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B4F1V2 (GPPA_PROMH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

EC=3.6.1.40
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene names
Name:gppA
Ordered Locus Names:PMI3311
OrganismProteus mirabilis (strain HI4320) [Complete proteome] [HAMAP]
Taxonomic identifier529507 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus

Protein attributes

Sequence length502 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity. HAMAP-Rule MF_01550

Catalytic activity

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate. HAMAP-Rule MF_01550

Pathway

Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2. HAMAP-Rule MF_01550

Sequence similarities

Belongs to the GppA/Ppx family. GppA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 502502Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase HAMAP-Rule MF_01550
PRO_1000192531

Sequences

Sequence LengthMass (Da)Tools
B4F1V2 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 4FFBECABE8723947

FASTA50256,417
        10         20         30         40         50         60 
MLKSSSLYAA IDLGSNSFHM LVVREIAGSI QVLSRVKRKV RLAAGLNKEN ELSEQAMERG 

        70         80         90        100        110        120 
WQCLRLFSEY LRDIPAEQIR VVATATLRIA KNADIFVAKA SEILGNTVHV ISGEEEARLI 

       130        140        150        160        170        180 
YRGVAHTTGG AEQRLVVDIG GGSTELVTGT GAKTTQLMSL SMGCVTWLER YFSDRSLTEE 

       190        200        210        220        230        240 
NFAQAQQAAK AILAPVAEKL IQQGWQVCVG ASGTVQALQE IMIAQGMDEL ITLPKLERLK 

       250        260        270        280        290        300 
QKAIECGKLE ELEIEGLTFE RALVFPSGLA ILIAIFETLH IENMILAGGA LREGLVYGML 

       310        320        330        340        350        360 
HLPIEQDIRQ RTLRNIQRRF QIDIEQAHRV QQLAEHFFIQ VSKSWQLDNR CRELLSSACA 

       370        380        390        400        410        420 
LHEIGLSVDF RQAPSHASYL VSHLDLPGYT PAQRRLIASF LRNQKGIIDL APLNQQNALP 

       430        440        450        460        470        480 
INQAYRLVRL LRLAIIFASR RRDDTLPALR LRTEDEKLII TLPHQWIAEH PLRAENLHEE 

       490        500 
IQLQSYVHWP LMLEEQNNSR IG 

« Hide

References

[1]"Complete genome sequence of uropathogenic Proteus mirabilis, a master of both adherence and motility."
Pearson M.M., Sebaihia M., Churcher C., Quail M.A., Seshasayee A.S., Luscombe N.M., Abdellah Z., Arrosmith C., Atkin B., Chillingworth T., Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H., Rabbinowitsch E., Walker D., Whithead S. expand/collapse author list , Thomson N.R., Rather P.N., Parkhill J., Mobley H.L.T.
J. Bacteriol. 190:4027-4037(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HI4320.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM942759 Genomic DNA. Translation: CAR46499.1.
RefSeqYP_002152996.1. NC_010554.1.

3D structure databases

ProteinModelPortalB4F1V2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING529507.PMI3311.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAR46499; CAR46499; PMI3311.
GeneID6800930.
KEGGpmr:PMI3311.
PATRIC20521332. VBIProMir120933_3237.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0248.
HOGENOMHOG000258672.
KOK01524.
OMAGLHIEYK.
OrthoDBEOG6M6JN6.

Enzyme and pathway databases

BioCycPMIR529507:GJIW-3387-MONOMER.
UniPathwayUPA00908; UER00884.

Family and domain databases

HAMAPMF_01550. GppA.
InterProIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamPF02541. Ppx-GppA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGPPA_PROMH
AccessionPrimary (citable) accession number: B4F1V2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: May 14, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways