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Protein

Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase 2

Gene

arnT2

Organism
Proteus mirabilis (strain HI4320)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.UniRule annotation

Catalytic activityi

4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid IV(A) = lipid II(A) + di-trans,octa-cis-undecaprenyl phosphate.UniRule annotation

Pathwayi: 4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis

This protein is involved in the pathway 4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis, which is part of Lipopolysaccharide metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway 4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis and in Lipopolysaccharide metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00037.

Protein family/group databases

CAZyiGT83. Glycosyltransferase Family 83.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase 2UniRule annotation (EC:2.4.2.43UniRule annotation)
Alternative name(s):
4-amino-4-deoxy-L-arabinose lipid A transferase 2UniRule annotation
Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferaseUniRule annotation
Undecaprenyl phosphate-alpha-L-Ara4N transferase 2UniRule annotation
Gene namesi
Name:arnT2UniRule annotation
Ordered Locus Names:PMI1047
OrganismiProteus mirabilis (strain HI4320)
Taxonomic identifieri529507 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesMorganellaceaeProteus
Proteomesi
  • UP000008319 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalUniRule annotationAdd BLAST21
Transmembranei85 – 105HelicalUniRule annotationAdd BLAST21
Transmembranei115 – 135HelicalUniRule annotationAdd BLAST21
Transmembranei137 – 157HelicalUniRule annotationAdd BLAST21
Transmembranei178 – 198HelicalUniRule annotationAdd BLAST21
Transmembranei208 – 228HelicalUniRule annotationAdd BLAST21
Transmembranei261 – 281HelicalUniRule annotationAdd BLAST21
Transmembranei295 – 315HelicalUniRule annotationAdd BLAST21
Transmembranei317 – 337HelicalUniRule annotationAdd BLAST21
Transmembranei352 – 372HelicalUniRule annotationAdd BLAST21
Transmembranei386 – 406HelicalUniRule annotationAdd BLAST21
Transmembranei410 – 430HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001379291 – 553Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase 2Add BLAST553

Interactioni

Protein-protein interaction databases

STRINGi529507.PMI1047.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 83 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105SA9. Bacteria.
COG1807. LUCA.
HOGENOMiHOG000273002.
KOiK07264.
OMAiAWRIFRD.
OrthoDBiPOG091H00H0.

Family and domain databases

HAMAPiMF_01165. ArnT_transfer. 1 hit.
InterProiIPR022839. ArnT_tfrase.
IPR003342. Glyco_trans_39/83.
[Graphical view]
PfamiPF02366. PMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4ETL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNNRASKIG AILLALFFVL TYLFPLNSRL LWQPDETRYA EISREMVVSG
60 70 80 90 100
NWIVPHMLDI RYFEKPIAGY WINNISQLIF GHTNFAVRFG SVISILLSAL
110 120 130 140 150
LIYLLARMMW RNRQVAFVAS LIYLSMFLVF SVGTYSVLDP MLALWVTASM
160 170 180 190 200
VCCFWALKAT TAKTRILAWI TLGLACGMAF MTKGFLALAI PVIVMIPVTL
210 220 230 240 250
YQKQFTRMLL YGVLAVLSAA LISLPWVLAV AKAEPDYWHY FFWVEHIQRF
260 270 280 290 300
SGDDAQHSSP FWYYIPIILL GVIPWLGLLP GALTSAWKKR RKRPELFFLL
310 320 330 340 350
CWFVVPFLFF SIAKGKLPTY MLPFMGPLAM LMAKYGVDCA RKFKMKALRI
360 370 380 390 400
NGYINIFIGV AAVVAILIIQ LVSSKPIYMP YEWSKWVLAI VAFSLWGIIG
410 420 430 440 450
YLCSTLNGKH WLWAASCSLG VSLCIGQAIP NSSIDGKLPQ EFIRQNIDTL
460 470 480 490 500
NASKYIVSNS VGVGAGLAWE LQRSDIYLYE RTGELTYGIE YPDSQHRLLK
510 520 530 540 550
PESFEQWLEN ARKEGNVSVV ITYKDPKKLA QMPRPEELVT NRRMAILTYE

KRK
Length:553
Mass (Da):63,064
Last modified:September 23, 2008 - v1
Checksum:iEA9B64AAE4EC1533
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM942759 Genomic DNA. Translation: CAR42273.1.
RefSeqiWP_012367836.1. NC_010554.1.

Genome annotation databases

EnsemblBacteriaiCAR42273; CAR42273; PMI1047.
GeneIDi6802570.
KEGGipmr:PMI1047.
PATRICi20516749. VBIProMir120933_1013.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM942759 Genomic DNA. Translation: CAR42273.1.
RefSeqiWP_012367836.1. NC_010554.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi529507.PMI1047.

Protein family/group databases

CAZyiGT83. Glycosyltransferase Family 83.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAR42273; CAR42273; PMI1047.
GeneIDi6802570.
KEGGipmr:PMI1047.
PATRICi20516749. VBIProMir120933_1013.

Phylogenomic databases

eggNOGiENOG4105SA9. Bacteria.
COG1807. LUCA.
HOGENOMiHOG000273002.
KOiK07264.
OMAiAWRIFRD.
OrthoDBiPOG091H00H0.

Enzyme and pathway databases

UniPathwayiUPA00037.

Family and domain databases

HAMAPiMF_01165. ArnT_transfer. 1 hit.
InterProiIPR022839. ArnT_tfrase.
IPR003342. Glyco_trans_39/83.
[Graphical view]
PfamiPF02366. PMT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARNT2_PROMH
AccessioniPrimary (citable) accession number: B4ETL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: November 2, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.