW31974.1.
    RefSeqiXP_002016084.1. XM_002016048.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0176299; FBpp0174791; FBgn0148294.
    GeneIDi6590516.
    KEGGidpe:Dper_GL10684.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH479181 Genomic DNA. Translation: EDW31974.1 .
    RefSeqi XP_002016084.1. XM_002016048.1.

    3D structure databases

    ProteinModelPortali B4GAM2.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C12.A09.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0176299 ; FBpp0174791 ; FBgn0148294 .
    GeneIDi 6590516.
    KEGGi dpe:Dper_GL10684.

    Organism-specific databases

    FlyBasei FBgn0148294. Dper\GL10684.

    Phylogenomic databases

    KOi K08588.
    OrthoDBi EOG7GN2M2.
    PhylomeDBi B4GAM2.

    Family and domain databases

    Gene3Di 3.40.532.10. 1 hit.
    InterProi IPR001578. Peptidase_C12_UCH.
    [Graphical view ]
    PANTHERi PTHR10589. PTHR10589. 1 hit.
    Pfami PF01088. Peptidase_C12. 1 hit.
    [Graphical view ]
    PRINTSi PR00707. UBCTHYDRLASE.
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MSH-3 / Tucson 14011-0111.49.

    Entry informationi

    Entry nameiCALYP_DROPE
    AccessioniPrimary (citable) accession number: B4GAM2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 13, 2010
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3