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B4F1V2

- GPPA_PROMH

UniProt

B4F1V2 - GPPA_PROMH

Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Proteus mirabilis (strain HI4320)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

    Catalytic activityi

    Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. guanosine pentaphosphate catabolic process Source: InterPro
    2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciPMIR529507:GJIW-3387-MONOMER.
    UniPathwayiUPA00908; UER00884.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
    Alternative name(s):
    Guanosine pentaphosphate phosphohydrolaseUniRule annotation
    pppGpp-5'-phosphohydrolaseUniRule annotation
    Gene namesi
    Name:gppAUniRule annotation
    Ordered Locus Names:PMI3311
    OrganismiProteus mirabilis (strain HI4320)
    Taxonomic identifieri529507 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus
    ProteomesiUP000008319: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 502502Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_1000192531Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi529507.PMI3311.

    Structurei

    3D structure databases

    ProteinModelPortaliB4F1V2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0248.
    HOGENOMiHOG000258672.
    KOiK01524.
    OMAiGLHIEYK.
    OrthoDBiEOG6M6JN6.

    Family and domain databases

    HAMAPiMF_01550. GppA.
    InterProiIPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view]
    PfamiPF02541. Ppx-GppA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4F1V2-1 [UniParc]FASTAAdd to Basket

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    MLKSSSLYAA IDLGSNSFHM LVVREIAGSI QVLSRVKRKV RLAAGLNKEN    50
    ELSEQAMERG WQCLRLFSEY LRDIPAEQIR VVATATLRIA KNADIFVAKA 100
    SEILGNTVHV ISGEEEARLI YRGVAHTTGG AEQRLVVDIG GGSTELVTGT 150
    GAKTTQLMSL SMGCVTWLER YFSDRSLTEE NFAQAQQAAK AILAPVAEKL 200
    IQQGWQVCVG ASGTVQALQE IMIAQGMDEL ITLPKLERLK QKAIECGKLE 250
    ELEIEGLTFE RALVFPSGLA ILIAIFETLH IENMILAGGA LREGLVYGML 300
    HLPIEQDIRQ RTLRNIQRRF QIDIEQAHRV QQLAEHFFIQ VSKSWQLDNR 350
    CRELLSSACA LHEIGLSVDF RQAPSHASYL VSHLDLPGYT PAQRRLIASF 400
    LRNQKGIIDL APLNQQNALP INQAYRLVRL LRLAIIFASR RRDDTLPALR 450
    LRTEDEKLII TLPHQWIAEH PLRAENLHEE IQLQSYVHWP LMLEEQNNSR 500
    IG 502
    Length:502
    Mass (Da):56,417
    Last modified:September 23, 2008 - v1
    Checksum:i4FFBECABE8723947
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM942759 Genomic DNA. Translation: CAR46499.1.
    RefSeqiYP_002152996.1. NC_010554.1.

    Genome annotation databases

    EnsemblBacteriaiCAR46499; CAR46499; PMI3311.
    GeneIDi6800930.
    KEGGipmr:PMI3311.
    PATRICi20521332. VBIProMir120933_3237.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM942759 Genomic DNA. Translation: CAR46499.1 .
    RefSeqi YP_002152996.1. NC_010554.1.

    3D structure databases

    ProteinModelPortali B4F1V2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 529507.PMI3311.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAR46499 ; CAR46499 ; PMI3311 .
    GeneIDi 6800930.
    KEGGi pmr:PMI3311.
    PATRICi 20521332. VBIProMir120933_3237.

    Phylogenomic databases

    eggNOGi COG0248.
    HOGENOMi HOG000258672.
    KOi K01524.
    OMAi GLHIEYK.
    OrthoDBi EOG6M6JN6.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00884 .
    BioCyci PMIR529507:GJIW-3387-MONOMER.

    Family and domain databases

    HAMAPi MF_01550. GppA.
    InterProi IPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view ]
    Pfami PF02541. Ppx-GppA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HI4320.

    Entry informationi

    Entry nameiGPPA_PROMH
    AccessioniPrimary (citable) accession number: B4F1V2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3