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Protein

Tudor domain-containing protein 5

Gene

Tdrd5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly (By similarity).By similarity

GO - Biological processi

  1. DNA methylation involved in gamete generation Source: UniProtKB
  2. P granule organization Source: UniProtKB
  3. spermatid development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Tudor domain-containing protein 5
Gene namesi
Name:Tdrd5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi1307078. Tdrd5.

Subcellular locationi

Cytoplasm By similarity
Note: Localizes to chromatoid body (CB) and pi-body (also called intermitochondrial cementin), 2 cytoplasmic ribonucleoprotein granules involved in RNA processing for spermatogenesis.By similarity

GO - Cellular componenti

  1. chromatoid body Source: UniProtKB
  2. pi-body Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 995995Tudor domain-containing protein 5PRO_0000408348Add
BLAST

Proteomic databases

PaxDbiB4F7C4.

Expressioni

Gene expression databases

GenevestigatoriB4F7C4.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005353.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 8074HTH OST-type 1PROSITE-ProRule annotationAdd
BLAST
Domaini122 – 19776HTH OST-type 2PROSITE-ProRule annotationAdd
BLAST
Domaini291 – 36575HTH OST-type 3PROSITE-ProRule annotationAdd
BLAST
Domaini533 – 59260TudorPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TDRD5 family.Curated
Contains 3 HTH OST-type domains.PROSITE-ProRule annotation
Contains 1 Tudor domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG317803.
GeneTreeiENSGT00730000110295.
HOGENOMiHOG000070453.
HOVERGENiHBG104306.
InParanoidiB4F7C4.
KOiK18407.
OMAiPKKLGFL.
OrthoDBiEOG7W6WKS.
PhylomeDBiB4F7C4.
TreeFamiTF342664.

Family and domain databases

InterProiIPR025605. OST-HTH/LOTUS_dom.
IPR002999. Tudor.
[Graphical view]
PfamiPF12872. OST-HTH. 3 hits.
PF00567. TUDOR. 1 hit.
[Graphical view]
SMARTiSM00333. TUDOR. 1 hit.
[Graphical view]
PROSITEiPS51644. HTH_OST. 3 hits.
PS50304. TUDOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4F7C4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEQERIQDC LRKEIRSLLI STKDGLTPQQ LEKEYLLMVG NHLPLRILGY
60 70 80 90 100
RSTMELVLDM PDVVSVCPCG DGTVILKAIP DESTKGIASL VAKQRRSHKV
110 120 130 140 150
RNSMQKGRSS VCSGRVPYRG RVPPILPAVV KSELKDLLAL SPVLLSDFEK
160 170 180 190 200
AFARRFGRSF QYMQYGFLSM FEVLSAASDV ICVEQTRAGS LLTLKKSASE
210 220 230 240 250
EKQREWPAGK IFTQPFRMKQ QGSYSTGFPV TKTRFSQPIS NMEPPKQVLS
260 270 280 290 300
MEKIPMFNTV EASRLSHTEK LNQLESTFKS VIAQIGPGGT VDPDLKHKIK
310 320 330 340 350
FVVSKFPQGL FISKLLGEFE LVFKEQLSPK QLGFLNVTEL VGALSDILRV
360 370 380 390 400
EFSEEKQDLL VFDADLRPLL PAGPLSSVRN SCLVQPDKRI EANAWASSPS
410 420 430 440 450
RNSLSTVAVK KTTWDCPLKN HKEAEQKAYK KPNLVVKPLQ LQVETNKSQL
460 470 480 490 500
SLSMANHDIP PDAVRAKKLC RLPPLDTSTL VGVFVEYIIS PSQFYVRIYS
510 520 530 540 550
RDSSELLEDM MIEMRRCYSN QLVSDRYVMP EYFIQPGHLC CVRISEDKWW
560 570 580 590 600
YRVIIHRILG KKEVEVFYPD FGNIGTVQKS SLRFLKCCYT KLPAQAIPCS
610 620 630 640 650
LAWVRPAEEH WTSKAILHFQ KLCGLKPLVG VVDEYIDGIL NIFLCDTSSN
660 670 680 690 700
EDVYFHHVLR TEGHAIVCRE NAPSKGFRDF NPPALYTNSS AAPGDMVLTE
710 720 730 740 750
LGHPAQQHYL NEDGEILQQP QQDINDEKSI SHLKSVSEEL LKDSKLGPLK
760 770 780 790 800
TRESCEEEPQ WSILKPKDPK EENEDEVPTG MPCLESVTIG DDIWDENWLP
810 820 830 840 850
LQAKMGKAGG PASHLFTSSL VGKKQYQTRG ETTRKDWCFS TSKDIWDDSW
860 870 880 890 900
QPLGLANDVK GRTHTPEGPI AQEKNIGTTR IRKQPDLQYP LDSSTLPKLE
910 920 930 940 950
EFYISLIKSQ QSAEGSQSEP ASIQTPLKPG QASSTAPSST PAAGDSPENH
960 970 980 990
SGSAPDFSEA LHSSKYSHGC LGSSCAVSHV QEPPALVPQC ERREA
Length:995
Mass (Da):111,327
Last modified:September 23, 2008 - v1
Checksum:iD802E761DDD5E1F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC168218 mRNA. Translation: AAI68218.1.
RefSeqiNP_001128212.1. NM_001134740.1.
UniGeneiRn.108460.

Genome annotation databases

EnsembliENSRNOT00000005353; ENSRNOP00000005353; ENSRNOG00000004018.
GeneIDi289129.
KEGGirno:289129.
UCSCiRGD:1307078. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC168218 mRNA. Translation: AAI68218.1.
RefSeqiNP_001128212.1. NM_001134740.1.
UniGeneiRn.108460.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005353.

Proteomic databases

PaxDbiB4F7C4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005353; ENSRNOP00000005353; ENSRNOG00000004018.
GeneIDi289129.
KEGGirno:289129.
UCSCiRGD:1307078. rat.

Organism-specific databases

CTDi163589.
RGDi1307078. Tdrd5.

Phylogenomic databases

eggNOGiNOG317803.
GeneTreeiENSGT00730000110295.
HOGENOMiHOG000070453.
HOVERGENiHBG104306.
InParanoidiB4F7C4.
KOiK18407.
OMAiPKKLGFL.
OrthoDBiEOG7W6WKS.
PhylomeDBiB4F7C4.
TreeFamiTF342664.

Miscellaneous databases

NextBioi629262.

Gene expression databases

GenevestigatoriB4F7C4.

Family and domain databases

InterProiIPR025605. OST-HTH/LOTUS_dom.
IPR002999. Tudor.
[Graphical view]
PfamiPF12872. OST-HTH. 3 hits.
PF00567. TUDOR. 1 hit.
[Graphical view]
SMARTiSM00333. TUDOR. 1 hit.
[Graphical view]
PROSITEiPS51644. HTH_OST. 3 hits.
PS50304. TUDOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiTDRD5_RAT
AccessioniPrimary (citable) accession number: B4F7C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: September 23, 2008
Last modified: January 7, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.