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B4EXS4

- B4EXS4_PROMH

UniProt

B4EXS4 - B4EXS4_PROMH

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Protein

Regulator of RpoS

Gene
rssB, PMI1491
Organism
Proteus mirabilis (strain HI4320)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Regulates the turnover of the sigma S factor (RpoS) by promoting its proteolysis in exponentially growing cells. Acts by binding and delivering RpoS to the ClpXP protease. RssB is not co-degraded with RpoS, but is released from the complex and can initiate a new cycle of RpoS recognition and degradation By similarity.UniRule annotation

GO - Molecular functioni

  1. phosphorelay response regulator activity Source: InterPro

GO - Biological processi

  1. positive regulation of proteolysis Source: UniProtKB-HAMAP
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. response to stress Source: UniProtKB-KW
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Stress responseUniRule annotation, Transcription, Transcription regulationUniRule annotation

Enzyme and pathway databases

BioCyciPMIR529507:GJIW-1502-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulator of RpoSUniRule annotation
Gene namesi
Name:rssBUniRule annotation
Ordered Locus Names:PMI1491Imported
OrganismiProteus mirabilis (strain HI4320)
Taxonomic identifieri529507 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus
ProteomesiUP000008319: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei59 – 5914-aspartylphosphate By similarityUniRule annotation

Post-translational modificationi

Phosphorylated. Phosphorylation stimulates the interaction with RpoS and, therefore, the proteolysis of RpoS By similarity.UniRule annotation

Keywords - PTMi

PhosphoproteinUniRule annotation

Interactioni

Subunit structurei

Binds to RpoS By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi529507.PMI1491.

Structurei

3D structure databases

ProteinModelPortaliB4EXS4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 124116Response regulatory By similarityUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the RssB family.UniRule annotation
Contains 1 response regulatory domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0784.
HOGENOMiHOG000119811.
KOiK02485.
OMAiHANVNTG.
OrthoDBiEOG69GZGV.

Family and domain databases

HAMAPiMF_00958. RssB.
InterProiIPR011006. CheY-like_superfamily.
IPR028616. RssB.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4EXS4-1 [UniParc]FASTAAdd to Basket

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MNKALVGKKI LIIDDEVVFR TMLTEYFSHE KACVYATDNG SQALLLLEEG    50
LRPDLILCDI RMPVMNGPTF LCHLEQRHWS FPVIAISCTD NMAEIDDMLR 100
FGAQDVFLKP VTNLAKLKQK VIEVLCPGFF ESELIARGQL GPLWNNLREQ 150
PHYIQSFVKQ MQPQVKQIVA GYNVNYRQLN DASQMGLLFD IATLSKDQII 200
FYCVDVSNDE ENGLLVALLL RVVFNRFLKA TEKRRFLPSM YNILNKINKM 250
LEDMGVRGSF PLILGYYHTK EKNILLASAG LRAEIKTENK KYVLNSGIPL 300
GTLHSLYINQ IKCVGIDWQC KIWNQHHKIN LMFSPIHKR 339
Length:339
Mass (Da):38,951
Last modified:September 23, 2008 - v1
Checksum:i3665BD57BD8CE9BD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM942759 Genomic DNA. Translation: CAR43129.1.
RefSeqiYP_002151222.1. NC_010554.1.

Genome annotation databases

EnsemblBacteriaiCAR43129; CAR43129; PMI1491.
GeneIDi6801877.
KEGGipmr:PMI1491.
PATRICi20517607. VBIProMir120933_1439.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM942759 Genomic DNA. Translation: CAR43129.1 .
RefSeqi YP_002151222.1. NC_010554.1.

3D structure databases

ProteinModelPortali B4EXS4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 529507.PMI1491.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR43129 ; CAR43129 ; PMI1491 .
GeneIDi 6801877.
KEGGi pmr:PMI1491.
PATRICi 20517607. VBIProMir120933_1439.

Phylogenomic databases

eggNOGi COG0784.
HOGENOMi HOG000119811.
KOi K02485.
OMAi HANVNTG.
OrthoDBi EOG69GZGV.

Enzyme and pathway databases

BioCyci PMIR529507:GJIW-1502-MONOMER.

Family and domain databases

HAMAPi MF_00958. RssB.
InterProi IPR011006. CheY-like_superfamily.
IPR028616. RssB.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view ]
Pfami PF00072. Response_reg. 1 hit.
[Graphical view ]
SMARTi SM00448. REC. 1 hit.
[Graphical view ]
SUPFAMi SSF52172. SSF52172. 1 hit.
PROSITEi PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HI4320Imported.

Entry informationi

Entry nameiB4EXS4_PROMH
AccessioniPrimary (citable) accession number: B4EXS4
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: June 11, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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