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B4F1V2

- GPPA_PROMH

UniProt

B4F1V2 - GPPA_PROMH

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Protein
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase
Gene
gppA, PMI3311
Organism
Proteus mirabilis (strain HI4320)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. guanosine pentaphosphate catabolic process Source: InterPro
  2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciPMIR529507:GJIW-3387-MONOMER.
UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase (EC:3.6.1.40)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene namesi
Name:gppA
Ordered Locus Names:PMI3311
OrganismiProteus mirabilis (strain HI4320)
Taxonomic identifieri529507 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus
ProteomesiUP000008319: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 502502Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation
PRO_1000192531Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi529507.PMI3311.

Structurei

3D structure databases

ProteinModelPortaliB4F1V2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiGLHIEYK.
OrthoDBiEOG6M6JN6.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4F1V2-1 [UniParc]FASTAAdd to Basket

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MLKSSSLYAA IDLGSNSFHM LVVREIAGSI QVLSRVKRKV RLAAGLNKEN    50
ELSEQAMERG WQCLRLFSEY LRDIPAEQIR VVATATLRIA KNADIFVAKA 100
SEILGNTVHV ISGEEEARLI YRGVAHTTGG AEQRLVVDIG GGSTELVTGT 150
GAKTTQLMSL SMGCVTWLER YFSDRSLTEE NFAQAQQAAK AILAPVAEKL 200
IQQGWQVCVG ASGTVQALQE IMIAQGMDEL ITLPKLERLK QKAIECGKLE 250
ELEIEGLTFE RALVFPSGLA ILIAIFETLH IENMILAGGA LREGLVYGML 300
HLPIEQDIRQ RTLRNIQRRF QIDIEQAHRV QQLAEHFFIQ VSKSWQLDNR 350
CRELLSSACA LHEIGLSVDF RQAPSHASYL VSHLDLPGYT PAQRRLIASF 400
LRNQKGIIDL APLNQQNALP INQAYRLVRL LRLAIIFASR RRDDTLPALR 450
LRTEDEKLII TLPHQWIAEH PLRAENLHEE IQLQSYVHWP LMLEEQNNSR 500
IG 502
Length:502
Mass (Da):56,417
Last modified:September 23, 2008 - v1
Checksum:i4FFBECABE8723947
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM942759 Genomic DNA. Translation: CAR46499.1.
RefSeqiYP_002152996.1. NC_010554.1.

Genome annotation databases

EnsemblBacteriaiCAR46499; CAR46499; PMI3311.
GeneIDi6800930.
KEGGipmr:PMI3311.
PATRICi20521332. VBIProMir120933_3237.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM942759 Genomic DNA. Translation: CAR46499.1 .
RefSeqi YP_002152996.1. NC_010554.1.

3D structure databases

ProteinModelPortali B4F1V2.
ModBasei Search...

Protein-protein interaction databases

STRINGi 529507.PMI3311.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR46499 ; CAR46499 ; PMI3311 .
GeneIDi 6800930.
KEGGi pmr:PMI3311.
PATRICi 20521332. VBIProMir120933_3237.

Phylogenomic databases

eggNOGi COG0248.
HOGENOMi HOG000258672.
KOi K01524.
OMAi GLHIEYK.
OrthoDBi EOG6M6JN6.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .
BioCyci PMIR529507:GJIW-3387-MONOMER.

Family and domain databases

HAMAPi MF_01550. GppA.
InterProi IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view ]
Pfami PF02541. Ppx-GppA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HI4320.

Entry informationi

Entry nameiGPPA_PROMH
AccessioniPrimary (citable) accession number: B4F1V2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: May 14, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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