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B4EUL1

- ARNT1_PROMH

UniProt

B4EUL1 - ARNT1_PROMH

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Protein

Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase 1

Gene

arnT1

Organism
Proteus mirabilis (strain HI4320)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.UniRule annotation

Catalytic activityi

4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid IV(A) = lipid II(A) + di-trans,octa-cis-undecaprenyl phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. mannosyltransferase activity Source: InterPro
  2. transferase activity, transferring pentosyl groups Source: InterPro

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-HAMAP
  2. lipopolysaccharide biosynthetic process Source: UniProtKB-KW
  3. protein O-linked glycosylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis

Enzyme and pathway databases

BioCyciPMIR529507:GJIW-275-MONOMER.
UniPathwayiUPA00037.

Protein family/group databases

CAZyiGT83. Glycosyltransferase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase 1UniRule annotation (EC:2.4.2.43UniRule annotation)
Alternative name(s):
4-amino-4-deoxy-L-arabinose lipid A transferase 1UniRule annotation
Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferaseUniRule annotation
Undecaprenyl phosphate-alpha-L-Ara4N transferase 1UniRule annotation
Gene namesi
Name:arnT1UniRule annotation
Ordered Locus Names:PMI0275
OrganismiProteus mirabilis (strain HI4320)
Taxonomic identifieri529507 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus
ProteomesiUP000008319: Chromosome

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 548548Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase 1PRO_0000380013Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi529507.PMI0275.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121HelicalUniRule annotationAdd
BLAST
Transmembranei89 – 10921HelicalUniRule annotationAdd
BLAST
Transmembranei114 – 13421HelicalUniRule annotationAdd
BLAST
Transmembranei137 – 15721HelicalUniRule annotationAdd
BLAST
Transmembranei180 – 20021HelicalUniRule annotationAdd
BLAST
Transmembranei214 – 23421HelicalUniRule annotationAdd
BLAST
Transmembranei263 – 28321HelicalUniRule annotationAdd
BLAST
Transmembranei292 – 31221HelicalUniRule annotationAdd
BLAST
Transmembranei314 – 33421HelicalUniRule annotationAdd
BLAST
Transmembranei347 – 36721HelicalUniRule annotationAdd
BLAST
Transmembranei382 – 40221HelicalUniRule annotationAdd
BLAST
Transmembranei405 – 42521HelicalUniRule annotationAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 83 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1807.
HOGENOMiHOG000273002.
OMAiYNILDPI.
OrthoDBiEOG6NKQWN.

Family and domain databases

HAMAPiMF_01165. ArnT_transfer.
InterProiIPR022839. ArnT_tfrase.
IPR003342. Glyco_trans_39.
[Graphical view]
PfamiPF02366. PMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4EUL1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNIAMTERYK WLLFFLFILL TYFIPLETRL LWQPDEIRYA EISREMLVSG
60 70 80 90 100
NWSVPYLLDI RYFEKPVLGY WINCIAQWLF GESHFAVRIV VVTSTLLTGW
110 120 130 140 150
LIYKAAMVVW RNSALAFNAM TVFLSSFLVL AIGTYNILDP IVTLFVTAAM
160 170 180 190 200
YSFLVALSTP NKKGKIIAYM GIGFFCALGF LTKGFIAVVL PALVFLVMAI
210 220 230 240 250
SQARFKEVVC YSSIALLALA ITAGPWVITV ALQAPDYWNY FFWVEHVQRF
260 270 280 290 300
IAKESARSQP TWFYIPIVIL GVLPWLGFLF GALKSAFSLK KGTLYFLLWF
310 320 330 340 350
TLFFAFFSAS KGKLLTYMLP CFVPLSILIA HYIEELKDRP DEKISKVNAS
360 370 380 390 400
INIAFGLMGI SAVIYSLYSA KFALYDTNET LKIVLAISGF LFWSVIGAGA
410 420 430 440 450
LFRQTQFLTM FCSIGLSLVI GYAIPEKIES RSTPENIIQR YYEPLSNKSY
460 470 480 490 500
LLTDEVGIGT SLAWGLKRTD IRLTETKGEL AYGLNYPDVK NKYYSLEQLL
510 520 530 540
ALIEANQYKG VAIVLVRPDR KQILTKLTTL KEKPIVEKEG DLTLVFFN
Length:548
Mass (Da):62,263
Last modified:September 23, 2008 - v1
Checksum:iB7084221A0FD460C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM942759 Genomic DNA. Translation: CAR40745.1.
RefSeqiWP_012367533.1. NC_010554.1.
YP_002150055.1. NC_010554.1.

Genome annotation databases

EnsemblBacteriaiCAR40745; CAR40745; PMI0275.
GeneIDi6802481.
KEGGipmr:PMI0275.
PATRICi20515209. VBIProMir120933_0265.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM942759 Genomic DNA. Translation: CAR40745.1 .
RefSeqi WP_012367533.1. NC_010554.1.
YP_002150055.1. NC_010554.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 529507.PMI0275.

Protein family/group databases

CAZyi GT83. Glycosyltransferase Family 83.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR40745 ; CAR40745 ; PMI0275 .
GeneIDi 6802481.
KEGGi pmr:PMI0275.
PATRICi 20515209. VBIProMir120933_0265.

Phylogenomic databases

eggNOGi COG1807.
HOGENOMi HOG000273002.
OMAi YNILDPI.
OrthoDBi EOG6NKQWN.

Enzyme and pathway databases

UniPathwayi UPA00037 .
BioCyci PMIR529507:GJIW-275-MONOMER.

Family and domain databases

HAMAPi MF_01165. ArnT_transfer.
InterProi IPR022839. ArnT_tfrase.
IPR003342. Glyco_trans_39.
[Graphical view ]
Pfami PF02366. PMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HI4320.

Entry informationi

Entry nameiARNT1_PROMH
AccessioniPrimary (citable) accession number: B4EUL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3