B4EWE1 (B4EWE1_PROMH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
3-ketoacyl-CoA thiolase EMBL CAR46952.1
EC=2.3.1.16 EMBL CAR46952.1

Gene names

Name:	fadA EMBL CAR46952.1
Ordered Locus Names:	PMI3549

Organism

Proteus mirabilis (strain HI4320) [Complete proteome] [HAMAP]

Taxonomic identifier

529507 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Proteus

Protein attributes

Sequence length	387 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. SAAS SAAS020613
Pathway	Lipid metabolism; fatty acid beta-oxidation. SAAS SAAS020613
Subunit structure	Heterotetramer of two alpha chains (fadB) and two beta chains (fadA) By similarity. SAAS SAAS020613
Sequence similarities	Belongs to the thiolase family. RuleBase RU003557

Ontologies

Keywords
Biological process	Fatty acid metabolism SAAS SAAS020613 Lipid degradation SAAS SAAS020613 Lipid metabolism
Cellular component	Cytoplasm SAAS SAAS020613
Molecular function	Acyltransferase RuleBase RU003558 SAAS SAAS012805 EMBL CAR46952.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid metabolic process Inferred from electronic annotation. Source: UniProtKB-KW lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	acetyl-CoA C-acyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B4EWE1 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 2D636102350B5672	FASTA	387	41,426
	10 20 30 40 50 60 MEKVVIIDGV RTPMGRSKGG AFRHVRAENL SAQLMQALLK RNPDIDPNDI GDVIWGCVQQ 70 80 90 100 110 120 TLEQGFNIAR NAALLAELPH KVPAVTVNRL CGSSMQALHD GARQIMLGES QVALIGGVEH 130 140 150 160 170 180 MGHVPMTYNA DFNPALNLSV AKASFSMGLT AEMLAKSFQI SREEQDKFAY RSHHLAALAT 190 200 210 220 230 240 QKGYFDNELV AINGHDTAGD FIRVSTDEVI RYNPSLDELA QLRPVFDPAT GSVTAGNSSA 250 260 270 280 290 300 VSDGASAMFI TSESYAKQHH LKPRAIIRSM AVTGCDPAIM GYGPVPATEI ALKKAGLTLS 310 320 330 340 350 360 DIDIFELNEA FAAQSLACMK KMNLLDSIDD KINLNGGAIA LGHPLGCSGA RITTTLLNIM 370 380 ERKDAQLGLA TMCIGLGQGI ATIIERV

References

[1]

"Complete genome sequence of uropathogenic Proteus mirabilis, a master of both adherence and motility." Pearson M.M., Sebaihia M., Churcher C., Quail M.A., Seshasayee A.S., Luscombe N.M., Abdellah Z., Arrosmith C., Atkin B., Chillingworth T., Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H., Rabbinowitsch E., Walker D., Whithead S. , Thomson N.R., Rather P.N., Parkhill J., Mobley H.L.T. J. Bacteriol. 190:4027-4037(2008) [PubMed: 18375554] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM942759 Genomic DNA. Translation: CAR46952.1.
RefSeq	YP_002153225.1. NC_010554.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B4EWE1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6800805.
GenomeReviews	Gene locus PMI3549 in contig AM942759_GR.
PATRIC	20521816. VBIProMir120933_3469.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG370930.
OMA	QDIVNIN.
ProtClustDB	PRK08947.
Family and domain databases
InterPro	IPR012805. FadA. IPR002155. Thiolase. IPR016039. Thiolase-like. IPR016038. Thiolase-like_subgr. IPR020615. Thiolase_acyl_enz_int_AS. IPR020610. Thiolase_AS. IPR020617. Thiolase_C. IPR020613. Thiolase_CS. IPR020616. Thiolase_N. [Graphical view]
Gene3D	G3DSA:3.40.47.10. Thiolase-like_subgr. 4 hits.
PANTHER	PTHR18919:SF35. PTHR18919:SF35. 1 hit. PTHR18919. Thiolase. 1 hit.
Pfam	PF02803. Thiolase_C. 1 hit. PF00108. Thiolase_N. 1 hit. [Graphical view]
PIRSF	PIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAM	SSF53901. Thiolase-like. 2 hits.
TIGRFAMs	TIGR01930. AcCoA-C-Actrans. 1 hit. TIGR02445. FadA. 1 hit.
PROSITE	PS00098. THIOLASE_1. 1 hit. PS00737. THIOLASE_2. 1 hit. PS00099. THIOLASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B4EWE1_PROMH

Accession

Primary (citable) accession number: B4EWE1

Entry history

Integrated into UniProtKB/TrEMBL:	September 23, 2008
Last sequence update:	September 23, 2008
Last modified:	December 14, 2011
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)