B4F183 (CAPP_PROMH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoenolpyruvate carboxylase
Short name=PEPC
Short name=PEPCase
EC=4.1.1.31

Gene names

Name:	ppc
Ordered Locus Names:	PMI3227

Organism

Proteus mirabilis (strain HI4320) [Complete proteome] [HAMAP]

Taxonomic identifier

529507 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Proteus › Proteus mirabilis

Protein attributes

Sequence length	878 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity. HAMAP-Rule MF_00595
Catalytic activity	Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-. HAMAP-Rule MF_00595
Cofactor	Magnesium By similarity. HAMAP-Rule MF_00595
Sequence similarities	Belongs to the PEPCase type 1 family.

Ontologies

Keywords
Biological process	Carbon dioxide fixation
Ligand	Magnesium
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	carbon fixation Inferred from electronic annotation. Source: HAMAP oxaloacetate metabolic process Inferred from electronic annotation. Source: HAMAP tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	magnesium ion binding Inferred from electronic annotation. Source: HAMAP phosphoenolpyruvate carboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 878	878	Phosphoenolpyruvate carboxylase HAMAP-Rule MF_00595		PRO_1000129836
Sites
	Active site	137	1	By similarity
	Active site	545	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B4F183 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 208C42D3EA1C9AA3	FASTA	878	98,678
	10 20 30 40 50 60 MNQQYSAMRS NVSMLGKLLG DTIKEALGEE ILDKVESIRK LSKSSRAGNE VQRQKLLLTL 70 80 90 100 110 120 QNLSNDELLP VARAFNQFLN LTNVAEQYHS ISPHGEAASN PVALAKLIER LKDKNFTNQQ 130 140 150 160 170 180 LKQAVEQISI ELVLTAHPTE IARRTLIHKL VEVNTCLSQL DHDDLADYER TNIMRRLRQL 190 200 210 220 230 240 VAQSWHTDEI RKIRPTPIDE AKWGFAVVEN SLWEGVPAFL REFNEQLEES IDYNLPVEAS 250 260 270 280 290 300 PIRFTSWMGG DRDGNPNVTA EITRHALLLS RWKAADLFLN DIQVLVSELS MTESTPELRE 310 320 330 340 350 360 LAGGADVAEP YREIAKQLRT RLQVTRDYLE QRIKGQQSLP PEGLLIDNSA LWEPLYACYQ 370 380 390 400 410 420 SLHQCGMRII ANGQLLDTLR RIRCFGLQLV RLDIRQESTN HTEALSELTQ YLELGDYASW 430 440 450 460 470 480 SEEQKQTFLL TELNSKRPLI PTHWQPSEAT KEVFETCRVI AESPKDSIAS YVISMAKVPS 490 500 510 520 530 540 DVLAVKLLLK EAGADIRLPV APLFETLEDL NNAESVMTRL FDIPWYRDLI DNKQMVMIGY 550 560 570 580 590 600 SDSAKDAGVM AASWAQYRAQ DALIKLCEKS GVTLTLFHGR GGTIGRGGAP AHAALLSQPP 610 620 630 640 650 660 GSLKGGLRVT EQGEMIRFKF GLPQVTISSL AHYAGAILEA NLLPPPEPKT AWIEVMDALS 670 680 690 700 710 720 DVSCEMYRGY VRGEKDFVPY FRAATPEGEL GKLPLGSRPA KRRPTGGVET LRAIPWIFAW 730 740 750 760 770 780 TQNRLMLPAW LGAGAALQHE IDNGKQAVLD DMCENWPFFN TRIAMLEMVY AKADLWLAEY 790 800 810 820 830 840 YDQRLVEENL WPLGAKLRQQ LSDDIKSVLA ISKDEHLMAD LPWVAESIAL RNVYTDPLNV 850 860 870 LQAELLQRSR THSESDPRIE QALMVTIAGI AAGMRNTG

References

[1]

"Complete genome sequence of uropathogenic Proteus mirabilis, a master of both adherence and motility." Pearson M.M., Sebaihia M., Churcher C., Quail M.A., Seshasayee A.S., Luscombe N.M., Abdellah Z., Arrosmith C., Atkin B., Chillingworth T., Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H., Rabbinowitsch E., Walker D., Whithead S. , Thomson N.R., Rather P.N., Parkhill J., Mobley H.L.T. J. Bacteriol. 190:4027-4037(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: HI4320.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM942759 Genomic DNA. Translation: CAR46321.1.
RefSeq	YP_002152912.1. NC_010554.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	529507.PMI3227.
Proteomic databases
PRIDE	B4F183.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAR46321; CAR46321; PMI3227.
GeneID	6801836.
KEGG	pmr:PMI3227.
PATRIC	20521132. VBIProMir120933_3154.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2352.
HOGENOM	HOG000238648.
KO	K01595.
OMA	AIPWVFG.
ProtClustDB	PRK00009.
Enzyme and pathway databases
BioCyc	PMIR529507:GJIW-3284-MONOMER.
Family and domain databases
HAMAP	MF_00595. PEPcase_type1.
InterPro	IPR021135. PEP_COase. IPR018129. PEP_COase_AS. IPR022805. PEP_COase_bac/pln-type. IPR015813. Pyrv/PenolPyrv_Kinase-like_dom. [Graphical view]
Pfam	PF00311. PEPcase. 1 hit. [Graphical view]
PRINTS	PR00150. PEPCARBXLASE.
SUPFAM	SSF51621. Pyrv/PenolPyrv_Kinase_cat. 1 hit.
PROSITE	PS00781. PEPCASE_1. 1 hit. PS00393. PEPCASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CAPP_PROMH

Accession

Primary (citable) accession number: B4F183

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 23, 2008
Last modified:	May 29, 2013
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program