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B4EPB7 (TYPH_BURCJ) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine phosphorylase

EC=2.4.2.4
Alternative name(s):
TdRPase
Gene names
Name:deoA
Ordered Locus Names:BceJ2315_69820
ORF Names:BCAS0729
OrganismBurkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315)) [Complete proteome] [HAMAP]
Taxonomic identifier216591 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex

Protein attributes

Sequence length438 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis By similarity. HAMAP-Rule MF_01628

Catalytic activity

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_01628

Pathway

Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2. HAMAP-Rule MF_01628

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01628

Sequence similarities

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 438438Thymidine phosphorylase HAMAP-Rule MF_01628
PRO_1000186248

Sequences

Sequence LengthMass (Da)Tools
B4EPB7 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: DF0B1C8397AA91D0

FASTA43845,426
        10         20         30         40         50         60 
MFLPQEFIRR KRDGQPLDRD GMAAFVRGVT DGSVTEGQVA AFAMAVYFND LSTDERVALT 

        70         80         90        100        110        120 
LAQRDSGDVL DWRALDLDGP VIDKHSTGGV GDVVSLMLGP MVAACGGYVP MISGRGLGHT 

       130        140        150        160        170        180 
GGTLDKLSAI PGYDVMPATD AFRRTVREVG VAIIGQTARL APADKRIYAI RDVTATVESV 

       190        200        210        220        230        240 
AMITASILSK KLAAGLDGLV MDVKVGSGAF MPTAEKSAEL ARSIVDVGNG AGMKTTAILT 

       250        260        270        280        290        300 
DMNQSLAPCA GNALEVACAI DYLTGKSRPA RLHDVTMALS AELLVTGGLA RDVGHAREKL 

       310        320        330        340        350        360 
QQALDSGAAA ERFARMVVAL GGPADLLDAP ARHLARAVVI VPVPAPASGV VQRVDCRALG 

       370        380        390        400        410        420 
LAVVALGGGR TRAEDAIDVS VGLSALAEIG QRVEAGEPLG FVHARDEATA AHAADAIRRG 

       430 
YVLGDTGEAP PTLYQRVD 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM747722 Genomic DNA. Translation: CAR57663.1.
RefSeqYP_002154100.1. NC_011002.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING216591.BCAS0729.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAR57663; CAR57663; BCAS0729.
GeneID6803969.
KEGGbcj:BCAS0729.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0213.
HOGENOMHOG000047313.
KOK00758.
OMAHYRITED.

Enzyme and pathway databases

UniPathwayUPA00578; UER00638.

Family and domain databases

Gene3D3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPMF_01628. Thymid_phosp.
InterProIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013465. Thymidine_Pase.
[Graphical view]
PANTHERPTHR10515. PTHR10515. 1 hit.
PfamPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFPIRSF000478. TP_PyNP. 1 hit.
SMARTSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsTIGR02643. T_phosphoryl. 1 hit.
TIGR02644. Y_phosphoryl. 1 hit.
PROSITEPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYPH_BURCJ
AccessionPrimary (citable) accession number: B4EPB7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: September 23, 2008
Last modified: June 11, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways