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B4G4E5

- PDE6_DROPE

UniProt

B4G4E5 - PDE6_DROPE

Protein

cGMP-specific 3',5'-cyclic phosphodiesterase

Gene

Pde6

Organism
Drosophila persimilis (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Has a role regulating cGMP transport in Malpighian tubule principal cells.By similarity

    Catalytic activityi

    Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

    Cofactori

    Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei764 – 7641Proton donorBy similarity
    Metal bindingi768 – 7681Divalent metal cation 1By similarity
    Metal bindingi804 – 8041Divalent metal cation 1By similarity
    Metal bindingi805 – 8051Divalent metal cation 1By similarity
    Metal bindingi805 – 8051Divalent metal cation 2By similarity
    Metal bindingi1023 – 10231Divalent metal cation 1By similarity

    GO - Molecular functioni

    1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cGMP metabolic process Source: UniProtKB
    2. signal transduction Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cGMP, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    cGMP-specific 3',5'-cyclic phosphodiesteraseBy similarity (EC:3.1.4.35)
    Gene namesi
    Name:Pde6By similarity
    ORF Names:GL24177
    OrganismiDrosophila persimilis (Fruit fly)
    Taxonomic identifieri7234 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000008744: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0161767. Dper\GL24177.

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity

    GO - Cellular componenti

    1. membrane Source: UniProtKB
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12731273cGMP-specific 3',5'-cyclic phosphodiesterasePRO_0000363692Add
    BLAST
    Propeptidei1274 – 12763Removed in mature formBy similarityPRO_0000363693

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1273 – 12731Cysteine methyl esterBy similarity
    Lipidationi1273 – 12731S-farnesyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Interactioni

    Subunit structurei

    Interacts with PrBP.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliB4G4E5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini290 – 442153GAF 1Sequence AnalysisAdd
    BLAST
    Domaini474 – 658185GAF 2Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi12 – 2110Poly-SerSequence Analysis

    Sequence similaritiesi

    Belongs to the cyclic nucleotide phosphodiesterase family.Sequence Analysis
    Contains 2 GAF domains.Sequence Analysis

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    KOiK13763.
    OrthoDBiEOG7RRF69.
    PhylomeDBiB4G4E5.

    Family and domain databases

    Gene3Di1.10.1300.10. 2 hits.
    3.30.450.40. 3 hits.
    InterProiIPR003018. GAF.
    IPR029016. GAF_dom_like.
    IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view]
    PfamiPF01590. GAF. 2 hits.
    PF00233. PDEase_I. 2 hits.
    [Graphical view]
    PRINTSiPR00387. PDIESTERASE1.
    SMARTiSM00065. GAF. 2 hits.
    SM00471. HDc. 1 hit.
    [Graphical view]
    SUPFAMiSSF55781. SSF55781. 3 hits.
    PROSITEiPS00126. PDEASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B4G4E5-1 [UniParc]FASTAAdd to Basket

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    MHELGTRQRP LSSSSSSSSS SNMTDVSAAA GGATAPAETA ATSSSASKPL     50
    TNGANKTSTA MAAPTTTPTT AATAAGAAEA GAIASVAGIS NQVKLEHHHR 100
    QSNNNRPVAP YPPVPAAKPK PTPTPTAESK FKSTSREVDV ALRPTPARSS 150
    TISPGVSIHT QTIQQESSSA KPGMSSSSSS AQQDVDEVAR LFEEKPEAFE 200
    KWLTERAPPE ALSRLQEFIE SRKPLKRPSV TSDLFQQWMS ASPTVQQKSP 250
    RSLSNSSASS TLPECRRHLM DLDEGELFME LIRDVANELD IDVLCHKILV 300
    NVGLLTHADR GSLFLAKGTP HNKYLVAKLF DVTQKTALKD AVTRASAEEI 350
    IIPFGIGIAG MVAQTKQMIN IKEAYKDARF NCEIDLKTGY KTNAILCMPI 400
    CNYEGDIIGV AQIINKTNGC MEFDEHDVEI FRRYLTFCGI GIQNAQLFEM 450
    SVQEYRRNQI LLNLARSIFE EQNNLECLVT KIMTEARELL NCERCSVFLV 500
    DLDCCEASHL EKIIEKPNQP EQRPTRAIMP GDSFDEKKMR NRFTVLFELG 550
    GEYQAASVSR PSKTELSTST LAQIAQFVAT TGQTVNICDV HEWVRDHNQI 600
    RAESEIDSTQ AILCMPIVNA QKIVIGVAQL INKANGVPFT ESDASIFEAF 650
    AIFCGLGIHN TQMYENACKL MAKQKVALEC LSYHATASQD QTEKLTQDAI 700
    AEAESYNLYS FTFTDFELVD DDTCRAVLRM FLQCNLVSQF QIPYDVLCRW 750
    VLSVRKNYRP VKYHNWRHAL NVAQTMFAML KTGKMERFMT DLEILGLLVA 800
    CLCHDLDHRG TNNAFQTKTE SPLAILYTTS TMEHHHFDQC VMILNSEGNN 850
    IFQPRTTRTF LLLARRFLRF DLLPFRAFTR ALRPLVRPLL ELDVLELPDP 900
    SRIFLLTVYL RLVTRTIFLP PPEDEEEEDE VEDSVVLVVA SVVVVVAVAA 950
    SVVLKAELDV EALSPEDYRS VMKTVESAIL STDLAMYFKK RNAFLELVEN 1000
    GEFDWQGEEK KDLLCGMMMT ACDVSAIAKP WEVQHKVAKL VADEFFDQGD 1050
    LEKLQLNTQP VAMMDRERKD ELPKMQVGFI DVICLPLYRV LCDTFPWITP 1100
    LYEGTLENRR NWQDLAEKVE MGLTWIDHDT IDKPVEEFAG CADEEIKDIE 1150
    FTVTTLNCNQ QAQHGAGAGG DDSHTPEHQR SGSRLSMKKT GALGKAVRSK 1200
    LSKTLYNSMD GSKPKTSLKL LESHVSEDMD DKSPTSPSQP PHAGGSVGRM 1250
    SASSSTSSAG TVVDKSKKRS KLCSLL 1276
    Length:1,276
    Mass (Da):141,612
    Last modified:September 23, 2008 - v1
    Checksum:iF1DCC81A89C5B141
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH479179 Genomic DNA. Translation: EDW24493.1.
    RefSeqiXP_002013507.1. XM_002013471.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0189792; FBpp0188284; FBgn0161767.
    GeneIDi6587461.
    KEGGidpe:Dper_GL24177.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH479179 Genomic DNA. Translation: EDW24493.1 .
    RefSeqi XP_002013507.1. XM_002013471.1.

    3D structure databases

    ProteinModelPortali B4G4E5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0189792 ; FBpp0188284 ; FBgn0161767 .
    GeneIDi 6587461.
    KEGGi dpe:Dper_GL24177.

    Organism-specific databases

    FlyBasei FBgn0161767. Dper\GL24177.

    Phylogenomic databases

    KOi K13763.
    OrthoDBi EOG7RRF69.
    PhylomeDBi B4G4E5.

    Family and domain databases

    Gene3Di 1.10.1300.10. 2 hits.
    3.30.450.40. 3 hits.
    InterProi IPR003018. GAF.
    IPR029016. GAF_dom_like.
    IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view ]
    Pfami PF01590. GAF. 2 hits.
    PF00233. PDEase_I. 2 hits.
    [Graphical view ]
    PRINTSi PR00387. PDIESTERASE1.
    SMARTi SM00065. GAF. 2 hits.
    SM00471. HDc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55781. SSF55781. 3 hits.
    PROSITEi PS00126. PDEASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MSH-3 / Tucson 14011-0111.49.

    Entry informationi

    Entry nameiPDE6_DROPE
    AccessioniPrimary (citable) accession number: B4G4E5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3