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B4F6U4

- PRD10_XENTR

UniProt

B4F6U4 - PRD10_XENTR

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Protein

PR domain zinc finger protein 10

Gene

prdm10

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri395 – 41723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri559 – 58123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri589 – 61123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri617 – 63923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri645 – 66824C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri673 – 69523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri701 – 72424C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri756 – 77924C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri801 – 82424C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri863 – 88624C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. methyltransferase activity Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
PR domain zinc finger protein 10 (EC:2.1.1.-)
Alternative name(s):
PR domain-containing protein 10
Gene namesi
Name:prdm10
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-985864. prdm10.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11731173PR domain zinc finger protein 10PRO_0000363966Add
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini248 – 366119SETPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi174 – 18411Poly-AspAdd
BLAST
Compositional biasi943 – 1058116Gln-richAdd
BLAST
Compositional biasi1157 – 11604Poly-Thr

Domaini

The SET domain is degenerated, suggesting that it has lost methyltransferase activity.

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SET domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri395 – 41723C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri559 – 58123C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri589 – 61123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri617 – 63923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri645 – 66824C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri673 – 69523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri701 – 72424C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri756 – 77924C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri801 – 82424C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri863 – 88624C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG053664.
InParanoidiB4F6U4.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR001214. SET_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 4 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS50280. SET. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4F6U4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDTKEGSPHV WPTSVEHQSN TAQVHFVPDG GSVAQIVYSD DQDRAQQQVV
60 70 80 90 100
YTADASSFTS VDASEHTLVY IHPVDGSQTL FTDQPQVAYV QQDATTQQVT
110 120 130 140 150
VLLPAAQSMN AANLAVLSGV SESAQTMSLD PVSQINRASL TVHDHRLPPM
160 170 180 190 200
EGADSSTTIN SLPSPNAHSD GKEDDDDDDD DDDDEEEEDD DGEDSDLDDW
210 220 230 240 250
EAEPPRPFDP NDLWCEECNN AHPSVCPKHG ALHPIPNRPV LTRARASLPL
260 270 280 290 300
VLYIDRFLGG VYSKRRIPKR TQFGPLEGPL VKKTELKDSY IHLKVALNSP
310 320 330 340 350
VDSEGAFQED LWFELSEESL CNWMMFVRPA QNHLEQNLVA YQYGQHIYFT
360 370 380 390 400
TIKNIEPKQE LKVWYAASYA EFVNEKIHDI TQEERKVLRE QEKNWPCYEC
410 420 430 440 450
NRRFMSSEQL QQHLNSHDEK LDFISRTKPR GRTRTRRKFG PGRRPGRPPK
460 470 480 490 500
FLRFDISSEN REKIDLGTQD LLQFHNKGPH FEDCGHSTLN GLEQSELTLG
510 520 530 540 550
TSTQGTPNQQ QATQLLPPNE ISTPVATTSI LTAEDMRRAK RIRNAALQHL
560 570 580 590 600
FIRKSFRPFK CLQCGKAFRE KEKLDQHLRF HGRDGNYPLT CDICNKGFIS
610 620 630 640 650
TSSLENHMKF HLDQKTYSCI FCPESFDRLD LLKDHVVVHI IDGCFSCPTC
660 670 680 690 700
KKRFTDFIQV KKHVRSFHSE KIYQCTECDK AFCRPDKLRL HMLRHSDRKD
710 720 730 740 750
FLCSTCGKQF KRKDKLREHM QRMHNPEREA KKADRTGRAK AFKPRLASTD
760 770 780 790 800
YESFMFKCRV CMMGFRRRGM LVNHLSKRHP EMKIDEVPEL TLPIIKPNRD
810 820 830 840 850
YYCQYCEKVY KSASKRKAHI LKNHPGAELP PSIRKLRPAG PGEPDPMLST
860 870 880 890 900
HTQLTGTIAT PPVCCPHCSK QYSSKTKMVQ HIRKKHPEFS LLPISVQAPV
910 920 930 940 950
LGTAPAVLTA DGTSGETVVT TDLLTQAMTE LSQTLTTEYR TPQGDFQRIQ
960 970 980 990 1000
YIPVSQTTGG MQQPQHIQLQ VVQVAQAQSP NQSQHSTVDM GQLHESQGYM
1010 1020 1030 1040 1050
QHAIQVQHIQ VAEPTSGTQS TPQVGGQALS PSSQEAEEVN PSQLQTPASQ
1060 1070 1080 1090 1100
AQANSAVQHA YLPSGWNSFR GYPSEIQMMA LPQGQYVIAE AAVGTPVTPV
1110 1120 1130 1140 1150
SSGQVKAVTQ THYVISEGQG VLDMKKSSSL AEEATPNPDH MEQPASNSSQ
1160 1170
TTQYIITTTT NMNGSSEVHI SKP
Length:1,173
Mass (Da):132,140
Last modified:September 23, 2008 - v1
Checksum:i03B08ECC73CD1BE3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC168013 mRNA. Translation: AAI68013.1.
RefSeqiNP_001135541.1. NM_001142069.1.
UniGeneiStr.58567.

Genome annotation databases

GeneIDi100216084.
KEGGixtr:100216084.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC168013 mRNA. Translation: AAI68013.1 .
RefSeqi NP_001135541.1. NM_001142069.1.
UniGenei Str.58567.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100216084.
KEGGi xtr:100216084.

Organism-specific databases

CTDi 56980.
Xenbasei XB-GENE-985864. prdm10.

Phylogenomic databases

HOVERGENi HBG053664.
InParanoidi B4F6U4.

Family and domain databases

Gene3Di 3.30.160.60. 5 hits.
InterProi IPR001214. SET_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 4 hits.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 10 hits.
[Graphical view ]
PROSITEi PS50280. SET. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiPRD10_XENTR
AccessioniPrimary (citable) accession number: B4F6U4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3