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B4EMA7 (B4EMA7_BURCJ) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable L-aspartate dehydrogenase HAMAP MF_01265
EC=1.4.1.21 HAMAP MF_01265
Gene names
Name:nadX HAMAP MF_01265
Ordered Locus Names:BceJ2315_52930
ORF Names:BCAM1845 EMBL CAR55703.1
OrganismBurkholderia cepacia (strain J2315 / LMG 16656) (Burkholderia cenocepacia (strain J2315)) [Complete proteome] [HAMAP] EMBL CAR55703.1
Taxonomic identifier216591 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length275 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate By similarity. HAMAP MF_01265

Catalytic activity

L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H. HAMAP MF_01265

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (dehydrogenase route): step 1/1. HAMAP MF_01265

Miscellaneous

The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia By similarity. HAMAP MF_01265

Sequence similarities

Belongs to the L-aspartate dehydrogenase family. HAMAP MF_01265

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2281 By similarity HAMAP MF_01265
Binding site1321NAD; via amide nitrogen By similarity HAMAP MF_01265
Binding site1981NAD By similarity HAMAP MF_01265

Sequences

Sequence LengthMass (Da)Tools
B4EMA7 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: DB1BFBF649EA2C0E

FASTA27528,406
        10         20         30         40         50         60 
MHDDQKRAHA PVDVAMIGFG AIGAAVYHAV EHDASLRVAH VIVPAHQRAA VQGELGDAVE 

        70         80         90        100        110        120 
VVSSVDALAR RPEFALECAG HSALVDHVVP LLKAGTDCAV ASIGALSDLA LLDVLSQAAD 

       130        140        150        160        170        180 
EGGTTVTLLS GAIGGIDALA SAKQGGLDEV LYVGRKPPLG WLGTPAEELC DLRAMTGEKV 

       190        200        210        220        230        240 
IFEGTARDAA RLYPKNANVA ATVALAGLGL DATHVRLIAD PAVARNVHRI TARGAFGEMS 

       250        260        270 
LEMSGKPLPD NPKTSALTAY SAIRALRNRA ARCVI

« Hide

References

[1]"Genomic analysis of Burkholderia cenocepacia J2315, an epidemic cystic fibrosis pathogen."
Holden M.T.G.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM747721 Genomic DNA. Translation: CAR55703.1.
RefSeqYP_002234456.1. NC_011001.1.

3D structure databases

ProteinModelPortalB4EMA7.
ModBaseSearch...

Protein-protein interaction databases

STRINGB4EMA7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6929479.
GenomeReviewsGene locus BceJ2315_52930 in contig AM747721_GR.
KEGGbcj:BCAM1845.
PATRIC19083039. VBIBurCen118154_5634.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG649642.
OMAECAGHSA.
ProtClustDBPRK13303.

Family and domain databases

HAMAPMF_01265. NadX.
[Tree]
InterProIPR005106. Asp/hSer_DH_NAD-bd.
IPR002811. Asp_DH.
IPR011182. Asp_DH_NAD_syn.
IPR020626. Asp_DH_NAD_syn_prok.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK06989.
PfamPF01958. DUF108. 1 hit.
PF03447. NAD_binding_3. 1 hit.
[Graphical view]
PIRSFPIRSF005227. Asp_dh_NAD_syn. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB4EMA7_BURCJ
AccessionPrimary (citable) accession number: B4EMA7
Entry history
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: December 14, 2011
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info