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B4F9M9

- B4F9M9_MAIZE

UniProt

B4F9M9 - B4F9M9_MAIZE

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Protein

Isocitrate dehydrogenase [NADP]

Gene
N/A
Organism
Zea mays (Maize)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei65 – 651Substrate By similarity
Binding sitei70 – 701NADP By similarityUniRule annotation
Binding sitei97 – 971Substrate By similarity
Binding sitei120 – 1201Substrate By similarityUniRule annotation
Sitei127 – 1271Critical for catalysis By similarityUniRule annotation
Sitei198 – 1981Critical for catalysis By similarityUniRule annotation
Metal bindingi238 – 2381Magnesium or manganese By similarityUniRule annotation
Binding sitei246 – 2461NADP By similarityUniRule annotation
Metal bindingi261 – 2611Magnesium or manganese By similarityUniRule annotation
Binding sitei314 – 3141NADP; via amide nitrogen and carbonyl oxygen By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi63 – 653NADP By similarityUniRule annotation
Nucleotide bindingi296 – 3016NADP By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
OrganismiZea mays (Maize)Imported
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogoneaeZea

Organism-specific databases

GrameneiB4F9M9.

Subcellular locationi

GO - Cellular componenti

  1. chloroplast stroma Source: EnsemblPlants/Gramene
  2. chloroplast thylakoid Source: EnsemblPlants/Gramene
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiB4F9M9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni82 – 887Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000019858.
KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4F9M9-1 [UniParc]FASTAAdd to Basket

« Hide

MDGDEMTRVI WKMIKDKLIF PYLELDVKYY DLGILNRDAT NDEVTVESAE    50
ATLKYNVAVK CATITPDETR VKEFKLKSMW RSPNGTIRNI LNGTVFREPI 100
LCKNIPRILS GWKKPICIGR HAFGDQYRAT DMIINGPGKL KMVFVPDGAD 150
PMELDVYDFK GPGVALSMYN VDESIRAFAE SSMAMALSKK WPLYLSTKNT 200
ILKKYDGRFK DIFQEVYEEQ WKEKFEENSI WYEHRLIDDM VAYAVKSDGG 250
YVWACKNYDG DVQSDFLAQG FGSLGLMTSV LLSSDGKTLE AEAAHGTVTR 300
HFRLHQKGQE TSTNSIASIF AWTRGLEHRA KLDKNDSLLD FTHKLESACV 350
ETVESGKMTK DLALLIHGPK VTREFYLSTE EFIDAVAQQL RGKIQLPTTV 400
Length:400
Mass (Da):45,428
Last modified:September 23, 2008 - v1
Checksum:iCD3FD43342C2F0C1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT033817 mRNA. Translation: ACF78822.1.
RefSeqiNP_001130558.1. NM_001137086.1.
UniGeneiZm.84941.

Genome annotation databases

GeneIDi100191657.
KEGGizma:100191657.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT033817 mRNA. Translation: ACF78822.1 .
RefSeqi NP_001130558.1. NM_001137086.1.
UniGenei Zm.84941.

3D structure databases

ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi B4F9M9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100191657.
KEGGi zma:100191657.

Organism-specific databases

Gramenei B4F9M9.

Phylogenomic databases

HOGENOMi HOG000019858.
KOi K00031.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: B73Imported.

Entry informationi

Entry nameiB4F9M9_MAIZE
AccessioniPrimary (citable) accession number: B4F9M9
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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