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B4F1A4

- SPEA_PROMH

UniProt

B4F1A4 - SPEA_PROMH

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Protein
Biosynthetic arginine decarboxylase
Gene
speA, PMI2094
Organism
Proteus mirabilis (strain HI4320)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine By similarity.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation
Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. arginine decarboxylase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. arginine catabolic process Source: InterPro
  2. putrescine biosynthetic process Source: UniProtKB-HAMAP
  3. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPMIR529507:GJIW-2130-MONOMER.
UniPathwayiUPA00186; UER00284.

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylase (EC:4.1.1.19)
Short name:
ADC
Gene namesi
Name:speA
Ordered Locus Names:PMI2094
OrganismiProteus mirabilis (strain HI4320)
Taxonomic identifieri529507 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus
ProteomesiUP000008319: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 635635Biosynthetic arginine decarboxylaseUniRule annotation
PRO_1000145597Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei103 – 1031N6-(pyridoxal phosphate)lysine By similarity

Proteomic databases

PRIDEiB4F1A4.

Interactioni

Protein-protein interaction databases

STRINGi529507.PMI2094.

Structurei

3D structure databases

ProteinModelPortaliB4F1A4.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni283 – 29311Substrate-binding Reviewed prediction
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
KOiK01585.
OMAiIDHYVDG.
OrthoDBiEOG676Z0R.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4F1A4-1 [UniParc]FASTAAdd to Basket

« Hide

MNDNIARKMQ QTYNITYWGG GYYCANNRGN ISVCPNPDVP EATLDLTELV    50
KQVQEEHSHL RLPALFCFPQ ILQHRLRSIN AAFHRARESY GYKGDYFLVY 100
PIKVNQQRRV IESLINAGEP LGLEAGSKAE LMAVLAHANM TSSVIVCNGY 150
KDREYIRLAL TGEKLGHKVF LVIEKMSEIK MVLEEAERLE VIPRLGVRAR 200
LASQGSGKWQ ASGGEKSKFG LAATQVLQLI DTLRQAGRLD SLQLLHFHLG 250
SQMANIRDIA TGVRESARFY VELHKLGVNI QYFDVGGGLG VDYEGTRSQS 300
DCSVNYGLNE YANNVIWAIG DACDENELPH PTVITESGRA LTAHHTVLIS 350
NVIGVERNEF TAITPPAEDA PRPIASLWET WEEMQTKGNS RSLREWLHDS 400
QLDLHDVHTQ YVHGMLSLTE RAWAEELYLN ICRHIQYDLD PSNRAHRPII 450
DELQERMSDK FYVNFSLFQS LPDAWGIDQL FPVLPIEGLD KPLDRRAVLL 500
DITCDSDGII DHYVDGDGVE TTMPMPAYDP EYPPMIGFFM VGAYQEILGN 550
MHNLFGDTAA VDVYLDEKGN LTYQLSEEGD TVADMLQYVK LNPAVLLERF 600
RTQVKNAQLD KALQEQFLTE FESGLYGYTY LEEEE 635
Length:635
Mass (Da):71,775
Last modified:September 23, 2008 - v1
Checksum:i3EA47042A44DCA3C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM942759 Genomic DNA. Translation: CAR44185.1.
RefSeqiYP_002151813.1. NC_010554.1.

Genome annotation databases

EnsemblBacteriaiCAR44185; CAR44185; PMI2094.
GeneIDi6803159.
KEGGipmr:PMI2094.
PATRICi20518867. VBIProMir120933_2043.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM942759 Genomic DNA. Translation: CAR44185.1 .
RefSeqi YP_002151813.1. NC_010554.1.

3D structure databases

ProteinModelPortali B4F1A4.
ModBasei Search...

Protein-protein interaction databases

STRINGi 529507.PMI2094.

Proteomic databases

PRIDEi B4F1A4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR44185 ; CAR44185 ; PMI2094 .
GeneIDi 6803159.
KEGGi pmr:PMI2094.
PATRICi 20518867. VBIProMir120933_2043.

Phylogenomic databases

eggNOGi COG1166.
HOGENOMi HOG000029191.
KOi K01585.
OMAi IDHYVDG.
OrthoDBi EOG676Z0R.

Enzyme and pathway databases

UniPathwayi UPA00186 ; UER00284 .
BioCyci PMIR529507:GJIW-2130-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPi MF_01417. SpeA.
InterProi IPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSi PR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR01273. speA. 1 hit.
PROSITEi PS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HI4320.

Entry informationi

Entry nameiSPEA_PROMH
AccessioniPrimary (citable) accession number: B4F1A4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: June 11, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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