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B4F6J6

- ATAD1_XENTR

UniProt

B4F6J6 - ATAD1_XENTR

Protein

ATPase family AAA domain-containing protein 1

Gene

atad1

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 2 (18 Apr 2012)
      Previous versions | rss
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    Functioni

    ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR). Required for NMDA-stimulated AMPAR internalization in an ATPase-dependent manner By similarity.By similarity

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi133 – 1408ATPSequence Analysis

    GO - Molecular functioni

    1. ATPase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATPase family AAA domain-containing protein 1 (EC:3.6.1.3)
    Gene namesi
    Name:atad1
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-5779938. atad1.

    Subcellular locationi

    Peroxisome By similarity. Cell junctionsynapsepostsynaptic cell membrane By similarity

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. peroxisome Source: UniProtKB-SubCell
    3. postsynaptic membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Peroxisome, Postsynaptic cell membrane, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 360360ATPase family AAA domain-containing protein 1PRO_0000416487Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei146 – 1461PhosphothreonineBy similarity
    Modified residuei322 – 3221PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Expressioni

    Gene expression databases

    BgeeiB4F6J6.

    Interactioni

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000020353.

    Structurei

    3D structure databases

    ProteinModelPortaliB4F6J6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AAA ATPase family.Curated

    Phylogenomic databases

    eggNOGiCOG0464.
    HOGENOMiHOG000225141.
    HOVERGENiHBG057074.
    OMAiYNCQVIV.
    OrthoDBiEOG7SR4MJ.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00004. AAA. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00674. AAA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4F6J6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVHGEAFSRP LSRNEVVGLI FRLTIFGAVT YFTIKWMVDA IDPTRKQKVE    50
    AQKQAEKLMR QIGVKNVKLT EYEMSIAAHL VDPLSMLVTW SDIAGLDDVI 100
    TDLKDTVILP IRKRYLFENS RLLQPPKGVL LYGPPGCGKT MIAKATAKEA 150
    GCRFINLQPS TLTDKWYGES QKLAAAVFSL AVKLQPSIIF IDEIDSFLRS 200
    RSSSDHEATA MMKAQFMSLW DGLDTDFNCQ VIVMGATNRP QDLDTAIMRR 250
    MPTRFHINQP SLKQREAILD LILRNESVDS HVDLMEIARG SDGFSGSDLK 300
    EMCRDAALLC VRDSVNNSSE ESPCEEIRPI HQQDLLRAID KMKRSKSATN 350
    QNVLMHVSLD 360
    Length:360
    Mass (Da):40,492
    Last modified:April 18, 2012 - v2
    Checksum:i428543C0E8C7A0DE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti185 – 1851Q → H in AAI67903. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAMC01046255 Genomic DNA. No translation available.
    BC167903 mRNA. Translation: AAI67903.1.
    RefSeqiNP_001135501.1. NM_001142029.1.
    UniGeneiStr.19240.

    Genome annotation databases

    GeneIDi100216041.
    KEGGixtr:100216041.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAMC01046255 Genomic DNA. No translation available.
    BC167903 mRNA. Translation: AAI67903.1 .
    RefSeqi NP_001135501.1. NM_001142029.1.
    UniGenei Str.19240.

    3D structure databases

    ProteinModelPortali B4F6J6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000020353.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100216041.
    KEGGi xtr:100216041.

    Organism-specific databases

    CTDi 84896.
    Xenbasei XB-GENE-5779938. atad1.

    Phylogenomic databases

    eggNOGi COG0464.
    HOGENOMi HOG000225141.
    HOVERGENi HBG057074.
    OMAi YNCQVIV.
    OrthoDBi EOG7SR4MJ.

    Gene expression databases

    Bgeei B4F6J6.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00004. AAA. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00674. AAA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. NIH - Xenopus Gene Collection (XGC) project
      Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiATAD1_XENTR
    AccessioniPrimary (citable) accession number: B4F6J6
    Secondary accession number(s): F7CNN7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2012
    Last sequence update: April 18, 2012
    Last modified: October 1, 2014
    This is version 38 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3