Reviewed, UniProtKB/Swiss-Prot B4EVC0 (PNCB_PROMH)

Names and origin

Protein names

Recommended name:
    Nicotinate phosphoribosyltransferase
      Short name=NAPRTase
    EC=2.4.2.11

Gene names

Name:	pncB
Ordered Locus Names:	PMI0767

Organism

Proteus mirabilis (strain HI4320) [Complete proteome] [HAMAP]

Taxonomic identifier

529507 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Proteus

Protein attributes

Sequence length	404 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00570
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP MF_00570
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NAPRTase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP nicotinate nucleotide biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nicotinate phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 404	404	Nicotinate phosphoribosyltransferase HAMAP MF_00570		PRO_1000129477

Sequences

	Sequence		Length	Mass (Da)
	B4EVC0-1 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: EE14D11DEC210512	FASTA	404	46,666
	10 20 30 40 50 60 MILDATPIIT SLLDTDAYKL HMQQAVYHHY SDIPVVAEFR CRSDERLGEY ATTLRHQVDM 70 80 90 100 110 120 MADLSLTNEE FGYLQSLPFF KNDYLQWFKH FRFKPEQVHI ATTADNQLTI KITGPWREVI 130 140 150 160 170 180 LWEVPLLALV SEIVHRARSP QITADDAVIQ LRKLIDIFYR DAAEQQIDLA DFKLMDFGTR 190 200 210 220 230 240 RRFSYDVQRA IVDELKNHFP YLIGTSNYHF AERMQLAPVG TQAHEWFQAH QQISPELANS 250 260 270 280 290 300 QRAALQSWLD EYPDQLGIAL TDCITMDAFL RDFDMPFASR YQGLRHDSGD PIEWGEKAIA 310 320 330 340 350 360 HYEKLGIDPM SKVLVFSDSL DFQKALVLYK HFHKRIRLIF GIGTRLTCNI PNITPLNIVI 370 380 390 400 KLVECNGKPV AKLSDSPGKT ICEDDEFVDK LRKAFDVPLV RQAC

References

[1]

"Complete genome sequence of uropathogenic Proteus mirabilis, a master of both adherence and motility." Pearson M.M., Sebaihia M., Churcher C., Quail M.A., Seshasayee A.S., Luscombe N.M., Abdellah Z., Arrosmith C., Atkin B., Chillingworth T., Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H., Rabbinowitsch E., Walker D., Whithead S. , Thomson N.R., Rather P.N., Parkhill J., Mobley H.L.T. J. Bacteriol. 190:4027-4037(2008) [PubMed: 18375554] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM942759 Genomic DNA. Translation: CAR41763.1.
RefSeq	YP_002150532.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6800791.
GenomeReviews	Gene locus PMI0767 in contig AM942759_GR.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	ALTDTFG.
Family and domain databases
HAMAP	MF_00570. [Tree]
InterPro	IPR006406. Nic_PRibTrfase. IPR015977. Nic_PRibTrfase-like. IPR007229. Nic_PRibTrfase-rel. [Graphical view]
PANTHER	PTHR11098:SF1. NAPRTase. 1 hit.
Pfam	PF04095. NAPRTase. 1 hit. [Graphical view]
PIRSF	PIRSF000484. NAPRT. 1 hit.
TIGRFAMs	TIGR01514. NAPRTase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PNCB_PROMH

Accession

Primary (citable) accession number: B4EVC0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	September 23, 2008
Last modified:	November 3, 2009
This is version 10 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)