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B4ET09

- FTHS_PROMH

UniProt

B4ET09 - FTHS_PROMH

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Proteus mirabilis (strain HI4320)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMIR529507:GJIW-684-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:PMI0670
OrganismiProteus mirabilis (strain HI4320)
Taxonomic identifieri529507 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeProteus
ProteomesiUP000008319: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Formate--tetrahydrofolate ligasePRO_1000196820Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi529507.PMI0670.

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4ET09-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKSDIEISHQ APLLPIQDIA KKINVDQDDI EFYGKYKAKF SQSIWSKITS
60 70 80 90 100
KKQGKLVLVT SINPTPAGEG KTTVTVGLGQ ALNQLGKSAI IALREPSLGP
110 120 130 140 150
CFGLKGGAAG GGYSQVVPME DLNLHFTGDF HAITSANNLL AAMLDNSLYQ
160 170 180 190 200
GNPLNINPKK IIFKRCMDMN DRALRHLVIG LGGDKDGVVR EDSFVITVAS
210 220 230 240 250
EIMSILCLAK DINDLKQRLA RIIVAYNYEG EPVSAEDLNA VGAMATLLKD
260 270 280 290 300
ALNPNLVQTL ENTPAIIHGG PFANIAHGCN SLRATKLALQ LADITVTEAG
310 320 330 340 350
FGADLGAEKF FDIKCRIGDL QPDCAVLVVT TKALKYNGGL GKTQWDHENL
360 370 380 390 400
TALATGIENL GKHIENLKKY GVPVIVTVNA YVTDSAKEHE FIAQYCQQRG
410 420 430 440 450
CRFAISQVWE KGGAGGIELA NQVIDTLEND APQFQLLYPD NMPLKQKIET
460 470 480 490 500
IAQEIYGAKG VTYNANAQEM LTKIEDMGFG HFPICMAKTQ YSLSDDPALL
510 520 530 540 550
GRPTDFTINI REVYVSAGAG FVVSLTGTIN TMPGLPKKPA AMAMDVDDHG

AIKGLF
Length:556
Mass (Da):59,996
Last modified:September 23, 2008 - v1
Checksum:i63FE610A8CA6C3E5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM942759 Genomic DNA. Translation: CAR41561.1.
RefSeqiYP_002150437.1. NC_010554.1.

Genome annotation databases

EnsemblBacteriaiCAR41561; CAR41561; PMI0670.
GeneIDi6800336.
KEGGipmr:PMI0670.
PATRICi20516023. VBIProMir120933_0652.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM942759 Genomic DNA. Translation: CAR41561.1 .
RefSeqi YP_002150437.1. NC_010554.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 529507.PMI0670.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAR41561 ; CAR41561 ; PMI0670 .
GeneIDi 6800336.
KEGGi pmr:PMI0670.
PATRICi 20516023. VBIProMir120933_0652.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci PMIR529507:GJIW-684-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HI4320.

Entry informationi

Entry nameiFTHS_PROMH
AccessioniPrimary (citable) accession number: B4ET09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: September 23, 2008
Last modified: October 1, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3