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B4EV14

- SYL_PROMH

UniProt

B4EV14 - SYL_PROMH

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Proteus mirabilis (strain HI4320)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei622 – 6221ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPMIR529507:GJIW-439-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:PMI0433
    OrganismiProteus mirabilis (strain HI4320)
    Taxonomic identifieri529507 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus
    ProteomesiUP000008319: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 860860Leucine--tRNA ligasePRO_1000091346Add
    BLAST

    Proteomic databases

    PRIDEiB4EV14.

    Structurei

    3D structure databases

    ProteinModelPortaliB4EV14.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi42 – 5211"HIGH" regionAdd
    BLAST
    Motifi619 – 6235"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4EV14-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQEQYRPEDI EQTIQEHWEK NNTFKVTEDN NKEKYYCLSM LPYPSGRLHM    50
    GHVRNYTIGD VISRYQRMLG KNVLQPIGWD AFGLPAEGAA VKNNTAPAPW 100
    TYENINYMKG QLKKLGFGYD WDREVTTCTP EYYRWEQWFF TKLYEKGLVY 150
    KKTSAVNWCP HDLTVLANEQ VIDGCCWRCD TPVERKEIPQ WFIKITDYAE 200
    ELLNDLDTLD EWPEQVKTMQ RNWIGRSEGV EITFDVADSD DTMTVYTTRP 250
    DTFMGVTYVA VAAGHPLAQK AAQNNPEIQH FIDECRNMKM AEAEMATMEK 300
    KGIATGLYAI HPLTQEKVAI WVANFVLMEY GTGAVMAVPG HDERDWEFAT 350
    KYGLPIKAVI ADAEGNQPDL STGALTEKNS LINSGEFSGL DNQAGFNAIA 400
    DKLTAMGVGE RKVNYRLRDW GVSRQRYWGA PIPMATLEDG SVVPVPDDQL 450
    PVILPEDVKM DGITSPIKAD PEWAKTTING QPALRETDTF DTFMESSWYY 500
    ARYTCPDYDK GMLDPKAANY WLPVDWYIGG IEHAIMHLMY FRFFHKLMRD 550
    AGLVNSDEPA KRLLCQGMVL ADAFYYTGED GARHWVSPAE AIVERDEKNR 600
    IIKATDSAGH ELTYAGMSKM SKSKNNGIDP QTMVERYGAD TVRLFMMFAA 650
    PPELTLEWQE SSVEGANRFL RRLWRLVHEH TEKGTTQSLD LATLTTEQKD 700
    LRRDLHKTIA KVSDDVGRRL AFNTAIAAIM ELMNKLTRAP QETEQDRALM 750
    QEALEAVVRM LSPIIPHACF VMWQALGGKE DIDVAPWPVA DEEAMVDDTK 800
    LIIVQVNGKV RGRITVPANS EKDYVQEMAT KEYSVAKYLE NVTVRKVIYV 850
    PGKLLNIVVG 860
    Length:860
    Mass (Da):97,782
    Last modified:September 23, 2008 - v1
    Checksum:i0A1F73948C0830A9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM942759 Genomic DNA. Translation: CAR41076.1.
    RefSeqiYP_002150205.1. NC_010554.1.

    Genome annotation databases

    EnsemblBacteriaiCAR41076; CAR41076; PMI0433.
    GeneIDi6802424.
    KEGGipmr:PMI0433.
    PATRICi20515543. VBIProMir120933_0421.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM942759 Genomic DNA. Translation: CAR41076.1 .
    RefSeqi YP_002150205.1. NC_010554.1.

    3D structure databases

    ProteinModelPortali B4EV14.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi B4EV14.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAR41076 ; CAR41076 ; PMI0433 .
    GeneIDi 6802424.
    KEGGi pmr:PMI0433.
    PATRICi 20515543. VBIProMir120933_0421.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci PMIR529507:GJIW-439-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 3 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 3 hits.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HI4320.

    Entry informationi

    Entry nameiSYL_PROMH
    AccessioniPrimary (citable) accession number: B4EV14
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3