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Protein

Isocitrate dehydrogenase [NADP]

Gene
N/A
Organism
Zea mays (Maize)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg2+ or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei65SubstrateUniRule annotation1
Binding sitei70NADPUniRule annotation1
Binding sitei97SubstrateUniRule annotation1
Binding sitei120SubstrateUniRule annotation1
Sitei127Critical for catalysisUniRule annotation1
Sitei198Critical for catalysisUniRule annotation1
Metal bindingi238Magnesium or manganeseUniRule annotation1
Binding sitei246NADPUniRule annotation1
Metal bindingi261Magnesium or manganeseUniRule annotation1
Binding sitei314NADP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi63 – 65NADPUniRule annotation3
Nucleotide bindingi296 – 301NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
OrganismiZea mays (Maize)Imported
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea

PTM / Processingi

Proteomic databases

PaxDbiB4F9M9.
PRIDEiB4F9M9.

Interactioni

Protein-protein interaction databases

STRINGi4577.GRMZM2G082581_P01.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 386Iso_dhInterPro annotationAdd BLAST386

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni82 – 88Substrate bindingUniRule annotation7

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1526. Eukaryota.
COG0538. LUCA.
HOGENOMiHOG000019858.
KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4F9M9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGDEMTRVI WKMIKDKLIF PYLELDVKYY DLGILNRDAT NDEVTVESAE
60 70 80 90 100
ATLKYNVAVK CATITPDETR VKEFKLKSMW RSPNGTIRNI LNGTVFREPI
110 120 130 140 150
LCKNIPRILS GWKKPICIGR HAFGDQYRAT DMIINGPGKL KMVFVPDGAD
160 170 180 190 200
PMELDVYDFK GPGVALSMYN VDESIRAFAE SSMAMALSKK WPLYLSTKNT
210 220 230 240 250
ILKKYDGRFK DIFQEVYEEQ WKEKFEENSI WYEHRLIDDM VAYAVKSDGG
260 270 280 290 300
YVWACKNYDG DVQSDFLAQG FGSLGLMTSV LLSSDGKTLE AEAAHGTVTR
310 320 330 340 350
HFRLHQKGQE TSTNSIASIF AWTRGLEHRA KLDKNDSLLD FTHKLESACV
360 370 380 390 400
ETVESGKMTK DLALLIHGPK VTREFYLSTE EFIDAVAQQL RGKIQLPTTV
Length:400
Mass (Da):45,428
Last modified:September 23, 2008 - v1
Checksum:iCD3FD43342C2F0C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT033817 mRNA. Translation: ACF78822.1.
RefSeqiNP_001130558.1. NM_001137086.1.
UniGeneiZm.84941.

Genome annotation databases

GeneIDi100191657.
KEGGizma:100191657.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT033817 mRNA. Translation: ACF78822.1.
RefSeqiNP_001130558.1. NM_001137086.1.
UniGeneiZm.84941.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi4577.GRMZM2G082581_P01.

Proteomic databases

PaxDbiB4F9M9.
PRIDEiB4F9M9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100191657.
KEGGizma:100191657.

Phylogenomic databases

eggNOGiKOG1526. Eukaryota.
COG0538. LUCA.
HOGENOMiHOG000019858.
KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB4F9M9_MAIZE
AccessioniPrimary (citable) accession number: B4F9M9
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: June 8, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.