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Protein

Bis(5'-nucleosyl)-tetraphosphatase, symmetrical

Gene

apaH

Organism
Proteus mirabilis (strain HI4320)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.UniRule annotation

Catalytic activityi

P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciPMIR529507:GJIW-2383-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetricalUniRule annotation (EC:3.6.1.41UniRule annotation)
Alternative name(s):
Ap4A hydrolaseUniRule annotation
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolaseUniRule annotation
Diadenosine tetraphosphataseUniRule annotation
Gene namesi
Name:apaHUniRule annotation
Ordered Locus Names:PMI2336
OrganismiProteus mirabilis (strain HI4320)
Taxonomic identifieri529507 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus
Proteomesi
  • UP000008319 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 273273Bis(5'-nucleosyl)-tetraphosphatase, symmetricalPRO_1000099328Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi529507.PMI2336.

Structurei

3D structure databases

ProteinModelPortaliB4F2I4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Ap4A hydrolase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DDT. Bacteria.
COG0639. LUCA.
HOGENOMiHOG000251871.
KOiK01525.
OMAiINAFTRM.
OrthoDBiPOG091H0691.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
HAMAPiMF_00199. ApaH. 1 hit.
InterProiIPR004617. ApaH.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000903. B5n-ttraPtase_sm. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
TIGRFAMsiTIGR00668. apaH. 1 hit.

Sequencei

Sequence statusi: Complete.

B4F2I4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATYLIGDVH GCYRELRQLL NQVNFDANQD TLWLTGDLVA RGPDSLEVLR
60 70 80 90 100
FVKSLGSALK LVLGNHDLHL LGVFAKISRN KPKDKLNELL NAPDADELIN
110 120 130 140 150
WLRRQPLLQV DEEKKIVMAH AGITPQWDLA TAKKCAREVE AILSSDSYPL
160 170 180 190 200
FINSMYGDMP NNWSPELTGL PRLRFSTNAF TRMRYCFPNG QLDMICKDKP
210 220 230 240 250
ENAPAPLKPW FDLPNQLPND YSIIFGHWAS LEGKGTPENI YALDTGCCWG
260 270
GVLTCLRWED KRYFIQPSLT HLP
Length:273
Mass (Da):30,986
Last modified:September 23, 2008 - v1
Checksum:i6A2C88E98878BD4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM942759 Genomic DNA. Translation: CAR44621.1.
RefSeqiWP_004245544.1. NC_010554.1.

Genome annotation databases

EnsemblBacteriaiCAR44621; CAR44621; PMI2336.
GeneIDi6800270.
KEGGipmr:PMI2336.
PATRICi20519366. VBIProMir120933_2283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM942759 Genomic DNA. Translation: CAR44621.1.
RefSeqiWP_004245544.1. NC_010554.1.

3D structure databases

ProteinModelPortaliB4F2I4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi529507.PMI2336.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAR44621; CAR44621; PMI2336.
GeneIDi6800270.
KEGGipmr:PMI2336.
PATRICi20519366. VBIProMir120933_2283.

Phylogenomic databases

eggNOGiENOG4105DDT. Bacteria.
COG0639. LUCA.
HOGENOMiHOG000251871.
KOiK01525.
OMAiINAFTRM.
OrthoDBiPOG091H0691.

Enzyme and pathway databases

BioCyciPMIR529507:GJIW-2383-MONOMER.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
HAMAPiMF_00199. ApaH. 1 hit.
InterProiIPR004617. ApaH.
IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000903. B5n-ttraPtase_sm. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
TIGRFAMsiTIGR00668. apaH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAPAH_PROMH
AccessioniPrimary (citable) accession number: B4F2I4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: September 7, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.