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B4F9M9

- B4F9M9_MAIZE

UniProt

B4F9M9 - B4F9M9_MAIZE

Protein

Isocitrate dehydrogenase [NADP]

Gene
N/A
Organism
Zea mays (Maize)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei65 – 651SubstrateUniRule annotation
    Binding sitei70 – 701NADP
    Binding sitei97 – 971SubstrateUniRule annotation
    Binding sitei120 – 1201SubstrateUniRule annotation
    Sitei127 – 1271Critical for catalysisUniRule annotation
    Sitei198 – 1981Critical for catalysisUniRule annotation
    Metal bindingi238 – 2381Magnesium or manganeseUniRule annotation
    Binding sitei246 – 2461NADP
    Metal bindingi261 – 2611Magnesium or manganeseUniRule annotation
    Binding sitei314 – 3141NADP; via amide nitrogen and carbonyl oxygen

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi63 – 653NADP
    Nucleotide bindingi296 – 3016NADP

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    OrganismiZea mays (Maize)Imported
    Taxonomic identifieri4577 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea

    Organism-specific databases

    GrameneiB4F9M9.

    Subcellular locationi

    GO - Cellular componenti

    1. chloroplast stroma Source: EnsemblPlants/Gramene
    2. chloroplast thylakoid Source: EnsemblPlants/Gramene

    PTM / Processingi

    Proteomic databases

    PRIDEiB4F9M9.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni82 – 887Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000019858.
    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4F9M9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDGDEMTRVI WKMIKDKLIF PYLELDVKYY DLGILNRDAT NDEVTVESAE    50
    ATLKYNVAVK CATITPDETR VKEFKLKSMW RSPNGTIRNI LNGTVFREPI 100
    LCKNIPRILS GWKKPICIGR HAFGDQYRAT DMIINGPGKL KMVFVPDGAD 150
    PMELDVYDFK GPGVALSMYN VDESIRAFAE SSMAMALSKK WPLYLSTKNT 200
    ILKKYDGRFK DIFQEVYEEQ WKEKFEENSI WYEHRLIDDM VAYAVKSDGG 250
    YVWACKNYDG DVQSDFLAQG FGSLGLMTSV LLSSDGKTLE AEAAHGTVTR 300
    HFRLHQKGQE TSTNSIASIF AWTRGLEHRA KLDKNDSLLD FTHKLESACV 350
    ETVESGKMTK DLALLIHGPK VTREFYLSTE EFIDAVAQQL RGKIQLPTTV 400
    Length:400
    Mass (Da):45,428
    Last modified:September 23, 2008 - v1
    Checksum:iCD3FD43342C2F0C1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT033817 mRNA. Translation: ACF78822.1.
    RefSeqiNP_001130558.1. NM_001137086.1.
    UniGeneiZm.84941.

    Genome annotation databases

    GeneIDi100191657.
    KEGGizma:100191657.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT033817 mRNA. Translation: ACF78822.1 .
    RefSeqi NP_001130558.1. NM_001137086.1.
    UniGenei Zm.84941.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi B4F9M9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100191657.
    KEGGi zma:100191657.

    Organism-specific databases

    Gramenei B4F9M9.

    Phylogenomic databases

    HOGENOMi HOG000019858.
    KOi K00031.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: B73Imported.

    Entry informationi

    Entry nameiB4F9M9_MAIZE
    AccessioniPrimary (citable) accession number: B4F9M9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 23, 2008
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)