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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Proteus mirabilis (strain HI4320)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPMIR529507:GJIW-2056-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:PMI2019
OrganismiProteus mirabilis (strain HI4320)
Taxonomic identifieri529507 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus
ProteomesiUP000008319 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 958958Glycine dehydrogenase (decarboxylating)PRO_1000132446Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei708 – 7081N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi529507.PMI2019.

Structurei

3D structure databases

ProteinModelPortaliB4F0N7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiMAGMYAV.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

B4F0N7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQTLTQLEY RDEFIRRHIG SSPEQIKEML DVVGISSLNE LTQKIVPDNI
60 70 80 90 100
QLATPPNVGG GATEQEALAE LKAIARKNKR FTSYIGMGYA PSVLPPVILR
110 120 130 140 150
NLLENPGWYT AYTPYQPEVS QGRLESLLNF QQVTIDYTGM DLASASLLDE
160 170 180 190 200
ATAAAEAMAM AKRVSKLKNA ERFFVADDIH PQTLDVVKTR ANTFGFEVIV
210 220 230 240 250
DKAEKVLELE GVFGVLLQQV GTTGEIHDYS QLISELKTRK IITSVAADLM
260 270 280 290 300
ALVLLTAPGQ QGADIVLGSA QRFGVPMGYG GPHAAFFACR DEYKRAMPGR
310 320 330 340 350
IIGVSRDAAG NRALRMAMQT REQHIRREKA NSNICTSQVL LANIAAMYAV
360 370 380 390 400
YHGPEGLKNI AQRIHRLTDI LAAGLIQNGM TLRHQTWFDT LTVETADKAG
410 420 430 440 450
VLQRAKDAEI NLRTDIVGAV GVTLSEVTTR EDVVRLIEII SGKAFSDDID
460 470 480 490 500
TLDALVASSS TSIPTAMLRK DAVLTHENFH LYHSETEMMR YMHRLENKDL
510 520 530 540 550
ALNQAMIPLG SCTMKLNAAA EMLPITWPEF TEMHPFCPPY QAQGYQIMIE
560 570 580 590 600
QLSNWLAAIT GYDAMCMQPN SGAQGEYAGL LAIRRYHQSR GEGNRHICLI
610 620 630 640 650
PSSAHGTNPA SAHMAGMTVV VVGCDENGNI DIADLKAKAE KHQAELSCVM
660 670 680 690 700
VTYPSTHGVY EEGIREVCEI IHQYGGQVYL DGANMNAQVG ITTPGFIGSD
710 720 730 740 750
VSHLNLHKTF CIPHGGGGPG MGPIGVKAHL APFVPGHSVV EMDGVTTQGA
760 770 780 790 800
VSAAQFGSAS ILPISWMYIR MMGSEGLKQA SQVAILNANY IAQRLKDDYD
810 820 830 840 850
ILYSGAEGYV AHECIIDIRP LKANYGISEM DVAKRLIDYG FHAPTMSFPV
860 870 880 890 900
AGTLMIEPTE SESKVEIDRF IDALLSIRAE IAQVDDGVWP IDDNPLVNAP
910 920 930 940 950
HTQYELVQEW SHSYSRECAV FPSEATKRNK YWPAVKRLDD VYGDRHLHCS

CAPISDYE
Length:958
Mass (Da):105,106
Last modified:September 23, 2008 - v1
Checksum:iC3AB3A118C4BFCF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM942759 Genomic DNA. Translation: CAR44064.1.
RefSeqiWP_004248527.1. NC_010554.1.

Genome annotation databases

EnsemblBacteriaiCAR44064; CAR44064; PMI2019.
GeneIDi6802088.
KEGGipmr:PMI2019.
PATRICi20518721. VBIProMir120933_1970.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM942759 Genomic DNA. Translation: CAR44064.1.
RefSeqiWP_004248527.1. NC_010554.1.

3D structure databases

ProteinModelPortaliB4F0N7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi529507.PMI2019.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAR44064; CAR44064; PMI2019.
GeneIDi6802088.
KEGGipmr:PMI2019.
PATRICi20518721. VBIProMir120933_1970.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiMAGMYAV.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciPMIR529507:GJIW-2056-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HI4320.

Entry informationi

Entry nameiGCSP_PROMH
AccessioniPrimary (citable) accession number: B4F0N7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: July 22, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.