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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Proteus mirabilis (strain HI4320)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei386UniRule annotation1
Active sitei514UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciPMIR529507:G1GJY-2863-MONOMER
UniPathwayiUPA00109; UER00181
UPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:PMI2754
OrganismiProteus mirabilis (strain HI4320)
Taxonomic identifieri529507 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesMorganellaceaeProteus
Proteomesi
  • UP000008319 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001257441 – 548Glucose-6-phosphate isomeraseAdd BLAST548

Proteomic databases

PRIDEiB4EYR8

Interactioni

Protein-protein interaction databases

STRINGi529507.PMI2754

Structurei

3D structure databases

SMRiB4EYR8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QP8 Bacteria
COG0166 LUCA
HOGENOMiHOG000261370
KOiK01810
OMAiTNSQHAF
OrthoDBiPOG091H04C3

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
Gene3Di1.10.1390.10, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR023096 G6P_Isomerase_C
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

B4EYR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNVNPTHTL AWKALEDHFA VMKDTEMKTL FSQDPSRFNT FSRTFSDQIL
60 70 80 90 100
VDFSKNRITQ ETLDKLQALA KECDVAGAIK SMFSGEKINC TEDRAVLHTA
110 120 130 140 150
LRNRSNTPVM VDGKDVMPEV NAVLHKMKVF SERVISGEWK GYTGKAITDV
160 170 180 190 200
VNIGIGGSDL GPYMVTEALR PYKNHLTMHF VSNVDGTHIA ETLKKCDPET
210 220 230 240 250
TLFLIASKTF TTQETMTNAH SARDWFLSAA KESAFVAKHF VALSTNSAEV
260 270 280 290 300
EKFGIDTANM FEFWDWVGGR YSLWSAIGLS IVLSIGYDNF EQLLSGAHAM
310 320 330 340 350
DNHFRTTEAE NNIPMILALI GIWYNNFFGT ETEAILPYDQ YMHRFAAYFQ
360 370 380 390 400
QGNMESNGKY IDRDGNKVSY QTGPIIWGEP GTNGQHAFYQ LIHQGTKLIP
410 420 430 440 450
CDFIAPAISH NPLSDHHAKL MSNFFAQTEA LAFGKTREQV DAEFASAGKD
460 470 480 490 500
PATMGYVAPF KVFEGNRPTN SILLKEITPY SLGALIAMYE HKIFVQGVIF
510 520 530 540
NIFTFDQWGV ELGKQLANRI LPELKGKESV NSHDSSTNNL INRYKAWR
Length:548
Mass (Da):61,540
Last modified:September 23, 2008 - v1
Checksum:i85B2F01213D3145B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM942759 Genomic DNA Translation: CAR45430.1
RefSeqiWP_004250104.1, NC_010554.1

Genome annotation databases

EnsemblBacteriaiCAR45430; CAR45430; PMI2754
GeneIDi6801939
KEGGipmr:PMI2754
PATRICifig|529507.6.peg.2683

Similar proteinsi

Entry informationi

Entry nameiG6PI_PROMH
AccessioniPrimary (citable) accession number: B4EYR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: June 20, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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