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B4EX94

- BETA_PROMH

UniProt

B4EX94 - BETA_PROMH

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Protein

Oxygen-dependent choline dehydrogenase

Gene
betA, PMI1459
Organism
Proteus mirabilis (strain HI4320)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei473 – 4731 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 3330FAD By similarityAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciPMIR529507:GJIW-1470-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenase (EC:1.1.99.1)
Short name:
CDH
Short name:
CHD
Alternative name(s):
Betaine aldehyde dehydrogenase (EC:1.2.1.8)
Short name:
BADH
Gene namesi
Name:betA
Ordered Locus Names:PMI1459
OrganismiProteus mirabilis (strain HI4320)
Taxonomic identifieri529507 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus
ProteomesiUP000008319: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Oxygen-dependent choline dehydrogenaseUniRule annotationPRO_1000133334Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi529507.PMI1459.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiYLQYACT.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4EX94-1 [UniParc]FASTAAdd to Basket

« Hide

MVYDYIIIGA GSAGNVLATR LTEDPDVTVL LLEAGGPDYR FDFRTQMPAA    50
LAYPLQGRRY NWAYETEPEP HMNNRRMECG RGKGLGGSSL INGMCYIRGN 100
AMDFDEWAKL PGLEDWNYLN CLPYFRKAET RDIGANDYHG DSGPVSVTTP 150
KKGNNVLFHA MVEAGVQAGY PRTDDLNGYQ QEGFGPMDRT VTPHGRRAST 200
ARGYLDQAKS RKNLTIETHA TTDIIEFEGK KASGVRYFKG TNTTPQHVKA 250
RKEILLCAGA IASPQILQRS GVGPEDVLNE FDISPVHVLP GVGQNLQDHL 300
EMYLQYECKQ PVSLYPALKW YNQPKIGAEW LFKGTGIGAS NQFEAGGFIR 350
SSEKFAWPNI QFHFLPVAIN YNGSNAVEVH GFQAHVGSMR SPSRGRIKIT 400
SRDPHQHPSI LFNYMSTEQD WQEFRAAIRI TREIMAQPAL DPYRGEEISP 450
GKDIQTDEQL DAFVRERAET AFHPCGSCKM GNDEMAVVDG AGRVHGIESL 500
RVIDASIMPN IITGNLNATT IMIAEKMADK IKGIKPLPAS QADYYVAGHS 550
PARRN 555
Length:555
Mass (Da):61,595
Last modified:September 23, 2008 - v1
Checksum:i759084978ECD3CE1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM942759 Genomic DNA. Translation: CAR43062.1.
RefSeqiYP_002151190.1. NC_010554.1.

Genome annotation databases

EnsemblBacteriaiCAR43062; CAR43062; PMI1459.
GeneIDi6802577.
KEGGipmr:PMI1459.
PATRICi20517543. VBIProMir120933_1407.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM942759 Genomic DNA. Translation: CAR43062.1 .
RefSeqi YP_002151190.1. NC_010554.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 529507.PMI1459.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR43062 ; CAR43062 ; PMI1459 .
GeneIDi 6802577.
KEGGi pmr:PMI1459.
PATRICi 20517543. VBIProMir120933_1407.

Phylogenomic databases

eggNOGi COG2303.
HOGENOMi HOG000139600.
KOi K00108.
OMAi YLQYACT.
OrthoDBi EOG67HJQP.

Enzyme and pathway databases

UniPathwayi UPA00529 ; UER00385 .
BioCyci PMIR529507:GJIW-1470-MONOMER.

Family and domain databases

HAMAPi MF_00750. Choline_dehydrogen.
InterProi IPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view ]
Pfami PF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsi TIGR01810. betA. 1 hit.
PROSITEi PS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HI4320.

Entry informationi

Entry nameiBETA_PROMH
AccessioniPrimary (citable) accession number: B4EX94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: September 3, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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