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Protein

ATPase family AAA domain-containing protein 1

Gene

atad1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR). Required for NMDA-stimulated AMPAR internalization in an ATPase-dependent manner (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi133 – 140ATPSequence analysis8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase family AAA domain-containing protein 1 (EC:3.6.1.3)
Gene namesi
Name:atad1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-5779938 atad1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Peroxisome, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004164871 – 360ATPase family AAA domain-containing protein 1Add BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei146PhosphothreonineBy similarity1
Modified residuei322PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiB4F6J6
PRIDEiB4F6J6

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000020353

Structurei

3D structure databases

ProteinModelPortaliB4F6J6
SMRiB4F6J6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

eggNOGiKOG0737 Eukaryota
COG0464 LUCA
HOGENOMiHOG000225141
HOVERGENiHBG057074
InParanoidiB4F6J6
KOiK22530
OMAiMPHLYSH
OrthoDBiEOG091G0CJ6

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00004 AAA, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

Sequencei

Sequence statusi: Complete.

B4F6J6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHGEAFSRP LSRNEVVGLI FRLTIFGAVT YFTIKWMVDA IDPTRKQKVE
60 70 80 90 100
AQKQAEKLMR QIGVKNVKLT EYEMSIAAHL VDPLSMLVTW SDIAGLDDVI
110 120 130 140 150
TDLKDTVILP IRKRYLFENS RLLQPPKGVL LYGPPGCGKT MIAKATAKEA
160 170 180 190 200
GCRFINLQPS TLTDKWYGES QKLAAAVFSL AVKLQPSIIF IDEIDSFLRS
210 220 230 240 250
RSSSDHEATA MMKAQFMSLW DGLDTDFNCQ VIVMGATNRP QDLDTAIMRR
260 270 280 290 300
MPTRFHINQP SLKQREAILD LILRNESVDS HVDLMEIARG SDGFSGSDLK
310 320 330 340 350
EMCRDAALLC VRDSVNNSSE ESPCEEIRPI HQQDLLRAID KMKRSKSATN
360
QNVLMHVSLD
Length:360
Mass (Da):40,492
Last modified:April 18, 2012 - v2
Checksum:i428543C0E8C7A0DE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti185Q → H in AAI67903 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01046255 Genomic DNA No translation available.
BC167903 mRNA Translation: AAI67903.1
RefSeqiNP_001135501.1, NM_001142029.1
XP_012821650.1, XM_012966196.2
UniGeneiStr.19240

Genome annotation databases

GeneIDi100216041
KEGGixtr:100216041

Similar proteinsi

Entry informationi

Entry nameiATAD1_XENTR
AccessioniPrimary (citable) accession number: B4F6J6
Secondary accession number(s): F7CNN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: April 18, 2012
Last modified: May 23, 2018
This is version 57 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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