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B4EXS4

- B4EXS4_PROMH

UniProt

B4EXS4 - B4EXS4_PROMH

Protein

Regulator of RpoS

Gene

rssB

Organism
Proteus mirabilis (strain HI4320)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Regulates the turnover of the sigma S factor (RpoS) by promoting its proteolysis in exponentially growing cells. Acts by binding and delivering RpoS to the ClpXP protease. RssB is not co-degraded with RpoS, but is released from the complex and can initiate a new cycle of RpoS recognition and degradation.UniRule annotation

    GO - Molecular functioni

    1. phosphorelay response regulator activity Source: InterPro

    GO - Biological processi

    1. positive regulation of proteolysis Source: UniProtKB-HAMAP
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. response to stress Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Stress responseUniRule annotation, Transcription, Transcription regulationUniRule annotation

    Enzyme and pathway databases

    BioCyciPMIR529507:GJIW-1502-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Regulator of RpoSUniRule annotation
    Gene namesi
    Name:rssBUniRule annotation
    Ordered Locus Names:PMI1491Imported
    OrganismiProteus mirabilis (strain HI4320)Imported
    Taxonomic identifieri529507 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus
    ProteomesiUP000008319: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei59 – 5914-aspartylphosphateUniRule annotation

    Post-translational modificationi

    Phosphorylated. Phosphorylation stimulates the interaction with RpoS and, therefore, the proteolysis of RpoS.UniRule annotation

    Keywords - PTMi

    PhosphoproteinUniRule annotation

    Interactioni

    Subunit structurei

    Binds to RpoS.UniRule annotation

    Protein-protein interaction databases

    STRINGi529507.PMI1491.

    Structurei

    3D structure databases

    ProteinModelPortaliB4EXS4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini9 – 124116Response regulatoryUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RssB family.UniRule annotation
    Contains 1 response regulatory domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0784.
    HOGENOMiHOG000119811.
    KOiK02485.
    OMAiHANVNTG.
    OrthoDBiEOG69GZGV.

    Family and domain databases

    HAMAPiMF_00958. RssB.
    InterProiIPR011006. CheY-like_superfamily.
    IPR028616. RssB.
    IPR001789. Sig_transdc_resp-reg_receiver.
    [Graphical view]
    PfamiPF00072. Response_reg. 1 hit.
    [Graphical view]
    SMARTiSM00448. REC. 1 hit.
    [Graphical view]
    SUPFAMiSSF52172. SSF52172. 1 hit.
    PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4EXS4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNKALVGKKI LIIDDEVVFR TMLTEYFSHE KACVYATDNG SQALLLLEEG    50
    LRPDLILCDI RMPVMNGPTF LCHLEQRHWS FPVIAISCTD NMAEIDDMLR 100
    FGAQDVFLKP VTNLAKLKQK VIEVLCPGFF ESELIARGQL GPLWNNLREQ 150
    PHYIQSFVKQ MQPQVKQIVA GYNVNYRQLN DASQMGLLFD IATLSKDQII 200
    FYCVDVSNDE ENGLLVALLL RVVFNRFLKA TEKRRFLPSM YNILNKINKM 250
    LEDMGVRGSF PLILGYYHTK EKNILLASAG LRAEIKTENK KYVLNSGIPL 300
    GTLHSLYINQ IKCVGIDWQC KIWNQHHKIN LMFSPIHKR 339
    Length:339
    Mass (Da):38,951
    Last modified:September 23, 2008 - v1
    Checksum:i3665BD57BD8CE9BD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM942759 Genomic DNA. Translation: CAR43129.1.
    RefSeqiYP_002151222.1. NC_010554.1.

    Genome annotation databases

    EnsemblBacteriaiCAR43129; CAR43129; PMI1491.
    GeneIDi6801877.
    KEGGipmr:PMI1491.
    PATRICi20517607. VBIProMir120933_1439.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM942759 Genomic DNA. Translation: CAR43129.1 .
    RefSeqi YP_002151222.1. NC_010554.1.

    3D structure databases

    ProteinModelPortali B4EXS4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 529507.PMI1491.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAR43129 ; CAR43129 ; PMI1491 .
    GeneIDi 6801877.
    KEGGi pmr:PMI1491.
    PATRICi 20517607. VBIProMir120933_1439.

    Phylogenomic databases

    eggNOGi COG0784.
    HOGENOMi HOG000119811.
    KOi K02485.
    OMAi HANVNTG.
    OrthoDBi EOG69GZGV.

    Enzyme and pathway databases

    BioCyci PMIR529507:GJIW-1502-MONOMER.

    Family and domain databases

    HAMAPi MF_00958. RssB.
    InterProi IPR011006. CheY-like_superfamily.
    IPR028616. RssB.
    IPR001789. Sig_transdc_resp-reg_receiver.
    [Graphical view ]
    Pfami PF00072. Response_reg. 1 hit.
    [Graphical view ]
    SMARTi SM00448. REC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52172. SSF52172. 1 hit.
    PROSITEi PS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HI4320Imported.

    Entry informationi

    Entry nameiB4EXS4_PROMH
    AccessioniPrimary (citable) accession number: B4EXS4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 23, 2008
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3