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Protein

High mobility group nucleosome-binding domain-containing protein 5

Gene

Hmgn5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group nucleosome-binding domain-containing protein 5
Alternative name(s):
Nucleosome-binding protein 11 Publication
Gene namesi
Name:Hmgn5By similarity
Synonyms:Nsbp1Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1597988. Hmgn5.

Subcellular locationi

  • Nucleus By similarity

  • Note: Associates with nucleosomes in euchromatin and is largely excluded from constitutive heterochromatin.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003909321 – 429High mobility group nucleosome-binding domain-containing protein 5Add BLAST429

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphothreonineBy similarity1
Cross-linki64Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei90PhosphoserineBy similarity1
Cross-linki98Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki98Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki121Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiB4F777.
PeptideAtlasiB4F777.
PRIDEiB4F777.

PTM databases

iPTMnetiB4F777.
PhosphoSitePlusiB4F777.

Expressioni

Tissue specificityi

Expressed in trophoblast giant cells.1 Publication

Inductioni

Up-regulated in differentiated trophoblast giant cells.1 Publication

Gene expression databases

BgeeiENSRNOG00000029078.
GenevisibleiB4F777. RN.

Interactioni

Protein-protein interaction databases

BioGridi596215. 1 interactor.
STRINGi10116.ENSRNOP00000047671.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi62 – 424Glu-richSequence analysisAdd BLAST363

Domaini

Specifically targeted by its C-terminus to nucleosomes in euchromatin.By similarity

Sequence similaritiesi

Belongs to the HMGN family.Sequence analysis

Phylogenomic databases

eggNOGiENOG410JCH1. Eukaryota.
ENOG410XQBG. LUCA.
GeneTreeiENSGT00730000111570.
HOGENOMiHOG000070450.
HOVERGENiHBG052673.
InParanoidiB4F777.
KOiK17045.
OMAiEYNNENA.
OrthoDBiEOG091G12C3.
TreeFamiTF105374.

Family and domain databases

InterProiIPR000079. HMGN_fam.
[Graphical view]
PfamiPF01101. HMG14_17. 1 hit.
[Graphical view]
PRINTSiPR00925. NONHISHMG17.
SMARTiSM00527. HMG17. 1 hit.
[Graphical view]
PROSITEiPS00355. HMG14_17. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4F777-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKRKAAGDA SQEPKRRSAR LSAMPVPFTP ELKPKRASTS RKTKTTNVVE
60 70 80 90 100
ESKDAGATTI PETKPEVVKG ECNMENAENG EAKIIEAPIS KMETEEVKEQ
110 120 130 140 150
INEDTEGDGG EKKEAVVTKG KNDELEANIQ DVEKDEDEKE HEDTGEEGED
160 170 180 190 200
GEREGGLKEK PDVAEIEDAK EAKDDEEKED KEKEDDKGGD GKKEEEKDDE
210 220 230 240 250
GEAETEEEVK EQQKEETEGD DGKCKVEENK EGRKESQHEE EGKEELHEED
260 270 280 290 300
GKEDLHEEDG KEDLHEEDGK EDLHEEEGKE DLHEEEGKED LHEEEGKEDL
310 320 330 340 350
HEEEGKEDLH EEEGKEDLHE EEGKEDLHEE EGKEDLHEED GKEGQHEEEG
360 370 380 390 400
KEDLHEEEGK EDLHEEDGKE GQHEEDGKKK ADGNEDRKEE EEQEAATEGN
410 420
DENKVEVEEE ADNKDFKEDG EKGEPVSTV
Length:429
Mass (Da):48,605
Last modified:September 23, 2008 - v1
Checksum:iEDDEC01ECC676BF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC168165 mRNA. Translation: AAI68165.1.
RefSeqiNP_001128178.1. NM_001134706.1.
UniGeneiRn.25395.

Genome annotation databases

EnsembliENSRNOT00000048744; ENSRNOP00000047671; ENSRNOG00000029078.
GeneIDi681284.
KEGGirno:681284.
UCSCiRGD:1597988. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC168165 mRNA. Translation: AAI68165.1.
RefSeqiNP_001128178.1. NM_001134706.1.
UniGeneiRn.25395.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi596215. 1 interactor.
STRINGi10116.ENSRNOP00000047671.

PTM databases

iPTMnetiB4F777.
PhosphoSitePlusiB4F777.

Proteomic databases

PaxDbiB4F777.
PeptideAtlasiB4F777.
PRIDEiB4F777.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000048744; ENSRNOP00000047671; ENSRNOG00000029078.
GeneIDi681284.
KEGGirno:681284.
UCSCiRGD:1597988. rat.

Organism-specific databases

CTDi681284.
RGDi1597988. Hmgn5.

Phylogenomic databases

eggNOGiENOG410JCH1. Eukaryota.
ENOG410XQBG. LUCA.
GeneTreeiENSGT00730000111570.
HOGENOMiHOG000070450.
HOVERGENiHBG052673.
InParanoidiB4F777.
KOiK17045.
OMAiEYNNENA.
OrthoDBiEOG091G12C3.
TreeFamiTF105374.

Miscellaneous databases

PROiB4F777.

Gene expression databases

BgeeiENSRNOG00000029078.
GenevisibleiB4F777. RN.

Family and domain databases

InterProiIPR000079. HMGN_fam.
[Graphical view]
PfamiPF01101. HMG14_17. 1 hit.
[Graphical view]
PRINTSiPR00925. NONHISHMG17.
SMARTiSM00527. HMG17. 1 hit.
[Graphical view]
PROSITEiPS00355. HMG14_17. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHMGN5_RAT
AccessioniPrimary (citable) accession number: B4F777
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: September 23, 2008
Last modified: November 30, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.