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Protein

Centrosomal protein of 57 kDa

Gene

Cep57

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Centrosomal protein which may be required for microtubule attachment to centrosomes. May act by forming ring-like structures around microtubules. Mediates nuclear translocation and mitogenic activity of the internalized growth factor FGF2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-RNO-380259. Loss of Nlp from mitotic centrosomes.
R-RNO-380270. Recruitment of mitotic centrosome proteins and complexes.
R-RNO-5620912. Anchoring of the basal body to the plasma membrane.
R-RNO-8854518. AURKA Activation by TPX2.

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 57 kDa
Short name:
Cep57
Alternative name(s):
Translokin
Gene namesi
Name:Cep57
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1309884. Cep57.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 499499Centrosomal protein of 57 kDaPRO_0000381817Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei53 – 531PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiB4F7A7.
PRIDEiB4F7A7.

Expressioni

Tissue specificityi

Ubiquitous (at protein level).1 Publication

Gene expression databases

GenevisibleiB4F7A7. RN.

Interactioni

Subunit structurei

Homodimer and homooligomer. Interacts with FGF2 and RAP80. Does not interact with FGF1 or FGF2 isoform 24 kDa. Interacts with microtubules (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009318.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni58 – 239182centrosome localization domain (CLD)By similarityAdd
BLAST
Regioni278 – 490213Mediates interaction with microtubulesBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili63 – 242180Sequence analysisAdd
BLAST
Coiled coili388 – 491104Sequence analysisAdd
BLAST

Domaini

The C-terminal region mediates the interaction with microtubules and is able to nucleate and bundles microtubules in vitro.By similarity
The centrosome localization domain (CLD) region mediates the localization to centrosomes and homooligomerization.By similarity

Sequence similaritiesi

Belongs to the translokin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IESE. Eukaryota.
ENOG410XPJC. LUCA.
GeneTreeiENSGT00530000063695.
HOGENOMiHOG000007408.
InParanoidiB4F7A7.
KOiK16762.
OMAiRHQPHLC.
OrthoDBiEOG7RBZ92.
PhylomeDBiB4F7A7.
TreeFamiTF329178.

Family and domain databases

InterProiIPR010597. Centrosomal_protein_57kDa.
IPR025913. Cep57_CLD.
IPR024957. Cep57_MT-bd_dom.
[Graphical view]
PANTHERiPTHR19336:SF11. PTHR19336:SF11. 1 hit.
PfamiPF14073. Cep57_CLD. 1 hit.
PF06657. Cep57_MT_bd. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4F7A7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAASVSAAS DSQFSSVLAE PSRSNGNMVH HSSSPYVLYP PDKPFLNSDL
60 70 80 90 100
RRSPNKPTFA YPESNSRAIF SALKNLQDKI RRLELERIRA EESVKTLSRE
110 120 130 140 150
TIEYKKVLDE QIQERENSKN EESKHNQELA SQLVAAENKC NLLEKQLEYM
160 170 180 190 200
RNMIKHAEME RTSVLEKQVS LERERQHDQS HVQSQLEKLD LLEQEYNRLT
210 220 230 240 250
AMQALAEKKM QELESKLHEE EQERKRMQAR AAELQSGIEA NRLIFEDRNT
260 270 280 290 300
SCVSTSTRKI KKKKSKPPEK KGFRNNFGAQ PHYRLCLGDM PFVAGTSTSP
310 320 330 340 350
SHAVVANVQH VLHLMKHHSR ALCNDRVVNS VPLAKQACSR GSKSKKSVAP
360 370 380 390 400
PSSSVNEELS DVLQTLQDEF GQMSFDHQQL TKLIQESPSE ELKDNLECEL
410 420 430 440 450
EALVRRMEAK ANQITKVRKY QAQLEKQSTD KQKELKGNKK TLDEEGNSSS
460 470 480 490
RSSVITRTTS KKDFTKQRPG EKSRKNLQLL KDMQTLQNSL QSSNVCWDY
Length:499
Mass (Da):57,040
Last modified:September 1, 2009 - v2
Checksum:i077C86BFE2B3C2C7
GO

Sequence cautioni

The sequence AAI68198.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence EDL78488.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC168198 mRNA. Translation: AAI68198.1. Different initiation.
CH473993 Genomic DNA. Translation: EDL78488.1. Sequence problems.
RefSeqiNP_001101594.2. NM_001108124.3.
XP_006242585.1. XM_006242523.2.
XP_006242586.1. XM_006242524.2.
UniGeneiRn.94972.

Genome annotation databases

EnsembliENSRNOT00000009318; ENSRNOP00000009318; ENSRNOG00000006792.
GeneIDi315423.
KEGGirno:315423.
UCSCiRGD:1309884. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC168198 mRNA. Translation: AAI68198.1. Different initiation.
CH473993 Genomic DNA. Translation: EDL78488.1. Sequence problems.
RefSeqiNP_001101594.2. NM_001108124.3.
XP_006242585.1. XM_006242523.2.
XP_006242586.1. XM_006242524.2.
UniGeneiRn.94972.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009318.

Proteomic databases

PaxDbiB4F7A7.
PRIDEiB4F7A7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009318; ENSRNOP00000009318; ENSRNOG00000006792.
GeneIDi315423.
KEGGirno:315423.
UCSCiRGD:1309884. rat.

Organism-specific databases

CTDi9702.
RGDi1309884. Cep57.

Phylogenomic databases

eggNOGiENOG410IESE. Eukaryota.
ENOG410XPJC. LUCA.
GeneTreeiENSGT00530000063695.
HOGENOMiHOG000007408.
InParanoidiB4F7A7.
KOiK16762.
OMAiRHQPHLC.
OrthoDBiEOG7RBZ92.
PhylomeDBiB4F7A7.
TreeFamiTF329178.

Enzyme and pathway databases

ReactomeiR-RNO-2565942. Regulation of PLK1 Activity at G2/M Transition.
R-RNO-380259. Loss of Nlp from mitotic centrosomes.
R-RNO-380270. Recruitment of mitotic centrosome proteins and complexes.
R-RNO-5620912. Anchoring of the basal body to the plasma membrane.
R-RNO-8854518. AURKA Activation by TPX2.

Miscellaneous databases

PROiB4F7A7.

Gene expression databases

GenevisibleiB4F7A7. RN.

Family and domain databases

InterProiIPR010597. Centrosomal_protein_57kDa.
IPR025913. Cep57_CLD.
IPR024957. Cep57_MT-bd_dom.
[Graphical view]
PANTHERiPTHR19336:SF11. PTHR19336:SF11. 1 hit.
PfamiPF14073. Cep57_CLD. 1 hit.
PF06657. Cep57_MT_bd. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "Cep57, a multidomain protein with unique microtubule and centrosomal localization domains."
    Momotani K., Khromov A.S., Miyake T., Stukenberg P.T., Somlyo A.V.
    Biochem. J. 412:265-273(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiCEP57_RAT
AccessioniPrimary (citable) accession number: B4F7A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: September 1, 2009
Last modified: July 6, 2016
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.