Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

B4F7C4 (TDRD5_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tudor domain-containing protein 5
Gene names
Name:Tdrd5
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length995 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly By similarity.

Subcellular location

Cytoplasm By similarity. Note: Localizes to chromatoid body (CB) and pi-body (also called intermitochondrial cementin), 2 cytoplasmic ribonucleoprotein granules involved in RNA processing for spermatogenesis By similarity.

Sequence similarities

Belongs to the TDRD5 family.

Contains 3 HTH OST-type domains.

Contains 1 Tudor domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 995995Tudor domain-containing protein 5
PRO_0000408348

Regions

Domain7 – 8074HTH OST-type 1
Domain122 – 19776HTH OST-type 2
Domain291 – 36575HTH OST-type 3
Domain533 – 59260Tudor

Sequences

Sequence LengthMass (Da)Tools
B4F7C4 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: D802E761DDD5E1F4

FASTA995111,327
        10         20         30         40         50         60 
MSEQERIQDC LRKEIRSLLI STKDGLTPQQ LEKEYLLMVG NHLPLRILGY RSTMELVLDM 

        70         80         90        100        110        120 
PDVVSVCPCG DGTVILKAIP DESTKGIASL VAKQRRSHKV RNSMQKGRSS VCSGRVPYRG 

       130        140        150        160        170        180 
RVPPILPAVV KSELKDLLAL SPVLLSDFEK AFARRFGRSF QYMQYGFLSM FEVLSAASDV 

       190        200        210        220        230        240 
ICVEQTRAGS LLTLKKSASE EKQREWPAGK IFTQPFRMKQ QGSYSTGFPV TKTRFSQPIS 

       250        260        270        280        290        300 
NMEPPKQVLS MEKIPMFNTV EASRLSHTEK LNQLESTFKS VIAQIGPGGT VDPDLKHKIK 

       310        320        330        340        350        360 
FVVSKFPQGL FISKLLGEFE LVFKEQLSPK QLGFLNVTEL VGALSDILRV EFSEEKQDLL 

       370        380        390        400        410        420 
VFDADLRPLL PAGPLSSVRN SCLVQPDKRI EANAWASSPS RNSLSTVAVK KTTWDCPLKN 

       430        440        450        460        470        480 
HKEAEQKAYK KPNLVVKPLQ LQVETNKSQL SLSMANHDIP PDAVRAKKLC RLPPLDTSTL 

       490        500        510        520        530        540 
VGVFVEYIIS PSQFYVRIYS RDSSELLEDM MIEMRRCYSN QLVSDRYVMP EYFIQPGHLC 

       550        560        570        580        590        600 
CVRISEDKWW YRVIIHRILG KKEVEVFYPD FGNIGTVQKS SLRFLKCCYT KLPAQAIPCS 

       610        620        630        640        650        660 
LAWVRPAEEH WTSKAILHFQ KLCGLKPLVG VVDEYIDGIL NIFLCDTSSN EDVYFHHVLR 

       670        680        690        700        710        720 
TEGHAIVCRE NAPSKGFRDF NPPALYTNSS AAPGDMVLTE LGHPAQQHYL NEDGEILQQP 

       730        740        750        760        770        780 
QQDINDEKSI SHLKSVSEEL LKDSKLGPLK TRESCEEEPQ WSILKPKDPK EENEDEVPTG 

       790        800        810        820        830        840 
MPCLESVTIG DDIWDENWLP LQAKMGKAGG PASHLFTSSL VGKKQYQTRG ETTRKDWCFS 

       850        860        870        880        890        900 
TSKDIWDDSW QPLGLANDVK GRTHTPEGPI AQEKNIGTTR IRKQPDLQYP LDSSTLPKLE 

       910        920        930        940        950        960 
EFYISLIKSQ QSAEGSQSEP ASIQTPLKPG QASSTAPSST PAAGDSPENH SGSAPDFSEA 

       970        980        990 
LHSSKYSHGC LGSSCAVSHV QEPPALVPQC ERREA 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC168218 mRNA. Translation: AAI68218.1.
RefSeqNP_001128212.1. NM_001134740.1.
UniGeneRn.108460.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000005353.

Proteomic databases

PaxDbB4F7C4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000005353; ENSRNOP00000005353; ENSRNOG00000004018.
GeneID289129.
KEGGrno:289129.
UCSCRGD:1307078. rat.

Organism-specific databases

CTD163589.
RGD1307078. Tdrd5.

Phylogenomic databases

eggNOGNOG317803.
GeneTreeENSGT00730000110295.
HOGENOMHOG000070453.
HOVERGENHBG104306.
OMAQKLYIPR.
OrthoDBEOG7W6WKS.
PhylomeDBB4F7C4.
TreeFamTF342664.

Gene expression databases

GenevestigatorB4F7C4.

Family and domain databases

InterProIPR025605. OST-HTH/LOTUS_dom.
IPR002999. Tudor.
[Graphical view]
PfamPF12872. OST-HTH. 3 hits.
PF00567. TUDOR. 1 hit.
[Graphical view]
SMARTSM00333. TUDOR. 1 hit.
[Graphical view]
PROSITEPS51644. HTH_OST. 3 hits.
PS50304. TUDOR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio629262.

Entry information

Entry nameTDRD5_RAT
AccessionPrimary (citable) accession number: B4F7C4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: September 23, 2008
Last modified: April 16, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families