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B4F0N7

- GCSP_PROMH

UniProt

B4F0N7 - GCSP_PROMH

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Proteus mirabilis (strain HI4320)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciPMIR529507:GJIW-2056-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:PMI2019
    OrganismiProteus mirabilis (strain HI4320)
    Taxonomic identifieri529507 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus
    ProteomesiUP000008319: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 958958Glycine dehydrogenase (decarboxylating)PRO_1000132446Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei708 – 7081N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi529507.PMI2019.

    Structurei

    3D structure databases

    ProteinModelPortaliB4F0N7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B4F0N7-1 [UniParc]FASTAAdd to Basket

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    MTQTLTQLEY RDEFIRRHIG SSPEQIKEML DVVGISSLNE LTQKIVPDNI    50
    QLATPPNVGG GATEQEALAE LKAIARKNKR FTSYIGMGYA PSVLPPVILR 100
    NLLENPGWYT AYTPYQPEVS QGRLESLLNF QQVTIDYTGM DLASASLLDE 150
    ATAAAEAMAM AKRVSKLKNA ERFFVADDIH PQTLDVVKTR ANTFGFEVIV 200
    DKAEKVLELE GVFGVLLQQV GTTGEIHDYS QLISELKTRK IITSVAADLM 250
    ALVLLTAPGQ QGADIVLGSA QRFGVPMGYG GPHAAFFACR DEYKRAMPGR 300
    IIGVSRDAAG NRALRMAMQT REQHIRREKA NSNICTSQVL LANIAAMYAV 350
    YHGPEGLKNI AQRIHRLTDI LAAGLIQNGM TLRHQTWFDT LTVETADKAG 400
    VLQRAKDAEI NLRTDIVGAV GVTLSEVTTR EDVVRLIEII SGKAFSDDID 450
    TLDALVASSS TSIPTAMLRK DAVLTHENFH LYHSETEMMR YMHRLENKDL 500
    ALNQAMIPLG SCTMKLNAAA EMLPITWPEF TEMHPFCPPY QAQGYQIMIE 550
    QLSNWLAAIT GYDAMCMQPN SGAQGEYAGL LAIRRYHQSR GEGNRHICLI 600
    PSSAHGTNPA SAHMAGMTVV VVGCDENGNI DIADLKAKAE KHQAELSCVM 650
    VTYPSTHGVY EEGIREVCEI IHQYGGQVYL DGANMNAQVG ITTPGFIGSD 700
    VSHLNLHKTF CIPHGGGGPG MGPIGVKAHL APFVPGHSVV EMDGVTTQGA 750
    VSAAQFGSAS ILPISWMYIR MMGSEGLKQA SQVAILNANY IAQRLKDDYD 800
    ILYSGAEGYV AHECIIDIRP LKANYGISEM DVAKRLIDYG FHAPTMSFPV 850
    AGTLMIEPTE SESKVEIDRF IDALLSIRAE IAQVDDGVWP IDDNPLVNAP 900
    HTQYELVQEW SHSYSRECAV FPSEATKRNK YWPAVKRLDD VYGDRHLHCS 950
    CAPISDYE 958
    Length:958
    Mass (Da):105,106
    Last modified:September 23, 2008 - v1
    Checksum:iC3AB3A118C4BFCF5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM942759 Genomic DNA. Translation: CAR44064.1.
    RefSeqiYP_002151742.1. NC_010554.1.

    Genome annotation databases

    EnsemblBacteriaiCAR44064; CAR44064; PMI2019.
    GeneIDi6802088.
    KEGGipmr:PMI2019.
    PATRICi20518721. VBIProMir120933_1970.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM942759 Genomic DNA. Translation: CAR44064.1 .
    RefSeqi YP_002151742.1. NC_010554.1.

    3D structure databases

    ProteinModelPortali B4F0N7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 529507.PMI2019.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAR44064 ; CAR44064 ; PMI2019 .
    GeneIDi 6802088.
    KEGGi pmr:PMI2019.
    PATRICi 20518721. VBIProMir120933_1970.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci PMIR529507:GJIW-2056-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HI4320.

    Entry informationi

    Entry nameiGCSP_PROMH
    AccessioniPrimary (citable) accession number: B4F0N7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3