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Protein

Delta-like protein

Gene

Dper\GL23608

Organism
Drosophila persimilis (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Putative Notch ligand involved in the mediation of Notch signaling.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental proteinUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-like proteinUniRule annotation
Gene namesi
Name:Dper\GL23608Imported
ORF Names:Dper_GL23608Imported, GL23608Imported
OrganismiDrosophila persimilis (Fruit fly)Imported
Taxonomic identifieri7234 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000008744 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0161198. Dper\GL23608.

Subcellular locationi

  • Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1235 – 125824HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini258 – 30245DSLInterPro annotationAdd
BLAST
Domaini303 – 33634EGF-likeInterPro annotationAdd
BLAST
Domaini370 – 40839EGF-likeInterPro annotationAdd
BLAST
Domaini509 – 54537EGF-likeInterPro annotationAdd
BLAST
Domaini595 – 63238EGF-likeInterPro annotationAdd
BLAST
Domaini634 – 66936EGF-likeInterPro annotationAdd
BLAST
Domaini671 – 70737EGF-likeInterPro annotationAdd
BLAST
Domaini709 – 74436EGF-likeInterPro annotationAdd
BLAST
Domaini782 – 81837EGF-likeInterPro annotationAdd
BLAST
Domaini820 – 85536EGF-likeInterPro annotationAdd
BLAST
Domaini918 – 95437EGF-likeInterPro annotationAdd
BLAST
Domaini956 – 99237EGF-likeInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DSL domain.UniRule annotation
Contains 14 EGF-like domains.UniRule annotation

Keywords - Domaini

EGF-like domainUniRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

KOiK06052.
OMAiMPGAPDK.
OrthoDBiEOG7BKCSS.
PhylomeDBiB4G2H2.

Family and domain databases

InterProiIPR001774. DSL.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 6 hits.
PF12661. hEGF. 1 hit.
PF07657. MNNL. 1 hit.
[Graphical view]
PRINTSiPR02059. JAGGEDFAMILY.
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 14 hits.
SM00179. EGF_CA. 9 hits.
SM00215. VWC_out. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 7 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 13 hits.
PS01186. EGF_2. 7 hits.
PS50026. EGF_3. 11 hits.
PS01187. EGF_CA. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4G2H2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYTMFRKHFR RKSTASQPSS SATSLAEESA AAAASTDSLR MSTTTTTTTT
60 70 80 90 100
TTTQRQRQRQ RQRPRQREFS ALPSTISDCR SLKSACNLIA LILILLVHKI
110 120 130 140 150
SAAGNFELEI LEISNTNSHL LSGYCCGMPP ELRATKTTGC SPCTTAFRLC
160 170 180 190 200
LKEYQTTEQG ASISTGCSFG NSTTKILGGS SFVLSDPGVG AIVLPFTFRW
210 220 230 240 250
TKSFTLILQA LDMYNTSYPD AERLIEETSY SGVILPSPEW KTLDHIGRNA
260 270 280 290 300
RITYRVRVQC AVTYYNTTCT TFCRPRDDQF GHYACGSEGQ KLCLNGWQGV
310 320 330 340 350
NCEEAICKTG CDPVHGKCDR PGECECRPGW RGPLCNECMV YPGCKHGSCN
360 370 380 390 400
GSAWKCVCDT NWGGILCDQD LNYCGTHEPC NHGGTCENTA PDQYRCTCAE
410 420 430 440 450
GLSGEQCEIV EHPCATQPCR NGGTCTLKPM NATRPPVYRI MRGMSTSMGK
460 470 480 490 500
PISRRNSIRS LANLRQESQN GSSNGGALGS SPGLPLTPLA AEFTCGCAAG
510 520 530 540 550
WTGPTCEINI DECAGGPCEH GGTCVDLIGG FRCECPPEWR GDVCQVDVNE
560 570 580 590 600
CEVPHAAQAV SANTLLTTTM ASAAIGSNLS SSAALLAALT SAVAASNAAS
610 620 630 640 650
TIGPCINARE CINEPGSFSC QCLEGWGGAT CAENLDDCVG QCKNGASCID
660 670 680 690 700
LVNDYRCACG PGYTGRDCET DIDECATSPC RNGGECVDMI GKFNCICPLG
710 720 730 740 750
YSGSLCEEAK DHCTPSPCLQ GRCLNTPGSY YCHCPPDRAG KHCEQLRPLC
760 770 780 790 800
SQPPCNEGCF ANVSSIATGT AAAAGTTTTT TTMTTPSGLP CSGHGSCEMS
810 820 830 840 850
DVGTFCKCHV GHTGTFCEHN LNECSPNPCR NGGICLDGDG DFTCECMSGW
860 870 880 890 900
TVRCLSLPFR FVWFRFPLQA SAARSGPPGA MPGSAKTEET CMPGAPDKAL
910 920 930 940 950
QPHCRCAPGW TGLFCAESID QCRGQPCHNG GTCESGAGWF RCLCAQGFSG
960 970 980 990 1000
PDCRINVNEC SPQPCQGGAT CIDGIGGYSC ICPPGRHGLR CEILLSDPKS
1010 1020 1030 1040 1050
ACLNASNTIS PYAALNQSQN WLDNALSGRS DDDEPCNACS SNLSGVCKQH
1060 1070 1080 1090 1100
EVCVPALSET CLSPPCNVRG DCRALEPSRR VAPPSLPAKA SCWPNQALVN
1110 1120 1130 1140 1150
ENCARLTILL DLERVGRGAS VEGLCSLVRV LLAAQLVKQP PSAPSQEPGL
1160 1170 1180 1190 1200
LMVLCDLKSG SNDTVELTVS SSKLNDPQLP VAVALLGELL SSRQLNGIQR
1210 1220 1230 1240 1250
RKELELQHAK LAALTSILEV KLETARVADG SGHSLLIGVL CGVFIVLVGF
1260 1270 1280 1290 1300
SIFISLYWKQ RLAYRSSSGM NLTPSLDALR HEEEKSNNLQ NEENLRRYTN
1310 1320 1330 1340 1350
PIKGSTSSLR STTGMELSLN PAPELAATAA SSSALHRSQP LFPPCDFERE
1360 1370 1380 1390 1400
LDSSTGLKQA HKRGSQILLH KTQNLDMKKN TVGSLDSPRK DFGKRSINCK
1410
SLPPPACDDG VDVLTTVMV
Length:1,419
Mass (Da):151,324
Last modified:September 23, 2008 - v1
Checksum:iE89A3A26F4760B7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH479179 Genomic DNA. Translation: EDW24017.1.
RefSeqiXP_002013031.1. XM_002012995.1.

Genome annotation databases

EnsemblMetazoaiFBtr0189223; FBpp0187715; FBgn0161198.
GeneIDi6587390.
KEGGidpe:Dper_GL23608.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH479179 Genomic DNA. Translation: EDW24017.1.
RefSeqiXP_002013031.1. XM_002012995.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0189223; FBpp0187715; FBgn0161198.
GeneIDi6587390.
KEGGidpe:Dper_GL23608.

Organism-specific databases

FlyBaseiFBgn0161198. Dper\GL23608.

Phylogenomic databases

KOiK06052.
OMAiMPGAPDK.
OrthoDBiEOG7BKCSS.
PhylomeDBiB4G2H2.

Family and domain databases

InterProiIPR001774. DSL.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 6 hits.
PF12661. hEGF. 1 hit.
PF07657. MNNL. 1 hit.
[Graphical view]
PRINTSiPR02059. JAGGEDFAMILY.
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 14 hits.
SM00179. EGF_CA. 9 hits.
SM00215. VWC_out. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 7 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 13 hits.
PS01186. EGF_2. 7 hits.
PS50026. EGF_3. 11 hits.
PS01187. EGF_CA. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 Genomes Consortium
    Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.
    , Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C., Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S., Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A., Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V., Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L., Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MSH-3 / Tucson 14011-0111.49Imported.

Entry informationi

Entry nameiB4G2H2_DROPE
AccessioniPrimary (citable) accession number: B4G2H2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: June 8, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.