B4EKS2 (UXUA_BURCJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannonate dehydratase
EC=4.2.1.8

Alternative name(s):
D-mannonate hydrolase

Gene names

Name:	uxuA
Ordered Locus Names:	BceJ2315_51210
ORF Names:	BCAM1672

Organism

Burkholderia cepacia (strain J2315 / LMG 16656) (Burkholderia cenocepacia (strain J2315)) [Complete proteome] [HAMAP]

Taxonomic identifier

216591 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › Burkholderia cepacia complex

Protein attributes

Sequence length	353 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O. HAMAP MF_00106
Pathway	Carbohydrate metabolism; pentose and glucuronate interconversion. HAMAP MF_00106
Sequence similarities	Belongs to the mannonate dehydratase family.

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glucuronate catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	mannonate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 353	353	Mannonate dehydratase HAMAP MF_00106		PRO_1000094212

Sequences

	Sequence		Length	Mass (Da)
	B4EKS2 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: ED6195AAFB840774	FASTA	353	39,141
	10 20 30 40 50 60 MKMSFRWYGE SDPVSLQYIR QIPGVTHIVS AIYDEPVGEV WPAHKIEALK ATIERAGLQF 70 80 90 100 110 120 DVVESVPVHE DIKLGKPGRD RLIDHYRQTI RHLGAAGIRV VCYNFMPVFD WTRTELSKTL 130 140 150 160 170 180 DDGSTCLAFS TDAVDRIDPN DGIALPGWDS SYRPEQLQAL LADYRDVDEN ALWANLEYFL 190 200 210 220 230 240 KAIIPVAEEA GVKMAIHPDD PPRPIFGLPR IVKNRDDLAR IVRLVDSPAN GLTLCSGSLG 250 260 270 280 290 300 AGPENDVEAL VREFGAMGRI HFAHIRNVKV DANGDFEETA HLSSCGSLDI AAIVKAYHDT 310 320 330 340 350 GFTGYVRPDH GRMIWGETGK PGYGLYDRAL GAVYLNGLWE ALAKFDRAPQ ASQ

References

[1]	"Genomic analysis of Burkholderia cenocepacia J2315, an epidemic cystic fibrosis pathogen." Holden M.T.G. Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: J2315 / LMG 16656.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM747721 Genomic DNA. Translation: CAR55529.1.
RefSeq	YP_002234284.1. NC_011001.1.
3D structure databases
ProteinModelPortal	B4EKS2.
ModBase	Search...
Protein-protein interaction databases
STRING	B4EKS2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6929314.
GenomeReviews	Gene locus BceJ2315_51210 in contig AM747721_GR.
KEGG	bcj:BCAM1672.
PATRIC	19082663. VBIBurCen118154_5447.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG585927.
OMA	DIKLGKP.
ProtClustDB	PRK03906.
Family and domain databases
HAMAP	MF_00106. UxuA. [Tree]
InterPro	IPR004628. Man_deHydtase. IPR013022. Xyl_isomerase-like_TIM-brl. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
KO	K01686.
Pfam	PF03786. UxuA. 1 hit. [Graphical view]
PIRSF	PIRSF016049. Man_dehyd. 1 hit.
SUPFAM	SSF51658. Xyl_isomerase-like_TIM-brl. 1 hit.
TIGRFAMs	TIGR00695. UxuA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UXUA_BURCJ

Accession

Primary (citable) accession number: B4EKS2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	September 23, 2008
Last modified:	January 25, 2012
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program