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B4EVC0 (PNCB_PROMH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nicotinate phosphoribosyltransferase

Short name=NAPRTase
EC=6.3.4.21
Gene names
Name:pncB
Ordered Locus Names:PMI0767
OrganismProteus mirabilis (strain HI4320) [Complete proteome] [HAMAP]
Taxonomic identifier529507 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus

Protein attributes

Sequence length404 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity. HAMAP-Rule MF_00570

Catalytic activity

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate. HAMAP-Rule MF_00570

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP-Rule MF_00570

Sequence similarities

Belongs to the NAPRTase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 404404Nicotinate phosphoribosyltransferase HAMAP-Rule MF_00570
PRO_1000129477

Sequences

Sequence LengthMass (Da)Tools
B4EVC0 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: EE14D11DEC210512

FASTA40446,666
        10         20         30         40         50         60 
MILDATPIIT SLLDTDAYKL HMQQAVYHHY SDIPVVAEFR CRSDERLGEY ATTLRHQVDM 

        70         80         90        100        110        120 
MADLSLTNEE FGYLQSLPFF KNDYLQWFKH FRFKPEQVHI ATTADNQLTI KITGPWREVI 

       130        140        150        160        170        180 
LWEVPLLALV SEIVHRARSP QITADDAVIQ LRKLIDIFYR DAAEQQIDLA DFKLMDFGTR 

       190        200        210        220        230        240 
RRFSYDVQRA IVDELKNHFP YLIGTSNYHF AERMQLAPVG TQAHEWFQAH QQISPELANS 

       250        260        270        280        290        300 
QRAALQSWLD EYPDQLGIAL TDCITMDAFL RDFDMPFASR YQGLRHDSGD PIEWGEKAIA 

       310        320        330        340        350        360 
HYEKLGIDPM SKVLVFSDSL DFQKALVLYK HFHKRIRLIF GIGTRLTCNI PNITPLNIVI 

       370        380        390        400 
KLVECNGKPV AKLSDSPGKT ICEDDEFVDK LRKAFDVPLV RQAC 

« Hide

References

[1]"Complete genome sequence of uropathogenic Proteus mirabilis, a master of both adherence and motility."
Pearson M.M., Sebaihia M., Churcher C., Quail M.A., Seshasayee A.S., Luscombe N.M., Abdellah Z., Arrosmith C., Atkin B., Chillingworth T., Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H., Rabbinowitsch E., Walker D., Whithead S. expand/collapse author list , Thomson N.R., Rather P.N., Parkhill J., Mobley H.L.T.
J. Bacteriol. 190:4027-4037(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HI4320.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM942759 Genomic DNA. Translation: CAR41763.1.
RefSeqYP_002150532.1. NC_010554.1.

3D structure databases

ProteinModelPortalB4EVC0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING529507.PMI0767.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAR41763; CAR41763; PMI0767.
GeneID6800791.
KEGGpmr:PMI0767.
PATRIC20516215. VBIProMir120933_0748.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1488.
HOGENOMHOG000284928.
KOK00763.
OMAQAVFHRY.
OrthoDBEOG6X10XB.

Enzyme and pathway databases

BioCycPMIR529507:GJIW-780-MONOMER.
UniPathwayUPA00253; UER00457.

Family and domain databases

HAMAPMF_00570. NAPRTase.
InterProIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PfamPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFPIRSF000484. NAPRT. 1 hit.
SUPFAMSSF51690. SSF51690. 1 hit.
TIGRFAMsTIGR01514. NAPRTase. 1 hit.
ProtoNetSearch...

Entry information

Entry namePNCB_PROMH
AccessionPrimary (citable) accession number: B4EVC0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways