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Protein

ATPase family AAA domain-containing protein 1

Gene

atad1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR). Required for NMDA-stimulated AMPAR internalization in an ATPase-dependent manner (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi133 – 140ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase family AAA domain-containing protein 1 (EC:3.6.1.3)
Gene namesi
Name:atad1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-5779938. atad1.

Subcellular locationi

  • Peroxisome By similarity
  • Cell junctionsynapsepostsynaptic cell membrane By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Peroxisome, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004164871 – 360ATPase family AAA domain-containing protein 1Add BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei146PhosphothreonineBy similarity1
Modified residuei322PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiB4F6J6.
PRIDEiB4F6J6.

Expressioni

Gene expression databases

BgeeiENSXETG00000009266.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000020353.

Structurei

3D structure databases

ProteinModelPortaliB4F6J6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

eggNOGiKOG0737. Eukaryota.
COG0464. LUCA.
HOGENOMiHOG000225141.
HOVERGENiHBG057074.
InParanoidiB4F6J6.
OMAiKWMMNQM.
OrthoDBiEOG091G0CJ6.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4F6J6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHGEAFSRP LSRNEVVGLI FRLTIFGAVT YFTIKWMVDA IDPTRKQKVE
60 70 80 90 100
AQKQAEKLMR QIGVKNVKLT EYEMSIAAHL VDPLSMLVTW SDIAGLDDVI
110 120 130 140 150
TDLKDTVILP IRKRYLFENS RLLQPPKGVL LYGPPGCGKT MIAKATAKEA
160 170 180 190 200
GCRFINLQPS TLTDKWYGES QKLAAAVFSL AVKLQPSIIF IDEIDSFLRS
210 220 230 240 250
RSSSDHEATA MMKAQFMSLW DGLDTDFNCQ VIVMGATNRP QDLDTAIMRR
260 270 280 290 300
MPTRFHINQP SLKQREAILD LILRNESVDS HVDLMEIARG SDGFSGSDLK
310 320 330 340 350
EMCRDAALLC VRDSVNNSSE ESPCEEIRPI HQQDLLRAID KMKRSKSATN
360
QNVLMHVSLD
Length:360
Mass (Da):40,492
Last modified:April 18, 2012 - v2
Checksum:i428543C0E8C7A0DE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti185Q → H in AAI67903 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01046255 Genomic DNA. No translation available.
BC167903 mRNA. Translation: AAI67903.1.
RefSeqiNP_001135501.1. NM_001142029.1.
XP_012821650.1. XM_012966196.2.
UniGeneiStr.19240.

Genome annotation databases

GeneIDi100216041.
KEGGixtr:100216041.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAMC01046255 Genomic DNA. No translation available.
BC167903 mRNA. Translation: AAI67903.1.
RefSeqiNP_001135501.1. NM_001142029.1.
XP_012821650.1. XM_012966196.2.
UniGeneiStr.19240.

3D structure databases

ProteinModelPortaliB4F6J6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000020353.

Proteomic databases

PaxDbiB4F6J6.
PRIDEiB4F6J6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100216041.
KEGGixtr:100216041.

Organism-specific databases

CTDi84896.
XenbaseiXB-GENE-5779938. atad1.

Phylogenomic databases

eggNOGiKOG0737. Eukaryota.
COG0464. LUCA.
HOGENOMiHOG000225141.
HOVERGENiHBG057074.
InParanoidiB4F6J6.
OMAiKWMMNQM.
OrthoDBiEOG091G0CJ6.

Gene expression databases

BgeeiENSXETG00000009266.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATAD1_XENTR
AccessioniPrimary (citable) accession number: B4F6J6
Secondary accession number(s): F7CNN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: April 18, 2012
Last modified: November 30, 2016
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.