UniProtKB - B4ETX3 (DDL_PROMH)
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Protein
D-alanine--D-alanine ligase
Gene
ddl
Organism
Proteus mirabilis (strain HI4320)
Status
Functioni
Cell wall formation.UniRule annotation
Catalytic activityi
ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotation
Cofactori
Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity
: peptidoglycan biosynthesis Pathwayi
This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotationView all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 302 | Magnesium or manganese 1UniRule annotation | 1 | |
Metal bindingi | 315 | Magnesium or manganese 1UniRule annotation | 1 | |
Metal bindingi | 315 | Magnesium or manganese 2UniRule annotation | 1 | |
Metal bindingi | 317 | Magnesium or manganese 2UniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 175 – 230 | ATPUniRule annotationAdd BLAST | 56 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- D-alanine-D-alanine ligase activity Source: UniProtKB-EC
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- cell wall organization Source: UniProtKB-KW
- peptidoglycan biosynthetic process Source: UniProtKB-UniPathway
- regulation of cell shape Source: UniProtKB-KW
Keywordsi
Molecular function | Ligase |
Biological process | Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis |
Ligand | ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
UniPathwayi | UPA00219. |
Names & Taxonomyi
Protein namesi | Recommended name: D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)Alternative name(s): D-Ala-D-Ala ligaseUniRule annotation D-alanylalanine synthetaseUniRule annotation |
Gene namesi | Name:ddlUniRule annotation Ordered Locus Names:PMI1243 |
Organismi | Proteus mirabilis (strain HI4320) |
Taxonomic identifieri | 529507 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Morganellaceae › Proteus › |
Proteomesi |
|
Subcellular locationi
- Cytoplasm UniRule annotation
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_1000091204 | 1 – 366 | D-alanine--D-alanine ligaseAdd BLAST | 366 |
Structurei
3D structure databases
ProteinModelPortali | B4ETX3. |
SMRi | B4ETX3. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 145 – 348 | ATP-graspUniRule annotationAdd BLAST | 204 |
Sequence similaritiesi
Belongs to the D-alanine--D-alanine ligase family.UniRule annotation
Phylogenomic databases
eggNOGi | ENOG4105CPF. Bacteria. COG1181. LUCA. |
HOGENOMi | HOG000011593. |
KOi | K01921. |
OMAi | RCDFFVI. |
OrthoDBi | POG091H06GK. |
Family and domain databases
Gene3Di | 3.30.1490.20. 1 hit. |
HAMAPi | MF_00047. Dala_Dala_lig. 1 hit. |
InterProi | View protein in InterPro IPR011761. ATP-grasp. IPR013815. ATP_grasp_subdomain_1. IPR000291. D-Ala_lig_Van_CS. IPR005905. D_ala_D_ala. IPR011095. Dala_Dala_lig_C. IPR011127. Dala_Dala_lig_N. IPR016185. PreATP-grasp_dom_sf. |
Pfami | View protein in Pfam PF07478. Dala_Dala_lig_C. 1 hit. PF01820. Dala_Dala_lig_N. 1 hit. |
PIRSFi | PIRSF039102. Ddl/VanB. 1 hit. |
SUPFAMi | SSF52440. SSF52440. 1 hit. |
TIGRFAMsi | TIGR01205. D_ala_D_alaTIGR. 1 hit. |
PROSITEi | View protein in PROSITE PS50975. ATP_GRASP. 1 hit. PS00843. DALA_DALA_LIGASE_1. 1 hit. PS00844. DALA_DALA_LIGASE_2. 1 hit. |
i Sequence
Sequence statusi: Complete.
B4ETX3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKLRVAIIF GGKSTEHQVS LQSAKNIINE LDRTKFDLCL IGINEQGQWH
60 70 80 90 100
EYAEDNYLIN SDNPSTISLS QPLRPVAIIP GSTRQQFISL TDGQPLAQID
110 120 130 140 150
VVFPIVHGAY GEDGTLQGLL HMIDMPYVGP NIMSSAACMD KDITKRLLDD
160 170 180 190 200
AGLAVAPFIT LMAHQLNDIS YNEVVEQLGL PLFIKPANLG SSVGISKVNN
210 220 230 240 250
EAEFNAALSM AFEYDLKVII ESAIVGREIE CAVLGNEEPE VSPCGEIVLN
260 270 280 290 300
DAFYAYNTKY IDDDGAKVVV PADLDNAISL HIRQTALKAY QVLNCLGMSR
310 320 330 340 350
VDVFLTEDNQ VIINEINTLP GFTNISMYPK LWQSTGLDYQ SLITKLIELA
360
LEHHKKTAVL KTKCEL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM942759 Genomic DNA. Translation: CAR42650.1. |
RefSeqi | WP_004242920.1. NC_010554.1. |
Genome annotation databases
EnsemblBacteriai | CAR42650; CAR42650; PMI1243. |
GeneIDi | 6800335. |
KEGGi | pmr:PMI1243. |
Similar proteinsi
Entry informationi
Entry namei | DDL_PROMH | |
Accessioni | B4ETX3Primary (citable) accession number: B4ETX3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 24, 2009 |
Last sequence update: | September 23, 2008 | |
Last modified: | March 28, 2018 | |
This is version 60 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |