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Protein

Dymeclin

Gene

Dym

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Necessary for correct organization of Golgi apparatus. Involved in bone development.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Dymeclin
Gene namesi
Name:Dym
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1309111. Dym.

Subcellular locationi

  • Cytoplasm
  • Golgi apparatus By similarity
  • Membrane By similarity; Lipid-anchor By similarity

  • Note: Sequence analysis programs predict 1 transmembrane region. However, it has been shown in human that it is not a stably anchored transmembrane protein but it weakly associates with the Golgi apparatus and shuttles between the Golgi and the cytosol (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 674673DymeclinPRO_0000365012Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineBy similarity

Post-translational modificationi

Myristoylated in vitro; myristoylation is not essential for protein targeting to Golgi compartment.By similarity

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiB4F766.
PeptideAtlasiB4F766.
PRIDEiB4F766.

Expressioni

Gene expression databases

GenevisibleiB4F766. RN.

Interactioni

Subunit structurei

Interacts with GOLM1 and PPIB.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024950.

Family & Domainsi

Sequence similaritiesi

Belongs to the dymeclin family.Curated

Phylogenomic databases

eggNOGiKOG2225. Eukaryota.
ENOG410XP0J. LUCA.
HOGENOMiHOG000006864.
HOVERGENiHBG057356.
InParanoidiB4F766.
OMAiIQNIDMV.
PhylomeDBiB4F766.
TreeFamiTF314870.

Family and domain databases

InterProiIPR019142. Dymeclin.
[Graphical view]
PANTHERiPTHR12895:SF9. PTHR12895:SF9. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B4F766-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSNSSKISD LPKNEYLKRL SGPEAISEND PFWNQLFSFS FSAPTSSTEL
60 70 80 90 100
KLLEEATISV CKSLVENNPR TGNLAALTKV FLARTRELRL SAECQNHIFI
110 120 130 140 150
WQTHNALFII CCLLKVFICE MSEEELQLHF TYEEKLPGTY TLCVLLGSDS
160 170 180 190 200
EDLLEELLCS LIQLITDTPL LDITYEISVE AISAMIVFLS CQLFHKEVLR
210 220 230 240 250
QSISHKYLMQ GPCLPYTSKL VKTLLYNFIR QEKPPPPGTH VFPQQSDGGG
260 270 280 290 300
LLYGLASGVA TGLWTVFTLG GVGSKAASPE LTSPLANQSL LLLLVLVNLT
310 320 330 340 350
DAPDIPNPYR QAVTSFKNTQ DSSPFPSSVP HTFQINFNSL YTTLCEQQTS
360 370 380 390 400
DQATLLLYTL LHQNANVRTY MLARTDMENL VLPILEILYH VEERNSHHVY
410 420 430 440 450
MALIILLILT EDDGFNRSIH EVILKNITWY SERVLTEISL GSLLILVVIR
460 470 480 490 500
TIQYNMTRTR DKYLHTNCLA ALANMSAQFR SLHQYAAQRI ISLFSLLSKK
510 520 530 540 550
HNKVLEQATQ SLRGSLSSSD VPLPDYAQDL SVIEEVIRMM LEIINSCLTN
560 570 580 590 600
SLHHNPNLVY ALLYKRDLFE QFRTHPSFQD IMQNIDLVIS FFSSRLLQSG
610 620 630 640 650
AELSVERVLE IIKQGVVALP KDRLKKFPEL KFKYVEEEQP EEFFIPYVWS
660 670
LVYNSAVGLY WNPQDIQLFA MDSD
Length:674
Mass (Da):76,491
Last modified:September 23, 2008 - v1
Checksum:i85691C69FDD44278
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC168151 mRNA. Translation: AAI68151.1.
UniGeneiRn.59303.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC168151 mRNA. Translation: AAI68151.1.
UniGeneiRn.59303.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024950.

Proteomic databases

PaxDbiB4F766.
PeptideAtlasiB4F766.
PRIDEiB4F766.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi1309111. Dym.

Phylogenomic databases

eggNOGiKOG2225. Eukaryota.
ENOG410XP0J. LUCA.
HOGENOMiHOG000006864.
HOVERGENiHBG057356.
InParanoidiB4F766.
OMAiIQNIDMV.
PhylomeDBiB4F766.
TreeFamiTF314870.

Miscellaneous databases

PROiB4F766.

Gene expression databases

GenevisibleiB4F766. RN.

Family and domain databases

InterProiIPR019142. Dymeclin.
[Graphical view]
PANTHERiPTHR12895:SF9. PTHR12895:SF9. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiDYM_RAT
AccessioniPrimary (citable) accession number: B4F766
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: September 23, 2008
Last modified: July 6, 2016
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.