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B4F7C4

- TDRD5_RAT

UniProt

B4F7C4 - TDRD5_RAT

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Protein
Tudor domain-containing protein 5
Gene
Tdrd5
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly By similarity.

GO - Biological processi

  1. DNA methylation involved in gamete generation Source: UniProtKB
  2. P granule organization Source: UniProtKB
  3. spermatid development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Tudor domain-containing protein 5
Gene namesi
Name:Tdrd5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi1307078. Tdrd5.

Subcellular locationi

Cytoplasm By similarity
Note: Localizes to chromatoid body (CB) and pi-body (also called intermitochondrial cementin), 2 cytoplasmic ribonucleoprotein granules involved in RNA processing for spermatogenesis By similarity.

GO - Cellular componenti

  1. chromatoid body Source: UniProtKB
  2. pi-body Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 995995Tudor domain-containing protein 5
PRO_0000408348Add
BLAST

Proteomic databases

PaxDbiB4F7C4.

Expressioni

Gene expression databases

GenevestigatoriB4F7C4.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005353.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 8074HTH OST-type 1
Add
BLAST
Domaini122 – 19776HTH OST-type 2
Add
BLAST
Domaini291 – 36575HTH OST-type 3
Add
BLAST
Domaini533 – 59260Tudor
Add
BLAST

Sequence similaritiesi

Belongs to the TDRD5 family.
Contains 3 HTH OST-type domains.
Contains 1 Tudor domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG317803.
GeneTreeiENSGT00730000110295.
HOGENOMiHOG000070453.
HOVERGENiHBG104306.
OMAiQKLYIPR.
OrthoDBiEOG7W6WKS.
PhylomeDBiB4F7C4.
TreeFamiTF342664.

Family and domain databases

InterProiIPR025605. OST-HTH/LOTUS_dom.
IPR002999. Tudor.
[Graphical view]
PfamiPF12872. OST-HTH. 3 hits.
PF00567. TUDOR. 1 hit.
[Graphical view]
SMARTiSM00333. TUDOR. 1 hit.
[Graphical view]
PROSITEiPS51644. HTH_OST. 3 hits.
PS50304. TUDOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4F7C4-1 [UniParc]FASTAAdd to Basket

« Hide

MSEQERIQDC LRKEIRSLLI STKDGLTPQQ LEKEYLLMVG NHLPLRILGY    50
RSTMELVLDM PDVVSVCPCG DGTVILKAIP DESTKGIASL VAKQRRSHKV 100
RNSMQKGRSS VCSGRVPYRG RVPPILPAVV KSELKDLLAL SPVLLSDFEK 150
AFARRFGRSF QYMQYGFLSM FEVLSAASDV ICVEQTRAGS LLTLKKSASE 200
EKQREWPAGK IFTQPFRMKQ QGSYSTGFPV TKTRFSQPIS NMEPPKQVLS 250
MEKIPMFNTV EASRLSHTEK LNQLESTFKS VIAQIGPGGT VDPDLKHKIK 300
FVVSKFPQGL FISKLLGEFE LVFKEQLSPK QLGFLNVTEL VGALSDILRV 350
EFSEEKQDLL VFDADLRPLL PAGPLSSVRN SCLVQPDKRI EANAWASSPS 400
RNSLSTVAVK KTTWDCPLKN HKEAEQKAYK KPNLVVKPLQ LQVETNKSQL 450
SLSMANHDIP PDAVRAKKLC RLPPLDTSTL VGVFVEYIIS PSQFYVRIYS 500
RDSSELLEDM MIEMRRCYSN QLVSDRYVMP EYFIQPGHLC CVRISEDKWW 550
YRVIIHRILG KKEVEVFYPD FGNIGTVQKS SLRFLKCCYT KLPAQAIPCS 600
LAWVRPAEEH WTSKAILHFQ KLCGLKPLVG VVDEYIDGIL NIFLCDTSSN 650
EDVYFHHVLR TEGHAIVCRE NAPSKGFRDF NPPALYTNSS AAPGDMVLTE 700
LGHPAQQHYL NEDGEILQQP QQDINDEKSI SHLKSVSEEL LKDSKLGPLK 750
TRESCEEEPQ WSILKPKDPK EENEDEVPTG MPCLESVTIG DDIWDENWLP 800
LQAKMGKAGG PASHLFTSSL VGKKQYQTRG ETTRKDWCFS TSKDIWDDSW 850
QPLGLANDVK GRTHTPEGPI AQEKNIGTTR IRKQPDLQYP LDSSTLPKLE 900
EFYISLIKSQ QSAEGSQSEP ASIQTPLKPG QASSTAPSST PAAGDSPENH 950
SGSAPDFSEA LHSSKYSHGC LGSSCAVSHV QEPPALVPQC ERREA 995
Length:995
Mass (Da):111,327
Last modified:September 23, 2008 - v1
Checksum:iD802E761DDD5E1F4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC168218 mRNA. Translation: AAI68218.1.
RefSeqiNP_001128212.1. NM_001134740.1.
UniGeneiRn.108460.

Genome annotation databases

EnsembliENSRNOT00000005353; ENSRNOP00000005353; ENSRNOG00000004018.
GeneIDi289129.
KEGGirno:289129.
UCSCiRGD:1307078. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC168218 mRNA. Translation: AAI68218.1 .
RefSeqi NP_001128212.1. NM_001134740.1.
UniGenei Rn.108460.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000005353.

Proteomic databases

PaxDbi B4F7C4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000005353 ; ENSRNOP00000005353 ; ENSRNOG00000004018 .
GeneIDi 289129.
KEGGi rno:289129.
UCSCi RGD:1307078. rat.

Organism-specific databases

CTDi 163589.
RGDi 1307078. Tdrd5.

Phylogenomic databases

eggNOGi NOG317803.
GeneTreei ENSGT00730000110295.
HOGENOMi HOG000070453.
HOVERGENi HBG104306.
OMAi QKLYIPR.
OrthoDBi EOG7W6WKS.
PhylomeDBi B4F7C4.
TreeFami TF342664.

Miscellaneous databases

NextBioi 629262.

Gene expression databases

Genevestigatori B4F7C4.

Family and domain databases

InterProi IPR025605. OST-HTH/LOTUS_dom.
IPR002999. Tudor.
[Graphical view ]
Pfami PF12872. OST-HTH. 3 hits.
PF00567. TUDOR. 1 hit.
[Graphical view ]
SMARTi SM00333. TUDOR. 1 hit.
[Graphical view ]
PROSITEi PS51644. HTH_OST. 3 hits.
PS50304. TUDOR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiTDRD5_RAT
AccessioniPrimary (citable) accession number: B4F7C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: September 23, 2008
Last modified: April 16, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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