B4F6U4 (PRD10_XENTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
PR domain zinc finger protein 10

Alternative name(s):
PR domain-containing protein 10

Gene names

Name:

prdm10

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	1173 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation By similarity.
Subcellular location	Nucleus By similarity.
Domain	The SET domain is degenerated, suggesting that it has lost mehtyltransferase activity.
Sequence similarities	Contains 10 C2H2-type zinc fingers. Contains 1 SET domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1173	1173	PR domain zinc finger protein 10		PRO_0000363966
Regions
	Domain	246 – 370	125	SET
	Zinc finger	395 – 417	23	C2H2-type 1
	Zinc finger	559 – 581	23	C2H2-type 2
	Zinc finger	589 – 611	23	C2H2-type 3
	Zinc finger	617 – 639	23	C2H2-type 4
	Zinc finger	645 – 668	24	C2H2-type 5
	Zinc finger	673 – 695	23	C2H2-type 6
	Zinc finger	701 – 724	24	C2H2-type 7
	Zinc finger	756 – 779	24	C2H2-type 8
	Zinc finger	801 – 824	24	C2H2-type 9
	Zinc finger	863 – 886	24	C2H2-type 10
	Compositional bias	174 – 184	11	Poly-Asp
	Compositional bias	943 – 1058	116	Gln-rich
	Compositional bias	1157 – 1160	4	Poly-Thr

Sequences

	Sequence		Length	Mass (Da)
	B4F6U4 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 03B08ECC73CD1BE3	FASTA	1,173	132,140
	10 20 30 40 50 60 MDTKEGSPHV WPTSVEHQSN TAQVHFVPDG GSVAQIVYSD DQDRAQQQVV YTADASSFTS 70 80 90 100 110 120 VDASEHTLVY IHPVDGSQTL FTDQPQVAYV QQDATTQQVT VLLPAAQSMN AANLAVLSGV 130 140 150 160 170 180 SESAQTMSLD PVSQINRASL TVHDHRLPPM EGADSSTTIN SLPSPNAHSD GKEDDDDDDD 190 200 210 220 230 240 DDDDEEEEDD DGEDSDLDDW EAEPPRPFDP NDLWCEECNN AHPSVCPKHG ALHPIPNRPV 250 260 270 280 290 300 LTRARASLPL VLYIDRFLGG VYSKRRIPKR TQFGPLEGPL VKKTELKDSY IHLKVALNSP 310 320 330 340 350 360 VDSEGAFQED LWFELSEESL CNWMMFVRPA QNHLEQNLVA YQYGQHIYFT TIKNIEPKQE 370 380 390 400 410 420 LKVWYAASYA EFVNEKIHDI TQEERKVLRE QEKNWPCYEC NRRFMSSEQL QQHLNSHDEK 430 440 450 460 470 480 LDFISRTKPR GRTRTRRKFG PGRRPGRPPK FLRFDISSEN REKIDLGTQD LLQFHNKGPH 490 500 510 520 530 540 FEDCGHSTLN GLEQSELTLG TSTQGTPNQQ QATQLLPPNE ISTPVATTSI LTAEDMRRAK 550 560 570 580 590 600 RIRNAALQHL FIRKSFRPFK CLQCGKAFRE KEKLDQHLRF HGRDGNYPLT CDICNKGFIS 610 620 630 640 650 660 TSSLENHMKF HLDQKTYSCI FCPESFDRLD LLKDHVVVHI IDGCFSCPTC KKRFTDFIQV 670 680 690 700 710 720 KKHVRSFHSE KIYQCTECDK AFCRPDKLRL HMLRHSDRKD FLCSTCGKQF KRKDKLREHM 730 740 750 760 770 780 QRMHNPEREA KKADRTGRAK AFKPRLASTD YESFMFKCRV CMMGFRRRGM LVNHLSKRHP 790 800 810 820 830 840 EMKIDEVPEL TLPIIKPNRD YYCQYCEKVY KSASKRKAHI LKNHPGAELP PSIRKLRPAG 850 860 870 880 890 900 PGEPDPMLST HTQLTGTIAT PPVCCPHCSK QYSSKTKMVQ HIRKKHPEFS LLPISVQAPV 910 920 930 940 950 960 LGTAPAVLTA DGTSGETVVT TDLLTQAMTE LSQTLTTEYR TPQGDFQRIQ YIPVSQTTGG 970 980 990 1000 1010 1020 MQQPQHIQLQ VVQVAQAQSP NQSQHSTVDM GQLHESQGYM QHAIQVQHIQ VAEPTSGTQS 1030 1040 1050 1060 1070 1080 TPQVGGQALS PSSQEAEEVN PSQLQTPASQ AQANSAVQHA YLPSGWNSFR GYPSEIQMMA 1090 1100 1110 1120 1130 1140 LPQGQYVIAE AAVGTPVTPV SSGQVKAVTQ THYVISEGQG VLDMKKSSSL AEEATPNPDH 1150 1160 1170 MEQPASNSSQ TTQYIITTTT NMNGSSEVHI SKP

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC168013 mRNA. Translation: AAI68013.1.
RefSeq	NP_001135541.1. NM_001142069.1.
UniGene	Str.58567.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100216084.
KEGG	xtr:100216084.
Organism-specific databases
CTD	56980.
Xenbase	XB-GENE-985864. prdm10.
Phylogenomic databases
HOVERGEN	HBG053664.
Family and domain databases
Gene3D	3.30.160.60. 5 hits.
InterPro	IPR001214. SET_dom. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF00096. zf-C2H2. 4 hits. [Graphical view]
SMART	SM00355. ZnF_C2H2. 10 hits. [Graphical view]
PROSITE	PS50280. SET. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 10 hits. PS50157. ZINC_FINGER_C2H2_2. 10 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PRD10_XENTR

Accession

Primary (citable) accession number: B4F6U4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	September 23, 2008
Last modified:	April 3, 2013
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program