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Protein

Choline transporter-like protein 2

Gene

Slc44a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Choline transporter.By similarity

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-RNO-1483191 Synthesis of PC
R-RNO-425366 Transport of bile salts and organic acids, metal ions and amine compounds
R-RNO-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Choline transporter-like protein 2
Alternative name(s):
Solute carrier family 44 member 2
Gene namesi
Name:Slc44a2
Synonyms:Ctl2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1309680 Slc44a2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33CytoplasmicSequence analysisAdd BLAST33
Transmembranei34 – 54HelicalSequence analysisAdd BLAST21
Topological domaini55 – 232ExtracellularSequence analysisAdd BLAST178
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Topological domaini254 – 256CytoplasmicSequence analysis3
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Topological domaini278 – 315ExtracellularSequence analysisAdd BLAST38
Transmembranei316 – 336HelicalSequence analysisAdd BLAST21
Topological domaini337 – 364CytoplasmicSequence analysisAdd BLAST28
Transmembranei365 – 385HelicalSequence analysisAdd BLAST21
Topological domaini386 – 453ExtracellularSequence analysisAdd BLAST68
Transmembranei454 – 476HelicalSequence analysisAdd BLAST23
Topological domaini477 – 503CytoplasmicSequence analysisAdd BLAST27
Transmembranei504 – 524HelicalSequence analysisAdd BLAST21
Topological domaini525 – 562ExtracellularSequence analysisAdd BLAST38
Transmembranei563 – 583HelicalSequence analysisAdd BLAST21
Topological domaini584 – 598CytoplasmicSequence analysisAdd BLAST15
Transmembranei599 – 619HelicalSequence analysisAdd BLAST21
Topological domaini620 – 637ExtracellularSequence analysisAdd BLAST18
Transmembranei638 – 658HelicalSequence analysisAdd BLAST21
Topological domaini659 – 705CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003597151 – 705Choline transporter-like protein 2Add BLAST705

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphothreonineBy similarity1
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi200N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi416N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiB4F795
PeptideAtlasiB4F795
PRIDEiB4F795

PTM databases

SwissPalmiB4F795
UniCarbKBiB4F795

Expressioni

Gene expression databases

BgeeiENSRNOG00000031824
GenevisibleiB4F795 RN

Interactioni

Subunit structurei

Interacts with COCH.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051322

Structurei

3D structure databases

SMRiB4F795
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1362 Eukaryota
ENOG410XS0P LUCA
GeneTreeiENSGT00550000074521
HOGENOMiHOG000007110
HOVERGENiHBG062155
InParanoidiB4F795
KOiK15377
OMAiQTWMAFM
OrthoDBiEOG091G04CQ
PhylomeDBiB4F795

Family and domain databases

InterProiView protein in InterPro
IPR007603 Choline_transptr-like
PANTHERiPTHR12385 PTHR12385, 1 hit
PfamiView protein in Pfam
PF04515 Choline_transpo, 1 hit

Sequencei

Sequence statusi: Complete.

B4F795-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKDSQHYYG KHGTPQKYDP TFKGPIYNRG CTDIICCVLL FLAIVGYVAV
60 70 80 90 100
GIIAWTHGDP RKVIYPTDSR GEFCGQKGTK NADKPFLFYF NIVKCASPLV
110 120 130 140 150
LLEFHCPTPQ ICVKQCPDRY LTFLSARNSR DFDYYKQFCV PGFKNNKGVA
160 170 180 190 200
EVLRDGECPA VIIPSKPLAQ RCFPAIHASK GVLMVGNETT YEDGHGTRKN
210 220 230 240 250
VTDLVEGAKK ANKVLEARQL AMQIFEDYTV SWYWIVIGLV IAMLLSLMFI
260 270 280 290 300
VLLRFLAGVM VWVMIVMVIL VLGYGIFHCY AEYSRLRGEA GSDVSLVDLG
310 320 330 340 350
FQTDLRVYLH LRQTWMAFMI ILSILEVVII LLLIFLRKRI LIAIALIKEA
360 370 380 390 400
SRAVGHVMCS MLYPLVTFFL LCLCIAYWAS TSVFLSTSNV AVYKIVDDTP
410 420 430 440 450
CPLLGKTCNP ETFPLNESRQ CPNGRCQFAF YGGESTYHRA LLGLQIFNAF
460 470 480 490 500
MFFWLANFVL ALGQVTLAGA FASYYWAMRK PDDMPAFPLF SAFGRALRYH
510 520 530 540 550
TGSLAFGSLI LAIVQIIRVM LEYLDQRLKA AQNKFAKFLM VCLKCCFWCL
560 570 580 590 600
EKFIKFLNRN AYIMIAIYGT NFCTSARNAF FLLMRNIIRV AVLDKVTDFL
610 620 630 640 650
FLLGKLLIVG SVGILAFFFF THRIRIVQDT APPLNYYWVP ILTVIIGSYL
660 670 680 690 700
IAHGFFSVYG MCVDTLFLCF LEDLERNDGS AERPYFMSST LKKLLNKTNK

KVAES
Length:705
Mass (Da):79,897
Last modified:September 23, 2008 - v1
Checksum:i1ADF61887F826F52
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473993 Genomic DNA Translation: EDL78302.1
BC168183 mRNA Translation: AAI68183.1
RefSeqiNP_001128187.1, NM_001134715.1
UniGeneiRn.140320

Genome annotation databases

EnsembliENSRNOT00000049973; ENSRNOP00000051322; ENSRNOG00000031824
GeneIDi363024
KEGGirno:363024
UCSCiRGD:1309680 rat

Similar proteinsi

Entry informationi

Entry nameiCTL2_RAT
AccessioniPrimary (citable) accession number: B4F795
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: September 23, 2008
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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