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Protein

Regulator of RpoS

Gene

rssB

Organism
Proteus mirabilis (strain HI4320)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Regulates the turnover of the sigma S factor (RpoS) by promoting its proteolysis in exponentially growing cells. Acts by binding and delivering RpoS to the ClpXP protease. RssB is not co-degraded with RpoS, but is released from the complex and can initiate a new cycle of RpoS recognition and degradation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processStress responseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of RpoSUniRule annotation
Gene namesi
Name:rssBUniRule annotation
Ordered Locus Names:PMI1491Imported
OrganismiProteus mirabilis (strain HI4320)Imported
Taxonomic identifieri529507 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesMorganellaceaeProteus
Proteomesi
  • UP000008319 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei594-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated. Phosphorylation stimulates the interaction with RpoS and, therefore, the proteolysis of RpoS.UniRule annotation

Keywords - PTMi

PhosphoproteinUniRule annotation

Interactioni

Subunit structurei

Binds to RpoS.UniRule annotation

Protein-protein interaction databases

STRINGi529507.PMI1491.

Structurei

3D structure databases

ProteinModelPortaliB4EXS4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 124Response regulatoryInterPro annotationAdd BLAST116

Sequence similaritiesi

Belongs to the RssB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105I93. Bacteria.
COG0784. LUCA.
HOGENOMiHOG000119811.
KOiK02485.
OMAiEERLFQD.
OrthoDBiPOG091H03L3.

Family and domain databases

HAMAPiMF_00958. RssB. 1 hit.
InterProiView protein in InterPro
IPR011006. CheY-like_superfamily.
IPR028616. RssB.
IPR010114. Sig_transdc_resp-reg_NtrC.
IPR001789. Sig_transdc_resp-reg_receiver.
PANTHERiPTHR32071:SF45. PTHR32071:SF45. 1 hit.
PfamiView protein in Pfam
PF00072. Response_reg. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiView protein in PROSITE
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

B4EXS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKALVGKKI LIIDDEVVFR TMLTEYFSHE KACVYATDNG SQALLLLEEG
60 70 80 90 100
LRPDLILCDI RMPVMNGPTF LCHLEQRHWS FPVIAISCTD NMAEIDDMLR
110 120 130 140 150
FGAQDVFLKP VTNLAKLKQK VIEVLCPGFF ESELIARGQL GPLWNNLREQ
160 170 180 190 200
PHYIQSFVKQ MQPQVKQIVA GYNVNYRQLN DASQMGLLFD IATLSKDQII
210 220 230 240 250
FYCVDVSNDE ENGLLVALLL RVVFNRFLKA TEKRRFLPSM YNILNKINKM
260 270 280 290 300
LEDMGVRGSF PLILGYYHTK EKNILLASAG LRAEIKTENK KYVLNSGIPL
310 320 330
GTLHSLYINQ IKCVGIDWQC KIWNQHHKIN LMFSPIHKR
Length:339
Mass (Da):38,951
Last modified:September 23, 2008 - v1
Checksum:i3665BD57BD8CE9BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM942759 Genomic DNA. Translation: CAR43129.1.
RefSeqiWP_012368013.1. NC_010554.1.

Genome annotation databases

EnsemblBacteriaiCAR43129; CAR43129; PMI1491.
GeneIDi6801877.
KEGGipmr:PMI1491.
PATRICi20517607. VBIProMir120933_1439.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM942759 Genomic DNA. Translation: CAR43129.1.
RefSeqiWP_012368013.1. NC_010554.1.

3D structure databases

ProteinModelPortaliB4EXS4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi529507.PMI1491.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAR43129; CAR43129; PMI1491.
GeneIDi6801877.
KEGGipmr:PMI1491.
PATRICi20517607. VBIProMir120933_1439.

Phylogenomic databases

eggNOGiENOG4105I93. Bacteria.
COG0784. LUCA.
HOGENOMiHOG000119811.
KOiK02485.
OMAiEERLFQD.
OrthoDBiPOG091H03L3.

Family and domain databases

HAMAPiMF_00958. RssB. 1 hit.
InterProiView protein in InterPro
IPR011006. CheY-like_superfamily.
IPR028616. RssB.
IPR010114. Sig_transdc_resp-reg_NtrC.
IPR001789. Sig_transdc_resp-reg_receiver.
PANTHERiPTHR32071:SF45. PTHR32071:SF45. 1 hit.
PfamiView protein in Pfam
PF00072. Response_reg. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiView protein in PROSITE
PS50110. RESPONSE_REGULATORY. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB4EXS4_PROMH
AccessioniPrimary (citable) accession number: B4EXS4
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: May 10, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.