B4F6J6 (ATAD1_XENTR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATPase family AAA domain-containing protein 1
EC=3.6.1.3

Gene names

Name:

atad1

Organism

Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]

Taxonomic identifier

8364 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length	360 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR). Required for NMDA-stimulated AMPAR internalization in an ATPase-dependent manner By similarity.
Catalytic activity	ATP + H2O = ADP + phosphate.
Subcellular location	Peroxisome By similarity. Cell junction › synapse › postsynaptic cell membrane By similarity.
Sequence similarities	Belongs to the AAA ATPase family.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Membrane Peroxisome Postsynaptic cell membrane Synapse
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW postsynaptic membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 360	360	ATPase family AAA domain-containing protein 1		PRO_0000416487
Regions
	Nucleotide binding	133 – 140	8	ATP Potential
Amino acid modifications
	Modified residue	146	1	Phosphothreonine By similarity
	Modified residue	322	1	Phosphoserine By similarity
Experimental info
	Sequence conflict	185	1	Q → H in AAI67903. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	B4F6J6 [UniParc]. Last modified April 18, 2012. Version 2. Checksum: 428543C0E8C7A0DE	FASTA	360	40,492
	10 20 30 40 50 60 MVHGEAFSRP LSRNEVVGLI FRLTIFGAVT YFTIKWMVDA IDPTRKQKVE AQKQAEKLMR 70 80 90 100 110 120 QIGVKNVKLT EYEMSIAAHL VDPLSMLVTW SDIAGLDDVI TDLKDTVILP IRKRYLFENS 130 140 150 160 170 180 RLLQPPKGVL LYGPPGCGKT MIAKATAKEA GCRFINLQPS TLTDKWYGES QKLAAAVFSL 190 200 210 220 230 240 AVKLQPSIIF IDEIDSFLRS RSSSDHEATA MMKAQFMSLW DGLDTDFNCQ VIVMGATNRP 250 260 270 280 290 300 QDLDTAIMRR MPTRFHINQP SLKQREAILD LILRNESVDS HVDLMEIARG SDGFSGSDLK 310 320 330 340 350 360 EMCRDAALLC VRDSVNNSSE ESPCEEIRPI HQQDLLRAID KMKRSKSATN QNVLMHVSLD

References

[1]

"The genome of the Western clawed frog Xenopus tropicalis." Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J., Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R., Gerhard D.S. , Goodstein D., Graves T., Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M., Rokhsar D.S. Science 328:633-636(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

NIH - Xenopus Gene Collection (XGC) project Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAMC01046255 Genomic DNA. No translation available. BC167903 mRNA. Translation: AAI67903.1.
RefSeq	NP_001135501.1. NM_001142029.1.
UniGene	Str.19240.
3D structure databases
ProteinModelPortal	B4F6J6.
ModBase	Search...
Protein-protein interaction databases
STRING	8364.ENSXETP00000020353.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100216041.
KEGG	xtr:100216041.
Organism-specific databases
CTD	84896.
Xenbase	XB-GENE-5779938. atad1.
Phylogenomic databases
eggNOG	COG0464.
HOGENOM	HOG000225141.
HOVERGEN	HBG057074.
OMA	EMCRNAS.
Gene expression databases
Bgee	B4F6J6.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR003959. ATPase_AAA_core. IPR003960. ATPase_AAA_CS. [Graphical view]
Pfam	PF00004. AAA. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS00674. AAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATAD1_XENTR

Accession

Primary (citable) accession number: B4F6J6
Secondary accession number(s): F7CNN7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 18, 2012
Last sequence update:	April 18, 2012
Last modified:	April 3, 2013
This is version 31 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program