Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Niban-like protein 1

Gene

Fam129b

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in apoptosis suppression.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Niban-like protein 1
Alternative name(s):
Protein FAM129B
Gene namesi
Name:Fam129b
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi1307018. Fam129b.

Subcellular locationi

  • Cytoplasmcytosol By similarity
  • Cell junctionadherens junction By similarity
  • Membrane By similarity; Lipid-anchor By similarity

  • Note: In exponentially growing cells, exclusively cytoplasmic. Cell membrane localization is observed when cells reach confluency and during telophase (By similarity). Phosphorylation may play a role in relocalization to the membrane (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 747746Niban-like protein 1PRO_0000412856Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity
Modified residuei568 – 5681PhosphoserineBy similarity
Modified residuei574 – 5741PhosphoserineBy similarity
Modified residuei605 – 6051PhosphoserineBy similarity
Modified residuei626 – 6261PhosphoserineCombined sources
Modified residuei641 – 6411PhosphoserineCombined sources
Modified residuei645 – 6451PhosphoserineCombined sources
Modified residuei648 – 6481PhosphoserineCombined sources
Modified residuei667 – 6671PhosphoserineBy similarity
Modified residuei672 – 6721PhosphoserineCombined sources
Modified residuei683 – 6831PhosphoserineBy similarity
Modified residuei693 – 6931PhosphoserineCombined sources
Modified residuei697 – 6971PhosphoserineCombined sources

Post-translational modificationi

As apoptosis proceeds, degraded via an proteasome-independent pathway, probably by caspases.By similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

PaxDbiB4F7E8.
PeptideAtlasiB4F7E8.
PRIDEiB4F7E8.

PTM databases

iPTMnetiB4F7E8.

Expressioni

Gene expression databases

GenevisibleiB4F7E8. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021689.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 192125PHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Niban family.Curated
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IFR1. Eukaryota.
ENOG41102BB. LUCA.
GeneTreeiENSGT00530000063284.
HOGENOMiHOG000220836.
HOVERGENiHBG026217.
InParanoidiB4F7E8.
OMAiPIDWGEE.
OrthoDBiEOG7GN2MC.
TreeFamiTF333351.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR026088. Niban-like.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR14392. PTHR14392. 1 hit.
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B4F7E8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDVLSTHLD DARRQNIAEK TEKILREFLR FYEDQYGVSL FNSMRHEIEG
60 70 80 90 100
TGPPQAQLLW RKVPLDERII FSGNLFQYQE DNKKWRNRFS LVPHNYGLVL
110 120 130 140 150
YENKVAYERQ IPPRAVINSA GYKVLTSLDQ YLELVGNSLP GTTSKSGSTP
160 170 180 190 200
ILKCPTQFPL ILWHPYARHY YFCMMTEAEQ DKWQAVLQDC VRHCNNGIPE
210 220 230 240 250
NSKVEGPAFT DAIRMYRQSK EQYGTWEMLC GNEVQILSNL VMEELGPALK
260 270 280 290 300
TELGPRLKGK PQERQRQWIQ ISDAVYRLVF EQAKVHFEEV LCKLQLARPA
310 320 330 340 350
MEAVIRTDMD QIITSKEHLA SKIRAFILPK AEVCVRNHVQ PYIPSILEAL
360 370 380 390 400
MVPTSQGFTE VRDVFFKEVT DMNLNVINEG GIDKLGEYME KLSQLAYHPL
410 420 430 440 450
KMQSCYEKME PLRLDGLQQR FDVSSTSVFK QRAQIHMREQ MDNAVYTFET
460 470 480 490 500
LLHQELGKGP TKEELCKSIQ RILERVLKKY DYDSSSVRKR FFREALLQIT
510 520 530 540 550
IPFLLKKLAP TCKSELPRFQ ELIFEDFARF ILVENTYEEV VLQTVMKDIL
560 570 580 590 600
QAVKEAAVQR KHNLYRDSVV LHNSDPNLHL LAEGAPIDWG EQYGDGGDGS
610 620 630 640 650
DSGGSPCPSE AATLTEKRRR AKQVVSVVQD EESGLPFEAG SEPPSPASPD
660 670 680 690 700
NVTELRGLLA QDLQAESSPP ASPLLNGAPV QESPQPMTVL EASPPASPLR
710 720 730 740
HLPPGKAVDL EPPKPSDQET GEKVSSPGSR PPIHTTTEDS AGVQTEF
Length:747
Mass (Da):84,731
Last modified:September 23, 2008 - v1
Checksum:iCE5CFDA3C47A2EE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474001 Genomic DNA. Translation: EDL93203.1.
BC168248 mRNA. Translation: AAI68248.1.
RefSeqiNP_001103355.1. NM_001109885.1.
UniGeneiRn.4205.

Genome annotation databases

EnsembliENSRNOT00000021689; ENSRNOP00000021689; ENSRNOG00000015845.
GeneIDi362115.
KEGGirno:362115.
UCSCiRGD:1307018. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH474001 Genomic DNA. Translation: EDL93203.1.
BC168248 mRNA. Translation: AAI68248.1.
RefSeqiNP_001103355.1. NM_001109885.1.
UniGeneiRn.4205.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021689.

PTM databases

iPTMnetiB4F7E8.

Proteomic databases

PaxDbiB4F7E8.
PeptideAtlasiB4F7E8.
PRIDEiB4F7E8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021689; ENSRNOP00000021689; ENSRNOG00000015845.
GeneIDi362115.
KEGGirno:362115.
UCSCiRGD:1307018. rat.

Organism-specific databases

CTDi64855.
RGDi1307018. Fam129b.

Phylogenomic databases

eggNOGiENOG410IFR1. Eukaryota.
ENOG41102BB. LUCA.
GeneTreeiENSGT00530000063284.
HOGENOMiHOG000220836.
HOVERGENiHBG026217.
InParanoidiB4F7E8.
OMAiPIDWGEE.
OrthoDBiEOG7GN2MC.
TreeFamiTF333351.

Miscellaneous databases

PROiB4F7E8.

Gene expression databases

GenevisibleiB4F7E8. RN.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR026088. Niban-like.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR14392. PTHR14392. 1 hit.
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-626; SER-641; SER-645; SER-648; SER-672; SER-693 AND SER-697, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNIBL1_RAT
AccessioniPrimary (citable) accession number: B4F7E8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: September 23, 2008
Last modified: July 6, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.