Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glycerol-3-phosphate acyltransferase

Gene

plsB

Organism
Proteus mirabilis (strain HI4320)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate.UniRule annotation

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase (plsB)
  2. no protein annotated in this organism
  3. Phosphatidate cytidylyltransferase (cdsA)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciPMIR529507:GJIW-2800-MONOMER.
UniPathwayiUPA00557; UER00612.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate acyltransferaseUniRule annotation (EC:2.3.1.15UniRule annotation)
Short name:
GPATUniRule annotation
Gene namesi
Name:plsBUniRule annotation
Ordered Locus Names:PMI2751
OrganismiProteus mirabilis (strain HI4320)
Taxonomic identifieri529507 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus
Proteomesi
  • UP000008319 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 827827Glycerol-3-phosphate acyltransferasePRO_1000123086Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi529507.PMI2751.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi307 – 3126HXXXXD motif

Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.UniRule annotation

Sequence similaritiesi

Belongs to the GPAT/DAPAT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E55. Bacteria.
COG2937. LUCA.
HOGENOMiHOG000218231.
KOiK00631.
OMAiEVIYVPC.
OrthoDBiPOG091H06BX.

Family and domain databases

HAMAPiMF_00393. Glyc3P_acyltrans. 1 hit.
InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 2 hits.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03703. plsB. 1 hit.

Sequencei

Sequence statusi: Complete.

B4EYR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAWRKLYYN TLNLPLKLLV KSKRVPTDPI TELGLDTSRS FLYVLPYHSK
60 70 80 90 100
ADLLTLRQQC LSLGLPDPLQ PIEINGTKLP AYVFIDDGPR VFRYYSPDPR
110 120 130 140 150
KDSVKTFHAY LDAHRNNPHL DIEMLPASVM FGRSPGREGH NGVPHLRLLN
160 170 180 190 200
GIQKFIAILW LGRDSFVRFS PTVSMRQMAN EHGTDTSIAR KLARVARIHF
210 220 230 240 250
SRQRLAAVGP KLPARQDLFN KLLASKAIEK AIEDEAKAKK ITLDKARKNA
260 270 280 290 300
TDIMEEIAAN FSYEAVRMTD RVLSWTWNKL YQGINVFNAE RVRQLAQDGH
310 320 330 340 350
EIVYVPCHRS HMDYLLLSYV LYHQGLVPPH IAAGINLNFW PAGPIFRHLG
360 370 380 390 400
AFFIRRTFKG NKLYSTIFRE YLGELFSRGY SIEYFVEGGR SRTGRLLDPK
410 420 430 440 450
TGTLSMTVQA MLRGETRPIS IVPIYIGYEH VMEVATYAKE LRGATKEKEG
460 470 480 490 500
FMQMIRGLRK LRNLGQGYVN FGEPISLSQY LNQAVPDWRD DIDPIEPQRP
510 520 530 540 550
SWLNPAVSAL ADNIMVNINN AASINAINLV STALLASRQR ALTKEQLLEQ
560 570 580 590 600
IDCYLQLLRN VPYSSDMVVP DKSSETLLAH ALQTDKFQVE QDSLGDIIIL
610 620 630 640 650
PRESAVLMTY YRNNTIHLMV TPSLIASIVL HHERIHRDDL MKQVELIFPL
660 670 680 690 700
IKAELFIRYE KEELPDVVNT LISELCRQRL ICCADDGILR INPARIRPLQ
710 720 730 740 750
LLAASVRETL QRYGITLSLL NFAPEISRAL LERESRILAQ RLSVLHGINA
760 770 780 790 800
PEFFDKAVFS TLVSTLREEG YLKDNEDILK ADASALYQVI AKLMSPEIRL
810 820
TIESVGVTED NNSAQAIEEN PESNMDK
Length:827
Mass (Da):94,030
Last modified:September 23, 2008 - v1
Checksum:i33074CE189BD8200
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM942759 Genomic DNA. Translation: CAR45420.1.
RefSeqiWP_012368492.1. NC_010554.1.

Genome annotation databases

EnsemblBacteriaiCAR45420; CAR45420; PMI2751.
GeneIDi6802057.
KEGGipmr:PMI2751.
PATRICi20520162. VBIProMir120933_2680.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM942759 Genomic DNA. Translation: CAR45420.1.
RefSeqiWP_012368492.1. NC_010554.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi529507.PMI2751.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAR45420; CAR45420; PMI2751.
GeneIDi6802057.
KEGGipmr:PMI2751.
PATRICi20520162. VBIProMir120933_2680.

Phylogenomic databases

eggNOGiENOG4105E55. Bacteria.
COG2937. LUCA.
HOGENOMiHOG000218231.
KOiK00631.
OMAiEVIYVPC.
OrthoDBiPOG091H06BX.

Enzyme and pathway databases

UniPathwayiUPA00557; UER00612.
BioCyciPMIR529507:GJIW-2800-MONOMER.

Family and domain databases

HAMAPiMF_00393. Glyc3P_acyltrans. 1 hit.
InterProiIPR022284. GPAT/DHAPAT.
IPR028354. GPAT_PlsB.
IPR002123. Plipid/glycerol_acylTrfase.
[Graphical view]
PANTHERiPTHR12563. PTHR12563. 2 hits.
PfamiPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFiPIRSF500064. GPAT. 1 hit.
PIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTiSM00563. PlsC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03703. plsB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPLSB_PROMH
AccessioniPrimary (citable) accession number: B4EYR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: September 7, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.