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Protein

DNA ligase

Gene

lig3

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:lig3Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Organism-specific databases

XenbaseiXB-GENE-5788004. lig3.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000042517.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000007653.
HOVERGENiHBG005515.
KOiK10776.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.30.1740.10. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
IPR001510. Znf_PARP.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF00645. zf-PARP. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
PS00347. PARP_ZN_FINGER_1. 1 hit.
PS50064. PARP_ZN_FINGER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4F6N5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAFLRLLAY QTKRTLGQSL TKVPLRVIFH ACWSQSPLHS ALHFQFFLRV
60 70 80 90 100
THFSNMAEQR YCVEYAKRGT AGCKKCKEKI GKGLVRIGKI VPNPFSESAG
110 120 130 140 150
DMKEWYHIKC MFEKLERARA TTKKIDDLTE LEGWQELQDC DKNLISQHVT
160 170 180 190 200
ELATKTAATP RKKTPSKEKQ SPAVQGTTST TAPAASPSLK FSGFSAKPSQ
210 220 230 240 250
SSSPPSSSTG SSLSTAKCDP KHKDCLLREF RKLCAMVAEQ PSYNSKTQII
260 270 280 290 300
RDFLTKGTSG DGFHGDTYLT VKLLLPGVIK SVYNLNDKQI VKHFSRIFNC
310 320 330 340 350
NQEEMVRDLE QGDVSETVRI FFEESKCFAP ASKSLLTIHE VDDLLTKLSK
360 370 380 390 400
MTKEEDQQNV LEDIAHRCTS NDLKCIIRLI KHDLKMNSGA KHVLDALDPN
410 420 430 440 450
AYDAFKASRN LGDVVERVLR NEQQAPGMKR TLSVQASLMT PVQPMLAEAC
460 470 480 490 500
KSIEYAMKKC PNGMYAEIKY DGERVQVHKN GDHFSYFSRS LKPVLPHKVA
510 520 530 540 550
HFKDFIPKAF PGGNSMILDA EVLLIDTNTG KPLPFGTLGV HKKAAFKDAN
560 570 580 590 600
VCLFVFDCIY FNGVSLMDRP LSERRKFMRD NMVEIPNHIL FSEMKHVTKA
610 620 630 640 650
SDLADMITRV IREGLEGLVL KDLKSNYEPG KRHWLKVKKD YLNEGAMADT
660 670 680 690 700
ADLAVLGAYY GKGANGGIMS IFLMGCYDPE SQKWCTVTKC SSGYDDATLQ
710 720 730 740 750
RLQKELNMVK ISKDPSKIPS WLKINKNYFP DFIIHDPKKA PIWEITGAEY
760 770 780 790 800
SKAEAHTAAG LSIRFPRCTR FRDDKDWKTA TTLQQLKELY RLSKEKSDFN
810 820 830 840 850
ITATSSQDED GSSESSSREN EGNSRQTASG SMVKKSKNAP SKSPGKDKTS
860 870 880 890
ESTKLPPPQK KEELPKAEKR KSQTPKTVQS KKVRKQHIEK CIQ
Length:893
Mass (Da):100,464
Last modified:September 23, 2008 - v1
Checksum:i797F437FB781E248
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC167946 mRNA. Translation: AAI67946.1.
RefSeqiNP_001016351.2. NM_001016351.3.
UniGeneiStr.26611.

Genome annotation databases

GeneIDi549105.
KEGGixtr:549105.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC167946 mRNA. Translation: AAI67946.1.
RefSeqiNP_001016351.2. NM_001016351.3.
UniGeneiStr.26611.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000042517.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi549105.
KEGGixtr:549105.

Organism-specific databases

CTDi3980.
XenbaseiXB-GENE-5788004. lig3.

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000007653.
HOVERGENiHBG005515.
KOiK10776.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
3.30.1740.10. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
IPR001510. Znf_PARP.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
PF00645. zf-PARP. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
PS00347. PARP_ZN_FINGER_1. 1 hit.
PS50064. PARP_ZN_FINGER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: N6Imported.
    Tissue: Fat bodyImported.

Entry informationi

Entry nameiB4F6N5_XENTR
AccessioniPrimary (citable) accession number: B4F6N5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: July 22, 2015
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.