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Protein

Isocitrate dehydrogenase [NADP]

Gene
N/A
Organism
Zea mays (Maize)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg2+ or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei65SubstrateUniRule annotation1
Binding sitei70NADPUniRule annotation1
Binding sitei97SubstrateUniRule annotation1
Binding sitei120SubstrateUniRule annotation1
Sitei127Critical for catalysisUniRule annotation1
Sitei198Critical for catalysisUniRule annotation1
Metal bindingi238Magnesium or manganeseUniRule annotation1
Binding sitei246NADPUniRule annotation1
Metal bindingi261Magnesium or manganeseUniRule annotation1
Binding sitei314NADP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi63 – 65NADPUniRule annotation3
Nucleotide bindingi296 – 301NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processTricarboxylic acid cycleUniRule annotation
LigandMagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
OrganismiZea mays (Maize)Imported
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea

PTM / Processingi

Proteomic databases

PRIDEiB4F9M9

Expressioni

Gene expression databases

ExpressionAtlasiB4F9M9 differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 386Iso_dhInterPro annotationAdd BLAST386

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni82 – 88Substrate bindingUniRule annotation7

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1526 Eukaryota
COG0538 LUCA
HOGENOMiHOG000019858
KOiK00031

Family and domain databases

InterProiView protein in InterPro
IPR019818 IsoCit/isopropylmalate_DH_CS
IPR004790 Isocitrate_DH_NADP
IPR024084 IsoPropMal-DH-like_dom
PANTHERiPTHR11822 PTHR11822, 1 hit
PfamiView protein in Pfam
PF00180 Iso_dh, 1 hit
PIRSFiPIRSF000108 IDH_NADP, 1 hit
SMARTiView protein in SMART
SM01329 Iso_dh, 1 hit
TIGRFAMsiTIGR00127 nadp_idh_euk, 1 hit
PROSITEiView protein in PROSITE
PS00470 IDH_IMDH, 1 hit

Sequencei

Sequence statusi: Complete.

B4F9M9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGDEMTRVI WKMIKDKLIF PYLELDVKYY DLGILNRDAT NDEVTVESAE
60 70 80 90 100
ATLKYNVAVK CATITPDETR VKEFKLKSMW RSPNGTIRNI LNGTVFREPI
110 120 130 140 150
LCKNIPRILS GWKKPICIGR HAFGDQYRAT DMIINGPGKL KMVFVPDGAD
160 170 180 190 200
PMELDVYDFK GPGVALSMYN VDESIRAFAE SSMAMALSKK WPLYLSTKNT
210 220 230 240 250
ILKKYDGRFK DIFQEVYEEQ WKEKFEENSI WYEHRLIDDM VAYAVKSDGG
260 270 280 290 300
YVWACKNYDG DVQSDFLAQG FGSLGLMTSV LLSSDGKTLE AEAAHGTVTR
310 320 330 340 350
HFRLHQKGQE TSTNSIASIF AWTRGLEHRA KLDKNDSLLD FTHKLESACV
360 370 380 390 400
ETVESGKMTK DLALLIHGPK VTREFYLSTE EFIDAVAQQL RGKIQLPTTV
Length:400
Mass (Da):45,428
Last modified:September 23, 2008 - v1
Checksum:iCD3FD43342C2F0C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT033817 mRNA Translation: ACF78822.1
RefSeqiNP_001130558.1, NM_001137086.1
UniGeneiZm.160438
Zm.84941

Genome annotation databases

GeneIDi100191657
KEGGizma:100191657

Similar proteinsi

Entry informationi

Entry nameiB4F9M9_MAIZE
AccessioniPrimary (citable) accession number: B4F9M9
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health