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B4F1A4

- SPEA_PROMH

UniProt

B4F1A4 - SPEA_PROMH

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Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Proteus mirabilis (strain HI4320)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Magnesium.UniRule annotation
Pyridoxal phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. arginine decarboxylase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine catabolic process Source: InterPro
  2. putrescine biosynthetic process Source: UniProtKB-HAMAP
  3. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPMIR529507:GJIW-2130-MONOMER.
UniPathwayiUPA00186; UER00284.

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
Short name:
ADCUniRule annotation
Gene namesi
Name:speAUniRule annotation
Ordered Locus Names:PMI2094
OrganismiProteus mirabilis (strain HI4320)
Taxonomic identifieri529507 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus
ProteomesiUP000008319: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 635635Biosynthetic arginine decarboxylasePRO_1000145597Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei103 – 1031N6-(pyridoxal phosphate)lysineUniRule annotation

Proteomic databases

PRIDEiB4F1A4.

Interactioni

Protein-protein interaction databases

STRINGi529507.PMI2094.

Structurei

3D structure databases

ProteinModelPortaliB4F1A4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni283 – 29311Substrate-bindingUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
KOiK01585.
OMAiIDHYVDG.
OrthoDBiEOG676Z0R.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4F1A4 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNDNIARKMQ QTYNITYWGG GYYCANNRGN ISVCPNPDVP EATLDLTELV
60 70 80 90 100
KQVQEEHSHL RLPALFCFPQ ILQHRLRSIN AAFHRARESY GYKGDYFLVY
110 120 130 140 150
PIKVNQQRRV IESLINAGEP LGLEAGSKAE LMAVLAHANM TSSVIVCNGY
160 170 180 190 200
KDREYIRLAL TGEKLGHKVF LVIEKMSEIK MVLEEAERLE VIPRLGVRAR
210 220 230 240 250
LASQGSGKWQ ASGGEKSKFG LAATQVLQLI DTLRQAGRLD SLQLLHFHLG
260 270 280 290 300
SQMANIRDIA TGVRESARFY VELHKLGVNI QYFDVGGGLG VDYEGTRSQS
310 320 330 340 350
DCSVNYGLNE YANNVIWAIG DACDENELPH PTVITESGRA LTAHHTVLIS
360 370 380 390 400
NVIGVERNEF TAITPPAEDA PRPIASLWET WEEMQTKGNS RSLREWLHDS
410 420 430 440 450
QLDLHDVHTQ YVHGMLSLTE RAWAEELYLN ICRHIQYDLD PSNRAHRPII
460 470 480 490 500
DELQERMSDK FYVNFSLFQS LPDAWGIDQL FPVLPIEGLD KPLDRRAVLL
510 520 530 540 550
DITCDSDGII DHYVDGDGVE TTMPMPAYDP EYPPMIGFFM VGAYQEILGN
560 570 580 590 600
MHNLFGDTAA VDVYLDEKGN LTYQLSEEGD TVADMLQYVK LNPAVLLERF
610 620 630
RTQVKNAQLD KALQEQFLTE FESGLYGYTY LEEEE
Length:635
Mass (Da):71,775
Last modified:September 23, 2008 - v1
Checksum:i3EA47042A44DCA3C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM942759 Genomic DNA. Translation: CAR44185.1.
RefSeqiYP_002151813.1. NC_010554.1.

Genome annotation databases

EnsemblBacteriaiCAR44185; CAR44185; PMI2094.
GeneIDi6803159.
KEGGipmr:PMI2094.
PATRICi20518867. VBIProMir120933_2043.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM942759 Genomic DNA. Translation: CAR44185.1 .
RefSeqi YP_002151813.1. NC_010554.1.

3D structure databases

ProteinModelPortali B4F1A4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 529507.PMI2094.

Proteomic databases

PRIDEi B4F1A4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR44185 ; CAR44185 ; PMI2094 .
GeneIDi 6803159.
KEGGi pmr:PMI2094.
PATRICi 20518867. VBIProMir120933_2043.

Phylogenomic databases

eggNOGi COG1166.
HOGENOMi HOG000029191.
KOi K01585.
OMAi IDHYVDG.
OrthoDBi EOG676Z0R.

Enzyme and pathway databases

UniPathwayi UPA00186 ; UER00284 .
BioCyci PMIR529507:GJIW-2130-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPi MF_01417. SpeA.
InterProi IPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSi PR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR01273. speA. 1 hit.
PROSITEi PS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HI4320.

Entry informationi

Entry nameiSPEA_PROMH
AccessioniPrimary (citable) accession number: B4F1A4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: October 1, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3