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Protein

Choline transporter-like protein 2

Gene

Slc44a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Choline transporter.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-RNO-1483191. Synthesis of PC.
R-RNO-425366. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Names & Taxonomyi

Protein namesi
Recommended name:
Choline transporter-like protein 2
Alternative name(s):
Solute carrier family 44 member 2
Gene namesi
Name:Slc44a2
Synonyms:Ctl2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1309680. Slc44a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333CytoplasmicSequence analysisAdd
BLAST
Transmembranei34 – 5421HelicalSequence analysisAdd
BLAST
Topological domaini55 – 232178ExtracellularSequence analysisAdd
BLAST
Transmembranei233 – 25321HelicalSequence analysisAdd
BLAST
Topological domaini254 – 2563CytoplasmicSequence analysis
Transmembranei257 – 27721HelicalSequence analysisAdd
BLAST
Topological domaini278 – 31538ExtracellularSequence analysisAdd
BLAST
Transmembranei316 – 33621HelicalSequence analysisAdd
BLAST
Topological domaini337 – 36428CytoplasmicSequence analysisAdd
BLAST
Transmembranei365 – 38521HelicalSequence analysisAdd
BLAST
Topological domaini386 – 45368ExtracellularSequence analysisAdd
BLAST
Transmembranei454 – 47623HelicalSequence analysisAdd
BLAST
Topological domaini477 – 50327CytoplasmicSequence analysisAdd
BLAST
Transmembranei504 – 52421HelicalSequence analysisAdd
BLAST
Topological domaini525 – 56238ExtracellularSequence analysisAdd
BLAST
Transmembranei563 – 58321HelicalSequence analysisAdd
BLAST
Topological domaini584 – 59815CytoplasmicSequence analysisAdd
BLAST
Transmembranei599 – 61921HelicalSequence analysisAdd
BLAST
Topological domaini620 – 63718ExtracellularSequence analysisAdd
BLAST
Transmembranei638 – 65821HelicalSequence analysisAdd
BLAST
Topological domaini659 – 70547CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 705705Choline transporter-like protein 2PRO_0000359715Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence analysis
Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence analysis
Glycosylationi416 – 4161N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiB4F795.
PRIDEiB4F795.

PTM databases

SwissPalmiB4F795.
UniCarbKBiB4F795.

Expressioni

Gene expression databases

GenevisibleiB4F795. RN.

Interactioni

Subunit structurei

Interacts with COCH.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051322.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1362. Eukaryota.
ENOG410XS0P. LUCA.
GeneTreeiENSGT00550000074521.
HOGENOMiHOG000007110.
HOVERGENiHBG062155.
InParanoidiB4F795.
KOiK15377.
OMAiQHYYGKH.
OrthoDBiEOG7FR7G4.
PhylomeDBiB4F795.

Family and domain databases

InterProiIPR007603. Choline_transptr-like.
[Graphical view]
PANTHERiPTHR12385. PTHR12385. 2 hits.
PfamiPF04515. Choline_transpo. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4F795-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKDSQHYYG KHGTPQKYDP TFKGPIYNRG CTDIICCVLL FLAIVGYVAV
60 70 80 90 100
GIIAWTHGDP RKVIYPTDSR GEFCGQKGTK NADKPFLFYF NIVKCASPLV
110 120 130 140 150
LLEFHCPTPQ ICVKQCPDRY LTFLSARNSR DFDYYKQFCV PGFKNNKGVA
160 170 180 190 200
EVLRDGECPA VIIPSKPLAQ RCFPAIHASK GVLMVGNETT YEDGHGTRKN
210 220 230 240 250
VTDLVEGAKK ANKVLEARQL AMQIFEDYTV SWYWIVIGLV IAMLLSLMFI
260 270 280 290 300
VLLRFLAGVM VWVMIVMVIL VLGYGIFHCY AEYSRLRGEA GSDVSLVDLG
310 320 330 340 350
FQTDLRVYLH LRQTWMAFMI ILSILEVVII LLLIFLRKRI LIAIALIKEA
360 370 380 390 400
SRAVGHVMCS MLYPLVTFFL LCLCIAYWAS TSVFLSTSNV AVYKIVDDTP
410 420 430 440 450
CPLLGKTCNP ETFPLNESRQ CPNGRCQFAF YGGESTYHRA LLGLQIFNAF
460 470 480 490 500
MFFWLANFVL ALGQVTLAGA FASYYWAMRK PDDMPAFPLF SAFGRALRYH
510 520 530 540 550
TGSLAFGSLI LAIVQIIRVM LEYLDQRLKA AQNKFAKFLM VCLKCCFWCL
560 570 580 590 600
EKFIKFLNRN AYIMIAIYGT NFCTSARNAF FLLMRNIIRV AVLDKVTDFL
610 620 630 640 650
FLLGKLLIVG SVGILAFFFF THRIRIVQDT APPLNYYWVP ILTVIIGSYL
660 670 680 690 700
IAHGFFSVYG MCVDTLFLCF LEDLERNDGS AERPYFMSST LKKLLNKTNK

KVAES
Length:705
Mass (Da):79,897
Last modified:September 23, 2008 - v1
Checksum:i1ADF61887F826F52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473993 Genomic DNA. Translation: EDL78302.1.
BC168183 mRNA. Translation: AAI68183.1.
RefSeqiNP_001128187.1. NM_001134715.1.
UniGeneiRn.140320.

Genome annotation databases

EnsembliENSRNOT00000049973; ENSRNOP00000051322; ENSRNOG00000031824.
GeneIDi363024.
KEGGirno:363024.
UCSCiRGD:1309680. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473993 Genomic DNA. Translation: EDL78302.1.
BC168183 mRNA. Translation: AAI68183.1.
RefSeqiNP_001128187.1. NM_001134715.1.
UniGeneiRn.140320.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051322.

PTM databases

SwissPalmiB4F795.
UniCarbKBiB4F795.

Proteomic databases

PaxDbiB4F795.
PRIDEiB4F795.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000049973; ENSRNOP00000051322; ENSRNOG00000031824.
GeneIDi363024.
KEGGirno:363024.
UCSCiRGD:1309680. rat.

Organism-specific databases

CTDi57153.
RGDi1309680. Slc44a2.

Phylogenomic databases

eggNOGiKOG1362. Eukaryota.
ENOG410XS0P. LUCA.
GeneTreeiENSGT00550000074521.
HOGENOMiHOG000007110.
HOVERGENiHBG062155.
InParanoidiB4F795.
KOiK15377.
OMAiQHYYGKH.
OrthoDBiEOG7FR7G4.
PhylomeDBiB4F795.

Enzyme and pathway databases

ReactomeiR-RNO-1483191. Synthesis of PC.
R-RNO-425366. Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds.

Miscellaneous databases

NextBioi682171.
PROiB4F795.

Gene expression databases

GenevisibleiB4F795. RN.

Family and domain databases

InterProiIPR007603. Choline_transptr-like.
[Graphical view]
PANTHERiPTHR12385. PTHR12385. 2 hits.
PfamiPF04515. Choline_transpo. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiCTL2_RAT
AccessioniPrimary (citable) accession number: B4F795
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: September 23, 2008
Last modified: February 17, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.