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B4F6J6

- ATAD1_XENTR

UniProt

B4F6J6 - ATAD1_XENTR

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Protein

ATPase family AAA domain-containing protein 1

Gene
atad1
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR). Required for NMDA-stimulated AMPAR internalization in an ATPase-dependent manner By similarity.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi133 – 1408ATP Reviewed prediction

GO - Molecular functioni

  1. ATPase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase family AAA domain-containing protein 1 (EC:3.6.1.3)
Gene namesi
Name:atad1
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-5779938. atad1.

Subcellular locationi

Peroxisome By similarity. Cell junctionsynapsepostsynaptic cell membrane By similarity

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. peroxisome Source: UniProtKB-SubCell
  3. postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Peroxisome, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360ATPase family AAA domain-containing protein 1PRO_0000416487Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei146 – 1461Phosphothreonine By similarity
Modified residuei322 – 3221Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Expressioni

Gene expression databases

BgeeiB4F6J6.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000020353.

Structurei

3D structure databases

ProteinModelPortaliB4F6J6.

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.

Phylogenomic databases

eggNOGiCOG0464.
HOGENOMiHOG000225141.
HOVERGENiHBG057074.
OMAiYNCQVIV.
OrthoDBiEOG7SR4MJ.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4F6J6-1 [UniParc]FASTAAdd to Basket

« Hide

MVHGEAFSRP LSRNEVVGLI FRLTIFGAVT YFTIKWMVDA IDPTRKQKVE    50
AQKQAEKLMR QIGVKNVKLT EYEMSIAAHL VDPLSMLVTW SDIAGLDDVI 100
TDLKDTVILP IRKRYLFENS RLLQPPKGVL LYGPPGCGKT MIAKATAKEA 150
GCRFINLQPS TLTDKWYGES QKLAAAVFSL AVKLQPSIIF IDEIDSFLRS 200
RSSSDHEATA MMKAQFMSLW DGLDTDFNCQ VIVMGATNRP QDLDTAIMRR 250
MPTRFHINQP SLKQREAILD LILRNESVDS HVDLMEIARG SDGFSGSDLK 300
EMCRDAALLC VRDSVNNSSE ESPCEEIRPI HQQDLLRAID KMKRSKSATN 350
QNVLMHVSLD 360
Length:360
Mass (Da):40,492
Last modified:April 18, 2012 - v2
Checksum:i428543C0E8C7A0DE
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti185 – 1851Q → H in AAI67903. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAMC01046255 Genomic DNA. No translation available.
BC167903 mRNA. Translation: AAI67903.1.
RefSeqiNP_001135501.1. NM_001142029.1.
UniGeneiStr.19240.

Genome annotation databases

GeneIDi100216041.
KEGGixtr:100216041.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAMC01046255 Genomic DNA. No translation available.
BC167903 mRNA. Translation: AAI67903.1 .
RefSeqi NP_001135501.1. NM_001142029.1.
UniGenei Str.19240.

3D structure databases

ProteinModelPortali B4F6J6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000020353.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100216041.
KEGGi xtr:100216041.

Organism-specific databases

CTDi 84896.
Xenbasei XB-GENE-5779938. atad1.

Phylogenomic databases

eggNOGi COG0464.
HOGENOMi HOG000225141.
HOVERGENi HBG057074.
OMAi YNCQVIV.
OrthoDBi EOG7SR4MJ.

Gene expression databases

Bgeei B4F6J6.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF00004. AAA. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00674. AAA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiATAD1_XENTR
AccessioniPrimary (citable) accession number: B4F6J6
Secondary accession number(s): F7CNN7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: April 18, 2012
Last modified: May 14, 2014
This is version 37 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi