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B4EVC0

- PNCB_PROMH

UniProt

B4EVC0 - PNCB_PROMH

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Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Proteus mirabilis (strain HI4320)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: InterPro

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciPMIR529507:GJIW-780-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:PMI0767
OrganismiProteus mirabilis (strain HI4320)
Taxonomic identifieri529507 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus
ProteomesiUP000008319: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Nicotinate phosphoribosyltransferasePRO_1000129477Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi529507.PMI0767.

Structurei

3D structure databases

ProteinModelPortaliB4EVC0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1488.
HOGENOMiHOG000284928.
KOiK00763.
OMAiQAVFHRY.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

B4EVC0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MILDATPIIT SLLDTDAYKL HMQQAVYHHY SDIPVVAEFR CRSDERLGEY
60 70 80 90 100
ATTLRHQVDM MADLSLTNEE FGYLQSLPFF KNDYLQWFKH FRFKPEQVHI
110 120 130 140 150
ATTADNQLTI KITGPWREVI LWEVPLLALV SEIVHRARSP QITADDAVIQ
160 170 180 190 200
LRKLIDIFYR DAAEQQIDLA DFKLMDFGTR RRFSYDVQRA IVDELKNHFP
210 220 230 240 250
YLIGTSNYHF AERMQLAPVG TQAHEWFQAH QQISPELANS QRAALQSWLD
260 270 280 290 300
EYPDQLGIAL TDCITMDAFL RDFDMPFASR YQGLRHDSGD PIEWGEKAIA
310 320 330 340 350
HYEKLGIDPM SKVLVFSDSL DFQKALVLYK HFHKRIRLIF GIGTRLTCNI
360 370 380 390 400
PNITPLNIVI KLVECNGKPV AKLSDSPGKT ICEDDEFVDK LRKAFDVPLV

RQAC
Length:404
Mass (Da):46,666
Last modified:September 23, 2008 - v1
Checksum:iEE14D11DEC210512
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM942759 Genomic DNA. Translation: CAR41763.1.
RefSeqiYP_002150532.1. NC_010554.1.

Genome annotation databases

EnsemblBacteriaiCAR41763; CAR41763; PMI0767.
GeneIDi6800791.
KEGGipmr:PMI0767.
PATRICi20516215. VBIProMir120933_0748.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM942759 Genomic DNA. Translation: CAR41763.1 .
RefSeqi YP_002150532.1. NC_010554.1.

3D structure databases

ProteinModelPortali B4EVC0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 529507.PMI0767.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR41763 ; CAR41763 ; PMI0767 .
GeneIDi 6800791.
KEGGi pmr:PMI0767.
PATRICi 20516215. VBIProMir120933_0748.

Phylogenomic databases

eggNOGi COG1488.
HOGENOMi HOG000284928.
KOi K00763.
OMAi QAVFHRY.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci PMIR529507:GJIW-780-MONOMER.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HI4320.

Entry informationi

Entry nameiPNCB_PROMH
AccessioniPrimary (citable) accession number: B4EVC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: October 1, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3