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Protein

Multidrug resistance protein MdtG

Gene

mdtG

Organism
Proteus mirabilis (strain HI4320)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein MdtGUniRule annotation
Gene namesi
Name:mdtGUniRule annotation
Ordered Locus Names:PMI1687
OrganismiProteus mirabilis (strain HI4320)
Taxonomic identifieri529507 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesMorganellaceaeProteus
Proteomesi
  • UP000008319 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei14 – 34HelicalUniRule annotationAdd BLAST21
Transmembranei52 – 72HelicalUniRule annotationAdd BLAST21
Transmembranei90 – 110HelicalUniRule annotationAdd BLAST21
Transmembranei113 – 133HelicalUniRule annotationAdd BLAST21
Transmembranei149 – 169HelicalUniRule annotationAdd BLAST21
Transmembranei171 – 191HelicalUniRule annotationAdd BLAST21
Transmembranei219 – 239HelicalUniRule annotationAdd BLAST21
Transmembranei254 – 274HelicalUniRule annotationAdd BLAST21
Transmembranei288 – 308HelicalUniRule annotationAdd BLAST21
Transmembranei318 – 338HelicalUniRule annotationAdd BLAST21
Transmembranei376 – 396HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004145811 – 402Multidrug resistance protein MdtGAdd BLAST402

Interactioni

Protein-protein interaction databases

STRINGi529507.PMI1687.

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C6X. Bacteria.
ENOG410ZVCH. LUCA.
HOGENOMiHOG000066093.
KOiK08161.
OMAiSYGFRTV.
OrthoDBiPOG091H029Y.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01528. MFS_MdtG. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR023692. Mutidrug-R_MdtG.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PRINTSiPR01035. TCRTETA.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4EYY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLKPRNNSW KQNLYIVWFG CFLTGAGFSL IMPFLPLYVE ELGIKDHESL
60 70 80 90 100
NLWTGVAFSI TFLFSAIAAP FWGKLSDRKG RKLMLLRSAL GMAIVMVLIG
110 120 130 140 150
FAQNIWQLLI LRALLGVLGG FVPNANALIA TQVPVKKSGW ALGTLSTGAV
160 170 180 190 200
SGALIGPLIG GILADLYGLR PVFFITAAVL FICFIVTLFF VSENFTPVSK
210 220 230 240 250
KDALSTQQVF SSLKNKRLVI CLFFTTMIIQ VATGSVTPIL TLYIRDLAGS
260 270 280 290 300
ISNLAFISGV IASVPGIAAL ISAPRFGKLG DRIGPDKVLI FTLGLSIFML
310 320 330 340 350
IPMALVSNYW ELGALRFLLG AVNAAMLPAV QTLILYNITP AIAGRIFSYN
360 370 380 390 400
QALRDVGNVT GPLMGAFVAA NYGFRAVFYF TAAVVFFNLI YSWISFRTPQ

RK
Length:402
Mass (Da):43,721
Last modified:September 23, 2008 - v1
Checksum:i3A46F4B6CDCBED01
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM942759 Genomic DNA. Translation: CAR43519.1.
RefSeqiWP_012368071.1. NC_010554.1.

Genome annotation databases

EnsemblBacteriaiCAR43519; CAR43519; PMI1687.
GeneIDi6801162.
KEGGipmr:PMI1687.
PATRICi20518027. VBIProMir120933_1638.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM942759 Genomic DNA. Translation: CAR43519.1.
RefSeqiWP_012368071.1. NC_010554.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi529507.PMI1687.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAR43519; CAR43519; PMI1687.
GeneIDi6801162.
KEGGipmr:PMI1687.
PATRICi20518027. VBIProMir120933_1638.

Phylogenomic databases

eggNOGiENOG4105C6X. Bacteria.
ENOG410ZVCH. LUCA.
HOGENOMiHOG000066093.
KOiK08161.
OMAiSYGFRTV.
OrthoDBiPOG091H029Y.

Family and domain databases

CDDicd06174. MFS. 1 hit.
HAMAPiMF_01528. MFS_MdtG. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR023692. Mutidrug-R_MdtG.
IPR001958. Tet-R_TetA/multi-R_MdtG.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
PRINTSiPR01035. TCRTETA.
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMDTG_PROMH
AccessioniPrimary (citable) accession number: B4EYY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: September 23, 2008
Last modified: November 2, 2016
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.