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B4F1A3

- SPEB_PROMH

UniProt

B4F1A3 - SPEB_PROMH

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Protein

Agmatinase

Gene

speB

Organism
Proteus mirabilis (strain HI4320)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of putrescine from agmatine.UniRule annotation

Catalytic activityi

Agmatine + H2O = putrescine + urea.UniRule annotation

Cofactori

Manganese.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi128 – 1281ManganeseUniRule annotation
Metal bindingi151 – 1511ManganeseUniRule annotation
Metal bindingi153 – 1531ManganeseUniRule annotation
Metal bindingi155 – 1551ManganeseUniRule annotation
Metal bindingi232 – 2321ManganeseUniRule annotation
Metal bindingi234 – 2341ManganeseUniRule annotation

GO - Molecular functioni

  1. agmatinase activity Source: UniProtKB-HAMAP
  2. manganese ion binding Source: InterPro

GO - Biological processi

  1. putrescine biosynthetic process from arginine Source: UniProtKB-UniPathway
  2. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Polyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciPMIR529507:GJIW-2129-MONOMER.
UniPathwayiUPA00534; UER00287.

Names & Taxonomyi

Protein namesi
Recommended name:
AgmatinaseUniRule annotation (EC:3.5.3.11UniRule annotation)
Alternative name(s):
Agmatine ureohydrolaseUniRule annotation
Short name:
AUHUniRule annotation
Gene namesi
Name:speBUniRule annotation
Ordered Locus Names:PMI2093
OrganismiProteus mirabilis (strain HI4320)
Taxonomic identifieri529507 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus
ProteomesiUP000008319: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306AgmatinasePRO_1000145618Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi529507.PMI2093.

Structurei

3D structure databases

ProteinModelPortaliB4F1A3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the arginase family. Agmatinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0010.
HOGENOMiHOG000204320.
KOiK01480.
OMAiKPDYSLY.
OrthoDBiEOG6R2GW5.

Family and domain databases

Gene3Di3.40.800.10. 1 hit.
HAMAPiMF_01418. SpeB.
InterProiIPR023694. Agmatinase.
IPR005925. Agmatinase-rel.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view]
PANTHERiPTHR11358. PTHR11358. 1 hit.
PfamiPF00491. Arginase. 1 hit.
[Graphical view]
PIRSFiPIRSF036979. Arginase. 1 hit.
TIGRFAMsiTIGR01230. agmatinase. 1 hit.
PROSITEiPS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4F1A3 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKNCTLGNET DNSLISNAFG FLRFPLNFQP YSSDADWVIT GVPFDMATSG
60 70 80 90 100
RAGTRHGPGA IRQISTNLAW EGHRWPWHFD MRERLKVVDC GDLVFNFGDA
110 120 130 140 150
QDMSDKLQAH TEKLLAAGKR CLTFGGDHFV TLPLLRAHAK HFGKMALVHF
160 170 180 190 200
DAHTDTYANG SKFDHGTMFY HAPNEGLIDP QHSVQIGIRT EHDTNNGFTV
210 220 230 240 250
LDAAQVNDRG VDDLVAQIKE IVGSLPVYLT FDIDCLDPAF APGTGTPVVG
260 270 280 290 300
GLTTDKALKM LRALQPLNIV GMDLVEVSPA YDQSDITALA GATIALDMLY

LQAAKK
Length:306
Mass (Da):33,473
Last modified:September 23, 2008 - v1
Checksum:iBFAD491A8881C77B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM942759 Genomic DNA. Translation: CAR44182.1.
RefSeqiYP_002151812.1. NC_010554.1.

Genome annotation databases

EnsemblBacteriaiCAR44182; CAR44182; PMI2093.
GeneIDi6803298.
KEGGipmr:PMI2093.
PATRICi20518865. VBIProMir120933_2042.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM942759 Genomic DNA. Translation: CAR44182.1 .
RefSeqi YP_002151812.1. NC_010554.1.

3D structure databases

ProteinModelPortali B4F1A3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 529507.PMI2093.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR44182 ; CAR44182 ; PMI2093 .
GeneIDi 6803298.
KEGGi pmr:PMI2093.
PATRICi 20518865. VBIProMir120933_2042.

Phylogenomic databases

eggNOGi COG0010.
HOGENOMi HOG000204320.
KOi K01480.
OMAi KPDYSLY.
OrthoDBi EOG6R2GW5.

Enzyme and pathway databases

UniPathwayi UPA00534 ; UER00287 .
BioCyci PMIR529507:GJIW-2129-MONOMER.

Family and domain databases

Gene3Di 3.40.800.10. 1 hit.
HAMAPi MF_01418. SpeB.
InterProi IPR023694. Agmatinase.
IPR005925. Agmatinase-rel.
IPR006035. Ureohydrolase.
IPR023696. Ureohydrolase_domain.
IPR020855. Ureohydrolase_Mn_BS.
[Graphical view ]
PANTHERi PTHR11358. PTHR11358. 1 hit.
Pfami PF00491. Arginase. 1 hit.
[Graphical view ]
PIRSFi PIRSF036979. Arginase. 1 hit.
TIGRFAMsi TIGR01230. agmatinase. 1 hit.
PROSITEi PS01053. ARGINASE_1. 1 hit.
PS51409. ARGINASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HI4320.

Entry informationi

Entry nameiSPEB_PROMH
AccessioniPrimary (citable) accession number: B4F1A3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: October 1, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3