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Protein

cGMP-specific 3',5'-cyclic phosphodiesterase

Gene

Pde6

Organism
Drosophila persimilis (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Has a role regulating cGMP transport in Malpighian tubule principal cells.By similarity

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei764Proton donorBy similarity1
Metal bindingi768Divalent metal cation 1By similarity1
Metal bindingi804Divalent metal cation 1By similarity1
Metal bindingi805Divalent metal cation 1By similarity1
Metal bindingi805Divalent metal cation 2By similarity1
Metal bindingi1023Divalent metal cation 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandcGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cGMP-specific 3',5'-cyclic phosphodiesteraseBy similarity (EC:3.1.4.35)
Gene namesi
Name:Pde6By similarity
ORF Names:GL24177
OrganismiDrosophila persimilis (Fruit fly)
Taxonomic identifieri7234 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000008744 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0161767. Dper\GL24177.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003636921 – 1273cGMP-specific 3',5'-cyclic phosphodiesteraseAdd BLAST1273
PropeptideiPRO_00003636931274 – 1276Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1273Cysteine methyl esterBy similarity1
Lipidationi1273S-farnesyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Interactioni

Subunit structurei

Interacts with PrBP.By similarity

Structurei

3D structure databases

ProteinModelPortaliB4G4E5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini290 – 442GAF 1Sequence analysisAdd BLAST153
Domaini474 – 658GAF 2Sequence analysisAdd BLAST185

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi12 – 21Poly-SerSequence analysis10

Sequence similaritiesi

Belongs to the cyclic nucleotide phosphodiesterase family.Sequence analysis

Keywords - Domaini

Repeat

Phylogenomic databases

KOiK13763.
OMAiLDCCEAS.
OrthoDBiEOG091G04JU.
PhylomeDBiB4G4E5.

Family and domain databases

CDDicd00077. HDc. 1 hit.
Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 2 hits.
InterProiView protein in InterPro
IPR003018. GAF.
IPR029016. GAF-like_dom_sf.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR036971. PDEase_catalytic_dom_sf.
IPR023174. PDEase_CS.
PfamiView protein in Pfam
PF01590. GAF. 2 hits.
PF00233. PDEase_I. 2 hits.
PRINTSiPR00387. PDIESTERASE1.
SMARTiView protein in SMART
SM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
SUPFAMiSSF55781. SSF55781. 3 hits.
PROSITEiView protein in PROSITE
PS00126. PDEASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B4G4E5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHELGTRQRP LSSSSSSSSS SNMTDVSAAA GGATAPAETA ATSSSASKPL
60 70 80 90 100
TNGANKTSTA MAAPTTTPTT AATAAGAAEA GAIASVAGIS NQVKLEHHHR
110 120 130 140 150
QSNNNRPVAP YPPVPAAKPK PTPTPTAESK FKSTSREVDV ALRPTPARSS
160 170 180 190 200
TISPGVSIHT QTIQQESSSA KPGMSSSSSS AQQDVDEVAR LFEEKPEAFE
210 220 230 240 250
KWLTERAPPE ALSRLQEFIE SRKPLKRPSV TSDLFQQWMS ASPTVQQKSP
260 270 280 290 300
RSLSNSSASS TLPECRRHLM DLDEGELFME LIRDVANELD IDVLCHKILV
310 320 330 340 350
NVGLLTHADR GSLFLAKGTP HNKYLVAKLF DVTQKTALKD AVTRASAEEI
360 370 380 390 400
IIPFGIGIAG MVAQTKQMIN IKEAYKDARF NCEIDLKTGY KTNAILCMPI
410 420 430 440 450
CNYEGDIIGV AQIINKTNGC MEFDEHDVEI FRRYLTFCGI GIQNAQLFEM
460 470 480 490 500
SVQEYRRNQI LLNLARSIFE EQNNLECLVT KIMTEARELL NCERCSVFLV
510 520 530 540 550
DLDCCEASHL EKIIEKPNQP EQRPTRAIMP GDSFDEKKMR NRFTVLFELG
560 570 580 590 600
GEYQAASVSR PSKTELSTST LAQIAQFVAT TGQTVNICDV HEWVRDHNQI
610 620 630 640 650
RAESEIDSTQ AILCMPIVNA QKIVIGVAQL INKANGVPFT ESDASIFEAF
660 670 680 690 700
AIFCGLGIHN TQMYENACKL MAKQKVALEC LSYHATASQD QTEKLTQDAI
710 720 730 740 750
AEAESYNLYS FTFTDFELVD DDTCRAVLRM FLQCNLVSQF QIPYDVLCRW
760 770 780 790 800
VLSVRKNYRP VKYHNWRHAL NVAQTMFAML KTGKMERFMT DLEILGLLVA
810 820 830 840 850
CLCHDLDHRG TNNAFQTKTE SPLAILYTTS TMEHHHFDQC VMILNSEGNN
860 870 880 890 900
IFQPRTTRTF LLLARRFLRF DLLPFRAFTR ALRPLVRPLL ELDVLELPDP
910 920 930 940 950
SRIFLLTVYL RLVTRTIFLP PPEDEEEEDE VEDSVVLVVA SVVVVVAVAA
960 970 980 990 1000
SVVLKAELDV EALSPEDYRS VMKTVESAIL STDLAMYFKK RNAFLELVEN
1010 1020 1030 1040 1050
GEFDWQGEEK KDLLCGMMMT ACDVSAIAKP WEVQHKVAKL VADEFFDQGD
1060 1070 1080 1090 1100
LEKLQLNTQP VAMMDRERKD ELPKMQVGFI DVICLPLYRV LCDTFPWITP
1110 1120 1130 1140 1150
LYEGTLENRR NWQDLAEKVE MGLTWIDHDT IDKPVEEFAG CADEEIKDIE
1160 1170 1180 1190 1200
FTVTTLNCNQ QAQHGAGAGG DDSHTPEHQR SGSRLSMKKT GALGKAVRSK
1210 1220 1230 1240 1250
LSKTLYNSMD GSKPKTSLKL LESHVSEDMD DKSPTSPSQP PHAGGSVGRM
1260 1270
SASSSTSSAG TVVDKSKKRS KLCSLL
Length:1,276
Mass (Da):141,612
Last modified:September 23, 2008 - v1
Checksum:iF1DCC81A89C5B141
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH479179 Genomic DNA. Translation: EDW24493.1.
RefSeqiXP_002013507.1. XM_002013471.1.

Genome annotation databases

EnsemblMetazoaiFBtr0189792; FBpp0188284; FBgn0161767.
GeneIDi6587461.
KEGGidpe:Dper_GL24177.

Similar proteinsi

Entry informationi

Entry nameiPDE6_DROPE
AccessioniPrimary (citable) accession number: B4G4E5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: September 23, 2008
Last modified: November 22, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families