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B4G4E5

- PDE6_DROPE

UniProt

B4G4E5 - PDE6_DROPE

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Protein

cGMP-specific 3',5'-cyclic phosphodiesterase

Gene

Pde6

Organism
Drosophila persimilis (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Has a role regulating cGMP transport in Malpighian tubule principal cells.By similarity

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei764 – 7641Proton donorBy similarity
Metal bindingi768 – 7681Divalent metal cation 1By similarity
Metal bindingi804 – 8041Divalent metal cation 1By similarity
Metal bindingi805 – 8051Divalent metal cation 1By similarity
Metal bindingi805 – 8051Divalent metal cation 2By similarity
Metal bindingi1023 – 10231Divalent metal cation 1By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cGMP metabolic process Source: UniProtKB
  2. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cGMP-specific 3',5'-cyclic phosphodiesteraseBy similarity (EC:3.1.4.35)
Gene namesi
Name:Pde6By similarity
ORF Names:GL24177
OrganismiDrosophila persimilis (Fruit fly)
Taxonomic identifieri7234 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000008744: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0161767. Dper\GL24177.

Subcellular locationi

Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity

GO - Cellular componenti

  1. membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12731273cGMP-specific 3',5'-cyclic phosphodiesterasePRO_0000363692Add
BLAST
Propeptidei1274 – 12763Removed in mature formBy similarityPRO_0000363693

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1273 – 12731Cysteine methyl esterBy similarity
Lipidationi1273 – 12731S-farnesyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Interactioni

Subunit structurei

Interacts with PrBP.By similarity

Structurei

3D structure databases

ProteinModelPortaliB4G4E5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini290 – 442153GAF 1Sequence AnalysisAdd
BLAST
Domaini474 – 658185GAF 2Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi12 – 2110Poly-SerSequence Analysis

Sequence similaritiesi

Belongs to the cyclic nucleotide phosphodiesterase family.Sequence Analysis
Contains 2 GAF domains.Sequence Analysis

Keywords - Domaini

Repeat

Phylogenomic databases

KOiK13763.
OrthoDBiEOG7RRF69.
PhylomeDBiB4G4E5.

Family and domain databases

Gene3Di1.10.1300.10. 2 hits.
3.30.450.40. 3 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 2 hits.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 3 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B4G4E5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHELGTRQRP LSSSSSSSSS SNMTDVSAAA GGATAPAETA ATSSSASKPL
60 70 80 90 100
TNGANKTSTA MAAPTTTPTT AATAAGAAEA GAIASVAGIS NQVKLEHHHR
110 120 130 140 150
QSNNNRPVAP YPPVPAAKPK PTPTPTAESK FKSTSREVDV ALRPTPARSS
160 170 180 190 200
TISPGVSIHT QTIQQESSSA KPGMSSSSSS AQQDVDEVAR LFEEKPEAFE
210 220 230 240 250
KWLTERAPPE ALSRLQEFIE SRKPLKRPSV TSDLFQQWMS ASPTVQQKSP
260 270 280 290 300
RSLSNSSASS TLPECRRHLM DLDEGELFME LIRDVANELD IDVLCHKILV
310 320 330 340 350
NVGLLTHADR GSLFLAKGTP HNKYLVAKLF DVTQKTALKD AVTRASAEEI
360 370 380 390 400
IIPFGIGIAG MVAQTKQMIN IKEAYKDARF NCEIDLKTGY KTNAILCMPI
410 420 430 440 450
CNYEGDIIGV AQIINKTNGC MEFDEHDVEI FRRYLTFCGI GIQNAQLFEM
460 470 480 490 500
SVQEYRRNQI LLNLARSIFE EQNNLECLVT KIMTEARELL NCERCSVFLV
510 520 530 540 550
DLDCCEASHL EKIIEKPNQP EQRPTRAIMP GDSFDEKKMR NRFTVLFELG
560 570 580 590 600
GEYQAASVSR PSKTELSTST LAQIAQFVAT TGQTVNICDV HEWVRDHNQI
610 620 630 640 650
RAESEIDSTQ AILCMPIVNA QKIVIGVAQL INKANGVPFT ESDASIFEAF
660 670 680 690 700
AIFCGLGIHN TQMYENACKL MAKQKVALEC LSYHATASQD QTEKLTQDAI
710 720 730 740 750
AEAESYNLYS FTFTDFELVD DDTCRAVLRM FLQCNLVSQF QIPYDVLCRW
760 770 780 790 800
VLSVRKNYRP VKYHNWRHAL NVAQTMFAML KTGKMERFMT DLEILGLLVA
810 820 830 840 850
CLCHDLDHRG TNNAFQTKTE SPLAILYTTS TMEHHHFDQC VMILNSEGNN
860 870 880 890 900
IFQPRTTRTF LLLARRFLRF DLLPFRAFTR ALRPLVRPLL ELDVLELPDP
910 920 930 940 950
SRIFLLTVYL RLVTRTIFLP PPEDEEEEDE VEDSVVLVVA SVVVVVAVAA
960 970 980 990 1000
SVVLKAELDV EALSPEDYRS VMKTVESAIL STDLAMYFKK RNAFLELVEN
1010 1020 1030 1040 1050
GEFDWQGEEK KDLLCGMMMT ACDVSAIAKP WEVQHKVAKL VADEFFDQGD
1060 1070 1080 1090 1100
LEKLQLNTQP VAMMDRERKD ELPKMQVGFI DVICLPLYRV LCDTFPWITP
1110 1120 1130 1140 1150
LYEGTLENRR NWQDLAEKVE MGLTWIDHDT IDKPVEEFAG CADEEIKDIE
1160 1170 1180 1190 1200
FTVTTLNCNQ QAQHGAGAGG DDSHTPEHQR SGSRLSMKKT GALGKAVRSK
1210 1220 1230 1240 1250
LSKTLYNSMD GSKPKTSLKL LESHVSEDMD DKSPTSPSQP PHAGGSVGRM
1260 1270
SASSSTSSAG TVVDKSKKRS KLCSLL
Length:1,276
Mass (Da):141,612
Last modified:September 23, 2008 - v1
Checksum:iF1DCC81A89C5B141
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH479179 Genomic DNA. Translation: EDW24493.1.
RefSeqiXP_002013507.1. XM_002013471.1.

Genome annotation databases

EnsemblMetazoaiFBtr0189792; FBpp0188284; FBgn0161767.
GeneIDi6587461.
KEGGidpe:Dper_GL24177.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH479179 Genomic DNA. Translation: EDW24493.1 .
RefSeqi XP_002013507.1. XM_002013471.1.

3D structure databases

ProteinModelPortali B4G4E5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0189792 ; FBpp0188284 ; FBgn0161767 .
GeneIDi 6587461.
KEGGi dpe:Dper_GL24177.

Organism-specific databases

FlyBasei FBgn0161767. Dper\GL24177.

Phylogenomic databases

KOi K13763.
OrthoDBi EOG7RRF69.
PhylomeDBi B4G4E5.

Family and domain databases

Gene3Di 1.10.1300.10. 2 hits.
3.30.450.40. 3 hits.
InterProi IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF01590. GAF. 2 hits.
PF00233. PDEase_I. 2 hits.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view ]
SUPFAMi SSF55781. SSF55781. 3 hits.
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MSH-3 / Tucson 14011-0111.49.

Entry informationi

Entry nameiPDE6_DROPE
AccessioniPrimary (citable) accession number: B4G4E5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: September 23, 2008
Last modified: November 26, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3