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B4F7C4

- TDRD5_RAT

UniProt

B4F7C4 - TDRD5_RAT

Protein

Tudor domain-containing protein 5

Gene

Tdrd5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly By similarity.By similarity

    GO - Biological processi

    1. DNA methylation involved in gamete generation Source: UniProtKB
    2. P granule organization Source: UniProtKB
    3. spermatid development Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Spermatogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tudor domain-containing protein 5
    Gene namesi
    Name:Tdrd5
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 13

    Organism-specific databases

    RGDi1307078. Tdrd5.

    Subcellular locationi

    Cytoplasm By similarity
    Note: Localizes to chromatoid body (CB) and pi-body (also called intermitochondrial cementin), 2 cytoplasmic ribonucleoprotein granules involved in RNA processing for spermatogenesis.By similarity

    GO - Cellular componenti

    1. chromatoid body Source: UniProtKB
    2. pi-body Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 995995Tudor domain-containing protein 5PRO_0000408348Add
    BLAST

    Proteomic databases

    PaxDbiB4F7C4.

    Expressioni

    Gene expression databases

    GenevestigatoriB4F7C4.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000005353.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 8074HTH OST-type 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini122 – 19776HTH OST-type 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini291 – 36575HTH OST-type 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini533 – 59260TudorPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TDRD5 family.Curated
    Contains 3 HTH OST-type domains.PROSITE-ProRule annotation
    Contains 1 Tudor domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG317803.
    GeneTreeiENSGT00730000110295.
    HOGENOMiHOG000070453.
    HOVERGENiHBG104306.
    OMAiQKLYIPR.
    OrthoDBiEOG7W6WKS.
    PhylomeDBiB4F7C4.
    TreeFamiTF342664.

    Family and domain databases

    InterProiIPR025605. OST-HTH/LOTUS_dom.
    IPR002999. Tudor.
    [Graphical view]
    PfamiPF12872. OST-HTH. 3 hits.
    PF00567. TUDOR. 1 hit.
    [Graphical view]
    SMARTiSM00333. TUDOR. 1 hit.
    [Graphical view]
    PROSITEiPS51644. HTH_OST. 3 hits.
    PS50304. TUDOR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4F7C4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEQERIQDC LRKEIRSLLI STKDGLTPQQ LEKEYLLMVG NHLPLRILGY    50
    RSTMELVLDM PDVVSVCPCG DGTVILKAIP DESTKGIASL VAKQRRSHKV 100
    RNSMQKGRSS VCSGRVPYRG RVPPILPAVV KSELKDLLAL SPVLLSDFEK 150
    AFARRFGRSF QYMQYGFLSM FEVLSAASDV ICVEQTRAGS LLTLKKSASE 200
    EKQREWPAGK IFTQPFRMKQ QGSYSTGFPV TKTRFSQPIS NMEPPKQVLS 250
    MEKIPMFNTV EASRLSHTEK LNQLESTFKS VIAQIGPGGT VDPDLKHKIK 300
    FVVSKFPQGL FISKLLGEFE LVFKEQLSPK QLGFLNVTEL VGALSDILRV 350
    EFSEEKQDLL VFDADLRPLL PAGPLSSVRN SCLVQPDKRI EANAWASSPS 400
    RNSLSTVAVK KTTWDCPLKN HKEAEQKAYK KPNLVVKPLQ LQVETNKSQL 450
    SLSMANHDIP PDAVRAKKLC RLPPLDTSTL VGVFVEYIIS PSQFYVRIYS 500
    RDSSELLEDM MIEMRRCYSN QLVSDRYVMP EYFIQPGHLC CVRISEDKWW 550
    YRVIIHRILG KKEVEVFYPD FGNIGTVQKS SLRFLKCCYT KLPAQAIPCS 600
    LAWVRPAEEH WTSKAILHFQ KLCGLKPLVG VVDEYIDGIL NIFLCDTSSN 650
    EDVYFHHVLR TEGHAIVCRE NAPSKGFRDF NPPALYTNSS AAPGDMVLTE 700
    LGHPAQQHYL NEDGEILQQP QQDINDEKSI SHLKSVSEEL LKDSKLGPLK 750
    TRESCEEEPQ WSILKPKDPK EENEDEVPTG MPCLESVTIG DDIWDENWLP 800
    LQAKMGKAGG PASHLFTSSL VGKKQYQTRG ETTRKDWCFS TSKDIWDDSW 850
    QPLGLANDVK GRTHTPEGPI AQEKNIGTTR IRKQPDLQYP LDSSTLPKLE 900
    EFYISLIKSQ QSAEGSQSEP ASIQTPLKPG QASSTAPSST PAAGDSPENH 950
    SGSAPDFSEA LHSSKYSHGC LGSSCAVSHV QEPPALVPQC ERREA 995
    Length:995
    Mass (Da):111,327
    Last modified:September 23, 2008 - v1
    Checksum:iD802E761DDD5E1F4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC168218 mRNA. Translation: AAI68218.1.
    RefSeqiNP_001128212.1. NM_001134740.1.
    UniGeneiRn.108460.

    Genome annotation databases

    EnsembliENSRNOT00000005353; ENSRNOP00000005353; ENSRNOG00000004018.
    GeneIDi289129.
    KEGGirno:289129.
    UCSCiRGD:1307078. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC168218 mRNA. Translation: AAI68218.1 .
    RefSeqi NP_001128212.1. NM_001134740.1.
    UniGenei Rn.108460.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000005353.

    Proteomic databases

    PaxDbi B4F7C4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000005353 ; ENSRNOP00000005353 ; ENSRNOG00000004018 .
    GeneIDi 289129.
    KEGGi rno:289129.
    UCSCi RGD:1307078. rat.

    Organism-specific databases

    CTDi 163589.
    RGDi 1307078. Tdrd5.

    Phylogenomic databases

    eggNOGi NOG317803.
    GeneTreei ENSGT00730000110295.
    HOGENOMi HOG000070453.
    HOVERGENi HBG104306.
    OMAi QKLYIPR.
    OrthoDBi EOG7W6WKS.
    PhylomeDBi B4F7C4.
    TreeFami TF342664.

    Miscellaneous databases

    NextBioi 629262.

    Gene expression databases

    Genevestigatori B4F7C4.

    Family and domain databases

    InterProi IPR025605. OST-HTH/LOTUS_dom.
    IPR002999. Tudor.
    [Graphical view ]
    Pfami PF12872. OST-HTH. 3 hits.
    PF00567. TUDOR. 1 hit.
    [Graphical view ]
    SMARTi SM00333. TUDOR. 1 hit.
    [Graphical view ]
    PROSITEi PS51644. HTH_OST. 3 hits.
    PS50304. TUDOR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiTDRD5_RAT
    AccessioniPrimary (citable) accession number: B4F7C4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3