ID ARNT1_PROMH Reviewed; 548 AA. AC B4EUL1; DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot. DT 23-SEP-2008, sequence version 1. DT 27-MAR-2024, entry version 100. DE RecName: Full=Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase 1 {ECO:0000255|HAMAP-Rule:MF_01165}; DE EC=2.4.2.43 {ECO:0000255|HAMAP-Rule:MF_01165}; DE AltName: Full=4-amino-4-deoxy-L-arabinose lipid A transferase 1 {ECO:0000255|HAMAP-Rule:MF_01165}; DE AltName: Full=Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase {ECO:0000255|HAMAP-Rule:MF_01165}; DE AltName: Full=Undecaprenyl phosphate-alpha-L-Ara4N transferase 1 {ECO:0000255|HAMAP-Rule:MF_01165}; GN Name=arnT1 {ECO:0000255|HAMAP-Rule:MF_01165}; GN OrderedLocusNames=PMI0275; OS Proteus mirabilis (strain HI4320). OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; OC Morganellaceae; Proteus. OX NCBI_TaxID=529507; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=HI4320; RX PubMed=18375554; DOI=10.1128/jb.01981-07; RA Pearson M.M., Sebaihia M., Churcher C., Quail M.A., Seshasayee A.S., RA Luscombe N.M., Abdellah Z., Arrosmith C., Atkin B., Chillingworth T., RA Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H., RA Rabbinowitsch E., Walker D., Whithead S., Thomson N.R., Rather P.N., RA Parkhill J., Mobley H.L.T.; RT "Complete genome sequence of uropathogenic Proteus mirabilis, a master of RT both adherence and motility."; RL J. Bacteriol. 190:4027-4037(2008). CC -!- FUNCTION: Catalyzes the transfer of the L-Ara4N moiety of the CC glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The CC modified arabinose is attached to lipid A and is required for CC resistance to polymyxin and cationic antimicrobial peptides. CC {ECO:0000255|HAMAP-Rule:MF_01165}. CC -!- CATALYTIC ACTIVITY: CC Reaction=4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis- CC undecaprenyl phosphate + lipid IVA = lipid IIA + di-trans,octa-cis- CC undecaprenyl phosphate.; EC=2.4.2.43; Evidence={ECO:0000255|HAMAP- CC Rule:MF_01165}; CC -!- PATHWAY: Lipopolysaccharide metabolism; 4-amino-4-deoxy-beta-L- CC arabinose-lipid A biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01165}. CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP- CC Rule:MF_01165}; Multi-pass membrane protein {ECO:0000255|HAMAP- CC Rule:MF_01165}. CC -!- SIMILARITY: Belongs to the glycosyltransferase 83 family. CC {ECO:0000255|HAMAP-Rule:MF_01165}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AM942759; CAR40745.1; -; Genomic_DNA. DR RefSeq; WP_012367533.1; NC_010554.1. DR AlphaFoldDB; B4EUL1; -. DR SMR; B4EUL1; -. DR CAZy; GT83; Glycosyltransferase Family 83. DR EnsemblBacteria; CAR40745; CAR40745; PMI0275. DR GeneID; 6802481; -. DR KEGG; pmr:PMI0275; -. DR PATRIC; fig|529507.6.peg.265; -. DR eggNOG; COG1807; Bacteria. DR HOGENOM; CLU_019200_2_1_6; -. DR UniPathway; UPA00037; -. DR Proteomes; UP000008319; Chromosome. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0103015; F:4-amino-4-deoxy-L-arabinose transferase activity; IEA:UniProtKB-EC. DR GO; GO:0000030; F:mannosyltransferase activity; IEA:InterPro. DR GO; GO:0009245; P:lipid A biosynthetic process; IEA:UniProtKB-UniRule. DR GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-KW. DR GO; GO:0006493; P:protein O-linked glycosylation; IEA:InterPro. DR HAMAP; MF_01165; ArnT_transfer; 1. DR InterPro; IPR022839; ArnT_tfrase. DR InterPro; IPR003342; Glyco_trans_39/83. DR PANTHER; PTHR33908; MANNOSYLTRANSFERASE YKCB-RELATED; 1. DR PANTHER; PTHR33908:SF3; UNDECAPRENYL PHOSPHATE-ALPHA-4-AMINO-4-DEOXY-L-ARABINOSE ARABINOSYL TRANSFERASE; 1. DR Pfam; PF02366; PMT; 1. PE 3: Inferred from homology; KW Cell inner membrane; Cell membrane; Glycosyltransferase; KW Lipid A biosynthesis; Lipid biosynthesis; Lipid metabolism; KW Lipopolysaccharide biosynthesis; Membrane; Transferase; Transmembrane; KW Transmembrane helix. FT CHAIN 1..548 FT /note="Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L- FT arabinose arabinosyl transferase 1" FT /id="PRO_0000380013" FT TRANSMEM 11..31 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01165" FT TRANSMEM 89..109 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01165" FT TRANSMEM 114..134 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01165" FT TRANSMEM 137..157 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01165" FT TRANSMEM 180..200 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01165" FT TRANSMEM 214..234 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01165" FT TRANSMEM 263..283 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01165" FT TRANSMEM 292..312 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01165" FT TRANSMEM 314..334 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01165" FT TRANSMEM 347..367 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01165" FT TRANSMEM 382..402 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01165" FT TRANSMEM 405..425 FT /note="Helical" FT /evidence="ECO:0000255|HAMAP-Rule:MF_01165" SQ SEQUENCE 548 AA; 62263 MW; B7084221A0FD460C CRC64; MNIAMTERYK WLLFFLFILL TYFIPLETRL LWQPDEIRYA EISREMLVSG NWSVPYLLDI RYFEKPVLGY WINCIAQWLF GESHFAVRIV VVTSTLLTGW LIYKAAMVVW RNSALAFNAM TVFLSSFLVL AIGTYNILDP IVTLFVTAAM YSFLVALSTP NKKGKIIAYM GIGFFCALGF LTKGFIAVVL PALVFLVMAI SQARFKEVVC YSSIALLALA ITAGPWVITV ALQAPDYWNY FFWVEHVQRF IAKESARSQP TWFYIPIVIL GVLPWLGFLF GALKSAFSLK KGTLYFLLWF TLFFAFFSAS KGKLLTYMLP CFVPLSILIA HYIEELKDRP DEKISKVNAS INIAFGLMGI SAVIYSLYSA KFALYDTNET LKIVLAISGF LFWSVIGAGA LFRQTQFLTM FCSIGLSLVI GYAIPEKIES RSTPENIIQR YYEPLSNKSY LLTDEVGIGT SLAWGLKRTD IRLTETKGEL AYGLNYPDVK NKYYSLEQLL ALIEANQYKG VAIVLVRPDR KQILTKLTTL KEKPIVEKEG DLTLVFFN //