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B4F9M9 (B4F9M9_MAIZE) Unreviewed, UniProtKB/TrEMBL

Last modified March 19, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108

EC=1.1.1.42 PIRNR PIRNR000108
OrganismZea mays (Maize) EMBL ACF78822.1
Taxonomic identifier4577 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea

Protein attributes

Sequence length400 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding63 – 653NADP By similarity
Nucleotide binding296 – 3016NADP By similarity
Region82 – 887Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2381Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2611Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site651Substrate By similarity PIRSR PIRSR000108-2
Binding site701NADP By similarity
Binding site971Substrate By similarity PIRSR PIRSR000108-2
Binding site1201Substrate By similarity PIRSR PIRSR000108-2
Binding site2461NADP By similarity
Binding site3141NADP; via amide nitrogen and carbonyl oxygen By similarity
Site1271Critical for catalysis By similarity PIRSR PIRSR000108-1
Site1981Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
B4F9M9 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: CD3FD43342C2F0C1

FASTA40045,428
        10         20         30         40         50         60 
MDGDEMTRVI WKMIKDKLIF PYLELDVKYY DLGILNRDAT NDEVTVESAE ATLKYNVAVK 

        70         80         90        100        110        120 
CATITPDETR VKEFKLKSMW RSPNGTIRNI LNGTVFREPI LCKNIPRILS GWKKPICIGR 

       130        140        150        160        170        180 
HAFGDQYRAT DMIINGPGKL KMVFVPDGAD PMELDVYDFK GPGVALSMYN VDESIRAFAE 

       190        200        210        220        230        240 
SSMAMALSKK WPLYLSTKNT ILKKYDGRFK DIFQEVYEEQ WKEKFEENSI WYEHRLIDDM 

       250        260        270        280        290        300 
VAYAVKSDGG YVWACKNYDG DVQSDFLAQG FGSLGLMTSV LLSSDGKTLE AEAAHGTVTR 

       310        320        330        340        350        360 
HFRLHQKGQE TSTNSIASIF AWTRGLEHRA KLDKNDSLLD FTHKLESACV ETVESGKMTK 

       370        380        390        400 
DLALLIHGPK VTREFYLSTE EFIDAVAQQL RGKIQLPTTV 

« Hide

References

[1]"Sequencing, mapping, and analysis of 27,455 maize full-length cDNAs."
Soderlund C., Descour A., Kudrna D., Bomhoff M., Boyd L., Currie J., Angelova A., Collura K., Wissotski M., Ashley E., Morrow D., Fernandes J., Walbot V., Yu Y.
PLoS Genet. 5:E1000740-E1000740(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: B73 EMBL ACF78822.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BT033817 mRNA. Translation: ACF78822.1.
RefSeqNP_001130558.1. NM_001137086.1.
UniGeneZm.84941.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEB4F9M9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100191657.
KEGGzma:100191657.

Organism-specific databases

GrameneB4F9M9.

Phylogenomic databases

HOGENOMHOG000019858.
KOK00031.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB4F9M9_MAIZE
AccessionPrimary (citable) accession number: B4F9M9
Entry history
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: March 19, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)