true2011-05-032024-01-2475TDRD5_RATThe status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).The MGC Project Teamdoi:10.1101/gr.25965042004Genome Res.142121-2127NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]BrainratTdrd5EukaryotaLOTUS_1_TDRD5LOTUS_2_TDRD5LOTUS_3_TDRD5Tudor_TDRD5LOTUS domain-likeLOTUS-likeOST-HTH/LOTUS_domSNase_OB-fold_sfTDRD5_LOTUS_2TudorTUDOR DOMAIN CONTAINING PROTEINTUDOR DOMAIN-CONTAINING PROTEIN 5OST-HTHTUDORTUDORTudor/PWWP/MBTHTH_OSTTUDORTudor domain-containing protein 5Tdrd5Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly (By similarity).Localizes to chromatoid body (CB) and pi-body (also called intermitochondrial cementin), 2 cytoplasmic ribonucleoprotein granules involved in RNA processing for spermatogenesis.Belongs to the TDRD5 family.Tudor domain-containing protein 51113271995HTH OST-type 1780HTH OST-type 2122197HTH OST-type 3291365Tudor533592Disordered747781Disordered857892Disordered911960Basic and acidic residues777Phosphoserine9462008-09-231111327e965f0e346cebcf32280b35caafc0eaeMSEQERIQDCLRKEIRSLLISTKDGLTPQQLEKEYLLMVGNHLPLRILGYRSTMELVLDMPDVVSVCPCGDGTVILKAIPDESTKGIASLVAKQRRSHKVRNSMQKGRSSVCSGRVPYRGRVPPILPAVVKSELKDLLALSPVLLSDFEKAFARRFGRSFQYMQYGFLSMFEVLSAASDVICVEQTRAGSLLTLKKSASEEKQREWPAGKIFTQPFRMKQQGSYSTGFPVTKTRFSQPISNMEPPKQVLSMEKIPMFNTVEASRLSHTEKLNQLESTFKSVIAQIGPGGTVDPDLKHKIKFVVSKFPQGLFISKLLGEFELVFKEQLSPKQLGFLNVTELVGALSDILRVEFSEEKQDLLVFDADLRPLLPAGPLSSVRNSCLVQPDKRIEANAWASSPSRNSLSTVAVKKTTWDCPLKNHKEAEQKAYKKPNLVVKPLQLQVETNKSQLSLSMANHDIPPDAVRAKKLCRLPPLDTSTLVGVFVEYIISPSQFYVRIYSRDSSELLEDMMIEMRRCYSNQLVSDRYVMPEYFIQPGHLCCVRISEDKWWYRVIIHRILGKKEVEVFYPDFGNIGTVQKSSLRFLKCCYTKLPAQAIPCSLAWVRPAEEHWTSKAILHFQKLCGLKPLVGVVDEYIDGILNIFLCDTSSNEDVYFHHVLRTEGHAIVCRENAPSKGFRDFNPPALYTNSSAAPGDMVLTELGHPAQQHYLNEDGEILQQPQQDINDEKSISHLKSVSEELLKDSKLGPLKTRESCEEEPQWSILKPKDPKEENEDEVPTGMPCLESVTIGDDIWDENWLPLQAKMGKAGGPASHLFTSSLVGKKQYQTRGETTRKDWCFSTSKDIWDDSWQPLGLANDVKGRTHTPEGPIAQEKNIGTTRIRKQPDLQYPLDSSTLPKLEEFYISLIKSQQSAEGSQSEPASIQTPLKPGQASSTAPSSTPAAGDSPENHSGSAPDFSEALHSSKYSHGCLGSSCAVSHVQEPPALVPQCERREAtruetruetruetruetruetruetruetrue