B4F7C4 (TDRD5_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tudor domain-containing protein 5

Gene names

Name:

Tdrd5

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	995 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly By similarity.
Subcellular location	Cytoplasm By similarity. Note: Localizes to chromatoid body (CB) and pi-body (also called intermitochondrial cementin), 2 cytoplasmic ribonucleoprotein granules involved in RNA processing for spermatogenesis By similarity.
Sequence similarities	Belongs to the TDRD5 family. Contains 3 HTH OST-type domains. Contains 1 Tudor domain.

Ontologies

Keywords
Biological process	Differentiation Spermatogenesis
Cellular component	Cytoplasm
Domain	Repeat
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA methylation involved in gamete generation Inferred from sequence or structural similarity. Source: UniProtKB P granule organization Inferred from sequence or structural similarity. Source: UniProtKB spermatid development Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	chromatoid body Inferred from sequence or structural similarity. Source: UniProtKB pi-body Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 995	995	Tudor domain-containing protein 5		PRO_0000408348
Regions
	Domain	7 – 80	74	HTH OST-type 1
	Domain	122 – 197	76	HTH OST-type 2
	Domain	291 – 365	75	HTH OST-type 3
	Domain	533 – 592	60	Tudor

Sequences

	Sequence		Length	Mass (Da)
	B4F7C4 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: D802E761DDD5E1F4	FASTA	995	111,327
	10 20 30 40 50 60 MSEQERIQDC LRKEIRSLLI STKDGLTPQQ LEKEYLLMVG NHLPLRILGY RSTMELVLDM 70 80 90 100 110 120 PDVVSVCPCG DGTVILKAIP DESTKGIASL VAKQRRSHKV RNSMQKGRSS VCSGRVPYRG 130 140 150 160 170 180 RVPPILPAVV KSELKDLLAL SPVLLSDFEK AFARRFGRSF QYMQYGFLSM FEVLSAASDV 190 200 210 220 230 240 ICVEQTRAGS LLTLKKSASE EKQREWPAGK IFTQPFRMKQ QGSYSTGFPV TKTRFSQPIS 250 260 270 280 290 300 NMEPPKQVLS MEKIPMFNTV EASRLSHTEK LNQLESTFKS VIAQIGPGGT VDPDLKHKIK 310 320 330 340 350 360 FVVSKFPQGL FISKLLGEFE LVFKEQLSPK QLGFLNVTEL VGALSDILRV EFSEEKQDLL 370 380 390 400 410 420 VFDADLRPLL PAGPLSSVRN SCLVQPDKRI EANAWASSPS RNSLSTVAVK KTTWDCPLKN 430 440 450 460 470 480 HKEAEQKAYK KPNLVVKPLQ LQVETNKSQL SLSMANHDIP PDAVRAKKLC RLPPLDTSTL 490 500 510 520 530 540 VGVFVEYIIS PSQFYVRIYS RDSSELLEDM MIEMRRCYSN QLVSDRYVMP EYFIQPGHLC 550 560 570 580 590 600 CVRISEDKWW YRVIIHRILG KKEVEVFYPD FGNIGTVQKS SLRFLKCCYT KLPAQAIPCS 610 620 630 640 650 660 LAWVRPAEEH WTSKAILHFQ KLCGLKPLVG VVDEYIDGIL NIFLCDTSSN EDVYFHHVLR 670 680 690 700 710 720 TEGHAIVCRE NAPSKGFRDF NPPALYTNSS AAPGDMVLTE LGHPAQQHYL NEDGEILQQP 730 740 750 760 770 780 QQDINDEKSI SHLKSVSEEL LKDSKLGPLK TRESCEEEPQ WSILKPKDPK EENEDEVPTG 790 800 810 820 830 840 MPCLESVTIG DDIWDENWLP LQAKMGKAGG PASHLFTSSL VGKKQYQTRG ETTRKDWCFS 850 860 870 880 890 900 TSKDIWDDSW QPLGLANDVK GRTHTPEGPI AQEKNIGTTR IRKQPDLQYP LDSSTLPKLE 910 920 930 940 950 960 EFYISLIKSQ QSAEGSQSEP ASIQTPLKPG QASSTAPSST PAAGDSPENH SGSAPDFSEA 970 980 990 LHSSKYSHGC LGSSCAVSHV QEPPALVPQC ERREA

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC168218 mRNA. Translation: AAI68218.1.
IPI	IPI00914238.
RefSeq	NP_001128212.1. NM_001134740.1.
UniGene	Rn.108460.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000005353.
Proteomic databases
PaxDb	B4F7C4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000005353; ENSRNOP00000005353; ENSRNOG00000004018.
GeneID	289129.
KEGG	rno:289129.
UCSC	RGD:1307078. rat.
Organism-specific databases
CTD	163589.
RGD	1307078. Tdrd5.
Phylogenomic databases
eggNOG	NOG317803.
GeneTree	ENSGT00530000063224.
HOGENOM	HOG000070453.
HOVERGEN	HBG104306.
OrthoDB	EOG41VK28.
Gene expression databases
Genevestigator	B4F7C4.
Family and domain databases
InterPro	IPR025605. OST-HTH/LOTUS_dom. IPR002999. Tudor. [Graphical view]
Pfam	PF12872. OST-HTH. 3 hits. PF00567. TUDOR. 1 hit. [Graphical view]
SMART	SM00333. TUDOR. 1 hit. [Graphical view]
PROSITE	PS51644. HTH_OST. 3 hits. PS50304. TUDOR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	629262.

Entry information

Entry name

TDRD5_RAT

Accession

Primary (citable) accession number: B4F7C4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 3, 2011
Last sequence update:	September 23, 2008
Last modified:	April 3, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program