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B4G4E5

- PDE6_DROPE

UniProt

B4G4E5 - PDE6_DROPE

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Protein
cGMP-specific 3',5'-cyclic phosphodiesterase
Gene
Pde6, GL24177
Organism
Drosophila persimilis (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Has a role regulating cGMP transport in Malpighian tubule principal cells By similarity.By similarity

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

Cofactori

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei764 – 7641Proton donor By similarity
Metal bindingi768 – 7681Divalent metal cation 1 By similarity
Metal bindingi804 – 8041Divalent metal cation 1 By similarity
Metal bindingi805 – 8051Divalent metal cation 1 By similarity
Metal bindingi805 – 8051Divalent metal cation 2 By similarity
Metal bindingi1023 – 10231Divalent metal cation 1 By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cGMP metabolic process Source: UniProtKB
  2. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cGMP-specific 3',5'-cyclic phosphodiesterase (EC:3.1.4.35)
Gene namesi
Name:Pde6
ORF Names:GL24177
OrganismiDrosophila persimilis (Fruit fly)
Taxonomic identifieri7234 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000008744: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0161767. Dper\GL24177.

Subcellular locationi

Cell membrane; Lipid-anchor; Cytoplasmic side By similarity By similarity

GO - Cellular componenti

  1. membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12731273cGMP-specific 3',5'-cyclic phosphodiesteraseBy similarity
PRO_0000363692Add
BLAST
Propeptidei1274 – 12763Removed in mature form By similarityBy similarity
PRO_0000363693

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1273 – 12731Cysteine methyl ester By similarityBy similarity
Lipidationi1273 – 12731S-farnesyl cysteine By similarityBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Interactioni

Subunit structurei

Interacts with PrBP By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliB4G4E5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini290 – 442153GAF 1
Add
BLAST
Domaini474 – 658185GAF 2
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi12 – 2110Poly-Ser

Sequence similaritiesi

Contains 2 GAF domains.

Keywords - Domaini

Repeat

Phylogenomic databases

KOiK13763.
OrthoDBiEOG7RRF69.
PhylomeDBiB4G4E5.

Family and domain databases

Gene3Di1.10.1300.10. 2 hits.
3.30.450.40. 3 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 2 hits.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 3 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B4G4E5-1 [UniParc]FASTAAdd to Basket

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MHELGTRQRP LSSSSSSSSS SNMTDVSAAA GGATAPAETA ATSSSASKPL     50
TNGANKTSTA MAAPTTTPTT AATAAGAAEA GAIASVAGIS NQVKLEHHHR 100
QSNNNRPVAP YPPVPAAKPK PTPTPTAESK FKSTSREVDV ALRPTPARSS 150
TISPGVSIHT QTIQQESSSA KPGMSSSSSS AQQDVDEVAR LFEEKPEAFE 200
KWLTERAPPE ALSRLQEFIE SRKPLKRPSV TSDLFQQWMS ASPTVQQKSP 250
RSLSNSSASS TLPECRRHLM DLDEGELFME LIRDVANELD IDVLCHKILV 300
NVGLLTHADR GSLFLAKGTP HNKYLVAKLF DVTQKTALKD AVTRASAEEI 350
IIPFGIGIAG MVAQTKQMIN IKEAYKDARF NCEIDLKTGY KTNAILCMPI 400
CNYEGDIIGV AQIINKTNGC MEFDEHDVEI FRRYLTFCGI GIQNAQLFEM 450
SVQEYRRNQI LLNLARSIFE EQNNLECLVT KIMTEARELL NCERCSVFLV 500
DLDCCEASHL EKIIEKPNQP EQRPTRAIMP GDSFDEKKMR NRFTVLFELG 550
GEYQAASVSR PSKTELSTST LAQIAQFVAT TGQTVNICDV HEWVRDHNQI 600
RAESEIDSTQ AILCMPIVNA QKIVIGVAQL INKANGVPFT ESDASIFEAF 650
AIFCGLGIHN TQMYENACKL MAKQKVALEC LSYHATASQD QTEKLTQDAI 700
AEAESYNLYS FTFTDFELVD DDTCRAVLRM FLQCNLVSQF QIPYDVLCRW 750
VLSVRKNYRP VKYHNWRHAL NVAQTMFAML KTGKMERFMT DLEILGLLVA 800
CLCHDLDHRG TNNAFQTKTE SPLAILYTTS TMEHHHFDQC VMILNSEGNN 850
IFQPRTTRTF LLLARRFLRF DLLPFRAFTR ALRPLVRPLL ELDVLELPDP 900
SRIFLLTVYL RLVTRTIFLP PPEDEEEEDE VEDSVVLVVA SVVVVVAVAA 950
SVVLKAELDV EALSPEDYRS VMKTVESAIL STDLAMYFKK RNAFLELVEN 1000
GEFDWQGEEK KDLLCGMMMT ACDVSAIAKP WEVQHKVAKL VADEFFDQGD 1050
LEKLQLNTQP VAMMDRERKD ELPKMQVGFI DVICLPLYRV LCDTFPWITP 1100
LYEGTLENRR NWQDLAEKVE MGLTWIDHDT IDKPVEEFAG CADEEIKDIE 1150
FTVTTLNCNQ QAQHGAGAGG DDSHTPEHQR SGSRLSMKKT GALGKAVRSK 1200
LSKTLYNSMD GSKPKTSLKL LESHVSEDMD DKSPTSPSQP PHAGGSVGRM 1250
SASSSTSSAG TVVDKSKKRS KLCSLL 1276
Length:1,276
Mass (Da):141,612
Last modified:September 23, 2008 - v1
Checksum:iF1DCC81A89C5B141
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH479179 Genomic DNA. Translation: EDW24493.1.
RefSeqiXP_002013507.1. XM_002013471.1.

Genome annotation databases

EnsemblMetazoaiFBtr0189792; FBpp0188284; FBgn0161767.
GeneIDi6587461.
KEGGidpe:Dper_GL24177.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH479179 Genomic DNA. Translation: EDW24493.1 .
RefSeqi XP_002013507.1. XM_002013471.1.

3D structure databases

ProteinModelPortali B4G4E5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0189792 ; FBpp0188284 ; FBgn0161767 .
GeneIDi 6587461.
KEGGi dpe:Dper_GL24177.

Organism-specific databases

FlyBasei FBgn0161767. Dper\GL24177.

Phylogenomic databases

KOi K13763.
OrthoDBi EOG7RRF69.
PhylomeDBi B4G4E5.

Family and domain databases

Gene3Di 1.10.1300.10. 2 hits.
3.30.450.40. 3 hits.
InterProi IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF01590. GAF. 2 hits.
PF00233. PDEase_I. 2 hits.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view ]
SUPFAMi SSF55781. SSF55781. 3 hits.
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MSH-3 / Tucson 14011-0111.49.

Entry informationi

Entry nameiPDE6_DROPE
AccessioniPrimary (citable) accession number: B4G4E5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi