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B4F0N7 (GCSP_PROMH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:PMI2019
OrganismProteus mirabilis (strain HI4320) [Complete proteome] [HAMAP]
Taxonomic identifier529507 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus

Protein attributes

Sequence length958 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 958958Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000132446

Amino acid modifications

Modified residue7081N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
B4F0N7 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: C3AB3A118C4BFCF5

FASTA958105,106
        10         20         30         40         50         60 
MTQTLTQLEY RDEFIRRHIG SSPEQIKEML DVVGISSLNE LTQKIVPDNI QLATPPNVGG 

        70         80         90        100        110        120 
GATEQEALAE LKAIARKNKR FTSYIGMGYA PSVLPPVILR NLLENPGWYT AYTPYQPEVS 

       130        140        150        160        170        180 
QGRLESLLNF QQVTIDYTGM DLASASLLDE ATAAAEAMAM AKRVSKLKNA ERFFVADDIH 

       190        200        210        220        230        240 
PQTLDVVKTR ANTFGFEVIV DKAEKVLELE GVFGVLLQQV GTTGEIHDYS QLISELKTRK 

       250        260        270        280        290        300 
IITSVAADLM ALVLLTAPGQ QGADIVLGSA QRFGVPMGYG GPHAAFFACR DEYKRAMPGR 

       310        320        330        340        350        360 
IIGVSRDAAG NRALRMAMQT REQHIRREKA NSNICTSQVL LANIAAMYAV YHGPEGLKNI 

       370        380        390        400        410        420 
AQRIHRLTDI LAAGLIQNGM TLRHQTWFDT LTVETADKAG VLQRAKDAEI NLRTDIVGAV 

       430        440        450        460        470        480 
GVTLSEVTTR EDVVRLIEII SGKAFSDDID TLDALVASSS TSIPTAMLRK DAVLTHENFH 

       490        500        510        520        530        540 
LYHSETEMMR YMHRLENKDL ALNQAMIPLG SCTMKLNAAA EMLPITWPEF TEMHPFCPPY 

       550        560        570        580        590        600 
QAQGYQIMIE QLSNWLAAIT GYDAMCMQPN SGAQGEYAGL LAIRRYHQSR GEGNRHICLI 

       610        620        630        640        650        660 
PSSAHGTNPA SAHMAGMTVV VVGCDENGNI DIADLKAKAE KHQAELSCVM VTYPSTHGVY 

       670        680        690        700        710        720 
EEGIREVCEI IHQYGGQVYL DGANMNAQVG ITTPGFIGSD VSHLNLHKTF CIPHGGGGPG 

       730        740        750        760        770        780 
MGPIGVKAHL APFVPGHSVV EMDGVTTQGA VSAAQFGSAS ILPISWMYIR MMGSEGLKQA 

       790        800        810        820        830        840 
SQVAILNANY IAQRLKDDYD ILYSGAEGYV AHECIIDIRP LKANYGISEM DVAKRLIDYG 

       850        860        870        880        890        900 
FHAPTMSFPV AGTLMIEPTE SESKVEIDRF IDALLSIRAE IAQVDDGVWP IDDNPLVNAP 

       910        920        930        940        950 
HTQYELVQEW SHSYSRECAV FPSEATKRNK YWPAVKRLDD VYGDRHLHCS CAPISDYE 

« Hide

References

[1]"Complete genome sequence of uropathogenic Proteus mirabilis, a master of both adherence and motility."
Pearson M.M., Sebaihia M., Churcher C., Quail M.A., Seshasayee A.S., Luscombe N.M., Abdellah Z., Arrosmith C., Atkin B., Chillingworth T., Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H., Rabbinowitsch E., Walker D., Whithead S. expand/collapse author list , Thomson N.R., Rather P.N., Parkhill J., Mobley H.L.T.
J. Bacteriol. 190:4027-4037(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HI4320.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM942759 Genomic DNA. Translation: CAR44064.1.
RefSeqYP_002151742.1. NC_010554.1.

3D structure databases

ProteinModelPortalB4F0N7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING529507.PMI2019.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAR44064; CAR44064; PMI2019.
GeneID6802088.
KEGGpmr:PMI2019.
PATRIC20518721. VBIProMir120933_1970.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAFDSRPYS.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycPMIR529507:GJIW-2056-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_PROMH
AccessionPrimary (citable) accession number: B4F0N7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families