Reviewed, UniProtKB/Swiss-Prot B4F2F5 (ARGA_PROMH)

Names and origin

Protein names

Recommended name:
    Amino-acid acetyltransferase
    EC=2.3.1.1
Alternative name(s):
    N-acetylglutamate synthase
      Short name=AGS
      Short name=NAGS

Gene names

Name:	argA
Ordered Locus Names:	PMI2307

Organism

Proteus mirabilis (strain HI4320) [Complete proteome] [HAMAP]

Taxonomic identifier

529507 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Proteus

Protein attributes

Sequence length	444 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate. HAMAP MF_01105
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4. HAMAP MF_01105
Subunit structure	Homohexamer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the acetyltransferase family. ArgA subfamily. Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	amino-acid N-acetyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 444	444	Amino-acid acetyltransferase HAMAP MF_01105		PRO_1000137051
Regions
	Domain	295 – 434	140	N-acetyltransferase

Sequences

	Sequence		Length	Mass (Da)
	B4F2F5-1 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 58C3705E0DD2684B	FASTA	444	49,390
	10 20 30 40 50 60 MKERSTELVD GFRHSVPYIN AHRGKTFVIM LGGEAIAHEN FPSIINDIGL LHSLGIRLVV 70 80 90 100 110 120 VYGARPQIDV ALEEQKISPL YHKHTRITDS KTLEVVKQSA GTLQLDITAR LSMSLSNTPL 130 140 150 160 170 180 QGAHINVVSG NFVIAQPLGV DDGVDYCHSG KIRRIDEEAI HRQLDNHAIV LIGPVAVSVT 190 200 210 220 230 240 GESFNLTSEE VATQLAIKLK AQKLIGFCSS QGVVDASGQI VSELLPNQAE ERIQALQTTG 250 260 270 280 290 300 DYHSGTVRFL RGAVTACRRG VERSHLLSYQ ADGAIVQELF SRDGIGTQIV MESAEKVRRA 310 320 330 340 350 360 NINDIGGILE LIRPLEQQGI LVRRSREQLE MEIDQFTIIE RDNLTIACAA LYPYQSEKIG 370 380 390 400 410 420 EMACVAVHPD YRSSCRGEVL LQRISTQAKQ MGLDKLFVLT TRSIHWFQEK GFTPAEIDKL 430 440 PIEKQALYNY QRRSKILILD LHKE

References

[1]

"Complete genome sequence of uropathogenic Proteus mirabilis, a master of both adherence and motility." Pearson M.M., Sebaihia M., Churcher C., Quail M.A., Seshasayee A.S., Luscombe N.M., Abdellah Z., Arrosmith C., Atkin B., Chillingworth T., Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H., Rabbinowitsch E., Walker D., Whithead S. , Thomson N.R., Rather P.N., Parkhill J., Mobley H.L.T. J. Bacteriol. 190:4027-4037(2008) [PubMed: 18375554] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM942759 Genomic DNA. Translation: CAR44559.1.
RefSeq	YP_002152025.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6803060.
GenomeReviews	Gene locus PMI2307 in contig AM942759_GR.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	DLIRPLE.
Family and domain databases
HAMAP	MF_01105. [Tree]
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR001048. Asp/Glu/Uridylate_kinase. IPR000182. GCN5-rel_AcTrfase. IPR010167. NH2A_AcTrfase_ArgA. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit. G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit.
Pfam	PF00696. AA_kinase. 1 hit. PF00583. Acetyltransf_1. 1 hit. [Graphical view]
PIRSF	PIRSF000423. ArgA. 1 hit.
TIGRFAMs	TIGR01890. N-Ac-Glu-synth. 1 hit.
PROSITE	PS51186. GNAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGA_PROMH

Accession

Primary (citable) accession number: B4F2F5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 23, 2008
Last modified:	November 3, 2009
This is version 8 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)