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B4EV14

- SYL_PROMH

UniProt

B4EV14 - SYL_PROMH

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Proteus mirabilis (strain HI4320)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei622 – 6221ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMIR529507:GJIW-439-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:PMI0433
OrganismiProteus mirabilis (strain HI4320)
Taxonomic identifieri529507 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus
ProteomesiUP000008319: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 860860Leucine--tRNA ligasePRO_1000091346Add
BLAST

Proteomic databases

PRIDEiB4EV14.

Structurei

3D structure databases

ProteinModelPortaliB4EV14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi619 – 6235"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4EV14-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQEQYRPEDI EQTIQEHWEK NNTFKVTEDN NKEKYYCLSM LPYPSGRLHM
60 70 80 90 100
GHVRNYTIGD VISRYQRMLG KNVLQPIGWD AFGLPAEGAA VKNNTAPAPW
110 120 130 140 150
TYENINYMKG QLKKLGFGYD WDREVTTCTP EYYRWEQWFF TKLYEKGLVY
160 170 180 190 200
KKTSAVNWCP HDLTVLANEQ VIDGCCWRCD TPVERKEIPQ WFIKITDYAE
210 220 230 240 250
ELLNDLDTLD EWPEQVKTMQ RNWIGRSEGV EITFDVADSD DTMTVYTTRP
260 270 280 290 300
DTFMGVTYVA VAAGHPLAQK AAQNNPEIQH FIDECRNMKM AEAEMATMEK
310 320 330 340 350
KGIATGLYAI HPLTQEKVAI WVANFVLMEY GTGAVMAVPG HDERDWEFAT
360 370 380 390 400
KYGLPIKAVI ADAEGNQPDL STGALTEKNS LINSGEFSGL DNQAGFNAIA
410 420 430 440 450
DKLTAMGVGE RKVNYRLRDW GVSRQRYWGA PIPMATLEDG SVVPVPDDQL
460 470 480 490 500
PVILPEDVKM DGITSPIKAD PEWAKTTING QPALRETDTF DTFMESSWYY
510 520 530 540 550
ARYTCPDYDK GMLDPKAANY WLPVDWYIGG IEHAIMHLMY FRFFHKLMRD
560 570 580 590 600
AGLVNSDEPA KRLLCQGMVL ADAFYYTGED GARHWVSPAE AIVERDEKNR
610 620 630 640 650
IIKATDSAGH ELTYAGMSKM SKSKNNGIDP QTMVERYGAD TVRLFMMFAA
660 670 680 690 700
PPELTLEWQE SSVEGANRFL RRLWRLVHEH TEKGTTQSLD LATLTTEQKD
710 720 730 740 750
LRRDLHKTIA KVSDDVGRRL AFNTAIAAIM ELMNKLTRAP QETEQDRALM
760 770 780 790 800
QEALEAVVRM LSPIIPHACF VMWQALGGKE DIDVAPWPVA DEEAMVDDTK
810 820 830 840 850
LIIVQVNGKV RGRITVPANS EKDYVQEMAT KEYSVAKYLE NVTVRKVIYV
860
PGKLLNIVVG
Length:860
Mass (Da):97,782
Last modified:September 23, 2008 - v1
Checksum:i0A1F73948C0830A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM942759 Genomic DNA. Translation: CAR41076.1.
RefSeqiYP_002150205.1. NC_010554.1.

Genome annotation databases

EnsemblBacteriaiCAR41076; CAR41076; PMI0433.
GeneIDi6802424.
KEGGipmr:PMI0433.
PATRICi20515543. VBIProMir120933_0421.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM942759 Genomic DNA. Translation: CAR41076.1 .
RefSeqi YP_002150205.1. NC_010554.1.

3D structure databases

ProteinModelPortali B4EV14.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi B4EV14.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR41076 ; CAR41076 ; PMI0433 .
GeneIDi 6802424.
KEGGi pmr:PMI0433.
PATRICi 20515543. VBIProMir120933_0421.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PMIR529507:GJIW-439-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HI4320.

Entry informationi

Entry nameiSYL_PROMH
AccessioniPrimary (citable) accession number: B4EV14
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3