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Protein

Carnitinyl-CoA dehydratase

Gene

caiD

Organism
Proteus mirabilis (strain HI4320)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA.UniRule annotation

Catalytic activityi

L-carnitinyl-CoA = (E)-4-(trimethylammonio)but-2-enoyl-CoA + H2O.UniRule annotation

Pathwayi: carnitine metabolism

This protein is involved in the pathway carnitine metabolism, which is part of Amine and polyamine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway carnitine metabolism and in Amine and polyamine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei111Important for catalytic activityUniRule annotation1
Sitei131Important for catalytic activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

UniPathwayiUPA00117.

Names & Taxonomyi

Protein namesi
Recommended name:
Carnitinyl-CoA dehydrataseUniRule annotation (EC:4.2.1.149UniRule annotation)
Alternative name(s):
Crotonobetainyl-CoA hydrataseUniRule annotation
Gene namesi
Name:caiDUniRule annotation
Ordered Locus Names:PMI2658
OrganismiProteus mirabilis (strain HI4320)
Taxonomic identifieri529507 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesMorganellaceaeProteus
Proteomesi
  • UP000008319 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001362591 – 261Carnitinyl-CoA dehydrataseAdd BLAST261

Interactioni

Protein-protein interaction databases

STRINGi529507.PMI2658.

Structurei

3D structure databases

ProteinModelPortaliB4EY26.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the enoyl-CoA hydratase/isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4106YT9. Bacteria.
COG1024. LUCA.
HOGENOMiHOG000027939.
KOiK08299.
OMAiMAAHFRI.
OrthoDBiPOG091H01K6.

Family and domain databases

Gene3Di1.10.12.10. 1 hit.
3.90.226.10. 1 hit.
HAMAPiMF_01051. CaiD. 1 hit.
InterProiIPR022852. Carnitinyl_CoA_dehydratase.
IPR029045. ClpP/crotonase-like_dom.
IPR014748. Crontonase_C.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view]
PfamiPF00378. ECH_1. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4EY26-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQSLHLTTR GSVLEIILDR PKANAIDAKT SHEMGEVFMR FRDDPSLRVA
60 70 80 90 100
IITGAGERFF CAGWDLKAAA EGEAPDADFG AGGFAGLTEL FDLNKPVIAA
110 120 130 140 150
INGYAFGGGF ELALAADMII CSDNASFALP EAQLGIVPDS GGVLRLPKRL
160 170 180 190 200
PPAIVNEMLM TGRRMNAQEA LRWGIANRVV SATELMDSAR ELADQIANSA
210 220 230 240 250
PLAVAALKEI YRATSELSIE EGYKLMRSGV LKYYPRVLHS EDALEGPLAF
260
AEKRSPEWKG R
Length:261
Mass (Da):28,184
Last modified:September 23, 2008 - v1
Checksum:i87BF6AE0A553FE43
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM942759 Genomic DNA. Translation: CAR45238.1.
RefSeqiWP_012368456.1. NC_010554.1.

Genome annotation databases

EnsemblBacteriaiCAR45238; CAR45238; PMI2658.
GeneIDi6802713.
KEGGipmr:PMI2658.
PATRICi20519974. VBIProMir120933_2586.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM942759 Genomic DNA. Translation: CAR45238.1.
RefSeqiWP_012368456.1. NC_010554.1.

3D structure databases

ProteinModelPortaliB4EY26.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi529507.PMI2658.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAR45238; CAR45238; PMI2658.
GeneIDi6802713.
KEGGipmr:PMI2658.
PATRICi20519974. VBIProMir120933_2586.

Phylogenomic databases

eggNOGiENOG4106YT9. Bacteria.
COG1024. LUCA.
HOGENOMiHOG000027939.
KOiK08299.
OMAiMAAHFRI.
OrthoDBiPOG091H01K6.

Enzyme and pathway databases

UniPathwayiUPA00117.

Family and domain databases

Gene3Di1.10.12.10. 1 hit.
3.90.226.10. 1 hit.
HAMAPiMF_01051. CaiD. 1 hit.
InterProiIPR022852. Carnitinyl_CoA_dehydratase.
IPR029045. ClpP/crotonase-like_dom.
IPR014748. Crontonase_C.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view]
PfamiPF00378. ECH_1. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAID_PROMH
AccessioniPrimary (citable) accession number: B4EY26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: November 2, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.