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B4F1A3

- SPEB_PROMH

UniProt

B4F1A3 - SPEB_PROMH

Protein

Agmatinase

Gene

speB

Organism
Proteus mirabilis (strain HI4320)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of putrescine from agmatine.UniRule annotation

    Catalytic activityi

    Agmatine + H2O = putrescine + urea.UniRule annotation

    Cofactori

    Manganese.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi128 – 1281ManganeseUniRule annotation
    Metal bindingi151 – 1511ManganeseUniRule annotation
    Metal bindingi153 – 1531ManganeseUniRule annotation
    Metal bindingi155 – 1551ManganeseUniRule annotation
    Metal bindingi232 – 2321ManganeseUniRule annotation
    Metal bindingi234 – 2341ManganeseUniRule annotation

    GO - Molecular functioni

    1. agmatinase activity Source: UniProtKB-HAMAP
    2. manganese ion binding Source: InterPro

    GO - Biological processi

    1. putrescine biosynthetic process from arginine Source: UniProtKB-UniPathway
    2. spermidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Polyamine biosynthesis, Putrescine biosynthesis, Spermidine biosynthesis

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciPMIR529507:GJIW-2129-MONOMER.
    UniPathwayiUPA00534; UER00287.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AgmatinaseUniRule annotation (EC:3.5.3.11UniRule annotation)
    Alternative name(s):
    Agmatine ureohydrolaseUniRule annotation
    Short name:
    AUHUniRule annotation
    Gene namesi
    Name:speBUniRule annotation
    Ordered Locus Names:PMI2093
    OrganismiProteus mirabilis (strain HI4320)
    Taxonomic identifieri529507 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus
    ProteomesiUP000008319: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 306306AgmatinasePRO_1000145618Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi529507.PMI2093.

    Structurei

    3D structure databases

    ProteinModelPortaliB4F1A3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the arginase family. Agmatinase subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0010.
    HOGENOMiHOG000204320.
    KOiK01480.
    OMAiKPDYSLY.
    OrthoDBiEOG6R2GW5.

    Family and domain databases

    Gene3Di3.40.800.10. 1 hit.
    HAMAPiMF_01418. SpeB.
    InterProiIPR023694. Agmatinase.
    IPR005925. Agmatinase-rel.
    IPR006035. Ureohydrolase.
    IPR023696. Ureohydrolase_domain.
    IPR020855. Ureohydrolase_Mn_BS.
    [Graphical view]
    PANTHERiPTHR11358. PTHR11358. 1 hit.
    PfamiPF00491. Arginase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036979. Arginase. 1 hit.
    TIGRFAMsiTIGR01230. agmatinase. 1 hit.
    PROSITEiPS01053. ARGINASE_1. 1 hit.
    PS51409. ARGINASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4F1A3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKNCTLGNET DNSLISNAFG FLRFPLNFQP YSSDADWVIT GVPFDMATSG    50
    RAGTRHGPGA IRQISTNLAW EGHRWPWHFD MRERLKVVDC GDLVFNFGDA 100
    QDMSDKLQAH TEKLLAAGKR CLTFGGDHFV TLPLLRAHAK HFGKMALVHF 150
    DAHTDTYANG SKFDHGTMFY HAPNEGLIDP QHSVQIGIRT EHDTNNGFTV 200
    LDAAQVNDRG VDDLVAQIKE IVGSLPVYLT FDIDCLDPAF APGTGTPVVG 250
    GLTTDKALKM LRALQPLNIV GMDLVEVSPA YDQSDITALA GATIALDMLY 300
    LQAAKK 306
    Length:306
    Mass (Da):33,473
    Last modified:September 23, 2008 - v1
    Checksum:iBFAD491A8881C77B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM942759 Genomic DNA. Translation: CAR44182.1.
    RefSeqiYP_002151812.1. NC_010554.1.

    Genome annotation databases

    EnsemblBacteriaiCAR44182; CAR44182; PMI2093.
    GeneIDi6803298.
    KEGGipmr:PMI2093.
    PATRICi20518865. VBIProMir120933_2042.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM942759 Genomic DNA. Translation: CAR44182.1 .
    RefSeqi YP_002151812.1. NC_010554.1.

    3D structure databases

    ProteinModelPortali B4F1A3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 529507.PMI2093.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAR44182 ; CAR44182 ; PMI2093 .
    GeneIDi 6803298.
    KEGGi pmr:PMI2093.
    PATRICi 20518865. VBIProMir120933_2042.

    Phylogenomic databases

    eggNOGi COG0010.
    HOGENOMi HOG000204320.
    KOi K01480.
    OMAi KPDYSLY.
    OrthoDBi EOG6R2GW5.

    Enzyme and pathway databases

    UniPathwayi UPA00534 ; UER00287 .
    BioCyci PMIR529507:GJIW-2129-MONOMER.

    Family and domain databases

    Gene3Di 3.40.800.10. 1 hit.
    HAMAPi MF_01418. SpeB.
    InterProi IPR023694. Agmatinase.
    IPR005925. Agmatinase-rel.
    IPR006035. Ureohydrolase.
    IPR023696. Ureohydrolase_domain.
    IPR020855. Ureohydrolase_Mn_BS.
    [Graphical view ]
    PANTHERi PTHR11358. PTHR11358. 1 hit.
    Pfami PF00491. Arginase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036979. Arginase. 1 hit.
    TIGRFAMsi TIGR01230. agmatinase. 1 hit.
    PROSITEi PS01053. ARGINASE_1. 1 hit.
    PS51409. ARGINASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HI4320.

    Entry informationi

    Entry nameiSPEB_PROMH
    AccessioniPrimary (citable) accession number: B4F1A3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3