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B4F2G6 (B4F2G6_PROMH) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thymidylate synthase HAMAP MF_00008
Short name=TS HAMAP MF_00008
Short name=TSase HAMAP MF_00008
EC=2.1.1.45 HAMAP MF_00008
Gene names
Name:thyA HAMAP MF_00008 EMBL CAR44584.1
Ordered Locus Names:PMI2318
OrganismProteus mirabilis (strain HI4320) [Complete proteome] [HAMAP]
Taxonomic identifier529507 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Proteus

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the sole de novo source of dTMP for DNA biosynthesis By similarity. HAMAP MF_00008

Catalytic activity

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. HAMAP MF_00008 RuleBase RU000500 SAAS SAAS023451

Pathway

Pyrimidine metabolism; dTTP biosynthesis. HAMAP MF_00008 RuleBase RU000500 SAAS SAAS023451

Subunit structure

Homodimer By similarity. HAMAP MF_00008 SAAS SAAS023451

Subcellular location

Cytoplasm By similarity HAMAP MF_00008.

Sequence similarities

Belongs to the thymidylate synthase family. RuleBase RU004150

Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily. HAMAP MF_00008

Ontologies

Keywords
   Biological processNucleotide biosynthesis SAAS SAAS023451 HAMAP MF_00008 RuleBase RU000500
   Cellular componentCytoplasm HAMAP MF_00008
   Molecular functionMethyltransferase HAMAP MF_00008 RuleBase RU000500 SAAS SAAS023451 EMBL CAR44584.1
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processdTMP biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionthymidylate synthase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1601 By similarity HAMAP MF_00008

Sequences

Sequence LengthMass (Da)Tools
B4F2G6 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 5BD467F4895BCFA2

FASTA28332,363
        10         20         30         40         50         60 
MKQYLALCQR IIDEGEWIDN KRTGTRCLTV INADLEYDVA NNQFPLITTR KSFYKAAIAE 

        70         80         90        100        110        120 
LLGYLRGYDN AAQFRAIGCN TWNANANENS AWLNNPHRKG EDDMGRVYGV QGRQWQRPDG 

       130        140        150        160        170        180 
SHFDQLRKVV DNLTNGIDDR GEIVTFYNPG ETALGCLRPC MHTHTFSLLG DRLYLTSYQR 

       190        200        210        220        230        240 
SCDVPLGLNF NQIQCFVLLA LVAQITGHKP GKAFHKIVNA HIYENQLPLM RDVQLKREPL 

       250        260        270        280 
PLPKLHINPN IKTLDDIETW VTTDDFSVEG YQCHEAIKYP FTV

« Hide

References

[1]"Complete genome sequence of uropathogenic Proteus mirabilis, a master of both adherence and motility."
Pearson M.M., Sebaihia M., Churcher C., Quail M.A., Seshasayee A.S., Luscombe N.M., Abdellah Z., Arrosmith C., Atkin B., Chillingworth T., Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H., Rabbinowitsch E., Walker D., Whithead S. expand/collapse author list , Thomson N.R., Rather P.N., Parkhill J., Mobley H.L.T.
J. Bacteriol. 190:4027-4037(2008) [PubMed: 18375554] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM942759 Genomic DNA. Translation: CAR44584.1.
RefSeqYP_002152036.1. NC_010554.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB4F2G6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6802757.
GenomeReviewsGene locus PMI2318 in contig AM942759_GR.
PATRIC20519330. VBIProMir120933_2265.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG588098.
OMAPIKYPFS.
ProtClustDBPRK01827.

Family and domain databases

HAMAPMF_00008. Thymidy_synth_bact.
[Tree]
InterProIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
Gene3DG3DSA:3.30.572.10. Thymidylat_synth_C. 1 hit.
PANTHERPTHR11549:SF2. Thymidylat_synth_C. 1 hit.
PfamPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSPR00108. THYMDSNTHASE.
SUPFAMSSF55831. Thymidylat_synth_C. 1 hit.
TIGRFAMsTIGR03284. Thym_sym. 1 hit.
PROSITEPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB4F2G6_PROMH
AccessionPrimary (citable) accession number: B4F2G6
Entry history
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: December 14, 2011
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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