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Protein

High mobility group nucleosome-binding domain-containing protein 5

Gene

Hmgn5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group nucleosome-binding domain-containing protein 5
Alternative name(s):
Nucleosome-binding protein 11 Publication
Gene namesi
Name:Hmgn5By similarity
Synonyms:Nsbp1Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1597988 Hmgn5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003909321 – 429High mobility group nucleosome-binding domain-containing protein 5Add BLAST429

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphothreonineBy similarity1
Cross-linki64Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei90PhosphoserineBy similarity1
Cross-linki98Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki98Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki121Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiB4F777
PeptideAtlasiB4F777
PRIDEiB4F777

PTM databases

iPTMnetiB4F777
PhosphoSitePlusiB4F777

Expressioni

Tissue specificityi

Expressed in trophoblast giant cells.1 Publication

Inductioni

Up-regulated in differentiated trophoblast giant cells.1 Publication

Gene expression databases

BgeeiENSRNOG00000029078
GenevisibleiB4F777 RN

Interactioni

Protein-protein interaction databases

BioGridi596215, 1 interactor
STRINGi10116.ENSRNOP00000047671

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi62 – 424Glu-richSequence analysisAdd BLAST363

Domaini

Specifically targeted by its C-terminus to nucleosomes in euchromatin.By similarity

Sequence similaritiesi

Belongs to the HMGN family.Sequence analysis

Phylogenomic databases

eggNOGiENOG410JCH1 Eukaryota
ENOG410XQBG LUCA
GeneTreeiENSGT00730000111570
HOGENOMiHOG000070450
HOVERGENiHBG052673
InParanoidiB4F777
KOiK17045
OMAiETQDETP
OrthoDBiEOG091G12C3
TreeFamiTF105374

Family and domain databases

InterProiView protein in InterPro
IPR000079 HMGN_fam
PfamiView protein in Pfam
PF01101 HMG14_17, 1 hit
PRINTSiPR00925 NONHISHMG17
SMARTiView protein in SMART
SM00527 HMG17, 1 hit
PROSITEiView protein in PROSITE
PS00355 HMG14_17, 1 hit

Sequencei

Sequence statusi: Complete.

B4F777-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKRKAAGDA SQEPKRRSAR LSAMPVPFTP ELKPKRASTS RKTKTTNVVE
60 70 80 90 100
ESKDAGATTI PETKPEVVKG ECNMENAENG EAKIIEAPIS KMETEEVKEQ
110 120 130 140 150
INEDTEGDGG EKKEAVVTKG KNDELEANIQ DVEKDEDEKE HEDTGEEGED
160 170 180 190 200
GEREGGLKEK PDVAEIEDAK EAKDDEEKED KEKEDDKGGD GKKEEEKDDE
210 220 230 240 250
GEAETEEEVK EQQKEETEGD DGKCKVEENK EGRKESQHEE EGKEELHEED
260 270 280 290 300
GKEDLHEEDG KEDLHEEDGK EDLHEEEGKE DLHEEEGKED LHEEEGKEDL
310 320 330 340 350
HEEEGKEDLH EEEGKEDLHE EEGKEDLHEE EGKEDLHEED GKEGQHEEEG
360 370 380 390 400
KEDLHEEEGK EDLHEEDGKE GQHEEDGKKK ADGNEDRKEE EEQEAATEGN
410 420
DENKVEVEEE ADNKDFKEDG EKGEPVSTV
Length:429
Mass (Da):48,605
Last modified:September 23, 2008 - v1
Checksum:iEDDEC01ECC676BF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC168165 mRNA Translation: AAI68165.1
RefSeqiNP_001128178.1, NM_001134706.1
UniGeneiRn.25395

Genome annotation databases

EnsembliENSRNOT00000048744; ENSRNOP00000047671; ENSRNOG00000029078
GeneIDi681284
KEGGirno:681284
UCSCiRGD:1597988 rat

Similar proteinsi

Entry informationi

Entry nameiHMGN5_RAT
AccessioniPrimary (citable) accession number: B4F777
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: September 23, 2008
Last modified: April 25, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health