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B4F1V2

- GPPA_PROMH

UniProt

B4F1V2 - GPPA_PROMH

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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Proteus mirabilis (strain HI4320)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. guanosine pentaphosphate catabolic process Source: InterPro
  2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciPMIR529507:GJIW-3387-MONOMER.
UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolaseUniRule annotation
pppGpp-5'-phosphohydrolaseUniRule annotation
Gene namesi
Name:gppAUniRule annotation
Ordered Locus Names:PMI3311
OrganismiProteus mirabilis (strain HI4320)
Taxonomic identifieri529507 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus
ProteomesiUP000008319: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_1000192531Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi529507.PMI3311.

Structurei

3D structure databases

ProteinModelPortaliB4F1V2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiGLHIEYK.
OrthoDBiEOG6M6JN6.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4F1V2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKSSSLYAA IDLGSNSFHM LVVREIAGSI QVLSRVKRKV RLAAGLNKEN
60 70 80 90 100
ELSEQAMERG WQCLRLFSEY LRDIPAEQIR VVATATLRIA KNADIFVAKA
110 120 130 140 150
SEILGNTVHV ISGEEEARLI YRGVAHTTGG AEQRLVVDIG GGSTELVTGT
160 170 180 190 200
GAKTTQLMSL SMGCVTWLER YFSDRSLTEE NFAQAQQAAK AILAPVAEKL
210 220 230 240 250
IQQGWQVCVG ASGTVQALQE IMIAQGMDEL ITLPKLERLK QKAIECGKLE
260 270 280 290 300
ELEIEGLTFE RALVFPSGLA ILIAIFETLH IENMILAGGA LREGLVYGML
310 320 330 340 350
HLPIEQDIRQ RTLRNIQRRF QIDIEQAHRV QQLAEHFFIQ VSKSWQLDNR
360 370 380 390 400
CRELLSSACA LHEIGLSVDF RQAPSHASYL VSHLDLPGYT PAQRRLIASF
410 420 430 440 450
LRNQKGIIDL APLNQQNALP INQAYRLVRL LRLAIIFASR RRDDTLPALR
460 470 480 490 500
LRTEDEKLII TLPHQWIAEH PLRAENLHEE IQLQSYVHWP LMLEEQNNSR

IG
Length:502
Mass (Da):56,417
Last modified:September 23, 2008 - v1
Checksum:i4FFBECABE8723947
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM942759 Genomic DNA. Translation: CAR46499.1.
RefSeqiYP_002152996.1. NC_010554.1.

Genome annotation databases

EnsemblBacteriaiCAR46499; CAR46499; PMI3311.
GeneIDi6800930.
KEGGipmr:PMI3311.
PATRICi20521332. VBIProMir120933_3237.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM942759 Genomic DNA. Translation: CAR46499.1 .
RefSeqi YP_002152996.1. NC_010554.1.

3D structure databases

ProteinModelPortali B4F1V2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 529507.PMI3311.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR46499 ; CAR46499 ; PMI3311 .
GeneIDi 6800930.
KEGGi pmr:PMI3311.
PATRICi 20521332. VBIProMir120933_3237.

Phylogenomic databases

eggNOGi COG0248.
HOGENOMi HOG000258672.
KOi K01524.
OMAi GLHIEYK.
OrthoDBi EOG6M6JN6.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .
BioCyci PMIR529507:GJIW-3387-MONOMER.

Family and domain databases

HAMAPi MF_01550. GppA.
InterProi IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view ]
Pfami PF02541. Ppx-GppA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HI4320.

Entry informationi

Entry nameiGPPA_PROMH
AccessioniPrimary (citable) accession number: B4F1V2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: October 1, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3