Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Proteus mirabilis (strain HI4320)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi65 – 72ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processOne-carbon metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:PMI0670
OrganismiProteus mirabilis (strain HI4320)
Taxonomic identifieri529507 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesMorganellaceaeProteus
Proteomesi
  • UP000008319 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001968201 – 556Formate--tetrahydrofolate ligaseAdd BLAST556

Interactioni

Protein-protein interaction databases

STRINGi529507.PMI0670.

Structurei

3D structure databases

SMRiB4ET09.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CKU. Bacteria.
COG2759. LUCA.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCGEIMTM.
OrthoDBiPOG091H01S8.

Family and domain databases

CDDicd00477. FTHFS. 1 hit.
HAMAPiMF_01543. FTHFS. 1 hit.
InterProiView protein in InterPro
IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF01268. FTHFS. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00721. FTHFS_1. 1 hit.

Sequencei

Sequence statusi: Complete.

B4ET09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSDIEISHQ APLLPIQDIA KKINVDQDDI EFYGKYKAKF SQSIWSKITS
60 70 80 90 100
KKQGKLVLVT SINPTPAGEG KTTVTVGLGQ ALNQLGKSAI IALREPSLGP
110 120 130 140 150
CFGLKGGAAG GGYSQVVPME DLNLHFTGDF HAITSANNLL AAMLDNSLYQ
160 170 180 190 200
GNPLNINPKK IIFKRCMDMN DRALRHLVIG LGGDKDGVVR EDSFVITVAS
210 220 230 240 250
EIMSILCLAK DINDLKQRLA RIIVAYNYEG EPVSAEDLNA VGAMATLLKD
260 270 280 290 300
ALNPNLVQTL ENTPAIIHGG PFANIAHGCN SLRATKLALQ LADITVTEAG
310 320 330 340 350
FGADLGAEKF FDIKCRIGDL QPDCAVLVVT TKALKYNGGL GKTQWDHENL
360 370 380 390 400
TALATGIENL GKHIENLKKY GVPVIVTVNA YVTDSAKEHE FIAQYCQQRG
410 420 430 440 450
CRFAISQVWE KGGAGGIELA NQVIDTLEND APQFQLLYPD NMPLKQKIET
460 470 480 490 500
IAQEIYGAKG VTYNANAQEM LTKIEDMGFG HFPICMAKTQ YSLSDDPALL
510 520 530 540 550
GRPTDFTINI REVYVSAGAG FVVSLTGTIN TMPGLPKKPA AMAMDVDDHG

AIKGLF
Length:556
Mass (Da):59,996
Last modified:September 23, 2008 - v1
Checksum:i63FE610A8CA6C3E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM942759 Genomic DNA. Translation: CAR41561.1.
RefSeqiWP_012367694.1. NC_010554.1.

Genome annotation databases

EnsemblBacteriaiCAR41561; CAR41561; PMI0670.
GeneIDi6800336.
KEGGipmr:PMI0670.
PATRICifig|529507.6.peg.652.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiFTHS_PROMH
AccessioniPrimary (citable) accession number: B4ET09
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: July 5, 2017
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families