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B4EUT1

- GMHA_PROMH

UniProt

B4EUT1 - GMHA_PROMH

Protein

Phosphoheptose isomerase

Gene

gmhA

Organism
Proteus mirabilis (strain HI4320)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.UniRule annotation

    Catalytic activityi

    D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi61 – 611ZincUniRule annotation
    Metal bindingi65 – 651ZincUniRule annotation
    Binding sitei65 – 651SubstrateUniRule annotation
    Binding sitei124 – 1241SubstrateUniRule annotation
    Metal bindingi172 – 1721ZincUniRule annotation
    Binding sitei172 – 1721SubstrateUniRule annotation
    Metal bindingi180 – 1801ZincUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. D-sedoheptulose 7-phosphate isomerase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-glycero-D-manno-heptose 7-phosphate biosynthetic process Source: UniProtKB-UniPathway
    2. lipopolysaccharide core region biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Carbohydrate metabolism

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciPMIR529507:GJIW-346-MONOMER.
    UniPathwayiUPA00041; UER00436.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoheptose isomeraseUniRule annotation (EC:5.3.1.28UniRule annotation)
    Alternative name(s):
    Sedoheptulose 7-phosphate isomeraseUniRule annotation
    Gene namesi
    Name:gmhAUniRule annotation
    Ordered Locus Names:PMI0349
    OrganismiProteus mirabilis (strain HI4320)
    Taxonomic identifieri529507 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus
    ProteomesiUP000008319: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 192192Phosphoheptose isomerasePRO_1000092284Add
    BLAST

    Proteomic databases

    PRIDEiB4EUT1.

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi529507.PMI0349.

    Structurei

    3D structure databases

    ProteinModelPortaliB4EUT1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini37 – 192156SISUniRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni52 – 543Substrate bindingUniRule annotation
    Regioni93 – 942Substrate bindingUniRule annotation
    Regioni119 – 1213Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the SIS family. GmhA subfamily.UniRule annotation
    Contains 1 SIS domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0279.
    HOGENOMiHOG000237571.
    KOiK03271.
    OMAiHVFSRYV.
    OrthoDBiEOG6384PC.

    Family and domain databases

    HAMAPiMF_00067. GmhA.
    InterProiIPR004515. Phosphoheptose_Isoase.
    IPR001347. SIS.
    [Graphical view]
    PfamiPF13580. SIS_2. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00441. gmhA. 1 hit.
    PROSITEiPS51464. SIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4EUT1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYQDLIRGEL TEAADTLSRF LQDDANIEAI QKAAVLLADS FKAGGKVLSC    50
    GNGGSHCDAM HFAEELTGRY RENRPGYPAI AISDVSHISC VSNDFGYEYV 100
    FSRYVEAVGK EGDVLLGIST SGNSGNIIKA ISAAREKGMK VITLTGKDGG 150
    KMAGSADIEI RVPHFGYADR IQEIHIKVIH ILIQLIEKEM EK 192
    Length:192
    Mass (Da):20,852
    Last modified:September 23, 2008 - v1
    Checksum:i93C044E549B39254
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM942759 Genomic DNA. Translation: CAR40905.1.
    RefSeqiYP_002150122.1. NC_010554.1.

    Genome annotation databases

    EnsemblBacteriaiCAR40905; CAR40905; PMI0349.
    GeneIDi6800936.
    KEGGipmr:PMI0349.
    PATRICi20515345. VBIProMir120933_0332.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM942759 Genomic DNA. Translation: CAR40905.1 .
    RefSeqi YP_002150122.1. NC_010554.1.

    3D structure databases

    ProteinModelPortali B4EUT1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 529507.PMI0349.

    Proteomic databases

    PRIDEi B4EUT1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAR40905 ; CAR40905 ; PMI0349 .
    GeneIDi 6800936.
    KEGGi pmr:PMI0349.
    PATRICi 20515345. VBIProMir120933_0332.

    Phylogenomic databases

    eggNOGi COG0279.
    HOGENOMi HOG000237571.
    KOi K03271.
    OMAi HVFSRYV.
    OrthoDBi EOG6384PC.

    Enzyme and pathway databases

    UniPathwayi UPA00041 ; UER00436 .
    BioCyci PMIR529507:GJIW-346-MONOMER.

    Family and domain databases

    HAMAPi MF_00067. GmhA.
    InterProi IPR004515. Phosphoheptose_Isoase.
    IPR001347. SIS.
    [Graphical view ]
    Pfami PF13580. SIS_2. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00441. gmhA. 1 hit.
    PROSITEi PS51464. SIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: HI4320.

    Entry informationi

    Entry nameiGMHA_PROMH
    AccessioniPrimary (citable) accession number: B4EUT1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3