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B4ET09 (FTHS_PROMH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:PMI0670
OrganismProteus mirabilis (strain HI4320) [Complete proteome] [HAMAP]
Taxonomic identifier529507 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus

Protein attributes

Sequence length556 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 556556Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000196820

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
B4ET09 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 63FE610A8CA6C3E5

FASTA55659,996
        10         20         30         40         50         60 
MKSDIEISHQ APLLPIQDIA KKINVDQDDI EFYGKYKAKF SQSIWSKITS KKQGKLVLVT 

        70         80         90        100        110        120 
SINPTPAGEG KTTVTVGLGQ ALNQLGKSAI IALREPSLGP CFGLKGGAAG GGYSQVVPME 

       130        140        150        160        170        180 
DLNLHFTGDF HAITSANNLL AAMLDNSLYQ GNPLNINPKK IIFKRCMDMN DRALRHLVIG 

       190        200        210        220        230        240 
LGGDKDGVVR EDSFVITVAS EIMSILCLAK DINDLKQRLA RIIVAYNYEG EPVSAEDLNA 

       250        260        270        280        290        300 
VGAMATLLKD ALNPNLVQTL ENTPAIIHGG PFANIAHGCN SLRATKLALQ LADITVTEAG 

       310        320        330        340        350        360 
FGADLGAEKF FDIKCRIGDL QPDCAVLVVT TKALKYNGGL GKTQWDHENL TALATGIENL 

       370        380        390        400        410        420 
GKHIENLKKY GVPVIVTVNA YVTDSAKEHE FIAQYCQQRG CRFAISQVWE KGGAGGIELA 

       430        440        450        460        470        480 
NQVIDTLEND APQFQLLYPD NMPLKQKIET IAQEIYGAKG VTYNANAQEM LTKIEDMGFG 

       490        500        510        520        530        540 
HFPICMAKTQ YSLSDDPALL GRPTDFTINI REVYVSAGAG FVVSLTGTIN TMPGLPKKPA 

       550 
AMAMDVDDHG AIKGLF 

« Hide

References

[1]"Complete genome sequence of uropathogenic Proteus mirabilis, a master of both adherence and motility."
Pearson M.M., Sebaihia M., Churcher C., Quail M.A., Seshasayee A.S., Luscombe N.M., Abdellah Z., Arrosmith C., Atkin B., Chillingworth T., Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H., Rabbinowitsch E., Walker D., Whithead S. expand/collapse author list , Thomson N.R., Rather P.N., Parkhill J., Mobley H.L.T.
J. Bacteriol. 190:4027-4037(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: HI4320.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM942759 Genomic DNA. Translation: CAR41561.1.
RefSeqYP_002150437.1. NC_010554.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING529507.PMI0670.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAR41561; CAR41561; PMI0670.
GeneID6800336.
KEGGpmr:PMI0670.
PATRIC20516023. VBIProMir120933_0652.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMALKHHGGV.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycPMIR529507:GJIW-684-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_PROMH
AccessionPrimary (citable) accession number: B4ET09
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: May 14, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways