Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Proteus mirabilis (strain HI4320)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:PMI0767
OrganismiProteus mirabilis (strain HI4320)
Taxonomic identifieri529507 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesMorganellaceaeProteus
Proteomesi
  • UP000008319 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001294771 – 404Nicotinate phosphoribosyltransferaseAdd BLAST404

Interactioni

Protein-protein interaction databases

STRINGi529507.PMI0767

Structurei

3D structure databases

ProteinModelPortaliB4EVC0
SMRiB4EVC0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RH7 Bacteria
COG1488 LUCA
HOGENOMiHOG000284928
KOiK00763
OMAiKLTMQCA
OrthoDBiPOG091H0197

Family and domain databases

CDDicd01401 PncB_like, 1 hit
HAMAPiMF_00570 NAPRTase, 1 hit
InterProiView protein in InterPro
IPR006406 Nic_PRibTrfase
IPR007229 Nic_PRibTrfase-Fam
IPR036068 Nicotinate_pribotase_like_C
PANTHERiPTHR11098 PTHR11098, 1 hit
PfamiView protein in Pfam
PF04095 NAPRTase, 1 hit
PIRSFiPIRSF000484 NAPRT, 1 hit
SUPFAMiSSF51690 SSF51690, 1 hit
TIGRFAMsiTIGR01514 NAPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

B4EVC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILDATPIIT SLLDTDAYKL HMQQAVYHHY SDIPVVAEFR CRSDERLGEY
60 70 80 90 100
ATTLRHQVDM MADLSLTNEE FGYLQSLPFF KNDYLQWFKH FRFKPEQVHI
110 120 130 140 150
ATTADNQLTI KITGPWREVI LWEVPLLALV SEIVHRARSP QITADDAVIQ
160 170 180 190 200
LRKLIDIFYR DAAEQQIDLA DFKLMDFGTR RRFSYDVQRA IVDELKNHFP
210 220 230 240 250
YLIGTSNYHF AERMQLAPVG TQAHEWFQAH QQISPELANS QRAALQSWLD
260 270 280 290 300
EYPDQLGIAL TDCITMDAFL RDFDMPFASR YQGLRHDSGD PIEWGEKAIA
310 320 330 340 350
HYEKLGIDPM SKVLVFSDSL DFQKALVLYK HFHKRIRLIF GIGTRLTCNI
360 370 380 390 400
PNITPLNIVI KLVECNGKPV AKLSDSPGKT ICEDDEFVDK LRKAFDVPLV

RQAC
Length:404
Mass (Da):46,666
Last modified:September 23, 2008 - v1
Checksum:iEE14D11DEC210512
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM942759 Genomic DNA Translation: CAR41763.1
RefSeqiWP_004244666.1, NC_010554.1

Genome annotation databases

EnsemblBacteriaiCAR41763; CAR41763; PMI0767
GeneIDi6800791
KEGGipmr:PMI0767

Similar proteinsi

Entry informationi

Entry nameiPNCB_PROMH
AccessioniPrimary (citable) accession number: B4EVC0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: April 25, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health