Reviewed, UniProtKB/Swiss-Prot B4F1A3 (SPEB_PROMH)

Names and origin

Protein names

Recommended name:
    Agmatinase
    EC=3.5.3.11
Alternative name(s):
    Agmatine ureohydrolase
      Short name=AUH

Gene names

Name:	speB
Ordered Locus Names:	PMI2093

Organism

Proteus mirabilis (strain HI4320) [Complete proteome] [HAMAP]

Taxonomic identifier

529507 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Proteus

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the formation of putrescine from agmatine By similarity.
Catalytic activity	Agmatine + H2O = putrescine + urea. HAMAP MF_01418
Cofactor	Manganese By similarity.
Pathway	Amine and polyamine biosynthesis; putrescine biosynthesis via agmatine pathway; putrescine from agmatine: step 1/1. HAMAP MF_01418
Sequence similarities	Belongs to the arginase family. Agmatinase subfamily.

Ontologies

Keywords
Biological process	Polyamine biosynthesis Putrescine biosynthesis Spermidine biosynthesis
Ligand	Manganese Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	putrescine biosynthetic process Inferred from electronic annotation. Source: HAMAP spermidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	agmatinase activity Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 306	306	Agmatinase HAMAP MF_01418		PRO_1000145618
Sites
	Metal binding	128	1	Manganese By similarity
	Metal binding	151	1	Manganese By similarity
	Metal binding	153	1	Manganese By similarity
	Metal binding	155	1	Manganese By similarity
	Metal binding	232	1	Manganese By similarity
	Metal binding	234	1	Manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	B4F1A3-1 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: BFAD491A8881C77B	FASTA	306	33,473
	10 20 30 40 50 60 MKNCTLGNET DNSLISNAFG FLRFPLNFQP YSSDADWVIT GVPFDMATSG RAGTRHGPGA 70 80 90 100 110 120 IRQISTNLAW EGHRWPWHFD MRERLKVVDC GDLVFNFGDA QDMSDKLQAH TEKLLAAGKR 130 140 150 160 170 180 CLTFGGDHFV TLPLLRAHAK HFGKMALVHF DAHTDTYANG SKFDHGTMFY HAPNEGLIDP 190 200 210 220 230 240 QHSVQIGIRT EHDTNNGFTV LDAAQVNDRG VDDLVAQIKE IVGSLPVYLT FDIDCLDPAF 250 260 270 280 290 300 APGTGTPVVG GLTTDKALKM LRALQPLNIV GMDLVEVSPA YDQSDITALA GATIALDMLY LQAAKK

References

[1]

"Complete genome sequence of uropathogenic Proteus mirabilis, a master of both adherence and motility." Pearson M.M., Sebaihia M., Churcher C., Quail M.A., Seshasayee A.S., Luscombe N.M., Abdellah Z., Arrosmith C., Atkin B., Chillingworth T., Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H., Rabbinowitsch E., Walker D., Whithead S. , Thomson N.R., Rather P.N., Parkhill J., Mobley H.L.T. J. Bacteriol. 190:4027-4037(2008) [PubMed: 18375554] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM942759 Genomic DNA. Translation: CAR44182.1.
RefSeq	YP_002151812.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6803298.
GenomeReviews	Gene locus PMI2093 in contig AM942759_GR.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	TNLAWEG.
Family and domain databases
HAMAP	MF_01418. [Tree]
InterPro	IPR005925. Agmatinase. IPR006035. Ureohydrolase. [Graphical view]
Gene3D	G3DSA:3.40.800.10. Ureohydrolase. 1 hit.
PANTHER	PTHR11358. Ureohydrolase. 1 hit.
Pfam	PF00491. Arginase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01230. agmatinase. 1 hit.
PROSITE	PS01053. ARGINASE_1. 1 hit. PS51409. ARGINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SPEB_PROMH

Accession

Primary (citable) accession number: B4F1A3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 23, 2008
Last modified:	November 3, 2009
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)